# overview
I am an Associate Professor of Pharmaceutical Sciences at Texas A&M Rangel College of Pharmacy (RCOP). I obtained my Ph.D. at Okayama University, Japan, in 2007. Since that, I have acquired ample experience in drug discovery research. Several years of experience in designing, synthesizing, and biological screening of selective tyrosine kinase inhibitors (TKIs) and for targeting the aggressive HER2-resistant breast cancer by selective allosteric and orthosteric kinase inhibitors. Conducting a successful scholarly activity to attract substantial extramural/intramural funding support worth $3.2 Million (as a PI, CO-I, and Consultant) in the United States and the Middle East. Mentoring many undergraduate, graduate, and Pharm-D students exposing them to meritorious research opportunities. Publishing more than 65 peer-reviewed articles and serving as Ad hoc grants/journals reviewer for several national and international institutions. I have served as an ad hoc reviewer for many scientific journals, an active member of several scientific associations, and a Chair of the Admission Committee at RCOP. Moreover, I have extensive experience in teaching Medicinal Chemistry and Drug Design for more than 25 years. I have demonstrated excellence in teaching Medicinal chemistry/Pharmacology for the Pharm-D and graduate students, to be recognized as "Teacher of the Year" in 2017 and 2021 and "Teaching Team of the Year" for 10 consecutive years at RCOP. Then, I received the "Texas A&M University-Distinguished Achievement Award" in 2019.

I have invited to speak at many national/international conferences. Accordingly, I received the "Early Career Faculty Research Award" for demonstrating sustained and impactful scholarship at RCOP.

# keywords[]
3404 Medicinal And Biomolecular Chemistry

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Anti-bovine Viral Diarrhea Virus Activity

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30 Agricultural, Veterinary And Food Sciences

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3404 Medicinal And Biomolecular Chemistry

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Extended Release, In-use Stability, Dissolution

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3404 Medicinal And Biomolecular Chemistry

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4.1 Discovery And Preclinical Testing Of Markers And Technologies

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Health Disparities And Racial Or Ethnic Minority Health Research

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3404 Medicinal And Biomolecular Chemistry

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3102 Bioinformatics And Computational Biology

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Vascular Endothelial Growth Factor (vegf)

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Networking And Information Technology R&d (nitrd)

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Machine Learning And Artificial Intelligence

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3404 Medicinal And Biomolecular Chemistry

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30 Agricultural, Veterinary And Food Sciences

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3002 Agriculture, Land And Farm Management

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30 Agricultural, Veterinary And Food Sciences

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Vascular Endothelial Growth Factor (vegf)

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4.2 Evaluation Of Markers And Technologies

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Health Disparities And Racial Or Ethnic Minority Health Research

# keywords[]
4.1 Discovery And Preclinical Testing Of Markers And Technologies

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# educationAndTraining[].organization.label
Okayama University - (Okayama, Okayama, Japan)

# awardsAndHonors[].label
Faculty Fellow for Innovation in High-Impact Learning Experiences

# publications[].label
Design and molecular modeling of novel P38 MAPK inhibitors targeting breast cancer, synthesized from oxygen heterocyclic natural compounds.

# publications[].label
HER2 Kinase-Targeted Breast Cancer Therapy: Design, Synthesis, and In Vitro and In Vivo Evaluation of Novel Lapatinib Congeners as Selective and Potent HER2 Inhibitors with Favorable Metabolic Stability.

# publications[].label
Design, synthesis and anticancer activity of benzofuran derivatives targeting VEGFR-2 tyrosine kinase

# publications[].label
Dysregulated gene expression predicts tumor aggressiveness in African-American prostate cancer patients.

# publications[].label
Distinct monoamine oxidase A and B populations in primate brain.

# publications[].publisher
Asian Network for Scientific Information

# publications[].label
Abstract B41: Transcriptome-wide profiling identifies novel differential genes associated with health disparity of prostate cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Design and synthesis of antivirals benzimidazoles and quinoxalines

# publications[].label
Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities.

# publications[].label
Antitumor studies. part 3: design, synthesis, antitumor activity, and molecular docking study of novel 2-methylthio-, 2-amino-, and 2-(N-substituted amino)-10-alkyl-2-deoxo-5-deazaflavins.

