# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# keywords[]
Von Hippel-Lindau Tumor Suppressor Protein

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell - Human

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell

# keywords[]
Mechanistic Target Of Rapamycin Complex 1

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Squamous Cell Carcinoma Of Head And Neck

# keywords[]
Von Hippel-Lindau Tumor Suppressor Protein

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
Networking And Information Technology R&d (nitrd)

# keywords[]
Machine Learning And Artificial Intelligence

# keywords[]
Atpases Associated With Diverse Cellular Activities

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
3102 Bioinformatics And Computational Biology

# publications[].label
Chemical genetic analysis of enoxolone inhibition of Clostridioides difficile toxin production reveals adenine deaminase and ATP synthase as antivirulence targets.

# publications[].label
Defining estrogenic mechanisms of bisphenol A analogs through high throughput microscopy-based contextual assays.

# publications[].label
Targeting neddylation and sumoylation in chemoresistant triple negative breast cancer.

# publications[].label
Cystic fibrosis cell models for high-throughput analysis and drug screening.

# publications[].label
Small Molecule Screening Identifies HSP90 as a Modifier of RNA Foci in Myotonic Dystrophy Type 1.

# publications[].label
Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells.

# publications[].label
Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Nav1.6complex in nucleus accumbens neurons.

# publications[].label
Screening of GPCR drugs for repurposing in breast cancer.

# publications[].label
SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract 1858: Rb deficient HPV+ HNSCC experienced enhanced sensitivity to aurora kinase inhibitors by altering the balance of MAD2 and TRIP13 levels

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Inhibition of GPX4 Induces the Death of p53-Mutant Triple-Negative Breast Cancer

# publications[].label
Chemically targeting the redox switch in AP1 transcription factor FOSB.

# publications[].label
Author Correction: Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells.

# publications[].label
deepOrganoid: A brightfield cell viability model for screening matrix-embedded organoids.

# publications[].label
Abstract P3060: Modeling Immune Checkpoint Inhibitor Associated Myocarditis In Vitro

# publications[].label
Abstract 453: Targeting FOXL2C402G vulnerabilities in adult type ovarian granulosa cell tumors

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract B20: Unbiased high-throughput screenings to identify combination therapies targeting RAS-mutated colorectal cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract 369: Identification of pathways that enhance cell death in NOTCH1-mutant HNSCC

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract 2847: Concurrent inactivation of PI3K and PLK1 is synergistic and overcomes acquired resistance to PI3K inhibitors in NOTCH1 MUT HNSCC

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
MOLECULAR LANDSCAPE OF A COMPREHENSIVE PANEL OF PEDIATRIC BRAIN CANCER PATIENT-DERIVED ORTHOTOPIC XENOGRAFT (PDOX) MODELS INFORM UNIQUE TARGETS FOR DRUG RESPONSIVENESS

# publications[].label
ATM functions at the peroxisome to induce pexophagy in response to ROS.

# publications[].label
Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state.

# publications[].label
Bexarotene - a novel modulator of AURKA and the primary cilium in VHL-deficient cells.

# publications[].label
Aurora kinase inhibitors cause cell death in HPV plus cells: A plausible treatment option for HPV plus cancers.

# publications[].label
Determining efficacy of combining the MEK inhibitor trametinib with vincristine identified by unbiased high throughput screening in RAS-mutated colorectal cancer cells

# publications[].label
Determining efficacy of drug combinations identified by unbiased high throughput screening for RAS-mutated colorectal cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Dual Chromatin and Cytoskeletal Remodeling by SETD2.

# publications[].label
Modeling immune checkpoint inhibitor associated myocarditis in vitro and its therapeutic implications.

# publications[].label
Endocrine disrupting chemicals differentially alter intranuclear dynamics and transcriptional activation of estrogen receptor-.

# publications[].label
Pharmacologic profiling of patient-derived xenograft models of primary treatment-nave triple-negative breast cancer.

# publications[].label
Identification of Histological Correlates of Overall Survival in Lower Grade Gliomas Using a Bag-of-words Paradigm: A Preliminary Analysis Based on Hematoxylin & Eosin Stained Slides from the Lower Grade Glioma Cohort of The Cancer Genome Atlas.

# publications[].label
EXTH-82. TUMOR ORGANOID PREDICTED THERAPEUTIC RESPONSES TO NOVEL EPIGENETIC DRUGS VIA HIGH-THROUGHPUT SCREENING

# publications[].label
Identification of pathways that enhance cell death in NOTCH1-mutant HNSCC.

# publications[].label
Computational precision therapeutics and drug repositioning

# publications[].label
Abstract 6620: PDX models of TNBC established from pre- and post-therapy tumors identify vulnerabilities of resistant disease

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
1723P The role of hepatocyte nuclear factor 1 homeobox B (HNF1B) loss in chromophobe RCC (ChRCC) development

# publications[].label
High throughput chemical profiling of chemoresistant triple negative breast cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS -mutated colorectal cancer.

