# positions[].organizations[].parent[].label
College of Agriculture and Life Sciences

# overview
The promise for the treatment of proliferative disorders, with incalculable potential benefits to human health, has driven basic research into the genetic control of cell division for decades. However, what determines when cells initiate their division remains mysterious. It is as if we are staring at a beautiful engine, with little knowledge about what turns it on. How cells are set off to a new round of cell division, remains as one of the most fundamental, unanswered questions. It is virtually unknown which cellular pathways affect initiation of division, which factors operate within each pathway, the extent of interactions between pathways, and how each pathway is molecularly linked to the machinery of cell division. Our studies aim to answer these questions using baker's yeast. This model organism has a machinery of cell division that is very similar to that of human cells, and it is suited for genetic and biochemical studies.

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

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2.2 Factors Relating To The Physical Environment

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3 Prevention Of Disease And Conditions, And Promotion Of Well-being

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Intracellular Signaling Peptides And Proteins

# educationAndTraining[].organization.label
Tufts University - (Medford, Massachusetts, United States)

# publications[].label
One-carbon metabolic enzymes are regulated during cell division and make distinct contributions to the metabolome and cell cycle progression in Saccharomyces cerevisiae.

# publications[].label
Chronological and replicative lifespan in yeast: do they meet in the middle?

# publications[].label
Evidence for control of nitrogen metabolism by a START-dependent mechanism in Saccharomyces cerevisiae.

# publications[].label
Lipid biosynthesis: When the cell cycle meets protein synthesis?

# publications[].label
A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems.

# publications[].label
A role for KEM1 at the START of the cell cycle in Saccharomyces cerevisiae.

# publications[].label
Hym1p affects cell cycle progression in Saccharomyces cerevisiae.

# publications[].label
A systematic analysis of cell cycle regulators in yeast reveals that most factors act independently of cell size to control initiation of division.

# publications[].label
Nutrient-specific effects in the coordination of cell growth with cell division in continuous cultures of Saccharomyces cerevisiae.

# publications[].label
Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast.

# publications[].label
Branched-chain amino acid synthesis is coupled to TOR activation early in the cell cycle in yeast.

# publications[].label
Perturbations of transcription and gene expression-associated processes alter distribution of cell size values in Saccharomyces cerevisiae

# publications[].label
Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Unbalanced Growth, Senescence and Aging.

# publications[].label
CDC64 encodes cytoplasmic alanyl-tRNA synthetase, Ala1p, of Saccharomyces cerevisiae.

# publications[].label
Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae.

# publications[].label
One-carbon metabolic enzymes are regulated during cell division and make distinct contributions to the metabolome and cell cycle progression in Saccharomyces cerevisiae

# publications[].label
Multiple metabolic requirements for size homeostasis and initiation of division in Saccharomyces cerevisiae.

# publications[].label
Novel regulatory factors interacting with the promoter of the gene encoding the mRNA cap binding protein (eIF4E) and their function in growth regulation.

# publications[].label
Editing of misaminoacylated tRNA controls the sensitivity of amino acid stress responses in Saccharomyces cerevisiae.

# publications[].label
Perturbations of Transcription and Gene Expression-Associated Processes Alter Distribution of Cell Size Values in Saccharomyces cerevisiae.

# publications[].label
Phenotypic associations among cell cycle genes in Saccharomyces cerevisiae

# publications[].label
An increase in mitochondrial DNA promotes nuclear DNA replication in yeast.

# publications[].label
Faraday on the fiscal benefits of science.

# publications[].label
The UV response in Saccharomyces cerevisiae involves the mitogen-activated protein kinase Slt2p.

# publications[].label
Systematic analysis of cell cycle effects of common drugs leads to the discovery of a suppressive interaction between gemfibrozil and fluoxetine.

# publications[].label
Scaling of G1 Duration with Population Doubling Time by a Cyclin in Saccharomyces cerevisiae.

# publications[].label
Coordination of cell growth with cell division.

# publications[].label
The unfolded protein response is not necessary for the G1/S transition, but it is required for chromosome maintenance in Saccharomyces cerevisiae.