# publications[].label
Comparison of Independent Culling Levels to Visual Selection Method in Improving Grain Sorghum Populations

# publications[].label
Synthesis, docking and biological activities of novel hybrids celecoxib and anthraquinone analogs as potent cytotoxic agents.

# publications[].label
A study on medicinal plants from Malaysia focused on Acalypha siamensis Oliv. ex Gage. isolation and structure of a new tetraterpene, acalyphaser A.

# publications[].label
Dual Targeting of VEGFR2 and C-Met Kinases via the Design and Synthesis of Substituted 3-(Triazolo-thiadiazin-3-yl)indolin-2-one Derivatives as Angiogenesis Inhibitors.

# publications[].label
Design, Synthesis, and Biological Evaluation of Some Novel Pyrrolizine Derivatives as COX Inhibitors with Anti-Inflammatory/Analgesic Activities and Low Ulcerogenic Liability.

# publications[].label
HER-2 kinase-targeted cancer therapy: Design, synthesis, and kinase profiling of novel quinazoline derivatives as selective antitumor hits

# publications[].label
Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors.

# publications[].label
Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities

# publications[].label
Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors.

# publications[].label
Abstract 3056: Structural optimization of lapatinib analogs for overcoming CNS metastases in breast cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
SN-38-cyclodextrin complexation and its influence on the solubility, stability, and in vitro anticancer activity against ovarian cancer.

# publications[].label
In-Situ Implant Formulation of Laurate and Myristate Prodrugs of Dolutegravir for Ultra-Long Delivery.

# publications[].label
Breaking barriers: Medicinal chemistry strategies and advanced in-silico approaches for overcoming the BBB and enhancing CNS penetration.

# publications[].label
Structure-activity relationship study of indole-2-carboxamides identifies a potent allosteric modulator for the cannabinoid receptor 1 (CB1).

# publications[].label
Exosomes are the Driving Force in Preparing the Soil for the Metastatic Seeds: Lessons from the Prostate Cancer.

# publications[].label
Design, synthesis, biological evaluation, and comparative Cox1 and Cox2 docking of p-substituted benzylidenamino phenyl esters of ibuprofenic and mefenamic acids.

# publications[].label
Antitumor and multikinase inhibition activities of some synthesized coumarin and benzofuran derivatives.

# publications[].label
In-use stability assessment of FDA approved metformin immediate release and extended release products for N-Nitrosodimethylamine and dissolution quality attributes.

# publications[].label
Design, synthesis, and antitumor efficacy of novel 5-deazaflavin derivatives backed by kinase screening, docking, and ADME studies.

# publications[].label
Synthesis and biological evaluation of indole-2-carboxamides bearing photoactivatable functionalities as novel allosteric modulators for the cannabinoid CB1 receptor.

# publications[].label
Benzodiazepine-induced photosensitivity reactions: A compilation of cases from literature review with Naranjo causality assessment.

# publications[].label
Reduction of lipophilicity at the lipophilic domain of RXR agonists enables production of subtype preference: RXRalpha-preferential agonist possessing a sulfonamide moiety.

# publications[].label
Synthesis and molecular docking studies of new furochromone derivatives as p38 MAPK inhibitors targeting human breast cancer MCF-7 cells.

# publications[].label
Abstract 5745: Selective anticancer activity and mechanistic insights of novel compounds identified through NCI-60 cancer cell line screening

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Exosomes-Mediated Transfer of Itga2 Promotes Migration and Invasion of Prostate Cancer Cells by Inducing Epithelial-Mesenchymal Transition.

# publications[].label
First record of Morchella pulchella from Pakistan

# publications[].label
Small extracellular vesicle-associated miR-6068 promotes aggressive phenotypes of prostate cancer through miR-6068/HIC2/SIRT1 axis.

# publications[].label
Studies on 16-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11.

# publications[].label
Targeting CDC7 sensitizes resistance melanoma cells to BRAFV600E-specific inhibitor by blocking the CDC7/MCM2-7 pathway.

# publications[].label
Molecular Docking and Prediction of Pharmacokinetic Properties of Dual Mechanism Drugs that Block MAO-B and Adenosine A(2A) Receptors for the Treatment of Parkinson's Disease.

