# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Serotonin Plasma Membrane Transport Proteins

# keywords[]
Calcium Release-activated Calcium Channel Protein 1 (orai1)

# educationAndTraining[].organization.label
Fudan University - (Shanghai, Shanghai, China)

# educationAndTraining[].organization.label
University of California, Irvine - (Irvine, California, United States)

# educationAndTraining[].organization.label
University of California, Irvine - (Irvine, California, United States)

# publications[].label
Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Purifying plasmid DNA from bacterial colonies using the QIAGEN Miniprep Kit.

# publications[].label
Measurement of shear stress-mediated intracellular calcium dynamics in human dermal lymphatic endothelial cells.

# publications[].label
Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai.

# publications[].label
Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis.

# publications[].label
Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells.

# publications[].label
Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.

# publications[].label
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension.

# publications[].label
Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3.

# publications[].label
Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Inactivation of Cdc42 in neural crest cells causes craniofacial and cardiovascular morphogenesis defects.

# publications[].label
Essential role of Cdc42 in cardiomyocyte proliferation and cell-cell adhesion during heart development.

# publications[].label
Attenuation of Blood-Brain Barrier Breakdown and Hyperpermeability by Calpain Inhibition.

# publications[].label
Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons.

# publications[].label
Inside-out Ca(2+) signalling prompted by STIM1 conformational switch.

# publications[].label
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.

# publications[].label
STIM1, an essential and conserved component of store-operated Ca2+ channel function.

# publications[].label
Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Molecular mechanisms underlying inhibition of STIM1-Orai1-mediated Ca2+ entry induced by 2-aminoethoxydiphenyl borate.

# publications[].label
STIM1 restores coronary endothelial function in type 1 diabetic mice.

# publications[].label
Atlastin regulates store-operated calcium entry for nerve growth factor-induced neurite outgrowth.

# publications[].label
Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca influx.

# publications[].label
A Cell Centered Database (CCDB) for multi-scale microscopy data management

# publications[].label
Orai1 function is essential for T cell homing to lymph nodes.

# publications[].publisher
The American Association of Immunologists

# publications[].label
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers.

# publications[].label
The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons.

# publications[].label
The application of genome-wide RNAi screens in exploring varieties of signaling transduction pathways.

# publications[].label
Molecular Mechanism of Store-Operated Ca2+ Signaling and CRAC Channel Activation Mediated by STIM & Orai

# publications[].label
Stromal interaction molecule 1 (STIM1) and Orai1 mediate histamine-evoked calcium entry and nuclear factor of activated T-cells (NFAT) signaling in human umbilical vein endothelial cells.

# researcherOn[].label
Molecular Control of Calcium Influx at the ER-Plasma Membrane Junctions

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of General Medical Science

# streetAddress
Texas A&M Health Science Center; Medical Physiology; 1114 TAMUS

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine