# positions[].organizations[].label
Center for Translational Research in Aging and Longevity

# positions[].organizations[].parent[].label
College of Education and Human Development

# overview
My research focuses on the metabolic alterations underlying involuntary weight loss and muscle wasting in chronic inflammatory diseases, involving the use of stable isotope methodologies, and the effects of dietary modulation and exercise intervention to restore metabolism and physical performance in these patients.

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
Alzheimer's Disease Including Alzheimer's Disease Related Dementias (ad/adrd)

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
Standardized Reduction; Pectoralis Muscle Area

# keywords[]
Alzheimer's Disease Including Alzheimer's Disease Related Dementias (ad/adrd)

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
Alzheimer's Disease Including Alzheimer's Disease Related Dementias (ad/adrd)

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
Alzheimer's Disease Including Alzheimer's Disease Related Dementias (ad/adrd)

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
Postabsorptive Whole Body Protein Balance

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
Alzheimer's Disease Including Alzheimer's Disease Related Dementias (ad/adrd)

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
4.2 Evaluation Of Markers And Technologies

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
Alzheimer's Disease Including Alzheimer's Disease Related Dementias (ad/adrd)

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
Tracer–tracee Ratios Of Amino Acids Corrected For Their Baseline Value

# keywords[]
Balanced Mixture Of Essential And Non-essential Amino Acids

# educationAndTraining[].organization.label
Maastricht University - (Maastricht, Limburg, Netherlands)

# awardsAndHonors[].label
Vernon R Young International Award for Amino Acid Research

# awardsAndHonors[].label
Enhancing Development and Generating Excellence in Scholarship (EDGES) Fellow

# publications[].label
Association between the anaerobic threshold and the break-point in the double product/work rate relationship

# publications[].label
Early signs of impaired gut function in patients with advanced cancer undergoing chemotherapy

# publications[].label
Characteristics of a Pseudomonas aeruginosa induced porcine sepsis model for multi-organ metabolic flux measurements.

# publications[].label
P.81 Body composition assessment by dual-energy X-rayabsorptiometry compared to deuterium dilution in patients with stable COPD

# publications[].label
Increasing intake of free essential amino acids twofold leads to doubling of the anabolic response in healthy older adults without reducing protein breakdown

# publications[].label
Impaired Arginine, Citrulline, and Glutamine Metabolism in Type 2 Diabetes (T2D)-Insights from a Stable Isotope Study

# publications[].label
DIETARY ESSENTIAL AMINO ACIDS ARE HIGHLY ANABOLIC IN PEDIATRIC PATIENTS WITH CYSTIC FIBROSIS CHARACTERIZED BY NUTRITIONAL FAILURE

# publications[].label
Altered Glutamate and Glutamine Kinetics in Autism Spectrum Disorder

# publications[].label
Disturbances in branched-chain amino acid profile and poor daily functioning in mildly depressed chronic obstructive pulmonary disease patients.

# publications[].label
Hyperammonemia impairs skeletal muscle protein synthesis via a novel Myostatin-ALK5-AMPK dependent mechanism

# publications[].label
Prolonged increase in glutamate whole body and intracellular production in older adults with COPD and healthy controls post-resistance exercise.

# publications[].label
Comparison of urine glycosaminoglycan excretion between children with autism spectrum disorder and typically developed children

# publications[].label
Effects of high or normal casein-, soy-, or whey with or without GMP- protein breakfasts on satiety, satiety hormones, and plasma amino acid responses.

# publications[].label
Obesity- and Sex-Related Disturbances in Arginine and Nitric Oxide Kinetics

# publications[].label
Tolerance to increased supplemented dietary intakes of methionine in healthy older adults

# publications[].label
COPD patients with a higher net catabolic response to resistance exercise and pre-existing muscle dysfunction complete less work during their exercise bout

# publications[].label
Altered glutamate metabolism is associated with reduced muscle glutathione levels in patients with emphysema.

# publications[].label
Reduced Short-Chain Fatty Acid (SCFA) Plasma Concentrations Are Associated with Decreased Psychological Well-Being in Clinically Stable Congestive Heart Failure Patients

# publications[].label
Metabolic and functional effects of glutamate intake in patients with chronic obstructive pulmonary disease (COPD).

# publications[].label
Effects of high and normal casein-, soy-, and whey-protein breakfasts on amino acid, satiety, and 'satiety' hormone responses

# publications[].label
Activated whole-body arginine pathway in high-active mice.

# publications[].label
Prolonged intermittent hypoxia causes mitochondrial dysfunction due to O-GlcNacylation of DRP1 in models of COPD (chronic obstructive pulmonary disease)

# publications[].label
-3 polyunsaturated fatty acid supplementation improves postabsorptive and prandial protein metabolism in patients with chronic obstructive pulmonary disease: a randomized clinical trial.

# publications[].label
PP099-SUN IMPAIRED WHOLE BODY NITRIC OXIDE SYNTHESIS AND UPREGULATED PROTEIN BREAKDOWN IN PATIENTS WITH ADVANCED NON-SMALL CELL LUNG CANCER

# publications[].label
Closed-loop Tactile Augmentation by Transcutaneous Stimulation on either the Foot Sole or the Palm to Improve Lateral Postural Balance

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
Compartmental tracer enrichment data analysis to measure intestinal short-chain fatty acid (scfa) production in health and disease

# publications[].label
Protein is an important but undervalued macronutrient in the nutritional care of patients with cystic fibrosis (vol 17, pg 515, 2014)

# publications[].label
Mainly Muscle, Jejunum, And Lung Fractional Protein Synthesis Rates Are Related To Whole-Body Protein Synthesis In The Pig

# publications[].label
Stimulated nitric oxide production and arginine deficiency in children with cystic fibrosis with nutritional failure.

