# positions[].organizations[].parent[].label
School of Veterinary Medicine and Biomedical Sciences

# overview
The development, control and diseases of the musculoskeletal system have been my scholarly interests for the past 35+ years.  Understanding how the musculoskeletal system adapts and progresses throughout life is the basis of my expertise.  My research focus has been the skeletal consequences of disease, such as breast cancer bone metastasis and multiple myeloma, fracture healing, osteoporosis, and most recently rare bone diseases.  Current research efforts include a focus on utilizing in vivo models (murine and large animals) to discover regulatory pathways fundamental to bone physiology and the development of rare bone disease preclinical model(s) that may provide novel insight into future therapeutic directions.  A critical aspect of my academic philosophy is an open door policy and the importance of one-on-one interactions.  We must strive to provide training and exposure for our students as they prepare for careers both in and out of academic medicine and research.  I emphatically believe that these teaching and mentoring experiences have shaped my scientific career and have helped mold my teaching and mentoring philosophy of placing the best professional, academic, social and personal development of faculty, students and staff  above all else.

# keywords[]
6 Evaluation Of Treatments And Therapeutic Interventions

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Basic Helix-loop-helix Leucine Zipper Transcription Factors

# keywords[]
Sterol Regulatory Element Binding Protein 1

# keywords[]
Positron Emission Tomography Computed Tomography

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
6 Evaluation Of Treatments And Therapeutic Interventions

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
GTP-Binding Protein Alpha Subunits, Gi-Go

# keywords[]
Receptor Activator Of Nuclear Factor-kappa B

# keywords[]
4.2 Evaluation Of Markers And Technologies

# keywords[]
4.1 Discovery And Preclinical Testing Of Markers And Technologies

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Spectrometry, Mass, Fast Atom Bombardment

# keywords[]
4.1 Discovery And Preclinical Testing Of Markers And Technologies

# keywords[]
Mgus, Monoclonal Gammopathy Of Unknown Significance

# keywords[]
Ggpps, Geranyl Geranyl Pyrophosphate Synthase Her2, Human Epidermal Growth Factor Receptor

# keywords[]
Asbmr, American Society Of Bone And Mineral Research

# keywords[]
Vegf, Vascular Endothelial Growth Factor

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Diseases And Disorders Of/related To Bone

# keywords[]
4.2 Evaluation Of Markers And Technologies

# keywords[]
4.1 Discovery And Preclinical Testing Of Markers And Technologies

# keywords[]
Interleukin Receptor Common Gamma Subunit

# keywords[]
Nk Cell Lectin-like Receptor Subfamily K

# keywords[]
Receptors, Tumor Necrosis Factor, Type I

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
4.1 Discovery And Preclinical Testing Of Markers And Technologies

# keywords[]
Receptor Activator Of Nuclear Factor-kappa B

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Receptors, Transforming Growth Factor Beta

# keywords[]
Receptor, Transforming Growth Factor-beta Type I

# keywords[]
4.1 Discovery And Preclinical Testing Of Markers And Technologies

# keywords[]
Receptors, Tumor Necrosis Factor, Type I

# keywords[]
Interleukin 1 Receptor Antagonist Protein

# educationAndTraining[].organization.label
Swinburne University of Technology - (Melbourne, Victoria, Australia)

# educationAndTraining[].organization.label
University of Melbourne - (Melbourne, Victoria, Australia)

# educationAndTraining[].organization.label
Merck Institute for Science Education - (Rahway, New Jersey, United States)

# awardsAndHonors[].label
Association of Former Students University-Level Distinguished Achievement Award, The

# publications[].label
The regulation of human chondrocyte and osteoblast differentiation by activin and inhibin.

# publications[].label
Effects of inhibins and activin on human osteoblast and osteoclast differentiation

# publications[].label
Parathyroid Hormones (PTH) Serum Variations Are Associated with Bortezomib Response in Multiple Myeloma Patients

# publications[].label
Heparanase inhibits osteoblastogenesis and shifts bone marrow progenitor cell fate in myeloma bone disease.

# publications[].label
Treatment with anti-Sclerostin antibody to stimulate mandibular bone formation.

# publications[].label
Resolving the Two "Bony" Faces of PPAR-gamma.

# publications[].label
Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Serum biomarker profile associated with high bone turnover and BMD in postmenopausal women.

# publications[].label
Orientation of load force influences mechanical stability in the human scaphoid: Implications for traumatic fractures

# publications[].label
Osteoblasts Are the Primary In Vivo Targets of Inhibin A Skeletal Anabolism.

# publications[].label
Digit specific denervation does not inhibit mouse digit tip regeneration.

# publications[].label
POSITIVE AND NEGATIVE GLUCOCORTICOID REGULATORY SEQUENCES OF THE OSTEOPONTIN GENE PROMOTER

# publications[].label
Investigation of the regulation of bone mass by mechanical loading: from quantitative cytochemistry to gene array.