# publications[].label
Structural-based design, synthesis, and antitumor activity of novel alloxazine analogues with potential selective kinase inhibition.

# publications[].label
Design and Synthesis of 4-O-Podophyllotoxin Sulfamate Derivatives as Potential Cytotoxic Agents.

# publications[].label
Identification of potent virtual leads and ADME prediction of isoxazolidine podophyllotoxin derivatives as topoisomerase II and tubulin inhibitors.

# publications[].label
Part II: New candidates of pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors.

# publications[].label
Synthesis, antitumor activity and molecular docking study of novel sulfonamide-Schiff's bases, thiazolidinones, benzothiazinones and their C-nucleoside derivatives.

# publications[].label
Exosomal microRNAs are associated with prostate cancer aggressiveness in African American patients

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Exosomes-associated miR-5001, miR-3692 and miR-4529 are novel biomarkers for aggressive prostate cancer and associated with poor prognosis in African American patients

# publications[].label
Exosomal microRNAs are associated with prostate cancer aggressiveness in African American patients

# publications[].label
Design, synthesis and anticancer activity of furochromone and benzofuran derivatives targeting VEGFR-2 tyrosine kinase

# publications[].label
Design, Synthesis, Antitumor Activity and Molecular Docking Study of Novel 5-Deazaalloxazine Analogs.

# publications[].label
Structure-based drug design and AutoDock study of potential protein tyrosine kinase inhibitors.

# publications[].label
Monoamine oxidase A and B inhibiting effect and molecular modeling of some synthesized coumarin derivatives.

# publications[].label
Evaluation of Exotic Grain Sorghum Genotypes for Yield Traits under Upper Egypt Conditions

# publications[].label
A spectrofluorimetric determination of aminoglycoside antibiotics through reaction of their Ruhemann's purple with sodium borohydride

# publications[].label
Metal- and Catalyst-Free Synthesis of 2-Substituted-Phthalimides Using 2-(Arenesulfonyl)Phthalimide as Key Reagents

# publications[].label
A comparative study of AutoDock and PMF scoring performances, and SAR of 2-substituted pyrazolotriazolopyrimidines and 4-substituted pyrazolopyrimidines as potent xanthine oxidase inhibitors.

# publications[].label
Cytokinin-containing seaweed and humic acid extracts associated with creeping bentgrass leaf cytokinins and drought resistance

# publications[].label
The Dimroth Rearrangement in the Heterocyclic Compounds Synthesis

# publications[].label
Part I. Synthesis, biological evaluation and docking studies of new 2-furylbenzimidazoles as antiangiogenic agents.

# publications[].label
Antitumor studies. Part 4: Design, synthesis, antitumor activity, and molecular docking study of novel 2-substituted 2-deoxoflavin-5-oxides, 2-deoxoalloxazine-5-oxides, and their 5-deaza analogs.

# publications[].label
Part I: Design, synthesis and biological evaluation of novel pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors with studying their activities alone and in combination with genotoxic drugs.

# publications[].label
Antitumor studies. Part 1: design, synthesis, antitumor activity, and AutoDock study of 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides as a new class of antitumor agents.

# publications[].label
Abstract 4466: Machine-learning-driven optimization of kinase inhibitors to overcome CNS efflux and target breast cancer brain metastases

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Analgesic agents without gastric damage: Design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors (vol 15, pg 1014, 2007)

# publications[].label
Rutin as promising drug for the treatment of Parkinson's disease: an assessment of MAO-B inhibitory potential by docking, molecular dynamics and DFT studies

# publications[].label
Optimization of chemical functionalities of indole-2-carboxamides to improve allosteric parameters for the cannabinoid receptor 1 (CB1).

# publications[].label
The plasticizer BBP selectively inhibits epigenetic regulator sirtuins.

# publications[].label
Molecular insights into the role of exosomes in health disparity of prostate cancer

# publications[].label
Antitumor studies -- part 2: structure-activity relationship study for flavin analogs including investigations on their in vitro antitumor assay and docking simulation into protein tyrosine kinase.

