# overview
The Fuchs-Young laboratory studies the basic mechanisms of breast carcinogenesis, including the interaction (cross-talk) between the estrogen receptor alpha (ERa), IGF-1 and p53 signaling cascades. Our research utilizes a variety of unique in vivo and in vitro models, including transgenic and humanized mice. An underlying theme of our research is the discovery of bio-physiological determinants of disparities in breast cancer incidence and outcome. Another project focuses on the interdependent regulation of ER and p53, and the role of racially disproportionate p53 polymorphisms in mediating breast cancer development and progression. A new project in the laboratory project is focused on investigating the impact of exposure to metabolic syndrome during different stages of development on metabolic function and mammary cancer risk. This line of research was initiated, in part, due to the obesity epidemic in the US, and the increasing prevalence of obesity in younger children. Initial results show that manipulation of gestational, lactational and post-weaning diet can have very significant effects on susceptibility to mammary carcinogenesis.

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
Emory University - (Atlanta, Georgia, United States)

# educationAndTraining[].organization.label
Vanderbilt University - (Nashville, Tennessee, United States)

# publications[].label
Overexpression of IGF-1 During Early Development Expands the Number of Mammary Stem Cells and Primes them for Transformation.

# publications[].label
Estrogen and progesterone receptor structure and action in breast cancer cells.

# publications[].label
Guiding Preclinical Medical Students in Finding, Synthesizing, and Communicating Translational Basic Research Literature: Roles for Basic Science Research Mentors.

# publications[].label
Raloxifene is a tissue-selective agonist/antagonist that functions through the estrogen receptor.

# publications[].label
Regulation of apoptosis in uterine leiomyomata.

# publications[].label
The Effect of a High Fat/High Sugar Diet on Physical Activity in Female Mice

# publications[].label
Developmental stage determines estrogen receptor alpha expression and non-genomic mechanisms that control IGF-1 signaling and mammary proliferation in mice.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
P4-05-02: Early Developmental Exposures to a High Carbohydrate/High Fat Diet Affect Glucose Metabolism and Mammary Cancer Susceptibility.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Early Dietary Exposures Epigenetically Program Mammary Cancer Susceptibility through IGF1-mediated Expansion of Mammary Stem Cells

# publications[].label
P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesis.

# publications[].label
Transgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands.

# publications[].label
Preclinical Studies of Raloxifene and Related Compounds

# publications[].label
Culture of Tumorigenic Cells on Protein Fibers Reveals Metastatic Cell Behaviors.

# publications[].label
Differential susceptibility to chemically induced thymic lymphomas in SENCARB and SSIN inbred mice.

# publications[].label
The Importance Of Accurate Measurements In Voluntary Wheel Running In Mice

# publications[].label
Estrogen receptor activation via activation function 2 predicts agonism of xenoestrogens in normal and neoplastic cells of the uterine myometrium.

# publications[].label
7,12-dimethylbenz(a)-anthracene (DMBA) & High Fat High Sugar Diet Decrease Physical Activity in Female Mice

# publications[].label
Altered hormonal responsiveness of proliferation and apoptosis during myometrial maturation and the development of uterine leiomyomas in the rat.

# publications[].label
Effects of raloxifene in a guinea pig model for leiomyomas.

# publications[].label
Dysregulation of IGF-I signaling in uterine leiomyoma.

# publications[].label
Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones.

# publications[].label
Public talks and science listens: a community-based participatory approach to characterizing environmental health risk perceptions and assessing recovery needs in the wake of hurricanes katrina and rita.

# publications[].label
Estrogen and Progesterone Receptor Activity in Breast Cancer Cells

# publications[].label
Detection of the HER-2/neu proto-oncogene protein p185erbB2 by a novel monoclonal antibody (MAB-145ww) in breast cancer membranes from oestrogen and progesterone receptor assays.

# publications[].label
Dynamic role of the codon 72 p53 single-nucleotide polymorphism in mammary tumorigenesis in a humanized mouse model.

# publications[].label
Localization of immunoreactive epidermal growth factor receptor in neonatal and adult rat hippocampus.