# publications[].label
Abstract P3-03-08: Identification of drugs that induce the death or suppress the growth of p53-mutant breast cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract 4994: Crizotinib enhances the efficacy of BX-795 identified by high-throughput screening of pan-active drugs in colorectal cancer cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
EphA2- and HDAC-Targeted Combination Therapy in Endometrial Cancer.

# publications[].label
PanCancer insights from The Cancer Genome Atlas: the pathologist's perspective.

# publications[].label
Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo.

# publications[].label
Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer.

# publications[].label
HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Systematic high-throughput combination drug screen to enhance poly (ADP-ribose) polymerase (PARP) inhibitor efficacy in ovarian cancer.

# publications[].publisher
American Society of Clinical Oncology (ASCO)

# publications[].label
Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus-Driven Cancers.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract 368: Aurora kinase inhibitors cause cell death in HPV+ cells: A plausible treatment option for HPV+ cancers

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract B171: BX-795 enhances the efficacy of crizotinib in colorectal cancer cells by altering the activity of aurora kinases

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
A transgenic mouse model of Down syndrome acute lymphoblastic leukemia identifies targetable vulnerabilities.

# publications[].label
Airway Secretory Cells Contain Both a Perinuclear Golgi Ribbon and Dispersed Golgi Satellites

# publications[].label
Unbiased high-throughput screenings to identify combination therapies targeting RAS-mutated colorectal cancer.

# publications[].label
Abstract GS1-09: Inhibition of GPX4 induces preferential death of p53-mutant triple-negative breast cancer cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Radiogenomics and Histomics in Glioblastoma: The Promise of Linking Image-Derived Phenotype with Genomic Information

# publications[].label
Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Systematic high-throughput combination drug screen to enhance poly (ADP-ribose) polymerase (PARP) inhibitor efficacy in ovarian cancer

# publications[].label
The Transcription Factor ETV5 Mediates BRAFV600E-Induced Proliferation and TWIST1 Expression in Papillary Thyroid Cancer Cells.

# publications[].label
Combined inhibition of HMGCoA reductase and mitochondrial complex I induces tumor regression of BRAF inhibitor-resistant melanomas.

# publications[].label
Targeting the Oncogenic Functions of an RNA-Binding Protein Involved in Hematologic Malignancies

# publications[].label
Abstract P6-10-19: Screening of GPCR-targeting drugs for repositioning in breast cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Rb deficient HPV plus HNSCC experienced enhanced sensitivity to aurora kinase inhibitors by altering the balance of MAD2 and TRIP13 levels

# publications[].label
Molecular pathways enhance drug response prediction using transfer learning from cell lines to tumors and patient-derived xenografts.

# publications[].label
Methylated -tubulin antibodies recognize a new microtubule modification on mitotic microtubules.

# publications[].label
A High-throughput Approach to Identify Effective Systemic Agents for the Treatment of Anaplastic Thyroid Carcinoma.

# publications[].label
Single cell transcriptomic profiling of ex vivo tumoroid models reveal therapeutic vulnerabilities of pancreatic ductal adenocarcinoma

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Combination of EphA2- and Wee1-Targeted Therapies in Endometrial Cancer.

# publications[].label
Epichaperome inhibition targets TP53-mutant AML and AML stem/progenitor cells.

# publications[].label
The licorice metabolite enoxolone attenuates Clostridioides difficile pathophysiology by corrupting its metabolic and toxin production networks

# publications[].label
A Novel Transgenic Mouse Model of Down Syndrome Acute Lymphoblastic Leukemia Identifies Targetable Vulnerabilities

# publications[].label
Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage.

# publications[].label
Gain-of-Function Chromatin Remodeling Activity of Oncogenic FOXL2-C134W Reprograms Glucocorticoid Receptor Occupancy to Drive Granulosa Cell Tumors.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Pharmacological Targeting of FGF14 Modulates Motivated Behavior by Increasing Medium Spiny Neuron Firing

# publications[].label
Rational Combination of CRM1 Inhibitor Selinexor and Olaparib Shows Synergy in Ovarian Cancer Cell Lines and Mouse Models.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition.

# publications[].label
High-throughput screening against protein:protein interaction interfaces reveals anti-cancer therapeutics as potent modulators of the voltage-gated Na+ channel complex.

# publications[].label
MODL-29. Molecular Landscape of a comprehensive panel of pediatric brain cancer Patient-derived orthotopic xenograft (PDOX) models inform unique targets for drug responsiveness

# publications[].label
Extracting Biological Knowledge from High Throughput Phenotypic Screens

# publications[].label
35P Enhancing efficacy of the MEK inhibitor trametinib in KRAS-mutated colorectal cancer cells

# publications[].label
Bacteria-to-human protein networks reveal origins of endogenous DNA damage

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine