# positions[].organizations[].parent[].label
College of Agriculture and Life Sciences

# overview
Dr. Turner's research program focuses on determining the impact of dietary constituents on regulatory processes that may protect against carcinogenesis and inflammation in the colon. Her lab is evaluating the effects of fiber sources and the specific phytochemicals contained within them on aspects of cellular proliferation or apoptosis, and microbial/epithelial cell interactions. The goal is to determine how these normal processes are being perturbed by chemical carcinogens, radiation or pro-inflammatory compounds, and how diet may mitigate the damage caused by them. Work conducted in the laboratory is currently funded by the United Sorghum Checkoff Board, the California Dried Plum Board, and the National Space Biomedical Research Institute.

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
Single-Strand Specific DNA And RNA Endonucleases

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
Receptors, Tumor Necrosis Factor, Member 25

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
3 Prevention Of Disease And Conditions, And Promotion Of Well-being

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# awardsAndHonors[].label
Certificate of recognition for the Development of Innovative Technology

# publications[].label
Space Environmental Factor Impacts upon Murine Colon Microbiota and Mucosal Homeostasis.

# publications[].label
Novel sorghum brans containing bioactive compounds alter colon microbiota in response to a DSS-induced chronic inflammatory state

# publications[].label
Establishment of a multicomponent dietary bioactive human equivalent dose to delete damaged Lgr5+ stem cells using a mouse colon tumor initiation model.

# publications[].label
Antagonism of CD95 signaling blocks butyrate induction of apoptosis in young adult mouse colonic cells

# publications[].label
Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats.

# publications[].label
Modulation of Colonic Microbiota Populations by Polyphenolic Containing Sorghum Brans May Protect Against Development of Metabolic Disease

# publications[].label
Dietary fish oil and pectin enhance colonocyte apoptosis in part through suppression of PPARdelta/PGE2 and elevation of PGE3.

# publications[].label
Natural and irradiated grapefruit pulp and their functional compounds suppress aberrant crypt foci and colonocyte proliferation

# publications[].label
Colonocyte DNA damage differs with diet but not age

# publications[].label
Association between red meat consumption and colon cancer: A systematic review of experimental results.

# publications[].label
Fish oil enhances targeted apoptosis during colon tumor initiation by down regulating Bcl-2.

# publications[].label
Shaping functional gut microbiota using dietary bioactives to reduce colon cancer risk.

# publications[].label
Differential activation of NF-kappa B in colonic mucosa of DSS-challenged rats consuming fermentable fiber sources

# publications[].label
Omega-3 fatty acid modulation of serum and osteocyte tumor necrosis factor- in adult mice exposed to ionizing radiation.

# publications[].label
Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Morphodensitometric analysis of protein kinase C beta(II) expression in rat colon: modulation by diet and relation to in situ cell proliferation and apoptosis.

# publications[].label
Colonic cyclopurines induced by azoxymethane and irradiation are decreased by dietary fish oil

# publications[].label
Increased dietary iron and radiation in rats promote oxidative stress, induce localized and systemic immune system responses, and alter colon mucosal environment.

# publications[].label
Fish oil decreases oxidative DNA damage by enhancing apoptosis in rat colon.

# publications[].label
Higher DNA adduct levels and lower apoptosis may explain the higher cancer susceptibility in the distal colon compared to the rest of the gastrointestinal tract

# publications[].label
The combination of dietary fish oil and butyrate decreases high-multiplicity aberrant crypt foci in experimentally induced colon cancer

# publications[].label
Chlorogenic acid reduced DSS-induced injury and NF-kappa B activation in a rat colitis model

# publications[].label
Influence of dietary lipid and butyrate on the coordination of proliferation, p27, differentiation and apoptosis in the same cell during the initiation stage of colon carcinogenesis

# publications[].label
Physical and mechanical characteristics of tibias from transgenic mice expressing mutant bovine growth hormone genes.

# publications[].label
Upregulation of p21Waf1/Cip1 expression in vivo by butyrate administration can be chemoprotective or chemopromotive depending on the lipid component of the diet.

# publications[].label
HUMAN NUTRITION | Cancer Health Concerns

# publications[].label
Combination of fish oil and pectin suppressed beta-catenin nuclear translocation, an important molecular event in colon carcinogenesis

# publications[].label
Rapidly cycling Lgr5+ stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk.

# publications[].label
MODIFICATION OF INVITRO AND INSITU DRY-MATTER DIGESTIBILITY OF FORAGES WITH CHEMICAL TREATMENT

# publications[].label
In vivo regulation of colonic cell proliferation, differentiation, apoptosis, and P27Kip1 by dietary fish oil and butyrate in rats.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
A diet containing fish oil and pectin ameliorates radiation-enhanced colon carcinogenesis by suppression of PPAR(delta) and PGE synthase-2 (PGES(2))and elevation of PGE(3)

# publications[].label
Chemoprotective fish oil/pectin diets temporally alter gene expression profiles in exfoliated colonocytes

# publications[].label
Potential protective mechanisms of wheat bran fiber.

# publications[].label
Differential response to dextran sodium sulfate (DSS)-induced oxidative DNA damage in rat small (SI) and large intestine (LI)

# publications[].label
Effects of chemoprotective diets on crypt adult stem cells u the cells of origin of colon cancer

# publications[].label
Reduction in DSS-induced enhancement of colonic injury and NF-kappa B activation in rats consuming a diet containing black sorghum bran

# publications[].label
High energy LET radiation as a risk modifier in colon carcinogenesis.

# publications[].label
Sorghum bran varieties differentially influence endogenous antioxidant enzymes to protect against oxidative stress during colon carcinogenesis

# publications[].label
Dietary fish oil down-regulates pro-inflammatory gene expression in colonocytes

# publications[].label
Parametric and nonparametric methods for understanding the relationship between carcinogen-induced DNA adduct levels in distal and proximal regions of the colon

# publications[].label
Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis (vol 139, pg 101, 2009)

# publications[].label
Impact of Novel Sorghum Bran Diets on DSS-Induced Colitis.

# publications[].label
Lime treatment of agricultural residues to improve rumen digestibility

# publications[].label
Understanding the relationship between carcinogen-induced DNA adduct levels in distal and proximal regions of the colon.

# publications[].label
Tissue-specific attenuation of endogenous DNA I-compounds in rats by carcinogen azoxymethane: possible role of dietary fish oil in colon cancer prevention.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Diet and carcinogen alter the fecal microbial populations of rats.

# publications[].label
Apigenin and naringenin decrease cell number in a dose dependent manner in non-transformed young adult mouse colonocytes (YAMC) but not in those expressing a dominant negative p53-mutant (mp53 YAMC)

# publications[].label
Relationship among proliferation, p27, differentiation and apoptosis measured by colocalization in the same cell as a function of carcinogen administration

# publications[].label
Bayesian Variable Selection in Clustering High-Dimensional Data With Substructure

# publications[].label
Suppression of early colon cancer lesions by apigenin and naringenin is in part due to their downregulation of p21, TLR-4, and MCT-1 expression

# publications[].label
NUTRIENT AND MICROSTRUCTURAL INDEXES OF MAIZE AND SORGHUM RESPONSES TO AMMONIA PRESSURIZATION/DEPRESSURIZATION

# publications[].label
Dried Plums Modify the Colon Luminal Metabolome in a Rat Model of Colon Carcinogenesis

# publications[].label
Dietary fish oil and pectin protect against oxidative DNA damage in rat intestinal epithelial cells due to heightened apoptosis induced by reactive oxygen species

# publications[].label
EFFECT OF TREATMENT TEMPERATURE ON DIETARY QUALITY OF AMMONIA FIBER EXPLOSION (AFEX) TREATED CASEIN FOR RATS

# publications[].label
A chemoprotective fish oil/pectin diet enhances apoptosis via Bcl-2 promoter methylation in rat azoxymethane-induced carcinomas.

# publications[].label
The chemopreventive action of quercetin decreases the number of high multiplicity aberrant crypt foci (ACF), reduces proliferation, and increases apoptosis in rat colonocytes.

# publications[].label
Plum polyphenols inhibit colorectal aberrant crypt foci formation in rats: potential role of the miR-143/protein kinase B/mammalian target of rapamycin axis.

# publications[].label
The microbiome and colorectal neoplasia: environmental modifiers of dysbiosis.

# publications[].label
Expression of mutant bovine growth hormone genes in mice perturbs age-related nutrient utilization patterns.

# publications[].label
Quercetin Suppresses Early Colon Carcinogenesis Partly through Inhibition of Inflammatory Mediators.

# publications[].publisher
International Society for Horticultural Science (ISHS)

# publications[].label
Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation.

# publications[].label
Evaluation of fecal mRNA reproducibility via a marginal transformed mixture modeling approach.

# publications[].label
Effects of sorghum [Sorghum bicolor (L.) Moench] crude extracts on starch digestibility, Estimated Glycemic Index (EGI), and Resistant Starch (Rs) contents of porridges.