# publications[].label
The type IBMP receptors ALK3 & ALK6 function similarly in controlling osteoblast and adipocyte differentiation from human mesenchymal stem cells.

# publications[].label
Circulating interleukin-8 levels explain breast cancer osteolysis in mice and humans.

# publications[].label
Specific immunolocalization of the human PTH/PTHrP receptor in classical human target tissues and ovary.

# publications[].label
Targeted deletion of the osteoblast endothelin a receptor alters bone formation in mice.

# publications[].label
NOX4 Deletion in Male Mice Exacerbates the Effect of Ethanol on Trabecular Bone and Osteoblastogenesis.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Targeted deletion of the osteoblast endothelin a receptor alters bone formation in mice

# publications[].label
INVIVO REGULATION OF ZIF268 MESSENGER-RNA EXPRESSION BY 17-BETA-ESTRADIOL IN THE RAT UTERUS

# publications[].label
Basic mechanisms responsible for osteolytic and osteoblastic bone metastases.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Neuropeptide Y Y2 antagonist treated ovariectomized mice exhibit greater bone mineral density.

# publications[].label
Relative estrogen receptor binding affinity and transcriptional activation by idoxifene.

# publications[].label
Advances in treating metastatic bone cancer: summary statement for the First Cambridge Conference.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Extensive Remineralization of Large Pelvic Lytic Lesions Following Total Therapy Treatment in Patients With Multiple Myeloma.

# publications[].label
Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading.

# publications[].label
1,25 dihydroxyvitamin D3 and dexamethasone induce the cyclooxygenase 1 gene in osteoclast-supporting stromal cells

# publications[].label
Activation of PPAR-gamma by rosiglitazone induces bone loss due to changes in the phenotype and function of bone mesenchymal cells

# publications[].label
Inhibin A enhances bone formation during distraction osteogenesis.

# publications[].label
The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity.

# publications[].label
Modeling the interactions between osteoblast and osteoclast activities in bone remodeling.

# publications[].label
Significance of 1,25-dihydroxyvitamin D3 receptor in primary breast cancers.

# publications[].label
Molecular characterization of the genomes of actinophages SH3, SH10, SH11, and SH12 infecting Streptomyces hygroscopicus.

# publications[].label
Bone metastasis: mechanisms and therapeutic opportunities.

# publications[].label
SELDI-TOF mass spectrometry discriminates PSA-stable and PSA-rising hormone-sensitive advanced prostate cancer.

# publications[].label
PTHrP(12-48) for the diagnosis of breast cancer bone metastasis

# publications[].label
Generation and characterization of human kidney cell lines stably expressing recombinant human PTH/PTHrP receptor: lack of interaction with a C-terminal human PTH peptide.

# publications[].label
The Short-Term Deleterious Skeletal Response to Hindlimb Suspension Involves Multi-Faceted Compromises in Cells of the Osteogenic Lineage

# publications[].label
Interrelationship between Metabolic and High Bone Mass Phenotype in a Mouse Model of Adult-Onset, Isolated, GH-Deficiency (AOiGHD).

# publications[].label
Influence of fat/carbohydrate ratio on progression of fatty liver disease and on development of osteopenia in male rats fed alcohol via total enteral nutrition (TEN).

# publications[].label
A role for N-cadherin in the development of the differentiated osteoblastic phenotype.

# publications[].label
EFFECTS OF RETINOIC ACID ON NORMAL AND NEOPLASTIC OSTEOBLASTIC CELLS

# publications[].label
Parathyroid hormone-related protein: isolation, molecular cloning, and mechanism of action.

# publications[].label
Interaction of Brucella abortus with Osteoclasts: a Step toward Understanding Osteoarticular Brucellosis and Vaccine Safety.

# publications[].label
FRAX is a robust predictor of baseline vertebral fractures in multiple myeloma patients.

# publications[].label
Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation.

# publications[].label
Regulation of postnatal trabecular bone formation by the osteoblast endothelin A receptor.

# publications[].label
Heparanase promotes the spontaneous metastasis of myeloma cells to bone.

# publications[].label
Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11 gene expression in forming surface P-selectin ligands in aggressive breast cancer cells.