# publications[].label
Amino acid kinetics and the response to nutrition in patients with cancer.

# publications[].label
The response of short-chain fatty acid (SCFA) production to inulin supplementation is reduced in very old adults compared to younger age groups

# publications[].label
In-vivo production of branched-chain amino acids, branched-chain keto acids, and -hydroxy -methylbutyric acid.

# publications[].label
Editorial: Crosstalk between organs and multimodal therapeutic approaches: new insights.

# publications[].label
Editorial: Evidence for nutrition support in wasting diseases: gaps and opportunities.

# publications[].label
Small Intestinal Dysfunction Attenuates the Anabolic Response to Feeding and Compromises Daily Functioning in Patients with Chronic Obstructive Pulmonary Disease

# publications[].label
Metabolomic changes to high-protein intake in patients with cancer: Toward precision nutrition approach

# publications[].label
Cytokine response to critical illness and its relation to amino acid metabolism.

# publications[].label
Use of body mass index percentile to identify fat-free mass depletion in children with cystic fibrosis.

# publications[].label
Does The Presence Of Comorbidities Affect Body Composition And Daily Functioning Differently In Young And Middle Older Adults?

# publications[].label
P363 A BREAKFAST WITH -LACTALBUMIN, GELATIN, OR GELATIN+TRP LOWERS ENERGY INTAKE COMPARED WITH A BREAKFAST WITH CASEIN, SOY, WHEY, OR WHEY-GMP

# publications[].label
Response of whole-body protein and urea turnover to exercise differs between patients with chronic obstructive pulmonary disease with and without emphysema.

# publications[].label
Impact of -hydroxy--methylbutyrate (HMB) on muscle loss and protein metabolism in critically ill patients: A RCT.

# publications[].label
Reduced arginine availability and nitric oxide synthesisin canceris related to impaired endogenous arginine synthesis.

# publications[].label
Metabolic phenotyping using kinetic measurements in young and older healthy adults.

# publications[].label
Prolonged intermittent hypoxia causes reductions in protein synthesis and sarcopenia associated with upregulation of the Hexosamine Biosynthesis Pathway in models of COPD

# publications[].label
American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation.

# publications[].label
O.38 Reduced muscle amino acid related oxidative metabolism in COPD

# publications[].label
Relation between resting energy expenditure and amino acid metabolism in the post-acute phase of catabolic critically ill patients.

# publications[].label
Plasma myokine response to acute (walking) exercise following exercise rehabilitation in mild cognitive impairment

# publications[].label
Short-term inulin supplementation comparably alters short-chain fatty acid (SCFA) production in healthy and chronic obstructive pulmonary disease (COPD) subjects

# publications[].label
A novel pulse tracer method to estimate the relationship between amino acid meal composition and its intracellular disposal.

# publications[].label
Tolerance to increased supplemented dietary intakes of methionine in healthy older adults.

# publications[].label
Baseline plasma essential amino acids are associated with lower levels of fatigue after weight loss in morbidly obese adults

# publications[].label
High anabolic potential of essential amino acid mixtures in advanced nonsmall cell lung cancer.

# publications[].label
Supplementation of soy protein with branched-chain amino acids alters protein metabolism in healthy elderly and even more in patients with chronic obstructive pulmonary disease.

# publications[].label
Effects of hypoxic hypoxia on O2 uptake and heart rate kinetics during heavy exercise.

# publications[].label
Functional Performance, Cognitive Function, And Amino Acid Kinetics In Response To Exercise Rehabilitation In Mild Cognitive Impairment

# publications[].label
Glutathione (GSH) Absolute Synthesis Rates (ASR) of Multiple Organs in a Pseudomonas aeroginosa (PM) induced Hyperdynamic Sepsis Pig Model

# publications[].label
24-HOUR PROTEIN, ARGININE AND CITRULLINE METABOLISM IN FED CRITICALLY ILL CHILDREN DOES NOT SHOW A CIRCADIAN RHYTHM

# publications[].label
Role of sex in nutrition research in aging and wasting disease.

# publications[].label
Role of specific dietary amino acids in clinical conditions.

# publications[].label
Skeletal muscle weakness is associated with wasting of extremity fat-free mass but not with airflow obstruction in patients with chronic obstructive pulmonary disease.

# publications[].label
OP016 DIETARY ESSENTIAL AMINO ACIDS ARE HIGHLY ANABOLIC IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

# publications[].label
Two weeks of very low-calorie diet maintains protein and amino acid turnover despite a large reduction in muscle mass

# publications[].label
Presence of early stage cancer does not impair the early protein metabolic response to major surgery.

# publications[].label
Acute skeletal muscle loss in SARS-CoV-2 infection contributes to poor clinical outcomes in COVID-19 patients.

# publications[].label
Sex related differences in muscle health and metabolism in chronic obstructive pulmonary disease.

# publications[].label
Hyperammonemia impairs skeletal muscle protein synthesis via a myostatin dependent mechanism

# publications[].label
Enhanced anabolic response to milk protein sip feeding in elderly subjects with COPD is associated with a reduced splanchnic extraction of multiple amino acids.

# publications[].label
Glutathione and glutamate levels in the diaphragm of patients with chronic obstructive pulmonary disease.

