# positions[].organizations[].parent[].label
College of Agriculture and Life Sciences

# overview
Development and pathogenesis share the common features of responding to environmental conditions to execute a program of gene expression resulting in new cell types.

An important question in plant pathogenesis is to understanding the functions of pathogen effectors and their host target(s). Fungal effectors play roles in suppressing host defense mechanisms, however, other biotrophic functions, such as manipulating host physiology to promote nutrient acquisition and cell-to-cell movement are possible. Therefore, identification of the full set of fungal proteins secreted during host invasion is a major effort in plant pathology research. Candidate effectors are generally identified by virtue of i) their expression in planta ii) assessing their activity on the host using purified proteins or by manipulating expression iii) detecting the rapid evolution of effector genes due to selective pressure from the host. My lab is using a combination of these approaches to identify and characterize a gene family of putative effectors from Magnaporthe oryzae, the rice blast fungus and define interactions with monocot hosts.

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Carbon-nitrogen Ligases With Glutamine As Amide-n-donor

# keywords[]
1.1 Normal Biological Development And Functioning

# educationAndTraining[].organization.label
Stanford University - (Stanford, California, United States)

# educationAndTraining[].organization.label
Purdue University - (West Lafayette, Indiana, United States)

# educationAndTraining[].organization.label
Indiana University Bloomington - (Bloomington, Indiana, United States)

# publications[].label
Recurrent locus-specific mutation resulting from a cryptic ectopic insertion in Neurospora.

# publications[].label
The Neurospora crassa pheromone precursor genes are regulated by the mating type locus and the circadian clock.

# publications[].label
Light and developmental regulation of the gene con-10 of Neurospora crassa.

# publications[].label
How Fungi Sense Sugars, Alcohols, and Amino Acids

# publications[].label
cpc-1, the general regulatory gene for genes of amino acid biosynthesis in Neurospora crassa, is differentially expressed during the asexual life cycle.

# publications[].label
Characterization of a 21 member effector gene family from the rice blast fungus

# publications[].label
A reliable microplate assay for determination of B-galactosidase activity in Neurospora crassa strains bearing lacZ fusions

# publications[].label
Isolation and Functional Analysis of Putative Effectors from Magnaporthe oryzae Using Integrated Genomic Approaches

# publications[].label
Magnaporthe oryzae CK2 Accumulates in Nuclei, Nucleoli, at Septal Pores and Forms a Large Ring Structure in Appressoria, and Is Involved in Rice Blast Pathogenesis.

# publications[].label
Gene discovery and gene expression in the rice blast fungus, Magnaporthe grisea: analysis of expressed sequence tags.

# publications[].label
Structure and dynamics of the microbial communities underlying the carboxylate platform for biofuel production.

# publications[].label
The genome sequence of the rice blast fungus Magnaporthe grisea.

# publications[].label
Magnaporthe as a model for understanding host-pathogen interactions.

# publications[].label
Developing Resources for Analysis of Secreted Proteins from Magnaporthe oryzae

# publications[].label
Organization and regulation of genes encoding biosynthetic enzymes in Bacillus subtilis.

# publications[].label
Analysis of two transcription activation elements in the promoter of the developmentally regulated con-10 gene of Neurospora crassa.

# publications[].label
Identification and characterization of in planta-expressed secreted effector proteins from Magnaporthe oryzae that induce cell death in rice.

# publications[].label
Hydrophobins and fungal infection of plants and animals.

# publications[].label
The rice blast story: from genome sequence to function

# publications[].label
Independent and Synergistic Activity of Synthetic Peptides Against Thiabendazole-Resistant Fusarium sambucinum.

# publications[].label
The arms race between Magnaporthe oryzae and rice: Diversity and interaction of Avr and R genes

# publications[].label
The exocyst complex: delivery hub for morphogenesis and pathogenesis in filamentous fungi.

# publications[].label
Biochemical and molecular characterization of a putative endoglucanase in Magnaporthe grisea.

# publications[].label
acon-3, the Neurospora crassa ortholog of the developmental modifier, medA, complements the conidiation defect of the Aspergillus nidulans mutant.

# publications[].label
vvd is required for light adaptation of conidiation-specific genes of Neurospora crassa, but not circadian conidiation.

# publications[].label
HAG Effector Evolution in Pyricularia Species and Plant Cell Death Suppression by HAG4.

# publications[].label
Cross-pathway and pathway-specific control of amino acid biosynthesis in Magnaporthe grisea.

# publications[].label
Magnaporthe oryzae CK2 is involved in rice blast pathogenesis and accumulates in nuclei, nucleoli, at septal and appressoria pores and forms a large ring structure in appressoria

# publications[].label
Detection of pur operon-attenuated mRNA and accumulated degradation intermediates in Bacillus subtilis.

# publications[].label
cot-1, a gene required for hyphal elongation in Neurospora crassa, encodes a protein kinase.

# publications[].label
rco-3, a gene involved in glucose transport and conidiation in Neurospora crassa.

# publications[].label
Functional analysis of pathogenicity genes in a genomics world.

# publications[].label
Fluffy, the major regulator of conidiation in Neurospora crassa, directly activates a developmentally regulated hydrophobin gene.

# publications[].label
WD40-repeat protein MoCreC is essential for carbon repression and is involved in conidiation, growth and pathogenicity of Magnaporthe oryzae.

# publications[].label
Carbon catabolite repression of gene expression and conidiation in Neurospora crassa.

# publications[].label
Cross-Pathway and Pathway-Specific Control of Amino Acid Biosynthesis in Magnaporthe grisea.

# publications[].label
Neurospora crassa ASM-1 complements the conidiation defect in a stuA mutant of Aspergillus nidulans.

# publications[].label
Interaction of a putative repressor protein with an extended control region of the Bacillus subtilis pur operon.

# publications[].label
Population genomic analysis of the rice blast fungus reveals specific events associated with expansion of three main clades.

# publications[].label
Morphogenesis and vegetative differentiation in filamentous fungi

# publications[].label
How Fungi Sense Sugars, Alcohols, and Amino Acids

# publications[].label
Cellular and Molecular Biology of Filamentous Fungi Preface

# publications[].label
Isolation of pheromone precursor genes of Magnaporthe grisea.

# publications[].label
MPG1, a gene encoding a fungal hydrophobin of Magnaporthe grisea, is involved in surface recognition.

# publications[].label
Emergence of a hybrid PKS-NRPS secondary metabolite cluster in a clonal population of the rice blast fungus Magnaporthe oryzae.

# publications[].label
Identification and characterization of MPG1, a gene involved in pathogenicity from the rice blast fungus Magnaporthe grisea.

# publications[].label
Directional Selection from Host Plants Is a Major Force Driving Host Specificity in Magnaporthe Species.

# publications[].label
Fungal biology and agriculture: revisiting the field.

# publications[].label
MGOS: A resource for studying Magnaporthe grisea and Oryza sativa interactions.

# publications[].label
Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism.

# publications[].label
A mitogen-activated protein kinase pathway essential for mating and contributing to vegetative growth in Neurospora crassa.

# publications[].label
Tissue-specific repression of starvation and stress responses of the Neurospora crassa con-10 gene is mediated by RCO1.

# publications[].label
Characterization of rco-1 of Neurospora crassa, a pleiotropic gene affecting growth and development that encodes a homolog of Tup1 of Saccharomyces cerevisiae.

# publications[].label
The fluffy gene of Neurospora crassa encodes a Gal4p-type C6 zinc cluster protein required for conidial development.

# publications[].label
A Magnaporthe Chitinase Interacts with a Rice Jacalin-Related Lectin to Promote Host Colonization.

# publications[].label
Bacillus subtilis pur operon expression and regulation.

# publications[].label
Comparative genome sequence analysis underscores mycoparasitism as the ancestral life style of Trichoderma.

# publications[].label
The genome sequence of the filamentous fungus Neurospora crassa.

# publications[].label
Overexpression of White Collar-1 (WC-1) activates circadian clock-associated genes, but is not sufficient to induce most light-regulated gene expression in Neurospora crassa.

# publications[].label
Mesophilic and thermophilic conditions select for unique but highly parallel microbial communities to perform carboxylate platform biomass conversion.

# publications[].label
Gene Ontology annotation of the rice blast fungus, Magnaporthe oryzae.

# publications[].label
Evolution and Regulation of a Large Effector Family of Pyricularia oryzae.

# publications[].label
Functional analysis of an alpha-1,2-mannosidase from Magnaporthe oryzae.

# publications[].label
Identification of peptaibols from Trichoderma virens and cloning of a peptaibol synthetase.

# publications[].label
Mutants of Neurospora crassa that alter gene expression and conidia development.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
The fluffy gene of Neurospora crassa is necessary and sufficient to induce conidiophore development.

# publications[].label
Identification of a gene from Neurospora crassa with similarity to a glucoamylase gene from Schwanniomyces occidentalis

# publications[].label
Temporal and spatial regulation of gene expression during asexual development of Neurospora crassa.

# publications[].label
Analysis of a virulence gene family of Pyricularia from cereal and grass hosts

# publications[].label
Neurospora: a new (?) model system for microbial genetics Neurospora 2000, Asilomar, CA, USA, 912 March 2000

# publications[].label
Transcriptional response to glucose starvation and functional analysis of a glucose transporter of Neurospora crassa.

# publications[].label
Retromer Is Essential for Autophagy-Dependent Plant Infection by the Rice Blast Fungus.

# publications[].label
Rab GTPases are essential for membrane trafficking-dependent growth and pathogenicity in Fusarium graminearum.

# publications[].label
The fluffy Gene of Neurospora crassa Is Necessary and Sufficient to Induce Conidiophore Development

# publications[].label
The Neurospora rca-1 gene complements an Aspergillus flbD sporulation mutant but has no identifiable role in Neurospora sporulation.

# publications[].label
Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis.

# publications[].label
Inhibition of pathogenicity of the rice blast fungus by Saccharomyces cerevisiae alpha-factor.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# researcherOn[].label
Molecular Analysis of Fungal Pathogenesis

# researcherOn[].awardedBy.label
National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States)

# streetAddress
Texas A&M University; Plant Pathology & Microbiology; 2132 TAMU

# organizations[]
College of Agriculture and Life Sciences

# schools[]
College of Agriculture and Life Sciences

# etdChairOf[].label
Li, Dan (2003-05). A map kinase pathway essential for mating and contributing to asexual development in Neurospora Crassa. Doctoral Dissertation.

# etdChairOf[].label
Shang, Yue (2003-05). Analysis of secreted proteins of Magnaporthe grisea and the search for protein effectors. Master's Thesis.

# etdChairOf[].label
Rerngsamran, Panan (2005-05). Functional analysis of fluffy, a transcriptional regulator for conidial development in Neurospora crassa. Doctoral Dissertation.

# etdChairOf[].label
Filippi, Marta Cristina (2004-08). Signalling pathway in appressorium formation in Magnaporthe grisea. Doctoral Dissertation.

# etdChairOf[].label
Xie, Xin (2003-08). Sugar sensing and regulation of conidiation in Neurospora crassa. Doctoral Dissertation.