# publications[].label
The Therapeutic Journey of Quinazoline as Anti-cancer Targeting Kinase Inhibitors.

# publications[].label
Health disparity of prostate cancer: Molecular insights into the role of exosomes

# publications[].label
Molecular docking studies of 1-(substituted phenyl)-3-(naphtha [1, 2-d] thiazol-2-yl) urea/thiourea derivatives with human adenosine A(2A) receptor.

# publications[].label
Adding Phytogenic Material and/or Organic Acids to Broiler Diets: Effect on Performance, Nutrient Digestibility and Net Profit

# publications[].label
Pyrrolizines: Design, synthesis, anticancer evaluation and investigation of the potential mechanism of action.

# publications[].label
Synthesis and molecular docking study of new benzofuran and furo[3,2-g]chromone-based cytotoxic agents against breast cancer and p38 MAP kinase inhibitors.

# publications[].label
Heterosis and Combining Ability in Grain Sorghum (sorghum bicolor (l.) Moench) Under Normal and Water Stress Conditions.

# publications[].label
Dopamine release and molecular modeling study of some coumarin derivatives.

# publications[].label
LY2087101 and dFBr share transmembrane binding sites in the (4)3(2)2 Nicotinic Acetylcholine Receptor.

# publications[].label
Antitumor studies. Part 5: Synthesis, antitumor activity, and molecular docking study of 5-(monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins.

# publications[].label
Synthesis, biological evaluation, and docking studies of new 2-furylbenzimidazoles as anti-angiogenic agents: part II.

# publications[].label
Exosomes-associated miR-5001, miR-3692 and miR-4529 are novel biomarkers for aggressive prostate cancer and associated with poor prognosis in African American patients

# publications[].label
Exosomes-associated miR-5001, miR-3692 and miR-4529 are novel biomarkers for aggressive prostate cancer and associated with poor prognosis in African American patients

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Novel alloxazine analogues: design, synthesis, and antitumour efficacy enhanced by kinase screening, molecular docking, and ADME studies.

# publications[].label
Antitumor studies: Design, synthesis, antitumor activity and molecular docking study of novel 2-deoxo-2-substituted-5-deazaalloxazines

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Studies on Regioselective Binding Mode of Steroid Molecules in Homology Modeled Cytochrome P450-2C11

# publications[].label
Design, novel one-pot green synthesis, and biological evaluation of pyrazolopyridine-congeners selectively targeting HER2+ breast cancer.

# publications[].label
Transcriptome-wide profiling identifies novel differential genes associated with health disparity of prostate cancer

# researcherOn[].label
Incorporating Innovative IPE between Pharmacy and Other Health-Related Disciplines into Pharmacy Curriculum to Explore Multiple Public Health Challenges.

# researcherOn[].awardedBy.label
Texas A&M Health Science Center - (College Station, Texas, United States)

# researcherOn[].awardedBy.preferredLabel
The Division of Research funds the Program to Enhance Scholarly and Creative Activities (PESCA).

# researcherOn[].label
Optimization of Selective Potent Kinase Inhibitors Targeting Aggressive HER2-Resistant Breast Cancer

# researcherOn[].awardedBy.label
Texas A&M University - (College Station, Texas, United States)

# researcherOn[].label
Preclinical Development and Emerging Strategies for Design of Selective Kinase Inhibitors Targeting Brain Metastasis of Resistant HER2+ Breast Cancer.

# researcherOn[].awardedBy.label
Prairie View A&M University - (Prairie View, Texas, United States)

# researcherOn[].label
Targeting Breast Cancer Brain Metastasis through Novel Dual HER2 / VEGFR2 Kinase Inhibitors Backed by Cellular and Molecular Profiling

# researcherOn[].awardedBy.label
Texas A&M University - (College Station, Texas, United States)

# researcherOn[].awardedBy.preferredLabel
Texas A&M Health-Innovative & High Impact grant

# researcherOn[].label
ASPIR2E: Aggie Student Pharmacists Initiative for Recruitment / Retention and Education.

# researcherOn[].awardedBy.label
Texas Higher Education Coordinating Board - (Austin, Texas, United States)

# researcherOn[].awardedBy.preferredLabel
Minority Health Research and Education Grant Program

# streetAddress
Mail Stop 1114 159 Reynolds Medical Building,; Lab 365; 