# preferredTitle
Certification Officer and Associate Professor

# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
The Stephan Lab is focused on drug discovery research.  Dr. Stephan directs both the Combinatorial Drug Discovery Program (CDDP) core and the Microphysiological Lead Optimization and Toxicity Screening (MLOTS) facilities.  The CDDP is a high throughput screening and automated microscopy core focused on discovering new therapeutics from library screening and drug repurposing alone or in multi-drug combinations.  MLOTS is a low to medium throughput core focused on lead optimization for new chemical entities with the capability of testing compounds in complex in vitro models (e.g., spheroids, organoids) and de-risking drug leads by evaluating their potential cardiovascular or CNS toxicities via micro electrode array or hepatotoxcity in a microfluidic liver model.

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Squamous Cell Carcinoma Of Head And Neck

# keywords[]
Von Hippel-Lindau Tumor Suppressor Protein

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Atpases Associated With Diverse Cellular Activities

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Vascular Endothelial Growth Factor Receptor-1

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
Von Hippel-Lindau Tumor Suppressor Protein

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Von Hippel-Lindau Tumor Suppressor Protein

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
3205 Medical Biochemistry And Metabolomics

# educationAndTraining[].organization.label
Vanderbilt University - (Nashville, Tennessee, United States)

# educationAndTraining[].organization.label
Brigham and Women's Hospital - (Boston, Massachusetts, United States)

# educationAndTraining[].organization.label
Vanderbilt University - (Nashville, Tennessee, United States)

# publications[].label
HGG-14. IDENTIFICATION OF PERSONALIZED ACTIVE AGENTS IN PEDIATRIC GLIOMAS THROUGH HIGH-THROUGHPUT DRUG SCREENING IN MATCHING PAIRS OF PATIENT DERIVED ORTHOTOPIC XENOGRAFT (PDOX) NEUROSPHERE AND MONOLAYER CELLS

# publications[].label
Role for nitric oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF.

# publications[].label
Abstract 695: Synergistic antitumor effects of polo like kinase inhibitor volasertib in combination with ionizing radiation in glioblastoma

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Microphysiological Systems Evaluation: Experience of TEX-VAL Tissue Chip Testing Consortium.

# publications[].label
Chemical genetic analysis of enoxolone inhibition of Clostridioides difficile toxin production reveals adenine deaminase and ATP synthase as antivirulence targets.

# publications[].label
Identification of Inhibitors of Integrin Cytoplasmic Domain Interactions With Syk.

# publications[].label
Targeting neddylation and sumoylation in chemoresistant triple negative breast cancer.

# publications[].label
HGG-01. RADIATION INCREASES PRE-CLINICAL EFFICACY OF OLIG2 INHIBITOR CT-179 IN PEDIATRIC GBM

# publications[].label
TMOD-21. TARGETING ANAPLASTIC MENINGIOMA WITH PANOBINOSTAT IN PATIENT-DERIVED ORTHOTOPIC XENOGRAFT (PDOX) MODELS DERIVED FROM A MATCHING PAIR OF PRIMARY AND RECURRENT TUMORS

# publications[].label
A high content clonogenic survival drug screen identifies mek inhibitors as potent radiation sensitizers for KRAS mutant non-small-cell lung cancer.

# publications[].label
Predicting high-throughput screening results with scalable literature-based discovery methods.

# publications[].label
Inhibition of GPX4 Induces the Death of p53-Mutant Triple-Negative Breast Cancer

# publications[].label
ATPS-19POLO LIKE KINASE INHIBITOR VOLASERTIB SYNERGISTICALLY IMPROVE RADIATION EFFICACY IN GLIOBLASTOMA

# publications[].label
Chemically targeting the redox switch in AP1 transcription factor FOSB.

# publications[].label
deepOrganoid: A brightfield cell viability model for screening matrix-embedded organoids.

# publications[].label
Abstract B20: Unbiased high-throughput screenings to identify combination therapies targeting RAS-mutated colorectal cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells.

# publications[].label
Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state.

# publications[].label
Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns.

# publications[].label
Bexarotene - a novel modulator of AURKA and the primary cilium in VHL-deficient cells.

# publications[].label
A global genomic and small molecule inhibitor interrogation of KIT mutant melanoma to reveal underlying biology and novel molecular targets

# publications[].label
Vascular endothelial growth factor, a multifunctional polypeptide.

# publications[].label
The polo-like kinase 1 inhibitor volasertib synergistically increases radiation efficacy in glioma stem cells.