# publications[].label
Promoting the STEM Pipeline and Enhancing STEM Career Awareness Through Participation in Authentic Research Activities (RTP, Diversity)

# publications[].publisher
American Society for Engineering Education

# publications[].label
Erratum: Regulation of apoptosis in uterine leiomyomata (Endocrinology (1997) 138 (3056-3064))

# publications[].label
Inhibition of estrogen-stimulated growth of uterine leiomyomas by selective estrogen receptor modulators.

# publications[].label
Rapid tumor development with a modified MCF-7 xenograft model.

# publications[].label
The Effect Of A High Fat/high Sugar Diet And Physical Activity On Body Fat Percentage And Bone Mineral Density

# publications[].label
Influence of Exogenous Estrogen Receptor Ligands on Uterine Leiomyoma: Evidence from an in Vitro/in Vivo Animal Model for Uterine Fibroids

# publications[].label
Calorie Restriction Promotes Constant Physical Activity Levels Throughout Total Lifetime of Female Mice

# publications[].label
Early Dietary Exposures Epigenetically Program Mammary Cancer Susceptibility through Igf1-Mediated Expansion of the Mammary Stem Cell Compartment.

# publications[].label
Efficacy of LGD1069 (Targretin), a retinoid X receptor-selective ligand, for treatment of uterine leiomyoma.

# publications[].label
Influence of exogenous estrogen receptor ligands on uterine leiomyoma: evidence from an in vitro/in vivo animal model for uterine fibroids.

# publications[].label
Early Exposure to a High Fat/High Sugar Diet Increases the Mammary Stem Cell Compartment and Mammary Tumor Risk in Female Mice.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Exercise effects on tumorigenesis in a p53-deficient mouse model of breast cancer.

# publications[].label
Addressing cancer health disparities using a global biopsychosocial approach.

# publications[].label
Effect of High Fat/High Sugar Diet & Physical Activity on Sex Hormone Concentrations

# publications[].label
Preclinical evidence for therapeutic efficacy of selective estrogen receptor modulators for uterine leiomyoma.

# publications[].label
Transdominant suppression of estrogen receptor signaling by progesterone receptor ligands in uterine leiomyoma cells.

# publications[].label
An in vivo/in vitro model to assess endocrine disrupting activity of xenoestrogens in uterine leiomyoma.

# publications[].label
Paracrine overexpression of insulin-like growth factor-1 enhances mammary tumorigenesis in vivo.

# publications[].label
Transcriptional regulation of estrogen receptor-alpha by p53 in human breast cancer cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# researcherOn[].label
Nutrition, Biostatistics and Bioinformatics Training Grant

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Regulatory Science in Environmental Health and Toxicology

# researcherOn[].awardedBy.label
National Institute of Environmental Health Sciences - (Durham, North Carolina, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Environmental Health Sciences

# researcherOn[].label
Role of P53 Polymorphisms In Disparities In Breast Carcinogenesis and Outcome

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Center on Minority Health and Health Disparities

# researcherOn[].label
Undoing the damage: reprogramming the effects of early high sugar/high fat diets through exercise

# researcherOn[].awardedBy.label
United States Army - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
DOD-Army-Medical Research and Materiel Command

# researcherOn[].label
Engineering Research Center for Precise Advanced Technologies and Health Systems for Underserved Populations (PATHS-UP)

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# researcherOn[].label
The MENTORS (Model Education Networks to Optimize Rural Science) Project

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of General Medical Science

# researcherOn[].label
The MENTORS (Model Education Networks to Optimize Rural Science) Project

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-Office of Director-Office of Research Infrastructure Programs

# researcherOn[].label
Texas A&M Center for Environmental Health Research

# researcherOn[].awardedBy.label
National Institute of Environmental Health Sciences - (Durham, North Carolina, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Environmental Health Sciences

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M Health Science Center; Molecular And Cellular Medicine; 1114 TAMUS

# etdChairOf[].label
Gunaratna, Ramesh Tharindu (2018-05). Dynamic Role of the Codon 72 P53 Single Nucleotide Polymorphism in Mammary Tumorigenesis in a Humanized Mouse Model. Doctoral Dissertation.