# publications[].label
Fish oil depresses the carcinogen-induced expression of COX-2 in rat colonic mucosa.

# publications[].label
A chemoprotective fish oil- and pectin-containing diet temporally alters gene expression profiles in exfoliated rat colonocytes throughout oncogenesis.

# publications[].label
Dried Plums Modify Fecal Short Chain Fatty Acid Concentrations and Gene Expression in a Rat Model of Colon Carcinogenesis

# publications[].label
Fish oil is protective against colon tumorigenesis by two distinct mechanisms in a site specific manner.

# publications[].label
Sorghum-based dietary intervention enriches Faecalibacterium prausnitzii in fecal samples of overweight individuals

# publications[].label
Wheat bran diet reduces tumor incidence in a rat model of colon cancer independent of effects on distal luminal butyrate concentrations.

# publications[].label
Anatomical site-specific response to DNA damage is related to later tumor development in the rat azoxymethane colon carcinogenesis model.

# publications[].label
Serum lipids in hypercholesterolemic men and women consuming oat bran and amaranth products

# publications[].label
Dietary fish oil enhances targeted apoptosis response to dextran sodium sulfate (DSS)-induced oxidative DNA damage in the top part of the colonic crypt

# publications[].label
Bran from black or brown sorghum suppresses colon carcinogenesis

# publications[].label
Novel sorghum brans containing bioactive compounds alter the production of microbial secondary metabolites in response to a DSS-induced chronic inflammatory state

# publications[].label
Antagonism of CD95 signaling blocks butyrate induction of apoptosis in young adult mouse colonic cells

# publications[].label
Aberrant crypt foci and semiparametric modeling of correlated binary data.

# publications[].label
Opportunities for nutritional amelioration of radiation-induced cellular damage.

# publications[].label
Bayesian hierarchical spatially correlated functional data analysis with application to colon carcinogenesis.

# publications[].label
Bioconversion of sorghum and cowpea by black soldier fly (Hermetia illucens (L.)) larvae for alternative protein production

# publications[].label
A diet of fish oil and pectin reduces colonic antioxidant enzymes creating an environment permissive for ROS-induced apoptosis

# publications[].label
Chlorogenic Acid and Quercetin in a Diet with Fermentable Fiber Influence Multiple Processes Involved in DSS-Induced Ulcerative Colitis but Do Not Reduce Injury.

# publications[].label
An increase in reactive oxygen species by dietary fish oil coupled with the attenuation of antioxidant defenses by dietary pectin enhances rat colonocyte apoptosis.

# publications[].label
Comparing automatic and manual image processing in FLARE assay analysis for colon carcinogenesis

# publications[].label
Quercetin decreases the number of high multiplicity aberrant crypt foci (ACF) but not the total number of ACF in rat colon

# publications[].label
Simulated galactic cosmic radiation enhances colon cancer in the rat, which is mediated by changes in gene expression that are influenced by dietary intervention.

# publications[].label
A combination of omega-3 fatty acids and a butyrate-producing fiber mitigates colon cancer development

# publications[].label
Quercetin does not significantly affect the protection of a fish oil diet in early colon careinogenesis

# publications[].label
Dietary fish oil may decrease colonic cell proliferation by upregulating p27Kip1 level in actively proliferating cells

# publications[].label
Homeostatic responses of colonic LGR5+ stem cells following acute in vivo exposure to a genotoxic carcinogen.

# publications[].label
Carotenoid bioaccessibility from nine raw carotenoid-storing fruits and vegetables using an in vitro model.

# publications[].label
A two-stage normalization method for partially degraded mRNA microarray data.

# publications[].label
Coordinated p27 Kip1 expression as a function of distance between crypts - Potential inter-crypt signaling

# publications[].label
Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis.

# publications[].label
Influence of incremental zeranol implant doses on the chemical and physical characteristics of third metacarpal bone and chemical composition of liver and soft tissue from feedlot steers.

# publications[].label
Polyphenol-rich sorghum brans alter colon microbiota and impact species diversity and species richness after multiple bouts of dextran sodium sulfate-induced colitis.

# publications[].label
A chemoprotective fish oil/pectin diet regulates the expression of the bcl-2 oncogene by altering CpG island methylator phenotype (CIMP) in colon cancer

# publications[].label
Diet induced rat colonic reactive oxygen species production is age dependent

# publications[].label
Oncogenic ras alters sensitivity of mouse colonocytes to butyrate and fatty acid mediated growth arrest and apoptosis.

# publications[].label
Glutathione metabolism and its implications for health.

# publications[].label
Non-invasive detection of fecal protein kinase C betaII and zeta messenger RNA: putative biomarkers for colon cancer.