# publications[].label
Chapter 3 Parathyroid Hormone-related Protein Gene Structure, Biosynthesis, Metabolism and Regulation

# publications[].label
A potential role for ajulemic acid in treatment of the Ewing family of tumors

# publications[].label
Genetic engineering a sheep model of Hypophosphatasia.

# publications[].label
The shortcomings of the GLAST knockout mouse [2]

# publications[].label
Benzophenone-modified parathyroid hormone (PTH) analogs as novel tools for photoaffinity scanning of ligand-receptor interactions

# publications[].label
Heparanase Promotes Osteolysis by Upregulating RANKL-A Novel Role for Heparanase in Multiple Myeloma.

# publications[].label
Parathyroid hormone-related protein purified from a human lung cancer cell line.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
PTH Regulation of FGF23 Fragments: A Tail in Two Acts.

# publications[].label
Characterization of retinoic acid- and cell-dependent sequences which regulate zif268 gene expression in osteoblastic cells.

# publications[].label
Skeletal Toxicity of Coplanar Polychlorinated Biphenyl Congener 126 in the Rat Is Aryl Hydrocarbon Receptor Dependent.

# publications[].label
Identification and cloning of a human urea transporter HUT11, which is downregulated during adipogenesis of explant cultures of human bone.

# publications[].label
Differential expression of Egr-1 in osteoarthritic compared to normal adult human articular cartilage.

# publications[].label
1 alpha, 25-Dihydroxyvitamin D3 specifically induces its own metabolism in a human cancer cell line.

# publications[].label
1,25 dihydroxyvitamin D3 and dexamethasone induce the cyclooxygenase 1 gene in osteoclast-supporting stromal cells

# publications[].label
New insights into interactions between the human PTH/PTHrPR and agonist/antagonist binding.

# publications[].label
PARATHYROID HORMONE-RELATED PROTEIN - ISOLATION, MOLECULAR-CLONING, AND MECHANISM OF ACTION

# publications[].label
Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease.

# publications[].label
Bone turnover across the menopause transition : The role of gonadal inhibins.

# publications[].label
Mechanically regulated expression of a neural glutamate transporter in bone: a role for excitatory amino acids as osteotropic agents?

# publications[].label
Retinoic acid stimulates transcriptional activity from the alkaline phosphatase promoter in the immortalized rat calvarial cell line, RCT-1.

# publications[].label
Glutamate receptors in bone cells suggest a paracrine role for excitatory amino acids in regulation of the skeleton?

# publications[].label
The effects of proteasome inhibitors on bone remodeling in multiple myeloma.

# publications[].label
New insight into the mechanism of cyclic AMP desensitization of the PTH/PTHrP receptor.

# publications[].label
Expression of an N-methyl-D-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone.

# publications[].label
Aromatase inhibition results in gain of bone mineral density in the spine and femur in female nude mice.

# publications[].label
Inhibin Directly Targets Suppression of Isolated Human Osteoclast Precursor Development and Activity

# publications[].label
Scoring-based analysis of protein patterns for identification of myeloma cancer

# publications[].label
Imaging bone blood perfusion: not just going with the flow.

# publications[].label
Daratumumab Single Agent and Daratumumab Plus Pomalidomide and Dexametasone in Relapsed/Refractory Multiple Myeloma: A Real Life Retrospective Evaluation

# publications[].label
Low bone mass in mice with null mutation in TG-interacting factor (TGIF): Impaired osteoblast function

# publications[].label
Short-term hindlimb unloading diminishes bone mineral density, area and blood flow in rats.

# publications[].label
Advancing treatment for metastatic bone cancer: consensus recommendations from the Second Cambridge Conference.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Glitazones, the anti-diabetic PPAR-gamma agonists, pose a significant risk of bone loss; Differential effects of rosiglitazone and netoglitazone

# publications[].label
Parathyroid Hormone-related Protein Gene Structure, Biosynthesis, Metabolism and Regulation

# publications[].label
Four distinct chondrocyte populations in the fetal bovine growth plate: highest expression levels of PTH/PTHrP receptor, Indian hedgehog, and MMP-13 in hypertrophic chondrocytes and their suppression by PTH (1-34) and PTHrP (1-40).

# publications[].label
Early detection of bone infection and differentiation from post-surgical inflammation using 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography (FDG-PET) in an animal model.

# publications[].label
A RANDOM PEPTIDE LIBRARY FOR IDENTIFICATION OF RGD-CONTAINING PEPTIDES WITH HIGH-AFFINITY FOR THE VITRONECTIN RECEPTOR

# publications[].label
A Link between the Gut and Bone: Bone Health Impacted by Changes in Gut Microbiota.

# publications[].label
IL-8 is involved in the development and growth of osteolytic bone lesions.

# publications[].label
Skeletal effects of 2-methoxyestradiol in combination with other prostate cancer therapies

# publications[].label
Vitamin D supplementation protects against bone loss associated with chronic alcohol administration in female mice.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Arginine 186 in the extracellular n-terminal region of the human parathyroid hormone 1 receptor is essential for contact with position 13 of the hormone

# publications[].label
Inhibin a reduces bone loss in hindlimb suspended mice by increasing osteoblast abundance.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Biomarkers that discriminate multiple myeloma patients with or without skeletal involvement detected using SELDI-TOF mass spectrometry and statistical and machine learning tools.