# publications[].label
Overcoming therapy resistance in stem cell-rich triple negative breast cancer through p38 MAP kinase inhibition

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract 1244: An in vitro biological assay to identify small molecule upregulators of let-7 miRNA in LIN28- positive ovarian cancer cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
EPCO-39. ADAPTIVE CONVERGENCE OF METHYLOMES REVEALS EPIGENETIC DRIVERS AND BOOSTERS OF REPEATED RELAPSES IN PATIENT-MATCHED CHILDHOOD EPENDYMOMAS AND IDENTIFIES TARGETS FOR ANTI-RECURRENCE THERAPIES

# publications[].label
Abstract P3-03-08: Identification of drugs that induce the death or suppress the growth of p53-mutant breast cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Bioluminescence Methodology for Ion Channel Studies.

# publications[].label
Abstract 4994: Crizotinib enhances the efficacy of BX-795 identified by high-throughput screening of pan-active drugs in colorectal cancer cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Publisher Correction: Epigenetic alterations of repeated relapses in patient-matched childhood ependymomas.

# publications[].label
Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus-Driven Cancers.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract 368: Aurora kinase inhibitors cause cell death in HPV+ cells: A plausible treatment option for HPV+ cancers

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
A Combination Strategy Targeting Enhancer Plasticity Exerts Synergistic Lethality Against Beti-Resistant Leukemia Cells

# publications[].label
Abstract B171: BX-795 enhances the efficacy of crizotinib in colorectal cancer cells by altering the activity of aurora kinases

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
PDTM-31. IDENTIFICATION OF PERSONALIZED ACTIVE AGENTS IN PEDIATRIC GLIOMAS THROUGH HIGH-THROUGHPUT DRUG SCREENING IN MATCHING PAIRS OF PATIENT DERIVED ORTHOTOPIC XENOGRAFT (PDOX) NEUROSPHERE AND MONOLAYER CELLS

# publications[].label
Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes.

# publications[].label
Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract 4214: Identification of personalized active agents in pediatric gliomas through high-throughput drug screening in matching pairs of patient derived orthotopic xenograft (PDOX) neurosphere and monolayer cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Combined inhibition of HMGCoA reductase and mitochondrial complex I induces tumor regression of BRAF inhibitor-resistant melanomas.

# publications[].label
Targeting the Oncogenic Functions of an RNA-Binding Protein Involved in Hematologic Malignancies

# publications[].label
Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling.

# publications[].label
Abstract P6-10-19: Screening of GPCR-targeting drugs for repositioning in breast cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas.

# publications[].label
Mapping the Relative Biological Effectiveness of Proton, Helium and Carbon Ions with High-Throughput Techniques.

# publications[].label
EPEN-46. DNA METHYLATION LANDSCAPE OF RECURRENT PEDIATRIC EPENDYMOMA IDENTIFIES KEY DRIVER EVENTS

# publications[].label
EXTH-08. NOVEL OLIG2 INHIBITOR DEMONSTRATES PRE-CLINICAL EFFICACY IN PEDIATRIC GBM

# publications[].label
Single cell transcriptomic profiling of ex vivo tumoroid models reveal therapeutic vulnerabilities of pancreatic ductal adenocarcinoma

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Epichaperome inhibition targets TP53-mutant AML and AML stem/progenitor cells.

# publications[].label
Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
High-throughput synthetic lethal drug screen to identify novel radiation sensitizers for KRAS mutant non-small cell lung cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Gain-of-Function Chromatin Remodeling Activity of Oncogenic FOXL2-C134W Reprograms Glucocorticoid Receptor Occupancy to Drive Granulosa Cell Tumors.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Defective Replication Stress Response Is Inherently Linked to the Cancer Stem Cell Phenotype.

# publications[].label
Abstract LB-041: Establishment and characterization of patient derived orthotopic xenograft mouse models representing a serial of primary and recurrent pediatric brain tumors

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition.

# publications[].label
Driver network as a biomarker: systematic integration and network modeling of multi-omics data to derive driver signaling pathways for drug combination prediction.