# publications[].label
Dietary alteration of reactive oxygen species (ROS) and antioxidant enzyme activity in rat colonocytes is age-dependent

# publications[].label
Fish oil and pectin enhance apoptosis in irradiated rat colonocytes via suppression of PGE synthase-2 and Wnt pathway

# publications[].label
Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility.

# publications[].label
Grapefruit and its isolated bioactive compounds act as colon cancer chemoprotectants in rats

# publications[].label
Dietary prevention of colon cancer induced by combined effect of carcinogen and radiation

# publications[].label
Dietary fat and fiber modulate the colonic redox environment during the initiation stage of radiation-enhanced colon carcinogenesis in rats

# publications[].label
A fish oil/pectin diet suppresses radiation-enhanced colon carcinogenesis via down-regulation of the beta-catenin signaling pathway

# publications[].label
Testing for spatial correlation in nonstationary binary data, with application to aberrant crypt foci in colon carcinogenesis.

# publications[].label
Can Acute Galactic Cosmic Radiation-induced Bone Loss Be Mitigated By Dietary Modulation Of Inflammatory Cytokines?

# publications[].label
Growth patterns and body composition of transgenic mice expressing mutated bovine somatotropin genes.

# publications[].label
Dietary lipid source alters fatty acid composition in mitochondrial membrane phospholipids and modulates mitochondrial function in rat colonocytes

# publications[].label
A Bayesian analysis of colonic crypt structure and coordinated response to carcinogen exposure incorporating missing crypts.

# publications[].label
Dietary fish oil, compared to corn oil, decreased oxidative DNA damage at the base and middle region of the colonic crypt in dextran sodium sulfate (DSS)-treated rats.

# publications[].label
Estrogen receptor alpha levels in rats consuming wheat bran and injected with azoxymethane

# publications[].label
Relationship between DNA adduct levels, repair enzyme, and apoptosis as a function of DNA methylation by azoxymethane.

# publications[].label
Dietary fish oil reduces N7-deoxymethylguanine adducts by enhancing apoptosis at the initiation stage of carcinogenesis in the small (SI) and large intestine (LI)

# publications[].label
Dietary fish oil and pectin protect against oxidative DNA damage despite an increase in reactive oxygen species in rat small and large intestine epithelial cells

# publications[].label
A fish oil/pectin diet beneficially altered gene profiles during radiation-enhanced colon carcinogenesis

# publications[].label
Biography of Joanne R Lupton (1944-2020).

# publications[].label
Physiological and hormonal responses of lambs repeatedly implanted with zeranol and provided two levels of feed intake.

# publications[].label
Fish oil enhances targeted apoptosis during colon tumor initiation in part by downregulating Bcl-2.

# publications[].label
Fish oil enhances targeted apoptosis of colonocytes within the first 12 hours of carcinogen exposure and results in lower levels of DNA damage compared to corn oil.

# publications[].label
Combined effect of radiation and a chemical carcinogen on the formation of aberrant crypt foci in rat colon.

# publications[].label
Differential response to DNA damage may explain different cancer susceptibility between small and large intestine.

# publications[].label
Dietary fiber and coronary disease: does the evidence support an association?

# publications[].label
Quercetin and chlorogenic acid affect butyrate excretion, NF-kappa B activity, and cell proliferation in DSS treated rats

# publications[].label
Regulation of bone characteristics by altered body composition in bGH transgenic mice.

# publications[].label
Dried plum diet protects from bone loss caused by ionizing radiation.

# publications[].label
Dietary phytate reduces proliferation and increases apoptosis in rat colonocytes

# publications[].label
A COMPARISON OF THE PROTEIN-REQUIREMENTS FOR GROWTH AND REPRODUCTION IN THE RAT

# publications[].label
Fish oil increases mitochondrial phospholipid unsaturation, upregulating reactive oxygen species and apoptosis in rat colonocytes.

