# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Receptor, Transforming Growth Factor-beta Type I

# keywords[]
Receptors, Transforming Growth Factor Beta

# keywords[]
Receptor, Transforming Growth Factor-beta Type Ii

# keywords[]
Receptors, Transforming Growth Factor Beta

# keywords[]
Receptor, Transforming Growth Factor-beta Type I

# keywords[]
Hypoxia-Inducible Factor 1, Alpha Subunit

# keywords[]
Receptors, Transforming Growth Factor Beta

# keywords[]
Receptor, Transforming Growth Factor-beta Type I

# keywords[]
Bone Morphogenetic Protein Receptors, Type II

# keywords[]
Bone Morphogenetic Protein Receptors, Type I

# educationAndTraining[].organization.label
University of California, Santa Barbara - (Santa Barbara, California, United States)

# educationAndTraining[].organization.label
University of Basel - (Basel, Basel-Stadt, Switzerland)

# educationAndTraining[].organization.label
University of California, Santa Barbara - (Santa Barbara, California, United States)

# educationAndTraining[].organization.label
University of California, Santa Barbara - (Santa Barbara, California, United States)

# publications[].label
Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN.

# publications[].label
Structural basis of BMP signalling inhibition by Noggin, a novel cystine knot protein

# publications[].label
Novel Allosteric Destabilizers as Therapeutics for Genetic Diseases and Trauma

# publications[].label
Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole-Exome Sequencing in a Patient with Delayed-Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1R206H -Specific Human Cellular and Zebrafish Models.

# publications[].label
ChemInform Abstract: Microgonotropens and Their Interactions with DNA. Part 1. Synthesis of the Tripyrrole Peptides DienMicrogonotropena, b, and c and Characterization of Their Interactions with dsDNA.

# publications[].label
Sequence-independent detection of gene family homologs: identification of a transcript encoding a molluscan serine protease homologous to the pancreatic enzymes of vertebrates.

# publications[].label
Chymotrypsin mRNA expression in digestive gland amoebocytes: cell specification occurs prior to metamorphosis and gut morphogenesis in the gastropod, Haliotis rufescens.

# publications[].label
Construction and characterization of three yeast-Escherichia coli shuttle vectors designed for rapid subcloning of yeast genes on small DNA fragments.

# publications[].label
Isolation of full-length RNA templates for reverse transcription from tissues rich in RNase and proteoglycans.

# publications[].label
Hypoxia-selective allosteric destabilization and degradation of a receptor protein kinase: potential prophylaxis by H-SAAD/Ds

# publications[].label
An ACVR1R375P pathogenic variant in two families with mild fibrodysplasia ossificans progressiva.

# publications[].label
Assembly of TbetaRI:TbetaRII:TGFbeta ternary complex in vitro with receptor extracellular domains is cooperative and isoform-dependent.

# publications[].label
The TR-I pre-helix extension is structurally ordered in the unbound form and its flanking prolines are essential for binding.

# publications[].label
Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor.

# publications[].label
Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3.

# publications[].label
Inhibitors of activin-like receptor kinases

# publications[].label
Pathogenic mechanisms of tooth agenesis linked to paired domain mutations in human PAX9.

# publications[].label
Nucleotide polymorphisms in the canine Noggin gene and their distribution among dog (Canis lupus familiaris) breeds.

# publications[].label
Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling.

# publications[].label
Activities of Dysregulated ALK2 Receptor Kinases Provide Insight Into the Protein Structural-Functional Basis of Fibrodysplasia Ossificans Progressiva

# publications[].label
Fibrodysplasia Ossificans Progressiva: Developmental Implications of a Novel Metamorphogene

# publications[].label
MICROGONOTROPENS AND THEIR INTERACTIONS WITH DNA .1. SYNTHESIS OF THE TRIPYRROLE PEPTIDES DIEN-MICROGONOTROPEN-A, DIEN-MICROGONOTROPEN-B, AND DIEN-MICROGONOTROPEN-C AND CHARACTERIZATION OF THEIR INTERACTIONS WITH DSDNA

# publications[].label
Preliminary characterization of the transcriptional and translational products of the Saccharomyces cerevisiae cell division cycle gene CDC28.

# publications[].label
Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice.

# publications[].label
Induced degradation of protein kinases by bifunctional small molecules: a next-generation strategy.

# publications[].label
In vitro analyses of the dysregulated R206H ALK2 kinase-FKBP12 interaction associated with heterotopic ossification in FOP.

# publications[].label
Structure and dynamics of the homodimeric dynein light chain km23.

# publications[].label
Functional modeling of the ACVR1 (R206H) mutation in FOP.

# publications[].label
Hypoxia-selective allosteric destabilization of activin receptor-like kinases: A potential therapeutic avenue for prophylaxis of heterotopic ossification.

# publications[].label
Functional analysis of alleged NOGGIN mutation G92E disproves its pathogenic relevance.

# publications[].label
Multi-system involvement in a severe variant of fibrodysplasia ossificans progressiva (ACVR1 c.772G>A; R258G): A report of two patients.

# researcherOn[].label
The Roles of Fam20c (dmp4) In Odontogenesis and Osteogenesis

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Dental and Craniofacial Research

# streetAddress
Texas A&M University College of Dentistry; Biomedical Sciences; 3302 Gaston Avenue