# publications[].label
Older Adults With Mild Cognitive Impairment Have A Specific Reduction In Glycine Production Which Is Related To An Abnormal Lipid Profile But Cannot Be Explained By Abdominal Obesity

# publications[].label
Exhaled nitric oxide during exercise in primary pulmonary hypertension and pulmonary fibrosis.

# publications[].label
Alterations in whole-body arginine metabolism in chronic obstructive pulmonary disease.

# publications[].label
Altered amino acid metabolism in chronic obstructive pulmonary disease: new therapeutic perspective?

# publications[].label
Casein protein results in higher prandial and exercise induced whole body protein anabolism than whey protein in chronic obstructive pulmonary disease.

# publications[].label
SUN-PP095: Systemic Muscle Dysfunction in Chronic Heart Failure Is Associated with Enhanced Myofibrillar Protein Breakdown but Preserved Muscle Mass

# publications[].label
PT08.3: Increased Amino Acid Turnover and Myofibrillar Protein Breakdown in Advanced Cancer are Associated with Decreased Muscle Strength and Physical Function

# publications[].label
Aging induced changes in arginine metabolism is dependent on sex

# publications[].label
Plantar or Palmar Tactile Augmentation Improves Lateral Postural Balance With Significant Influence from Cognitive Load.

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
Prediabetes differently affects valine metabolism in females

# publications[].label
Einfluss Einer Einwchigen Inulin-Supplementierung Auf Die Darm-Mikrobiota und Kurzkettige Fettsuren Bei Jungen und lteren Erwachsenen: Ergebnisse Einer Randomisierten, Doppelblinden Crossover-Studie

# publications[].label
OR25: Disturbed Branched-Chain Amino Acid Metabolism in COPD with Abdominal Obesity is More Pronounced in Women but not Associated with More Impaired Functional Performance

# publications[].label
Inflammation predicts change in energy expenditure in patients with cancer on a high-protein diet: Insights from the prime trial

# publications[].label
Biological sex and age-associated changes in muscle and brain health in Chronic Obstructive Pulmonary Disease: A large cross-sectional study.

# publications[].label
Copd patients with abdominal obesity have preserved muscle health despite BCAA metabolic disturbances

# publications[].label
Mild cognitive impairment in copd is associated with reduced functional performance, independent of disease characteristics, nutritional status, or plasma amino acid changes

# publications[].label
Abdominal obesity in COPD is associated with specific metabolic and functional phenotypes.

# publications[].label
Short-Term High Dose Inulin Supplementation Does Not Improve Cognitive Function In Healthy And Diseased Participants

# publications[].label
Factors contributing to alterations in skeletal muscle and plasma amino acid profiles in patients with chronic obstructive pulmonary disease.

# publications[].label
Glutamine supplementation, citrulline production, and de novo arginine synthesis: is there a relation?

# publications[].label
NOVEL METHOD TO MEASURE FAT AND PROTEIN DIGESTION RATE AND THE ACUTE RESPONSE TO PANCREATIC ENZYME INTAKE IN PEDIATRIC AND ADULT PATIENTS WITH CYSTIC FIBROSIS

# publications[].label
Microrna expression in cancer-related muscle loss: findings from the prime trial

# publications[].label
Absorption kinetics of amino acids, peptides, and intact proteins.

# publications[].label
Muscle breakdown determines Arginine (ARG) availability during hyperdynamic sepsis in the pig

# publications[].label
Different patterns of chronic tissue wasting among patients with chronic obstructive pulmonary disease.

# publications[].label
Disturbances in large neutral amino acid profile and poor daily functioning in mildly depressed chronic obstructive pulmonary disease patients

# publications[].label
Lower Plasma Short-Chain Fatty Acids Are Associated With Increased Leg Muscle Fatigue in (Morbidly) Obese Adults

# publications[].label
Impaired intestinal function is associated with lower muscle and cognitive health and well-being in patients with congestive heart failure.

# publications[].label
Enhanced De Novo Arginine Synthesis And Protein Turnover In Pediatric Cystic Fibrosis Patients With Nutritional Failure

# publications[].label
Magnitude of protein catabolic response in critically ill subjects is associated with multiple amino acid and lipolysis related metabolic disturbances

# publications[].label
Compromised Glutamine - Glutamate Metabolism in a Pseudomonas Aeruginosa Induced Hyperdynamic Sepsis-Recovery Pig Model During an Anabolic Nutritional Intervention

# publications[].label
Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults.

# publications[].label
Absence of post-prandial gut anabolism after intake of a low quality protein meal

# publications[].label
Association between the anaerobic threshold and the break-point in the double product/work rate relationship.

# publications[].label
The importance of protein sources to support muscle anabolism in cancer: An expert group opinion.

# publications[].label
Skeletal muscle fibre-type shifting and metabolic profile in patients with chronic obstructive pulmonary disease.

# publications[].label
Regulation of nitric oxide production in health and disease.

# publications[].label
Intermittent hypoxia causes skeletal muscle protein OGlc-Nacylation: A potential mediator of sarcopenia in COPD

# publications[].label
Baseline clinical but not metabolic characteristics of cancer subjects dropping out of a clinical trial during chemotherapy are different from non-dropout subjects

# publications[].label
SUN-P046: Depressed Mood and Cognitive Functions in Patients with Cancer are Associated with Alterations in Tryptophan Metabolism

# publications[].label
The effect of a glutamate load on symptoms of the Chinese restaurant syndrome

# publications[].label
Short-chain fatty acid kinetics and concentrations are higher after inulin supplementation in young and older adults: a randomized trial.

# publications[].label
Muscle protein catabolism and splanchnic arginine consumption drive arginine dysregulation during Pseudomonas Aeruginosa induced early acute sepsis in swine.

