# positions[].organizations[].parent[].label
College of Veterinary Medicine and Biomedical Sciences

# positions[].organizations[].parent[].label
School of Veterinary Medicine and Biomedical Sciences

# overview
Molecular aspects of viral replication, pathogenesis, and evolution. The major focus of the laboratory is the retrovirus, equine infectious anemia virus. EIAV studies include evolution of virulence during rapid virus passage, modification of cell signaling pathways mediated by viral glycoproteins, effects of proinflammatory cytokines on virus replication and disease, and detailed mapping of EIAV virulence determinants. We also study the recently discovered avian bornavirus, etiological agent of proventricular dilatation disease of parrots, in conjunction with colleagues from the Schubot center.

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

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International Committee On Taxonomy Of Viruses

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Reverse Transcriptase Polymerase Chain Reaction

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United States Department Of Veterans Affairs

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Reverse Transcriptase Polymerase Chain Reaction

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Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
Louisiana State University - (Baton Rouge, Louisiana, United States)

# educationAndTraining[].organization.label
University of Massachusetts Dartmouth - (New Bedford, Massachusetts, United States)

# publications[].label
Avian bornaviruses: diagnosis, isolation, and genotyping.

# publications[].label
Antigenic variation and lentivirus persistence: variations in envelope gene sequences during EIAV infection resemble changes reported for sequential isolates of HIV.

# publications[].label
Aquatic Bird Bornavirus-Associated Disease in Free-Living Canada Geese ( Branta canadensis ) in the Northeastern USA.

# publications[].label
SU proteins from virulent and avirulent EIAV demonstrate distinct biological properties.

# publications[].label
Differential effects of virulent and avirulent equine infectious anemia virus on macrophage cytokine expression.

# publications[].label
Characterization of infectious molecular clones of equine infectious anaemia virus.

# publications[].label
Erratum: Expression, characterisation and mutagenesis of the aspartic proteinase from equine infectious anaemia virus, (Eur. J. Biochem. Volume 241, No. 2 (667+669))

# publications[].label
Characterization of a new genotype of avian bornavirus from wild ducks.

# publications[].label
Taxonomy of the order Mononegavirales: update 2016.

# publications[].label
EIAV genomic organization: further characterization by sequencing of purified glycoproteins and cDNA.

# publications[].label
Characterization of the antigenic domains of the major core protein (p26) of equine infectious anemia virus.

# publications[].label
Histopathology and the detection of avian bornavirus in the nervous system of birds diagnosed with proventricular dilatation disease.

# publications[].label
Bornaviruses in North American waterfowl

# publications[].label
Influence of long terminal repeat and env on the virulence phenotype of equine infectious anemia virus.

# publications[].label
High hospital admission rates and inappropriate care.

# publications[].label
Studies on immunity and immunopathogenesis of parrot bornaviral disease in cockatiels.

# publications[].label
Strengthening the Interaction of the Virology Community with the International Committee on Taxonomy of Viruses (ICTV) by Linking Virus Names and Their Abbreviations to Virus Species.

# publications[].label
Characterization and mutational studies of equine infectious anemia virus dUTPase.

# publications[].label
The isolation, pathogenesis, diagnosis, transmission, and control of avian bornavirus and proventricular dilatation disease.

# publications[].label
Measuring retention in HIV care: the elusive gold standard.

# publications[].label
Simultaneous quantitation of equine cytokine mRNAs using a multi-probe ribonuclease protection assay.

# publications[].label
The role of retroviral dUTPases in replication and virulence.

# publications[].label
Complete genome sequence of avian bornavirus genotype 1 from a Macaw with proventricular dilatation disease.

# publications[].label
High prevalence of serum antibodies to equine infectious anemia virus reverse transcriptase.

# publications[].label
Lentivirus genomic organization: the complete nucleotide sequence of the env gene region of equine infectious anemia virus.

# publications[].label
Validation of quantitative polymerase chain reaction assays for measuring cytokine expression in equine macrophages.

# publications[].label
Possibility and Challenges of Conversion of Current Virus Species Names to Linnaean Binomials.

# publications[].label
Horses naturally infected with EIAV harbor 2 distinct SU populations but are monophyletic with respect to IN.

# publications[].label
Genomic alterations associated with persistent infections by equine infectious anaemia virus, a retrovirus.

# publications[].label
Unusual and severe lesions of proventricular dilatation disease in cockatiels (Nymphicus hollandicus) acting as healthy carriers of avian bornavirus (ABV) and subsequently infected with a virulent strain of ABV.

# publications[].label
LENTIVIRUS GENOMIC ORGANIZATION - COMPLETE NUCLEOTIDE-SEQUENCE OF THE ENV GENE REGION OF EQUINE INFECTIOUS-ANEMIA VIRUS (EIAV) AND ITS RELATIONSHIP TO HTLV-III AND VISNA VIRUS

# publications[].label
Avian Vaccination: Current Options and Strategies.

# publications[].label
Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales.

# publications[].label
The pathogenesis of proventricular dilatation disease.

# publications[].label
Viruses: From understanding to investigation

# publications[].label
Taxonomy of the order Mononegavirales: update 2017.

# publications[].label
2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales.

# publications[].label
Long terminal repeat sequences of equine infectious anaemia virus are a major determinant of cell tropism.

# publications[].label
The pathogenesis of bornaviral diseases in mammals.

# publications[].label
Use of avian bornavirus isolates to induce proventricular dilatation disease in conures.

# publications[].publisher
Centers for Disease Control and Prevention (CDC)

# publications[].label
2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales.

# publications[].label
Rapid emergence of novel antigenic and genetic variants of equine infectious anemia virus during persistent infection.

# publications[].label
Health-related quality of life in patients served by the Department of Veterans Affairs: results from the Veterans Health Study.

# publications[].label
Disease induction by virus derived from molecular clones of equine infectious anemia virus.

# publications[].label
Characterization of equine infectious anemia virus dUTPase: growth properties of a dUTPase-deficient mutant.

# publications[].label
How to set up a focused utilization review effort.

# publications[].label
Cytokine expression by adult equine neutrophils following exposure to virulent and avirulent - Rhodococcus equi in vitro

# publications[].label
Localization of conserved and variable antigenic domains of equine infectious anemia virus envelope glycoproteins using recombinant env-encoded protein fragments produced in Escherichia coli.

# publications[].label
Assuring rural hospital patient safety: what should be the priorities?

# publications[].label
Taxonomy of the order Mononegavirales: second update 2018.

# publications[].label
Avian Bornaviruses in North American Gulls.

# publications[].label
Identification of cellular proteins interacting with equine infectious anemia virus S2 protein.

# publications[].label
EIAV S2 enhances pro-inflammatory cytokine and chemokine response in infected macrophages.

# publications[].label
Course and extent of variation of equine infectious anemia virus during parallel persistent infections.

# publications[].label
Proventricular dilatation disease in cockatiels (Nymphicus hollandicus) after infection with a genotype 2 avian bornavirus.

# publications[].publisher
Association of Avian Veterinarians (AAV)

# publications[].label
Expression, characterisation and mutagenesis of the aspartic proteinase from equine infectious anaemia virus.

# publications[].label
Molecular basis of the pathobiology of lentiviruses.

# publications[].label
Purification and characterization of recombinant equine infectious anemia virus reverse transcriptase.

# publications[].label
Virulence determinants of equine infectious anemia virus.

# publications[].label
Incorporation of uracil into viral DNA correlates with reduced replication of EIAV in macrophages.

# publications[].label
An unusual retrovirus-like sequence identified in human DNA.

# publications[].label
Cytokine expression by neutrophils of adult horses stimulated with virulent and avirulent Rhodococcus equi in vitro.

# publications[].label
The diagnosis of proventricular dilatation disease: use of a Western blot assay to detect antibodies against avian Borna virus.

# publications[].label
Age-related changes in cytokine expression by neutrophils of foals stimulated with virulent Rhodococcus equi in vitro.

# publications[].label
GENETIC ORGANIZATION AND FUNCTIONAL-ANALYSIS OF THE GENE-PRODUCTS OF EQUINE INFECTIOUS-ANEMIA VIRUS (EIAV)

# publications[].label
Taxonomy of the order Mononegavirales: update 2019.

# publications[].label
Taxonomy of the order Mononegavirales: update 2018.

# publications[].label
Detection and characterization of a distinct bornavirus lineage from healthy Canada geese (Branta canadensis).

# publications[].label
The S2 accessory gene of equine infectious anemia virus is essential for expression of disease in ponies.

# streetAddress
Texas A&M University; Vet Med Pathobiology; 4467 TAMU

# organizations[]
College of Veterinary Medicine and Biomedical Sciences

# organizations[]
School of Veterinary Medicine and Biomedical Sciences

# schools[]
College of Veterinary Medicine and Biomedical Sciences

# schools[]
School of Veterinary Medicine and Biomedical Sciences