# publications[].label
High-throughput screening against protein:protein interaction interfaces reveals anti-cancer therapeutics as potent modulators of the voltage-gated Na+ channel complex.

# publications[].label
Author Correction: Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns.

# publications[].label
GSK3 regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer.

# publications[].label
Identification of the extracellular domains of Flt-1 that mediate ligand interactions.

# publications[].label
JAK2 regulates Nav1.6 channel function via FGF14Y158 phosphorylation.

# publications[].label
HG-18NOVEL OLIG2 INHIBITOR DEMONSTRATES PRE-CLINICAL EFFICACY IN PEDIATRIC GBM

# publications[].label
Vascular endothelial growth factor is essential for hyperglycemia-induced structural and functional alterations of the peritoneal membrane.

# publications[].label
DrugMoaMiner: A computational tool for mechanism of action discovery and personalized drug sensitivity prediction

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
Abstract 4669: Overcoming therapy resistance in stem cell-rich triple negative breast cancer through p38 MAP kinase inhibition

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis.

# publications[].label
Small Molecule Screening Identifies HSP90 as a Modifier of RNA Foci in Myotonic Dystrophy Type 1.

# publications[].label
Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells

# publications[].label
Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells.

# publications[].label
Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Nav1.6complex in nucleus accumbens neurons.

# publications[].label
Screening of GPCR drugs for repurposing in breast cancer.

# publications[].label
Abstract 1858: Rb deficient HPV+ HNSCC experienced enhanced sensitivity to aurora kinase inhibitors by altering the balance of MAD2 and TRIP13 levels

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Cloning a profibrotic stem cell variant in idiopathic pulmonary fibrosis.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Author Correction: Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells.

# publications[].label
Identification of personalized active agents in pediatric medulloblastoma through high-throughput drug screening in matching pairs of patient derived orthotopic xenograft neurosphere and monolayer cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract 453: Targeting FOXL2C402G vulnerabilities in adult type ovarian granulosa cell tumors

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
CHRONIC THERAPY WITH BFGF ANTIBODY REDUCES BALLOON INJURY-INDUCED INTIMAL THICKENING IN RAT CAROTID-ARTERY

# publications[].label
A global genomic and small molecule inhibitor interrogation of KIT mutant melanoma to reveal underlying biology and novel molecular targets.

# publications[].publisher
American Society of Clinical Oncology (ASCO)

# publications[].label
MOLECULAR LANDSCAPE OF A COMPREHENSIVE PANEL OF PEDIATRIC BRAIN CANCER PATIENT-DERIVED ORTHOTOPIC XENOGRAFT (PDOX) MODELS INFORM UNIQUE TARGETS FOR DRUG RESPONSIVENESS

# publications[].label
Abstract 1662: In vivo drug response evaluation in anaplastic thyroid cancer patient-derived tumor xenografts following high-throughput screening

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Pharmacogenomic screen identifies KMT2D mutations as a biomarker of sensitivity to Aurora kinase inhibition in head and neck and cervical squamous cell carcinoma

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract 1379: High throughput screening to identify molecules that alter VHL stability

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
TMOD-39. IDENTIFICATION OF EFFICACIOUS AGENTS IN PEDIATRIC EPENDYMOMA THROUGH HIGH-THROUGHPUT DRUG SCREENING IN MATCHING PAIRS OF PATIENT DERIVED ORTHOTOPIC XENOGRAFT (PDOX) NEUROSPHERE AND MONOLAYER CELLS

# publications[].label
Determining efficacy of drug combinations identified by unbiased high throughput screening for RAS-mutated colorectal cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells.

# publications[].label
Pharmacologic profiling of patient-derived xenograft models of primary treatment-nave triple-negative breast cancer.

# publications[].label
Xenotransplantation of pediatric low grade gliomas confirms the enrichment of BRAF V600E mutation and preservation of CDKN2A deletion in a novel orthotopic xenograft mouse model of progressive pleomorphic xanthoastrocytoma.