# publications[].label
Interleukin-8 expression does not correlate with estrogen receptor status in human breast cancer

# publications[].label
RETINOIC ACID REGULATION OF THE ZIF268 PROMOTER IS MEDIATED VIA A UNIQUE NONCONSENSUS RESPONSIVE SEQUENCE

# publications[].label
The Somatotrope as a Metabolic Sensor: Deletion of Leptin Receptors Causes Obesity

# publications[].label
Heparanase supports tumor metastasis to bone

# publications[].label
Inflammatory Cytokines and Their Role in Bone Metastasis and Osteolysis

# publications[].label
Glitazones have divergent effects on bone cell differentiation and TGF beta/BMP signaling

# publications[].label
Heparanase enhances local and systemic osteolysis in multiple myeloma by upregulating the expression and secretion of RANKL.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Identification of a novel parathyroid hormone-responsive gene in human osteoblastic cells.

# publications[].label
Response to continuous and pulsatile PTH dosing: a mathematical model for parathyroid hormone receptor kinetics.

# publications[].label
Role of glycosylation on expression end functions of the human parathyroid hormone parathyroid hormone-related protein (PTH/PTHrP) receptor.

# publications[].label
Presentation and Management of Venomous Snakebites: Should All Patients Be Transferred to a Tertiary Referral Hospital?

# publications[].label
Pattern of gene expression following rat tibial marrow ablation.

# publications[].label
Expression of interleukin 8 and not parathyroid hormone-related protein by human breast cancer cells correlates with bone metastasis in vivo.

# publications[].label
Bone: Will breast cancer chemoprevention stand on 'solid bone'?

# publications[].label
Metastasis and bone loss: advancing treatment and prevention.

# publications[].label
Regulation of bone mass by mechanical loading: microarchitecture and genetics.

# publications[].label
Tumor-derived syndecan-1 mediates distal cross-talk with bone that enhances osteoclastogenesis.

# publications[].label
Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) for determining prognosis in advanced stage hormone relapsing prostate cancer.

# publications[].label
Preliminary characterization of serum biomarkers for multiple myeloma with bone metastasis using SELDI-TOF mass spectrometry.

# publications[].label
Surgical thyroparathyroidectomy prevents progression of 5TGM1 murine multiple myeloma in vivo.

# publications[].label
Distinct regulation of bone and muscle maintenance during hindlimb suspension by concentric and eccentric exercise.

# publications[].label
Reambulation Reverses Disuse-Stimulated Bone Loss Via Normalization of Mesenchymal Cell and Osteoclast Differentiation.

# publications[].label
Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.

# publications[].label
Testis-specific overexpression of SMAD4 causes dwarfism in mice.

# publications[].label
Presence of 1,25-dihydroxyvitamin D3 receptors in established human cancer cell lines in culture.

# publications[].label
Skeletal response to whole body vibration and dietary calcium and phosphorus in growing pigs.

# publications[].label
Retinoic acid increases zif268 early gene expression in rat preosteoblastic cells.

# publications[].label
Intractable hypercalcaemia due to parathyroid hormone-related peptide secretion by a carcinoid tumour.

# publications[].label
CLONING OF THE MOUSE THROMBIN RECEPTOR FROM OSTEOBLASTIC CELLS AND REGULATION OF ITS EXPRESSION BY 1,25-DIHYDROXYVITAMIN-D(3) AND PARATHYROID-HORMONE

# publications[].label
Sc65 is a novel endoplasmic reticulum protein that regulates bone mass homeostasis.

# publications[].label
Update on bone-modifying agents in metastatic breast cancer.

# publications[].label
Bone is a target for the antidiabetic compound rosiglitazone.

# publications[].label
Approaches to studying the biomolecular interaction between the parathyroid hormone/parathyroid hormone-related protein receptor and its ligands.