# publications[].label
Sulfur amino acid metabolism and related metabotypes of autism spectrum disorder: A review of biochemical evidence for a hypothesis.

# publications[].label
Aging affects arginine, citrulline, and valine kinetics differently in males with chronic comorbidities

# publications[].label
The Role of (Pre) Frailty in Muscle Health and Related Amino Acid Metabolism Measured by Stable Isotope Tracers

# publications[].label
Editorial: The role of targeted nutritional modulation alongside exercise rehabilitation to improve systemic health outcomes in chronic diseases.

# publications[].label
Prolonged disturbances in citrulline metabolism following resistance exercise in COPD.

# publications[].label
New advances in stable tracer methods to assess whole-body protein and amino acid metabolism.

# publications[].label
Impairments in Protein Digestion and Absorption Attenuate the Anabolic Response to Feeding in Patients with Congestive Heart Failure (FS09-03-19)

# publications[].label
Whole Body Leucine and -Ketoisocaproate Turnover and Transamination in Chronic Obstructive Pulmonary Disease

# publications[].label
Impaired whole-body arginine metabolism in type 2 diabetes

# publications[].label
-hydroxy--methylbutyrate (HMB) production in human subjects

# publications[].label
Branched-Chain Amino Acid Kinetics Are Not Sex Specific In Prediabetes

# publications[].label
Effects of exercise on amino acid metabolism in patients with chronic obstructive pulmonary disease.

# publications[].label
Baseline plasma IL-6 in colorectal cancer patients predicts the anabolic effects of increasing protein intake: Findings from the prime trial

# publications[].label
Effect of glutamate ingestion on whole-body glutamate turnover in healthy elderly and patients with chronic obstructive pulmonary disease.

# publications[].label
Metabolic and molecular responses to leucine-enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis

# publications[].label
A four-compartment compartmental model to assess net whole body protein breakdown using a pulse of phenylalanine and tyrosine stable isotopes in humans.

# publications[].label
Using the phenylalanine (PHE) stable isotope pulse method to measure intracellular protein breakdown and metabolic shunting in the context of sepsis in the pig

# publications[].label
Increased amino acid turnover and myofibrillar protein breakdown in advanced cancer are associated with muscle weakness and impaired physical function.

# publications[].label
Dual-energy X-ray absorptiometry in the clinical evaluation of body composition and bone mineral density in patients with chronic obstructive pulmonary disease.

# publications[].label
-hydroxy -methylbutyric acid (hmb) supplementation reduced whole body protein breakdown in the early recovery phase of sepsis in the pig

# publications[].label
MON-PP284: The Anabolic Properties of Casein Hydrolysate are not Modified by Adding Either Leucine, Carbohydrates or Both in Healthy Older Adults and Copd Patients

# publications[].label
Systemic but not fecal short-chain fatty acid (SCFA) concentrations reflect intestinal SCFA production as assessed by novel stable isotope method

# publications[].label
SUN-P277: Metabolic Phenotyping to Provide Insight in Mechanisms Underlying Muscle Weakness and Wasting in Patients with Cancer

# publications[].label
The role of adipose and muscle tissue breakdown on interorgan energy substrate fluxes in a Pseudomonas aeruginosa induced sepsis model in female pigs.

# publications[].label
Obesity- and sex-related metabolism of arginine and nitric oxide in adults.

# publications[].label
Reduced Plasma Short-Chain Fatty Acid (SCFA) Concentrations Are Not Associated With Markers of Muscle Health in Non-Small Cell Lung Cancer

# publications[].label
Is -hydroxy -methylbutyrate an effective anabolic agent to improve outcome in older diseased populations?

# publications[].label
Dietary Essential Amino Acids Are Highly Anabolic In Patients With Non-Small Cell Lung Cancer With Severe Muscle Wasting

# publications[].label
Acute Skeletal Muscle Loss in Patients with SARS-CoV-2 Infection Contributes to Poor Clinical Outcomes Including Mortality

# publications[].label
Preserved anabolic threshold and capacity as estimated by a novel stable tracer approach suggests no anabolic resistance or increased requirements in weight stable COPD patients.

# publications[].label
Excessive nitrogen uptake by the liver limits the anabolic response to enteral amino acids intervention during early sepsis-recovery

# publications[].label
Mild Cognitive Impairment Is Associated With Markers of Muscle Weakness and Reduced Bone Density, and Specific Metabolic Alterations Despite Preserved Physical Activity

# publications[].label
Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer.

# publications[].label
PP288-SUN: Surgery Reduces DE Novo Arginine Production Independent of the Presence of Breast Cancer

# publications[].tags
12 Responsible Consumption and Production

# publications[].label
Increased Whole Body -hydroxy--methylbutyrate Production in Chronic Obstructive Pulmonary Disease

# publications[].label
Lower basal net protein breakdown is linked to more impaired muscle quality, physical activity level, lung function, and protein intake in COPD patients and sedentary control subjects

# publications[].label
Contribution of the respiratory muscles to the lactic acidosis of heavy exercise in COPD.

# publications[].label
Dietary protein, metabolism, and body-weight regulation: dose-response effects

# publications[].label
Muscle fiber type IIX atrophy is involved in the loss of fat-free mass in chronic obstructive pulmonary disease.

# publications[].label
Differential metabolic effects of casein and soy protein meals on skeletal muscle in healthy volunteers.