# publications[].label
Abstract 2945: Arsenic trioxide sensitizes glioma stem cells to brain penetrant PI3K and mTOR inhibitor GDC-0084

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract LB-320: PPTC testing of an OLIG2 inhibitor CT-179 in patient-derived orthotopic xenograft mouse models of pediatric GBM

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
High-throughput in vitro screening of glioma stem cell lines: Evaluation of over 350 tyrosine kinase inhibitors

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Mechanistic Aspects of Biphenyl Urea-Based Analogues in Triple-Negative Breast Cancer Cell Lines

# publications[].label
High throughput chemical profiling of chemoresistant triple negative breast cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Links between retinal vascular dysfunction induced by elevated glucose levels and VEGF

# publications[].label
High-Content Screening Identifies Src Family Kinases as Potential Regulators of AR-V7 Expression and Androgen-Independent Cell Growth.

# publications[].label
Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo.

# publications[].label
Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer.

# publications[].label
DDIS-19. USING MATCHED PRIMARY AND RECURRENT PEDIATRIC BRAIN TUMOR ORTHOTOPIC MOUSE MODELS(PDOX) TO ILLUSTRATE THE GENETIC REVOLUTION AND TO INFORM NEW ANTI-RECURRENT PERSONALIZED THERAPIES

# publications[].label
High Throughput Clonogenic Survival Screen Identifies Novel Radiation Sensitizers for K-ras Mutant Non-Small Cell Lung Cancer

# publications[].label
Systematic high-throughput combination drug screen to enhance poly (ADP-ribose) polymerase (PARP) inhibitor efficacy in ovarian cancer.

# publications[].publisher
American Society of Clinical Oncology (ASCO)

# publications[].label
Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy.

# publications[].label
Results of a high-throughput screen to identify compounds that modulate VHL proteostasis.

# publications[].publisher
American Society of Clinical Oncology (ASCO)

# publications[].label
Spatial mapping of the biologic effectiveness of scanned particle beams: towards biologically optimized particle therapy.

# publications[].label
Abstract GS1-09: Inhibition of GPX4 induces preferential death of p53-mutant triple-negative breast cancer cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer.

# publications[].label
Abstract 4819: High-throughput screening of glioma stem-like cells (GSCs) identifies synergistic therapeutic combination of FGFR inhibitor and CDK4/6 inhibitor

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract LB-320: PPTC testing of an OLIG2 inhibitor CT-179 in patient-derived orthotopic xenograft mouse models of pediatric GBM

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
High content clonogenic survival assay for drug library screening identifies potent radiation sensitizers for non-small cell lung cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
High-throughput and in silico screenings in drug discovery.

# publications[].label
A High-throughput Approach to Identify Effective Systemic Agents for the Treatment of Anaplastic Thyroid Carcinoma.

# publications[].label
Combination of EphA2- and Wee1-Targeted Therapies in Endometrial Cancer.

# publications[].label
Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Primary and Recurrent Meningioma.

# publications[].label
The licorice metabolite enoxolone attenuates Clostridioides difficile pathophysiology by corrupting its metabolic and toxin production networks

# publications[].label
Role for heparin-binding growth factors in glucose-induced vascular dysfunction.

# publications[].label
A Novel Transgenic Mouse Model of Down Syndrome Acute Lymphoblastic Leukemia Identifies Targetable Vulnerabilities

# publications[].label
Comprehensive pharmacogenomic profiling of human papillomavirus-positive and -negative squamous cell carcinoma identifies sensitivity to aurora kinase inhibition in KMT2D mutants

# publications[].label
Rational Combination of CRM1 Inhibitor Selinexor and Olaparib Shows Synergy in Ovarian Cancer Cell Lines and Mouse Models.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
TMOD-41. TWO NOVEL SETS OF PATIENT DERIVED ORTHOTOPIC XENOGRAFT MOUSE MODELS (PDOX) ESTABLISHED FROM MATCHING PRIMARY AND RECURRENT PEDIATRIC BRAIN TUMORS

# publications[].label
Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity.

# publications[].label
MODL-29. Molecular Landscape of a comprehensive panel of pediatric brain cancer Patient-derived orthotopic xenograft (PDOX) models inform unique targets for drug responsiveness

# publications[].label
Development of Novel Monoclonal Antibodies for the, Analysis of Functional Sites in FGF-2

# publications[].label
PD-0065: Utilizing a high-throughput approach to identify effective agents for aggressive thyroid cancer

# researcherOn[].label
TEX-VAL: Texas A&M Tissue Chip Validation Consortium

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M Health Science Center; TMC3 Collaborative Research Building; 7255 Helix Park Ave

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine