# overview
Our laboratory conducts research in:

1. The characterization and application of standardized mesenchymal stem cells (MSCs) derived from iPS cells and their extracellular vesicles (EVs). Current application focuses on treating diseases caused by over-activation of immune system, such as Sjogren's syndrome, an autoimmune disease causing dry eyes and dry mouth, and cytokine storm caused by infections.

2. Roles of tissue-resident macrophages in the development, homeostasis, and regeneration of salivary glands damaged by radiation therapy for cancer.

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Fibroblast Growth Factor Receptor (FGFR)

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Receptors, Tumor Necrosis Factor, Member 10c

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Bone Morphogenetic Protein Receptors, Type I

# educationAndTraining[].organization.label
Fourth Military Medical University - (Xi'an, Shaanxi, China)

# educationAndTraining[].organization.label
University of Pennsylvania - (Philadelphia, Pennsylvania, United States)

# educationAndTraining[].organization.label
Fourth Military Medical University - (Xi'an, Shaanxi, China)

# educationAndTraining[].organization.label
University of Dundee - (Dundee, United Kingdom)

# educationAndTraining[].organization.label
University of Aberdeen - (Aberdeen, United Kingdom)

# educationAndTraining[].organization.label
Fourth Military Medical University - (Xi'an, Shaanxi, China)

# publications[].label
Differentially expressed gene profiles between multidrug resistant gastric adenocarcinoma cells and their parental cells.

# publications[].label
iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers.

# publications[].label
Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis.

# publications[].label
Biomimetic nanovesicles made from iPS cell-derived mesenchymal stem cells for targeted therapy of triple-negative breast cancer.

# publications[].label
Wnt/-catenin signaling regulates postnatal development and regeneration of the salivary gland.

# publications[].label
Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.

# publications[].label
Intragland Shh gene delivery mitigated irradiation-induced hyposalivation in a miniature pig model.

# publications[].label
Rescue Effects and Underlying Mechanisms of Intragland Shh Gene Delivery on Irradiation-Induced Hyposalivation.

# publications[].label
Wnt/-catenin signaling for dental regeneration

# publications[].label
WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation.

# publications[].label
Extracellular vesicle mimics made from iPS cell-derived mesenchymal stem cells improve the treatment of metastatic prostate cancer.

# publications[].label
A Salivary Gland Resident Macrophage Subset Regulating Radiation Responses.

# publications[].label
A scalable system for generation of mesenchymal stem cells derived from induced pluripotent cells employing bioreactors and degradable microcarriers.

# publications[].label
Characterization of a pluripotent stem cell-derived matrix with powerful osteoregenerative capabilities.

# publications[].label
Transient activation of hedgehog pathway rescued irradiation-induced hyposalivation by preserving salivary stem/progenitor cells and parasympathetic innervation.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Inhibitory Effects of iPSC-MSCs and Their Extracellular Vesicles on the Onset of Sialadenitis in a Mouse Model of Sjgren's Syndrome.

# publications[].label
Derivation and Characterization of Mesenchymal Stem Cells from iPS Cells.

# publications[].label
Delivery of Sonic Hedgehog Gene Repressed Irradiation-induced Cellular Senescence in Salivary Glands by Promoting DNA Repair and Reducing Oxidative Stress.

# publications[].label
MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages.

# publications[].label
The Wnt signaling mediator tcf1 is required for expression of foxd3 during Xenopus gastrulation.

# publications[].label
GATA transcription factors integrate Wnt signalling during heart development.

# publications[].label
Inhibition of TGF-/Smad signaling by BAMBI blocks differentiation of human mesenchymal stem cells to carcinoma-associated fibroblasts and abolishes their protumor effects.

# publications[].label
-Catenin Signaling Biases Multipotent Lingual Epithelial Progenitors to Differentiate and Acquire Specific Taste Cell Fates.

# publications[].label
WNT/-Catenin signaling maintains regenerating adult oral appendage organs and promotes stem cell expansion and de novo organ development

# publications[].label
Inhibitory Effects of Extracellular Vesicles from iPS-Cell-Derived Mesenchymal Stem Cells on the Onset of Sialadenitis in Sjgren's Syndrome Are Mediated by Immunomodulatory Splenocytes and Improved by Inhibiting miR-125b.

# publications[].label
[Cloning, prokaryotic expression of LAIR and identification of their immunological reactivities].

# publications[].label
Preparation and characterization of monoclonal antibodies against GAM protein: a novel gp130-associated molecule.

# publications[].label
Transient Activation of Hedgehog Signaling Inhibits Cellular Senescence and Inflammation in Radiated Swine Salivary Glands through Preserving Resident Macrophages.

# publications[].label
Erratum: iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers.

# publications[].label
Mesenchymal stem cells in progression and treatment of cancers

# publications[].label
Identification of Molecules Responsible for Therapeutic Effects of Extracellular Vesicles Produced from iPSC-Derived MSCs on Sjogren's Syndrome.

# publications[].label
The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain.

# publications[].label
Wnt/beta-catenin signaling in oral tissue development and disease.

# publications[].label
Transient Activation of the Hedgehog-Gli Pathway Rescues Radiotherapy-Induced Dry Mouth via Recovering Salivary Gland Resident Macrophages.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Editorial: Approaches That Foster a Pro-Regenerative Environment.

# publications[].label
Fibroblast growth factor signaling is essential for self-renewal of dental epithelial stem cells.

# publications[].label
Molecular cues for development and regeneration of salivary glands.

# publications[].label
Effects of perindopril on soluble intercellular adhesion molecule-1 in patients with congestive heart failure.

# publications[].label
Functional Restoration of Salivary Glands After Radiotherapy: Roles of Wnt and Hedgehog Pathways

# publications[].label
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles.

# publications[].label
Preparation and characterization of a set of monoclonal antibodies to TRAIL and TRAIL receptors DR4, DR5, DcR1, and DcR2.

# publications[].label
Concurrent transient activation of Wnt/-catenin pathway prevents radiation damage to salivary glands.

# publications[].label
Distinct roles for Xenopus Tcf/Lef genes in mediating specific responses to Wnt/beta-catenin signalling in mesoderm development.

# publications[].label
Prevalence of human parvovirus B19 DNA in cardiac tissues of patients with congenital heart diseases indicated by nested PCR and in situ hybridization.

# publications[].label
Constitutive activation of -catenin signaling in embryonic surface epithelium results in global acquisition of hair follicle fate

# publications[].label
-catenin Initiates Tooth Neogenesis in Adult Rodent Incisors

# publications[].label
Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a -catenin-dependent manner.

# researcherOn[].label
Therapeutic Effects of MSC-Derived Extracellular Vesicles on Sjögren's Syndrome

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Dental and Craniofacial Research

# researcherOn[].label
Roles of resident macrophages in salivary gland development, homeostasis, regeneration, and function restoration after radiotherapy (Liu, Fei)

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Therapeutic mechanisms of iPSC-MSC derived extracellular vesicles on dry mouth caused by Sjogren's syndrome or radiotherapy

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Nanoparticles Made from iPS Cell-Derived Mesenchymal Stem Cells as Standardized Natural Platforms for Targeted Treatment of Drug-Resistant Prostate Cancer

# researcherOn[].awardedBy.label
United States Army - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
DOD-Army-Medical Research and Materiel Command

# researcherOn[].label
Mechanisms of Hedgehop Mediated Rescue of Radiation-Induced Hyposalivation

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Dental and Craniofacial Research

# streetAddress
Texas A&M Health Science Center; Regenerative Medicine; 1114 TAMUS

# inTheNews[].label
Presidential Clinical Research Partnership Grants Fund Six Research Projects

# inTheNews[].label
Primitive Stem Cells Could Be Used For Complicated Bone Fractures