# publications[].label
MON-PP218: Increased Whole Body Transamination and Oxidation of Leucine in Chronic Heart Failure

# publications[].label
PT03.2: High Intensity Resistance Exercise Induces Whole Body Protein Catabolism in Patients with Chronic Obstructive Pulmonary Disease

# publications[].label
Compromised muscle function and physical activity during recovery of sepsis in an ICU-acquired weakness translational pig model

# publications[].label
Impaired Metabolism of Brain-Related Amino Acids and Early Signs of Poor Motor Control and Cognitive Dysfunction in the Pre-stage of Frailty

# publications[].label
Postprandial concentration of circulating branched chain amino acids are able to predict the carbohydrate content of the ingested mixed meal.

# publications[].label
Metabolic Consequences of Supplemented Methionine in a Clinical Context.

# publications[].label
SUN-PP050: Unchanged Taurine Production in Patients with Stable Chronic Heart Failure

# publications[].label
A Comprehensive Compartmental Model for the Assessment of Net Whole Body Protein Breakdown, Using a Pulse of Phenylalanine and Tyrosine Stable Isotopes in Humans

# publications[].label
EXERCISE ENERGETICS DURING HEAVY EXERCISE UNDER VARYING FIO2

# publications[].label
Muscle loss phenotype in COPD is associated with adverse outcomes in the UK Biobank.

# publications[].label
Whole body citrulline production, but not arginine production, is increased with aging in healthy humans

# publications[].label
Enhanced Splanchnic Extraction Of Nutritional Arginine And Lower Citrulline Production Play A Role In The Reduced Systemic Availability Of Arginine In The Early Recovery Phase Of Sepsis In The Pig

# publications[].label
NUTRITIONAL FAILURE IS ASSOCIATED WITH ENHANCED WHOLE BODY PROTEIN TURNOVER AND CATABOLISM IN PEDIATRIC PATIENTS WITH CYSTIC FIBROSIS

# publications[].label
Plasma concentrations of glutamate, serine, citrulline, arginine, glycine and threonine are predictive of impaired fasting glucose in COPD patients

# publications[].label
Quantitative Computed Tomography Assessment of Pectoralis and Erector Spinae Muscle Area and Disease Severity in Chronic Obstructive Pulmonary Disease Referred for Lung Volume Reduction.

# publications[].label
Gas exchange responses to continuous incremental cycle ergometry exercise in primary pulmonary hypertension in humans.

# publications[].label
Increased whole body hydroxyproline production as assessed by a new stable isotope technique is associated with hip and spine bone mineral loss in cystic fibrosis.

# publications[].label
MON-PP280: Individual Protein Requirements of Older Adults Measured with a Stable Isotope Multi-Step Feeding Approach

# publications[].label
Impaired Muscle Health and Amino Acid Kinetics in Older Adults With Mild Cognitive Impairment and the Role of Comorbidities

# publications[].label
Compartmental analysis: a new approach to estimate protein breakdown and meal response in health and critical illness.

# publications[].label
Transorgan short-chain fatty acid fluxes in the fasted and postprandial state in the pig.

# publications[].label
Meal anabolic capacity, measured by either non- or compartmental analysis after pulse tracer administration, is not different between HMB or LEU added to an essential amino acid mixture in older adults

# publications[].label
SUN-P047: The Acute Effects of Tryptophan Enriched Whey Protein on Cognitive Functions in Older Adults with Mild Cognitive Impairment

# publications[].label
Skeletal Muscle Weakness Is Associated with Specific Alterations in Amino Acid Metabolism in Patients with Chronic Obstructive Pulmonary Disease

# publications[].label
One-week of inulin supplementation increases the abundance of SCFA-producing bacteria and enzymes of SCFA production in young and older adults: A randomized, double-blind, crossover study

# publications[].label
Amino acid kinetics in the critically ill.

# publications[].label
Corrigendum to "Prolonged increase in glutamate whole body and intracellular production in older adults with COPD and healthy controls post-resistance exercise" [Metabolism, Volume 168, July 2025, 156185].

# publications[].label
Walking exercise alters protein digestion, amino acid absorption, and whole body protein kinetics in older adults with and without COPD.

# publications[].label
Malnourished Patients With Chronic Obstructive Pulmonary Disease Respond Anabolic To Bolus Feeding Of Both Casein And Whey Protein With No Additional Effect Of Leucine Addition

# publications[].label
COPD-Related Sarcopenia Is a Major Public Health Issue That Increases the Risk for Mortality

# publications[].label
Isoleucine supplementation for ten days does not modify protein and branched-chain amino acid turnover in type 2 diabetes

# publications[].label
Altered interorgan response to feeding in patients with chronic obstructive pulmonary disease.

# publications[].label
A Minimal Compartmental Model for the Assessment of Net Whole Body Protein Breakdown, Using a Pulse of Phenylalanine and Tyrosine Stable Isotopes in Humans

# publications[].label
Remodelling of primary human CD4+ T cell plasma membrane order by n-3 PUFA.

# publications[].label
Nutritional depletion in relation to respiratory and peripheral skeletal muscle function in out-patients with COPD.

# publications[].label
Non-essential Amino Acids Are Needed to Attenuate ICU Acquired Muscle Weakness (ICU-AW) in a Pig Model of Sepsis Recovery

# publications[].label
24-Hour protein, arginine and citrulline metabolism in fed critically ill children - A stable isotope tracer study.

# publications[].label
Dose-dependent satiating effect of whey relative to casein or soy.

# publications[].label
Comprehensive metabolic amino acid flux analysis in critically ill patients.

# publications[].label
MON-P178: Low Bioimpedance Phase Angle Indicates Muscle Catabolism and Loss of Muscle and Cognitive Function in Chronic Obstructive Pulmonary Disease

# publications[].label
Intestinal dysfunction in chronic disease.

# publications[].label
A low postabsorptive whole body protein balance is associated with markers of poor daily physical functioning in Chronic Obstructive Pulmonary Disease.