# publications[].label
N-methyl-D-aspartate receptor (NMDAR1) transcript heterogeneity in bone cells

# publications[].label
Decreased bone formation accompanies aging in a mouse model of distraction osteogenesis.

# publications[].label
PTH expression, not always where you think ..

# publications[].label
Heparanase promotes the spontaneous metastasis of myeloma cells to bone

# publications[].label
Proteomic analysis of bone cancer: a review of current and future developments.

# publications[].label
The Role of Adipocyte Lineage Cells in Myeloma Growth and Dissemination in Bone

# publications[].label
Production of parathyroid hormone-related protein by a rat parathyroid cell line.

# publications[].label
Sulfate transport and PAPS synthesis in immortalized chondrocytic C20/A4 cells

# publications[].label
Direct mapping of an agonist-binding domain within the parathyroid hormone/parathyroid hormone-related protein receptor by photoaffinity crosslinking.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Inhibitor of DASH proteases affects expression of adhesion molecules in osteoclasts and reduces myeloma growth and bone disease.

# publications[].label
Distinct mechanisms of action of selective estrogen receptor modulators in breast and osteoblastic cells.

# publications[].label
Prospective evaluation of bone histomorphometric changes associated to bortezomib in multiple myeloma patients

# publications[].label
Coupling of the PTH/PTHrP receptor to multiple G-proteins. Direct demonstration of receptor activation of Gs, Gq/11, and Gi(1) by [alpha-32P]GTP-gamma-azidoanilide photoaffinity labeling.

# publications[].label
Parathyroid hormone-related protein in hypercalcaemia of malignancy.

# publications[].label
Physiological Concentrations of Inhibin A Are Anabolic, Affecting both Trabecular and Cortical Bone in Normal Intact Mice.

# publications[].label
Alterations in skeletal perfusion with simulated microgravity: a possible mechanism for bone remodeling.

# publications[].label
Bone turnover across the menopause transition: correlations with inhibins and follicle-stimulating hormone.

# publications[].label
Differential effects of PTH(1-34) and PTH(7-34) on bone and aorta in experimental renal

# publications[].label
Parathyroid hormone receptor mediates the anti-myeloma effect of proteasome inhibitors.

# publications[].label
PTH/PTHRP HYBRIDS - INSIGHTS INTO STRUCTURAL FEATURES OF 2 DISTINCT HORMONES

# publications[].label
Somatotropes as Metabolic Sensors: Selective Deletion of Leptin Receptors Causes Obesity

# publications[].label
Inhibin A reduces bone but not muscle loss in hindlimb suspended mice.

# publications[].label
Parathyroid hormone-receptor interactions identified directly by photocross-linking and molecular modeling studies.

# publications[].label
Decreased Endosteal Intramembranous Bone Formation Accompanies Aging in a Mouse Model of Distraction Osteogenesis

# publications[].label
PTHrP(12-48) for the diagnosis of breast cancer bone metastasis.

# publications[].publisher
American Society of Clinical Oncology (ASCO)

# publications[].label
Bisphosphonate use in the horse: what is good and what is not?

# publications[].label
Absence of evidence is not evidence of absence. The shortcomings of the GLAST knockout mouse.

# publications[].label
A Plasma Proteomic Profile that Predicts Breast Cancer Metastasis to Bone.

# publications[].label
Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formation.

# publications[].label
Effect of Bone Allograft in Multiple Myeloma Spine Surgeries.

# publications[].label
Concurrent septic arthritis and osteomyelitis in children.

# publications[].label
HUMAN PTHRP GENE-TRANSCRIPTION IS STIMULATED BY ESTROGEN, EGF AND TGF-BETA

# publications[].label
PHOTOAFFINITY CROSS-LINKING OF A POTENT PTH ANTAGONIST (BENZOPHENONE-CONTAINING) TO RECOMBINANT HUMAN PTH RECEPTOR

# publications[].label
Isolation, biochemistry and molecular biology of the PTH-related protein of malignant hypercalcemia

# publications[].label
Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasis.

# publications[].label
PROTECTION AGAINST ETHANOL-INDUCED OSTEOPENIA IN FEMALE MICE BY DIETARY ANTIOXIDANTS

# publications[].label
The Somatotrope as a Metabolic Sensor: Deletion of Leptin Receptors Causes Obesity

# publications[].label
Anabolic actions of inhibin a during distraction osteogenesis.

# publications[].label
Inhibin prevents orchidectomy-induced bone loss and is anabolic in intact mice by increasing osteoblast activity.

# publications[].label
TASR-1 regulates alternative splicing of collagen genes in chondrogenic cells.

# publications[].label
Molecular characterization of the EGF receptor and involvement of glycosyl moieties in the binding of EGF to its receptor on a clonal osteosarcoma cell line, UMR 106-06.

# publications[].label
Identification of alternate, functional adhesive domains in an osteoblast-derived N-cadherin expressing cell line.

# publications[].label
Partial Protection by Dietary Antioxidants Against Ethanol-Induced Osteopenia and Changes in Bone Morphology in Female Mice.