# publications[].label
Branched chain amino acid synthesis is coupled to TOR activation early in the cell cycle in yeast

# publications[].label
Bem1p, a scaffold signaling protein, mediates cyclin-dependent control of vacuolar homeostasis in Saccharomyces cerevisiae.

# publications[].label
Late-life dietary folate restriction reduces biosynthetic processes without compromising healthspan in mice.

# publications[].label
Ribosomal proteins: mutant phenotypes by the numbers and associated gene expression changes.

# publications[].label
A low dilution rate microchemostat array with programmable cell population control

# publications[].label
Proteins associated with the doubling time of the NCI-60 cancer cell lines.

# publications[].label
Abundances of transcripts, proteins, and metabolites in the cell cycle of budding yeast reveals coordinate control of lipid metabolism

# publications[].label
Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism.

# publications[].label
Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity.

# publications[].label
Translational control of MPS1 links protein synthesis with the initiation of cell division and spindle pole body duplication in yeast

# publications[].label
Dcr2 targets Ire1 and downregulates the unfolded protein response in Saccharomyces cerevisiae.

# publications[].label
Sulfur metabolism actively promotes initiation of cell division in yeast.

# publications[].label
Phenotypic Associations Among Cell Cycle Genes in Saccharomyces cerevisiae.

# publications[].label
Scaling of G1 duration with population doubling time by a cyclin in Saccharomyces cerevisiae

# publications[].label
An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc.

# publications[].label
Saccharomyces cerevisiae deletion strains with complex DNA content profiles.

# publications[].label
The G1 cyclin Cln3p controls vacuolar biogenesis in Saccharomyces cerevisiae.

# publications[].label
mRNA-binding proteins and cell cycle progression.

# publications[].label
The budding index of Saccharomyces cerevisiae deletion strains identifies genes important for cell cycle progression.

# publications[].label
Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae.

# publications[].label
Genetic determinants of cell size at birth and their impact on cell cycle progression in Saccharomyces cerevisiae.

# publications[].label
Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import.

# publications[].label
Ribosome profiling the cell cycle: lessons and challenges.

# publications[].label
Translate to divide: ontrol of the cell cycle by protein synthesis.

# publications[].label
A new enrichment approach identifies genes that alter cell cycle progression in Saccharomyces cerevisiae.

# publications[].label
The Dcr2p phosphatase destabilizes Sic1p in Saccharomyces cerevisiae.

# publications[].label
Translational control of lipogenesis links protein synthesis and phosphoinositide signaling with nuclear division

# publications[].label
Microchemostat array with small-volume fraction replenishment for steady-state microbial culture.

# publications[].tags
12 Responsible Consumption and Production

# publications[].label
Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells.

# publications[].label
Translational control of lipogenesis links protein synthesis and phosphoinositide signaling with nuclear division in Saccharomyces cerevisiae.

# publications[].label
CDK control of membrane-bound organelle homeostasis.

# researcherOn[].label
Coupling of Protein Synthesis with Cell Division

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of General Medical Science

# researcherOn[].label
Mechanisms that scale eukaryotic cell cycle phases

# researcherOn[].awardedBy.label
National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States)

# streetAddress
Texas A&M University; Biochemistry & Biophysics; 2128 TAMU

# schools[]
College of Agriculture and Life Sciences

# etdChairOf[].label
Hoose, Scott Allen (2012-10). Systematic Analysis of Genetic and Pharmaceutical Modulators of the Eukaryotic Cell Cycle. Doctoral Dissertation.

# etdChairOf[].label
Guo, Jinbai (2007-09). Control of cell division by nutrients, and ER stress signaling in Saccharomyces cerevisiae. Doctoral Dissertation.

# etdChairOf[].label
Pathak, Ritu (2007-04). Regulation of initiation of division in Saccharomyces cerevisiae: characterization of the role of DCR2, GID8, and KEM1 in completion of START. Doctoral Dissertation.

# etdChairOf[].label
Han, Bong Kwan (2007-04). The G1 cyclin Cln3p regulates vacuole homeostasis through phosphorylation of a scaffold protein, Bem1p, in Saccharomyces cerevisiae. Doctoral Dissertation.

# etdChairOf[].label
Blank, Heidi M. (2010-07). Linking Sulfur Metabolism to the Cell Division Machinery in Yeast. Doctoral Dissertation.