# publications[].label
Metabolic kinetics and muscle and brain health markers in older adults, and the role of age and presence of chronic morbidities: A large cross-sectional cohort study.

# publications[].label
Effects of alpha-lactalbumin, gelatin with or without added tryptophan-protein breakfasts on hunger, 'satiety' hormones, and protein kinetics

# publications[].label
Whole-body short-chain fatty acid (SCFA) production rates and plasma concentrations are not associated with health characteristics in human adults

# publications[].label
Effects of high and normal soyprotein breakfasts on satiety and subsequent energy intake, including amino acid and 'satiety' hormone responses.

# publications[].label
Enhanced anabolic capacity, but unchanged anabolic threshold in clinically-stable normal weight patients with chronic obstructive pulmonary disease

# publications[].label
Enhanced levels of whole-body protein turnover in patients with chronic obstructive pulmonary disease.

# publications[].label
Editorial: Interplay between systemic health features and gut dysbiosis in aging and clinical (wasting) conditions.

# publications[].label
Reduced lung glutamate (GLU) production is the cause of decreased systemic glutamate availability in hyperdynamic sepsis

# publications[].label
Sex Related Differences In Amino Acid Metabolism In Chronic Obstructive Pulmonary Disease

# publications[].label
The Role of Comorbidities on Aging-Induced Changes in Muscle Health and Amino Acid Kinetics

# publications[].label
Comprehensive amino acid flux analysis in the post-acute phase of critically ill post-surgery patients, compared to healthy matched subjects

# publications[].label
Greater whole-body myofibrillar protein breakdown in cachectic patients with chronic obstructive pulmonary disease.

# publications[].label
No changes in fasting and 24-hour glucose levels in type 2 diabetic subjects observed after 10 days of L-Isoleucine supplementation

# publications[].label
Protein is an important but undervalued macronutrient in the nutritional care of patients with cystic fibrosis.

# publications[].label
Phenylalanine isotope pulse method to measure effect of sepsis on protein breakdown and membrane transport in the pig.

# publications[].label
Whole Body Production of Butyrate, but Not of Acetate or Propionate, Is Reduced in Adults With Prediabetes

# publications[].label
Protein anabolic resistance in cancer: does it really exist?

# publications[].label
SUN-PP094: Cognitive Deficits and Increased Depression in Patients with Chronic Obstructive Pulmonary Disease with Reduced Whole Body Tryptophan Consumption Ratio

# publications[].label
Short-chain fatty acid production in accessible and inaccessible body pools as assessed by novel stable tracer pulse approach is reduced by aging independent of presence of COPD.

# publications[].label
Risk Factors for Postural and Functional Balance Impairment in Patients with Chronic Obstructive Pulmonary Disease.

# publications[].label
PT03.6: Resistance Exercise Induces Alterations in Whole Body Branched Chain Amino Acids (BCAA), Keto Acids (BCKA), and B-Hydroxy-B-Methylbutyrate (HMB) Metabolism in Patients with Chronic Obstructive Pulmonary Disease

# publications[].label
OR031: Comparable Meal Related Enhanced Protein Anabolism Between a One-Time Bolus Meal and Continuous Sip Feeding in Patients with Chronic Obstructive Pulmonary Disease

# publications[].label
Habitual physical inactivity in older adults is associated with reduced whole body glutamine production, both in healthy and with chronic obstructive pulmonary disease

# publications[].label
Working Memory Precision and Associative Binding in Mild Cognitive Impairment.

# publications[].label
A critical evaluation of the anabolic response after bolus or continuous feeding in COPD and healthy older adults.

# publications[].label
Quantitative Differences in Interorgan Kinetics of Short-Chain Fatty Acids (SCFA)

# publications[].label
Altered interorgan response to feeding in patients with chronic obstructive pulmonary disease

# publications[].label
Intestinal function is impaired in patients with Chronic Obstructive Pulmonary Disease.

# publications[].label
Decreased whole-body and splanchnic glutamate metabolism in healthy elderly men and patients with chronic obstructive pulmonary disease in the postabsorptive state and in response to feeding.

# publications[].label
Mild cognitive impairment in chronic obstructive pulmonary disease is associated with an imbalance of specific non-essential amino acids

# publications[].label
Statin treatment reduces leucine turnover, but does not affect endogenous production of beta-hydroxy-beta-methylbutyrate (HMB).

# publications[].label
Cognitive and muscle health, and related amino acid kinetics in older adults with Mild Cognitive Impairment, and the effect of comorbidities

# publications[].label
Correction: Protein fractional synthesis rates within tissues of high- and low-active mice.

# publications[].label
MON-PP217: Whole Body Production of 3-Hydroxy-3-Methylbutyrate (HMB) in Obese Subjects with Chronic Disease

# publications[].label
MON-PP121: Skeletal Muscle Weakness in Chronic Obstructive Pulmonary Disease is Associated with Disturbances in Glutamate Related Metabolism

# publications[].label
MON-P130: B-Hydroxy-B-Methylbutyrate (HMB) Plasma Levels are Strongly Related to Muscle Mass and Strength in Patients with Chronic Obstructive Pulmonary Disease

# publications[].label
Methods for diagnosing impaired absorption of amino acids, monosaccharides and fatty acids

# publications[].label
The effect of repeated ingestion of glutamate or glutamine on plasma glutamate levels

# publications[].label
The acute changes in intracellular amino acid production during sepsis do not relate to plasma concentrations.