# publications[].label
Myeloma cell-derived Runx2 promotes myeloma progression in bone.

# publications[].label
THE DIFFERENTIAL PATTERN OF GENE-EXPRESSION DURING BONE-FORMATION FOLLOWING RAT TIBIAL MARROW ABLATION

# publications[].label
Identification and cloning of a human urea transporter HUT11, which is downregulated during adipogenesis of explant cultures of human bone

# publications[].label
Thymic PTH Increases After Thyroparathyroidectomy in C57BL/KaLwRij Mice.

# publications[].label
Breast cancer metastasis to bone: it is not all about PTHrP.

# publications[].label
Gender- and tissue-specific effects of 1,25-Dihydroxyvitamin D and EB1089 in intestine and bone of mature rats.

# publications[].label
PTHrP(12-48) Modulates the Bone Marrow Microenvironment and Suppresses Human Osteoclast Differentiation and Lifespan.

# publications[].label
Bisphosphonates in veterinary medicine: The new horizon for use.

# publications[].label
Design, synthesis and utility of novel benzophenone-containing calcitonin analogs for photoaffinity labeling the calcitonin receptor.

# publications[].label
Monthly administration of a novel PTH-collagen binding domain fusion protein is anabolic in mice.

# publications[].label
Heparanase Promotes the Osteolytic Phenotype in Multiple Myeloma

# publications[].label
Diagnosis of pancreatic cancer using serum proteomic profiling.

# publications[].label
Loss of functional NADPH oxidase 2 protects against alcohol-induced bone resorption in female p47phox-/- mice.

# publications[].label
Structure of the 5' flanking region of the gene encoding human parathyroid-hormone-related protein (PTHrP).

# publications[].label
Meeting report from skeletal complications of malignancy IV

# publications[].label
The effect of rosiglitazone, an anti-diabetic PPAR-gamma agonist, on bone mass and architecture in growing, adult, and aged mice

# publications[].label
Heparanase promotes myeloma bone disease by regulating the bone microenvironment

# publications[].label
Heparanase Promotes Osteolysis by Upregulating RANKL A Novel Role for Heparanase in Multiple Myeloma.

# publications[].label
The selective oestrogen receptor modulators idoxifene and raloxifene have fundamentally different cell-specific oestrogen-response element (ERE)-dependent/independent mechanisms in vitro.

# publications[].label
Probing the bimolecular interactions of parathyroid hormone with the human parathyroid hormone/parathyroid hormone-related protein receptor. 1. Design, synthesis and characterization of photoreactive benzophenone-containing analogs of parathyroid hormone.

# publications[].label
What determines the complex phenotype of osteolytic tumors?

# publications[].label
Reactive Oxygen Species Differentially Regulate Bone Turnover in an Age-Specific Manner in Catalase Transgenic Female Mice.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Identification of plasma biomarkers that predict breast cancer bone metastasis

# publications[].label
Impaired bone formation during distraction osteogenesis in ZDF rats.

# publications[].label
Adjuvant bisphosphonates in breast cancer: the ABCSG-12 study.

# publications[].label
Bayesian approach to analysis of protein patterns for identification of myeloma cancer

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
CLONING AND CHARACTERIZATION OF THE HUMAN PTH PTHRP RECEPTOR

# publications[].label
Inhibition of Multiple Myeloma (MM) Growth and Preservation of Bone with Combined Radiotherapy and Anti-angiogenic Agent

# publications[].label
Identification of differentially expressed genes from explant cultures of human bone that have undergone adipogenesis.

# publications[].label
Utility of an allograft tendon for scoliosis correction via the costo-transverse foreman.

# publications[].label
Arginine 186 in the extracellular N-terminal region of the human parathyroid hormone 1 receptor is essential for contact with position 13 of the hormone.

# publications[].label
CHARACTERIZATION OF PTH-REGULATED GENES IN HUMAN SAOS-2/B10 CELLS BY MESSENGER-RNA DIFFERENTIAL DISPLAY

# publications[].label
Relationship of bicipital groove rotation with humeral head retroversion: a three-dimensional computed tomographic analysis.

# publications[].label
A TRIAL TO CLONE A MOLECULE(S) RESPONSIBLE FOR INDUCTION OF OSTEOCLAST DIFFERENTIATION

# publications[].label
Mechanisms of bone metastases of breast cancer.

# publications[].label
High bone mass in mice with hyperfunctional platelets and a point mutation in the platelet glycoprotein (GP) Ib-IX receptor.

