# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
The research in my laboratory focuses on the study of cellular responses to mechano-chemical stresses from a biophysical perspective. Biophysics research represents an applied field of science at the interface of physics, biology, engineering, and medicine. Our lab uses live vascular cells as a model system because endothelial and smooth muscle cells reside 'in vivo' in a mechanically active environment that is continuously changing. Using real-time imaging of live cells is the only way to directly monitor cellular responses to mechano-chemical stimulation. Moreover, single-cell imaging experiments allow discrete measurements of transient microscopic events that may be masked by a macroscopic average behavior, and will aid in understanding such behavior.

# keywords[]
5102 Atomic, Molecular And Optical Physics

# keywords[]
4009 Electronics, Sensors And Digital Hardware

# keywords[]
5102 Atomic, Molecular And Optical Physics

# keywords[]
4009 Electronics, Sensors And Digital Hardware

# keywords[]
5102 Atomic, Molecular And Optical Physics

# keywords[]
4009 Electronics, Sensors And Digital Hardware

# keywords[]
5102 Atomic, Molecular And Optical Physics

# keywords[]
4009 Electronics, Sensors And Digital Hardware

# keywords[]
5102 Atomic, Molecular And Optical Physics

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
4009 Electronics, Sensors And Digital Hardware

# keywords[]
5102 Atomic, Molecular And Optical Physics

# keywords[]
5102 Atomic, Molecular And Optical Physics

# keywords[]
Receptor, Platelet-Derived Growth Factor Beta

# educationAndTraining[].organization.label
Rice University - (Houston, Texas, United States)

# educationAndTraining[].organization.label
University of Bucharest - (Bucharest, Romania)

# educationAndTraining[].organization.label
Texas A&M Health Science Center - (College Station, Texas, United States)

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# educationAndTraining[].organization.label
Institutul de Fizica Atomica - (Măgurele, Romania)

# awardsAndHonors[].label
Faculty Early Career Development (CAREER) Program

# publications[].label
Histamine effects on endothelial cell fibronectin interaction studied by atomic force microscopy.

# publications[].label
Integrins and regulation of the microcirculation: from arterioles to molecular studies using atomic force microscopy.

# publications[].label
Quantification and confocal imaging of protein specific molecularly imprinted polymers.

# publications[].label
Extracellular matrix effect on RhoA signaling modulation in vascular smooth muscle cells.

# publications[].label
Effect of aging on vascular smooth muscle contractility in skeletal muscle resistance arteries

# publications[].label
Effect of Tensile Stress on Smooth Muscle Cells

# publications[].label
Dichroic mirror for high power Nd:YAG laser

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Age-Associated Dysregulation of Integrin Function in Vascular Smooth Muscle.

# publications[].label
Short-duration increases in intraluminal pressure improve vasoconstrictor responses in aged skeletal muscle feed arteries.

# publications[].label
Measurements of the cross-bridge attachment/detachment process within intact sarcomeres by surface plasmon resonance.

# publications[].id
 a study using atomic force microscopy (AFM)

# publications[].label
Regulation of fibronectin (FN) adhesion to vascular smooth muscle (VSM) 5l integrin

# publications[].label
Smooth Muscle-Alpha Actin R149C Pathogenic Variant Downregulates Integrin Recruitment at Cell-Matrix Adhesions and Decreases Cellular Contractility.

# publications[].label
RhoA-induced cytoskeletal tension controls adaptive cellular remodeling to mechanical signaling.

# publications[].label
Force Transduction In Smooth Muscle Cells

# publications[].label
Multiple solutions provided by analytical synthesis in admittance matching; application to dichroic mirrors

# publications[].label
Thin films for variable reflectance laser mirrors

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
DESIGN OF GRADED REFLECTIVITY MIRRORS FOR YAG ND LASERS

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Importance of mechanical signals in promoting exercise-induced improvements in vasomotor function of aged skeletal muscle resistance arteries.

# publications[].label
Applications of Atomic Force Microscopy for Adhesion Force Measurements in Mechanotransduction.

# publications[].label
On the solutions of the single layer synthesis with symmetrical three layer periods

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Aging Alters Integrinmediated Vascular Smooth Muscle Function in Soleus Feed Arteries

# publications[].label
Mechanically Induced Cell Signaling Stimulates Real-Time Cytoskeleton Remodeling

# publications[].label
LPA effect on integrin recruitment and actin remodeling in aged vascular smooth muscle cells

# publications[].label
Atomic force-multi-optical imaging integrated microscope for monitoring molecular dynamics in live cells.

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Inhibition of cardiac contractility by RGD-dependent integrins

# publications[].label
Exercise-like mechanical stimulation improves myogenic responses in aged skeletal muscle resistance arteries

# publications[].label
Dichroic mirror for diode pumped YAG:Nd laser

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Demonstration of differences in adhesion to fibronectin (FN)after histamine (HIST) in endothelial cells using the atomic force microscope (AFM)

# publications[].label
Design of broadband dichroic mirrors using admittance matching

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Short-term increases in pressure and shear stress attenuate age-related declines in endothelial function in skeletal muscle feed arteries.

# publications[].label
Application of force with an atomic force microscope to a fibronectin - Alpha5 betal integrin focal contact in vascular smooth muscle cells (VSMC) induces a force generating response

# publications[].label
Live Cell Response to Mechanical Stimulation Studied by Integrated Optical and Atomic Force Microscopy

# publications[].label
Nck enables directional cell migration through the coordination of polarized membrane protrusion with adhesion dynamics.