# publications[].label
OR004: Protein Fractional Synthesis Rates (FSR) of Multiple Organs in a Pseudomonas aeruginosa (PM) Induced Hyperdynamic Sepsis Pig Model

# publications[].label
A breakfast with alpha-lactalbumin, gelatin, or gelatin + TRP lowers energy intake at lunch compared with a breakfast with casein, soy, whey, or whey-GMP.

# publications[].label
Methods for diagnosing impaired absorption of amino acids, monosaccharides and fatty acids

# publications[].label
Anabolic Capacity in Healthy Older Adults Using Compartmental Analysis Is Dependent on the Essential Amino Acid Composition of a Meal

# publications[].label
BODY MASS INDEX THRESHOLD TO PREDICT LOSS OF MUSCLE MASS & COMPROMISED LUNG FUNCTION IN PEDIATRIC PATIENTS WITH CYSTIC FIBROSIS

# publications[].label
Inhibition of jejunal protein synthesis and breakdown in Pseudomonas aeruginosa-induced sepsis pig model.

# publications[].label
Protein fractional synthesis rates within tissues of high- and low-active mice.

# publications[].label
L-Citrulline Supplementation Stimulates De Novo Arginine Synthesis In The Early Recovery Phase Of Sepsis In The Pig

# publications[].label
Severely Compromised Anabolic Response to Nutrition in a Pseudomonas aeroginosa (PM) Induced Hyper-dynamic Sepsis-Recovery Pig Model

# publications[].label
Exercise-induced lactate increase in relation to muscle substrates in patients with chronic obstructive pulmonary disease.

# publications[].label
Plasma Short-Chain Fatty Acid (SCFA) Concentrations Are Related to Cognition and Adipose Tissue Mass but Not Muscle Function in Older Adults

# publications[].label
Comparison of the effects of a high- and normal-casein breakfast on satiety, 'satiety' hormones, plasma amino acids and subsequent energy intake.

# publications[].label
ATTENUATION AND STIMULATION OF EXERCISE HYPERPNEA AS RELATED TO INSPIRED O2 CONCENTRATION

# publications[].label
Compartmental Analysis Estimates Higher Postabsorptive Protein Breakdown in Healthy Individuals, Affecting Its Balance With Dietary Protein Needs

# publications[].label
MON-PP282: Exhaled Concentration of Nitric Oxide (Feno) Does not Reflect the Upregulated Whole Body Nitric Oxide Synthesis in Patients with Chronic Obstructive Pulmonary Disease

# publications[].label
Hydrolyzed casein and whey protein meals comparably stimulate net whole-body protein synthesis in COPD patients with nutritional depletion without an additional effect of leucine co-ingestion.

# publications[].label
Plasma Glycine Concentration but Not Whole Body Production Production Rate Is a Marker of Abdominal Obesity in Older Adults Independent of the Presence of a Chronic Disease

# publications[].label
OP013 WHOLE BODY DE NOVO ARGININE PRODUCTION AND NITRIC OXIDE SYNTHESIS ARE REDUCED IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

# publications[].label
Metabolic effects of glutamine and glutamate ingestion in healthy subjects and in persons with chronic obstructive pulmonary disease.

# publications[].label
SUN-P123: Deficits in Cognitive Flexibility in COPD are Linked to Changes in Metabolism of Branched-Chain Amino Acids

# publications[].label
Comparison of urine glycosaminoglycan excretion between children with autism spectrum disorder and typically developed children

# publications[].label
Effects of acute oral feeding on protein metabolism and muscle protein synthesis in individuals with cancer.

# publications[].label
Sex differences in muscle health and amino acid kinetics in older adults with and without mild cognitive impairment

# publications[].label
Functional and metabolic effects of omega-3 polyunsaturated fatty acid supplementation and the role of -hydroxy--methylbutyrate addition in chronic obstructive pulmonary disease: A randomized clinical trial.

# publications[].label
Comprehensive Metabolic Amino Acid Flux Analysis In Critically Ill Male And Female Patients

# publications[].label
Use of Oxygen Therapy, Cognitive Dysfunction, and Comorbidities Are Risk Factors for Impaired Balance Function in Chronic Obstructive Pulmonary Disease

# publications[].label
Females have a different metabolic response to critical illness, measured by comprehensive amino acid flux analysis.

# publications[].label
Enhanced levels of whole-body protein turnover in patients with chronic obstructive pulmonary disease

# publications[].label
Early Signs of Impaired Gut Function Affect Daily Functioning in Patients With Advanced Cancer Undergoing Chemotherapy.

# publications[].label
Skeletal muscle glutamate metabolism in health and disease: state of the art.

# publications[].label
Whole body protein anabolism in COPD patients and healthy older adults is not enhanced by adding either carbohydrates or leucine to a serving of protein.

# publications[].label
Determination of -hydroxy--methylbutyrate concentration and enrichment in human plasma using chemical ionization gas chromatography tandem mass spectrometry.

# publications[].label
O.71 Differentiation between depletion of fat-free mass(FFM) and fat-mass (FM) among emphysema and chronic bronchitis

# publications[].label
Effects of complete whey-protein breakfasts versus whey without GMP-breakfasts on energy intake and satiety.

# publications[].label
PP238-SUN INCREASED WHOLE BODY HYDROXYPROLINE PRODUCTION IS ASSOCIATED WITH HIP AND SPINE BONE MINERAL LOSS IN PEDIATRIC PATIENTS WITH CYSTIC FIBROSIS

# publications[].label
Fighting frailty, (osteo)sarcopenia, and fatigue: importance of unified definitions, accurate target identification, and high-quality clinical trials.