# publications[].label
MALE NOX4 KNOCKOUT MICE ARE NOT PROTECTED AGAINST THE EFFECTS OF CHRONIC ETHANOL CONSUMPTION ON BONE TURNOVER

# publications[].label
A prospective evaluation of the biochemical, metabolic, hormonal and structural bone changes associated with bortezomib response in multiple myeloma patients.

# publications[].label
The role of IL-8 in the complex phenotype of osteolytic breast cancer

# publications[].label
Presence of 1,25-dihydroxyvitamin D<inf>3</inf>receptors in cancer cells in culture

# publications[].label
Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Direct mapping of interactions between PTH and the PTH/PTHrP receptor by photoaffinity crosslinking: Identification of two distinct contact domains.

# publications[].label
Inhibin A is an endocrine stimulator of bone mass and strength.

# publications[].label
Osteoprotective selective estrogen receptor modulators exhibit their effects through distinct cell-specific mechanisms.

# publications[].label
1,25 dihydroxyvitamin D3 and dexamethasone induce the cyclooxygenase 1 gene in osteoclast-supporting stromal cells.

# publications[].label
Interleukin-8 expression does not correlate with estrogen receptor status in human breast cancer

# publications[].label
Atypical femoral fractures from bisphosphonate in cancer patients - Review.

# publications[].label
The genotype of metastatic and non-metastatic breast cancer cells provides insight into their phenotype.

# publications[].label
Obesity is associated with larger soft-tissue sarcomas, more surgical complications, and more complex wound closures (obesity leads to larger soft-tissue sarcomas).

# publications[].label
Heparanase Promotes the Osteolytic Phenotype in Multiple Myeloma

# publications[].label
Increased bone loss during disuse in aged animals may be due to impaired BMP responsiveness.

# publications[].label
Differential effects of intermittent PTH(1-34) and PTH(7-34) on bone microarchitecture and aortic calcification in experimental renal failure.

# publications[].label
Sclerostin Antibody Treatment Stimulates Bone Formation to Normalize Bone Mass in Male Down Syndrome Mice.

# publications[].label
Parathyroid Hormones (PTH) Serum Variations Are Associated with Bortezomib Response in Multiple Myelomal Patients.

# publications[].label
A mathematical model of PTH receptor desensitization discriminates intermittent from continuous PTH administration.

# publications[].label
Frequency of 1,25-dihydroxyvitamin D3 receptor in human breast cancer.

# publications[].label
MULTIPLE PROMOTERS, ALTERNATE SPLICING AND FACTORS INFLUENCING TRANSCRIPTIONAL REGULATION OF THE HUMAN PARATHYROID HORMONE-RELATED PROTEIN GENE

# publications[].label
Heparanase promotes myeloma progression by inducing mesenchymal features and motility of myeloma cells.

# publications[].label
Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures.

# publications[].label
Aging alters the skeletal response to disuse in the rat.

# publications[].label
Effects of alcohol injection in rat sciatic nerve as a model for Morton's neuroma treatment.

# publications[].label
New bone formation is impaired in a model of type 1 diabetes mellitus.

# publications[].label
Indian hedgehog (Ihh) is required for endochondral bone formation after birth.

# publications[].label
Proteomic Analysis of Patient Plasma Identifies Parathyroid Hormone Related Protein (PTHrP12-48) as a Potential Biomarker of Breast Cancer Bone Metastasis.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis: a role for the tumor necrosis factor signaling axis.

# publications[].label
FREQUENCY OF 1,25-DIHYDROXYVITAMIN-D3 RECEPTOR IN HUMAN-BREAST CANCER

# publications[].label
Male mice with elevated C-type natriuretic peptide-dependent guanylyl cyclase-B activity have increased osteoblasts, bone mass and bone strength.

# publications[].label
RETINOIC ACID STIMULATES TRANSCRIPTIONAL ACTIVITY FROM THE ALKALINE-PHOSPHATASE PROMOTER IN THE IMMORTALIZED RAT CALVARIAL CELL-LINE, RCT-1

# publications[].label
Development of a photoreactive parathyroid hormone antagonist to probe antagonist-receptor bimolecular interaction.

# publications[].label
Rosiglitazone inhibits bone regeneration and causes significant accumulation of fat at sites of new bone formation.

# publications[].label
Comparison of biomechanical properties of alloderm and enduragen as static facial sling biomaterials.

# publications[].label
Nutlin-3 treatment spares cisplatin-induced inhibition of bone healing while maintaining osteosarcoma toxicity.