# publications[].label
Influence of cell stiffness on adhesion force between 51 integrin and fibronectin in intact cells using atomic force microscopy

# publications[].label
Upregulated expression of immune function genes in rat lymphatic vessels

# publications[].label
Dichroic mirror design by complete admittance matching

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Integration of AFM with Optical Microscopy Techniques

# publications[].label
Design of graded-reflectivity mirrors using rotating masks

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Vascular Smooth Muscle Contractile Function Declines With Age in Skeletal Muscle Feed Arteries.

# publications[].label
Effects of Aging on IntegrinMediated Vascular Smooth Muscle Contractility in Soleus Muscle Feed Arteries

# publications[].label
EDGE FILTERS WITH THIN DIELECTRIC LAYERS

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Contractility and adhesion to the matrix is impaired in vascular smooth muscle from Acta2 R149C mice

# publications[].label
Functional coupling between adhesion strength and cell stiffness depends on cytoskeletal tension modulation.

# publications[].label
Time-dependent changes in smooth muscle cell stiffness and focal adhesion area in response to cyclic equibiaxial stretch.

# publications[].label
Mg2+ modulates integrin-extracellular matrix interaction in vascular smooth muscle cells studied by atomic force microscopy.

# publications[].label
Use of surface-enhanced Raman spectroscopy for the detection of human integrins.

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Effect of cytoskeletal tension on vascular smooth muscle cell adhesion.

# publications[].label
Ion-assisted deposition of E-gun evaporated ITO films at low substrate temperatures

# publications[].label
Modulation of Integrin-Extracellular Matrix Adhesions by RhoA and Src

# publications[].label
Selective regulation of cytoskeletal tension and cell-matrix adhesion by RhoA and Src.

# publications[].label
Stretch-induced mechanical stimulation effects on vascular smooth muscle contractility in aged resistance arteries

# publications[].label
RhoA-src crosstalk modulates cell stiffness and adhesion to the matrix

# publications[].label
Live cell response to mechanical stimulation studied by integrated optical and atomic force microscopy.

# publications[].label
Vascular smooth muscle stiffness and its role in aging.

# publications[].label
Integrinmediated Vasoconstrictor Function Declines with Age in Skeletal Muscle Resistance Arteries

# publications[].label
Integrated Imaging Techniques Applied to Live Cell Biophysics

# publications[].label
Extracellular matrix modulates mechanical characteristics of cell-matrix adhesions

# publications[].label
Variable reflectivity mirrors with all profiled layers

# publications[].label
Mechanochemical simulation of stress fiber

# publications[].label
Endothelial NCK2 promotes atherosclerosis progression in male but not female Nck1-null atheroprone mice.

# publications[].label
Vascular smooth muscle cells: Key players in arterial aging

# publications[].label
Loss of smooth muscle -actin effects on mechanosensing and cell-matrix adhesions.

# publications[].label
Mechanical properties of the interaction between fibronectin and alpha5beta1-integrin on vascular smooth muscle cells studied using atomic force microscopy.

# publications[].label
Total internal reflection fluorescence (TIRF) microscopy.

# publications[].label
Integrated microscopy for real-time imaging of mechanotransduction studies in live cells.

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Aging Alters Functional Properties of Cell-Matrix Adhesions in Vascular Smooth Muscle Cells

# publications[].label
Cytoskeletal tension modulates cellular responses to mechanical stimuli

# publications[].label
Interferential filter design with continuously variable refractive index

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Smooth muscle hyperplasia due to loss of smooth muscle -actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-.

# publications[].label
Vascular smooth muscle cells (VSMC) mechanically respond to application of force to the fibronectin-5 1 integrin bond

# publications[].label
Myosin and alpha-actinin regulation of stress fiber contractility under tensile stress

# publications[].label
Effect of Aging on Vascular Smooth Muscle Myogenic Contractility in Soleus Muscle Feed Arteries

# publications[].label
Regional atherosclerotic plaque properties in ApoE-/- mice quantified by atomic force, immunofluorescence, and light microscopy.

# publications[].label
Dielectric mirrors coating of the active medium for diode pumped Erbium laser

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
From ligand-receptor interaction to whole cell manipulation using atomic force microscopy

# publications[].label
Demonstration of differences in adhesion to fibronectin (FN) after histamine (HIST) in endothelial cells using the atomic force microscope (AFM)

# publications[].label
Matrix remodeling and stress relaxation are impaired in vascular smooth muscle from Acta2-/mice.

# researcherOn[].label
Cytoskeleton remodeling regulates contractile function and mechanosensing in vascular smooth muscle

# researcherOn[].awardedBy.label
American Heart Association - (New York, New York, United States)

# researcherOn[].label
Career: Integrated Scanning and Optical Imaging Techniques To Enable Understanding of Live Cell Dynamics-From Molecular Biology

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# researcherOn[].label
Integrins as regulators of vascular contractility in aged resistance arteries

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M Health Science Center; Medical Physiology; 1114 TAMUS

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine

# inTheNews[].label
Six Postdoctoral Researchers Earn At Texas A&M Symposium

# etdChairOf[].label
Sreenivasappa, Harini Bytaraya (2014-12). Mechanical Signaling Induced Cellular Remodeling Studied By Integrated Optical And Atomic Force Microscopy. Doctoral Dissertation.