# publications[].label
Presence of chronic morbidities alters skeletal muscle health and amino acid kinetics in mild cognitive impairment.

# publications[].label
Editorial: Energy needs: quick and easy to measure.

# publications[].label
The acute effects of alpha-lactalbumin intake on tryptophan metabolites and mood in older adults with Mild Cognitive Impairment.

# publications[].label
SUN-PP026: Reduced Protein Synthesis and Breakdown in Jejunal Mucosal Biopsies in a Live Bacteria Induced Hyperdynamic Sepsis Pig Model

# publications[].label
Presence or Absence of Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease is Associated With Distinct Phenotypes.

# publications[].label
Effects of casein-, soy-, whey with or without GMP-, alpha-lactalbumin-, or gelatin with or without added tryptophan-protein breakfasts on energy intake

# publications[].label
Increased muscle myofibrillar protein breakdown rates using 3-methylhistidine (tau-mHIS) stable isotopes in a Pseudomonas aeroginosa (PM) induced hyperdynamic sepsis pig model

# publications[].label
-Hydroxy -Methylbutyric Acid (Hmb) Supplementation Stimulates Muscle Protein Synthesis In The Early Recovery Phase Of Sepsis In The Pig.

# publications[].label
Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis.

# publications[].label
Responses to constant work rate bicycle ergometry exercise in primary pulmonary hypertension: the effect of inhaled nitric oxide.

# publications[].label
Changes in Whole-Body Amino Acid Metabolism in Response to 2 Weeks of the Very-Low Calorie Diet Are Not Affected by Gender

# publications[].label
Plasma concentrations of proline, citrulline, and glutamate are predictive of impaired fasting glucose

# publications[].label
Reduced plasma glycine concentration in healthy and chronically diseased older adults: a marker of visceral adiposity?

# publications[].label
Acute effects of breakfasts containing alpha-lactalbumin, or gelatin with or without added tryptophan, on hunger, 'satiety' hormones and amino acid profiles.

# publications[].label
Prediabetes Is Associated with Specific Changes in Valine Metabolism

# publications[].label
Irish Thoracic Society, Irish Gerontological Society, 16th All Ireland Social Medicine Meetings. 1996, 1997. Abstracts.

# publications[].label
Aging In Older Adults Induces Changes In Arginine And Glutamine Kinetics, Partly Independent of The Presence of Comorbidities

# publications[].label
New stable isotope method to measure protein digestibility and response to pancreatic enzyme intake in cystic fibrosis.

# publications[].label
Increased Amino Acid Turnover and Net Protein Breakdown but Preserved Muscle and Cognitive Function in Obese Middle-Age Adults

# publications[].label
Total weight loss obtained after 2 weeks of very low caloric diet is strongly associated with baseline (net) protein catabolic and glutamine production rates

# publications[].label
Protein Digestion, but Not Amino Acid Absorption, Is Compromised During Feeding in Chronic Obstructive Pulmonary Disease

# publications[].label
Presence or Absence of Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease is Associated With Distinct Phenotypes

# publications[].label
Does whole body measured splanchnic extraction of amino acids with stable isotopes tracers in the prandial state represent tracee splanchnic extraction?

# publications[].label
Metabolic flux analysis of branched-chain amino and keto acids (BCAA, BCKA) and -hydroxy -methylbutyric acid across multiple organs in the pig.

# publications[].label
Cognitive Function Is More Impaired in Chronic Obstructive Pulmonary Disease Patients with Skeletal Muscle Dysfunction and Is Associated with Disturbances in Tryptophan Metabolism

# publications[].label
Impact of -hydroxy--methylbutyrate (HMB) in critically ill patients on the endocrine axis - A post-hoc cohort study of the HMB-ICU trial.

# publications[].label
Comprehensive metabolic flux analysis to explain skeletal muscle weakness in COPD.

# publications[].label
Age-Specific Differences in Whole-Body Amino Acid Kinetics

# publications[].label
The Rationale for Vitamin, Mineral, and Cofactor Treatment in the Precision Medical Care of Autism Spectrum Disorder.

# publications[].label
Quantitative CT Assessment of Pectoralis and Erector Spinae Muscle Area and Disease Severity in COPD

# publications[].label
Multi-omics Identified Pathways Associated With Altered Skeletal Muscle Oxidative Metabolism in COPD Patients

# publications[].label
Dietary essential amino acids are highly anabolic in pediatric patients with cystic fibrosis.

# publications[].label
Predicting The Presence Of Prediabetes By A Combination Of Plasma Amino Acid Metabolic Data.

# publications[].label
Muscle wasting and changes in muscle protein metabolism in chronic obstructive pulmonary disease.

# publications[].label
Reduced Transamination of Valine and Isoleucine During Intake of a Leucine-Enriched Essential Amino Acid Mixture in Healthy Older Adults

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Heart, Lung, and Blood Institute

# researcherOn[].label
A longitudinal investigation of the cerebellum in adulthood: anatomical and network changes, motor function, and cognition

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Nutritional Modulation to Minimize Resistance Exercise Induced Metabolic Deregulations and Improve Training Responsiveness in Chronic Obstructive Pulmonary Disease

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Heart, Lung, and Blood Institute

# streetAddress
Texas A&M University; Health And Kinesiology; 4243 TAMU

# organizations[]
College of Education and Human Development

# organizations[]
"Center for Translational Research in Aging and Longevity"@en-US

# organizations[]
Center for Translational Research in Aging and Longevity

# schools[]
College of Education and Human Development

# etdChairOf[].label
Park, Jaekwan (2019-05). Risk Factors Contributing to a Postural Balance Impairment in COPD Patients. Master's Thesis.