# publications[].label
Fish oil and pectin may suppress colon carcinogenesis via inhibition of the MAPK and TGF beta pathways

# publications[].label
Reduced iNOS and COX-2 levels are associated with enhanced apoptosis induced by grapefruit pulp and limonin in rat colonocytes

# publications[].label
Effects of Brans from Specialty Sorghum Varieties on In Vitro Starch Digestibility of Soft and Hard Sorghum Endosperm Porridges

# publications[].label
Dietary n-3 PUFA alter colonocyte mitochondrial membrane composition and function.

# publications[].label
Dietary fish oil and butyrate may protect against colon cancer by inducing mitochondria-dependent apoptosis in the promotion stage of carcinogenesis

# publications[].label
Dietary fish oil plus butyrate protect against colon cancer by increasing reactive oxygen species and decreasing mitochondrial membrane potential in the promotion stage of tumorigenesis

# publications[].label
Rats consuming bran from black and brown sorghums have lower short chain fatty acid concentrations and fewer aberrant colonic crypts

# publications[].label
Apigenin and naringenin suppress high multiplicity aberrant crypt foci formation and cell proliferation in rat colon

# publications[].label
Nonparametric estimation of correlation functions in longitudinal and spatial data, with application to colon carcinogenesis experiments

# publications[].label
Dietary fish oil may protect against colon cancer by altering mitochondrial function thereby creating a permissive environment for butyrate-induced apoptosis

# publications[].label
Dietary lipid source alters quercetin effects on antioxidant enzyme/phase I and II gene expression in rat colon

# researcherOn[].label
Radiation-induced Apoptosis Avoidance and Colon Tumorigenesis: Epigenetic Regulation in Adult Stem Cells

# researcherOn[].awardedBy.label
Johnson Space Center - (Houston, Texas, United States)

# researcherOn[].label
Chemoprotective Effects of Natural Products on Colonic Adult Stem Cells

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Mitigating Radiation Induced Bone Loss via Dietary Modulation of Inflammatory Cytokines

# researcherOn[].awardedBy.label
Johnson Space Center - (Houston, Texas, United States)

# researcherOn[].label
Attenuation of Space Radiation-induced Pro-oxidant and Fibrotic Signaling in the Heart by Nutritional and Genetic Interventions: Adventures in Tissue Sharing

# researcherOn[].awardedBy.label
Johnson Space Center - (Houston, Texas, United States)

# researcherOn[].label
Iron Overload and Oxidative Damage: Regulators of Bone Homeostasis in the Space Environment

# researcherOn[].awardedBy.label
Ames Research Center - (Mountain View, California, United States)

# researcherOn[].label
Nutrition, Biostatistics and Bioinformatics Training Grant

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
ROLE OF DIETARY PHYTOCHEMICALS IN PREVENTION OF COLON CANCER AND INFLAMMATION

# researcherOn[].awardedBy.label
National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States)

# streetAddress
Texas A&M University; Nutrition & Food Science; 2253 TAMU

# organizations[]
College of Agriculture and Life Sciences

# schools[]
College of Agriculture and Life Sciences

# etdChairOf[].label
Swift, Sibyl Nichole (2010-08). Energy Restriction Effects on Estrogen Status and the Skeletal Response to Loading. Doctoral Dissertation.

# etdChairOf[].label
Paulhill, Kimberly Jones (2008-08). Quercetin and Dietary Lipids Alter the Cellular Redox Environment of the Colonocyte in the Promotion Stage of Colon Carcinogenesis.. Master's Thesis.

# etdChairOf[].label
Piefer, Leigh (2012-08). Quercetin and Chlorogenic Acid Mitigate DSS-Induced Changes in Expression of Select Pro-Inflammatory Cytokines and Short Chain Fatty Acid Transporter Genes. Master's Thesis.

# etdChairOf[].label
Yuen, Evelyn P (2013-05). Effects of High Dietary Iron and Gamma Radiation on Oxidative Stress and Bone. Master's Thesis.

# etdChairOf[].label
Ritchie, Lauren E (2013-12). Diet, Disease State, and the Space Environment Modify the Intestinal Microbiota and Mucosal Environment via Microbiota-directed Alterations in Colonocyte Signalling. Doctoral Dissertation.

# etdChairOf[].label
Apanasovich, Tatiyana Vladimirovna (2004-08). Testing for spatial correlation and semiparametric spatial modeling of binary outcomes with application to aberrant crypt foci in colon carcinogenesis experiments. Doctoral Dissertation.

# etdChairOf[].label
Leonardi, Tety (2003-05). Dietary apigenin and naringenin protect against colon carcinogenesis by lowering high multiplicity aberrant crypt foci and enhancing apoptosis in azoxymethane-treated rats. Master's Thesis.

# etdChairOf[].label
Lewis, Jayme Beth (2008-12). Effects of bran from sorghum grains containing different classes and levels of bioactive compounds in colon carcinogenesis. Master's Thesis.

# etdChairOf[].label
Daniels, Wesley Danielle (2014-12). Apigenin and Naringenin Increase Apoptosis and Decrease Proliferation via Transcriptional Regulation. Master's Thesis.