# publications[].label
Distinct mechanisms of action of selective estrogen receptor modulators in breast and osteoblastic cells

# publications[].label
Skeletal effects of 2-methoxyestradiol in combination with other prostate cancer therapies

# publications[].label
Anti-IL-8 therapy inhibits breast cancer growth and osteolysis in vivo.

# publications[].label
Cell-surface carbohydrate expression supports breast cancer colonization of bone.

# publications[].label
Microcomputed tomography assessment of glenoid component cementation techniques in total shoulder arthroplasty.

# publications[].label
Genetic engineering a large animal model of human hypophosphatasia in sheep.

# publications[].label
Low bone mass and impaired fracture healing in mouse models of Trisomy21 (Down syndrome).

# publications[].label
Heparanase promotes the spontaneous metastasis of myeloma cells to bone.

# publications[].label
Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment.

# publications[].label
Cancer: Update on bone-modifying agents in metastatic breast cancer (vol 7, pg 380, 2011)

# publications[].label
Highly activated and expanded natural killer cells for multiple myeloma immunotherapy.

# publications[].label
Cisplatin inhibits bone healing during distraction osteogenesis.

# publications[].label
Inositol 1-,4-,5-trisphosphate-dependent Ca2+ signaling by the recombinant human PTH/PTHrP receptor stably expressed in a human kidney cell line.

# publications[].label
Heparanase Promotes Myeloma Metastasis By Inducing EMT-like Features in Both Myeloma Cells and Endothelial Cells

# publications[].label
Characterization of the glycosylation profile of the human breast cancer cell line, MDA-231, and a bone colonizing variant.

# publications[].label
Genetically Engineering a Sheep Model of Hypophosphatasia

# publications[].label
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy.

# publications[].label
PTHrP(12-48) localization is intracellular and it inhibits cell proliferation and osteoclastogenesis

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Netoglitazone is a PPAR-gamma ligand with selective effects on bone and fat.

# publications[].label
A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Role of glycosylation in expression and function of the human parathyroid hormone/parathyroid hormone-related protein receptor.

# publications[].label
Identification of parathyroid hormone-related protein in canine apocrine adenocarcinoma of the anal sac.

# publications[].label
Null mutation in TG-interacting factor (TGIF) causes abnormalities in skeletal development and low bone mass.

# publications[].label
Back to the Future: Evaluation of the Role of Glutamate in Bone Cells.

# publications[].label
The Distinct Biological Activity of Interleukin 8 Isoforms.

# publications[].label
Hybridization of blind source separation and rough sets for proteomic biomarker identification

# publications[].label
Inhibin a prevents orchidectomy-induced bone loss in mice.

# publications[].label
Genistein supplementation increases bone turnover but does not prevent alcohol-induced bone loss in male mice.

# publications[].label
NOVEL GENES REGULATED BY MECHANICAL LOADING OF BONE IN-VIVO INCLUDE A GLUTAMATE ASPARTATE TRANSPORTER (GLAST) PROTEIN

# publications[].label
Systemic Interleukin 8 Increases Bone Resorption In Vivo

# publications[].label
Characterization of adipocyte differentiation from primary human osteoblasts.

# publications[].label
Hormonal causes of menopausal bone resorption.

# publications[].label
Identification of N-cadherin expression in bone and regulation of cadherin expression during bone formation and resorption in vivo.

# publications[].label
Transforming growth factor beta receptor I kinase inhibitor increases bone mass in normal mice

# publications[].label
Interaction of insulin and dibutyryl cyclic on 1,25-(OH)<inf>2</inf>D<inf>3</inf>inhibition of breast cancer cell growth

# publications[].label
The irradiation of bone: old idea, new insight.

# publications[].label
The multigene nature of the osteolytic tumor phenotype

# publications[].label
Interleukin 8 regulation of RANKL is a mechanism for the metastatic potential of human breast cancer cells.

# publications[].label
Detrimental Effects of Abdominal Irradiation on the Skeleton in Growing Mice.

# publications[].label
Tumor-derived interleukin-8 stimulates osteolysis independent of the receptor activator of nuclear factor-kappaB ligand pathway.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Breast cancer-induced osteoclast formation does not require RANKL

# publications[].label
A 26-year-old Woman With Bilateral Leg Pain and Pruritus.

# publications[].label
New insights into interactions between the human PTH/PTHrP receptor and agonist/antagonist binding.

# publications[].label
Regulation of osteoblastogenesis and bone mass by Wnt10b.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Distinct ligand specificity of two parathyroid hormone receptor subtypes.

# publications[].label
Identification of PTHrP(12-48) as a plasma biomarker associated with breast cancer bone metastasis.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Characterization of serum biomarkers for pancreatic cancer using SELDI-TOF mass spectrometry: Preliminary findings

# publications[].label
Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment regulates growth, angiogenesis and metastasis of myeloma tumors

# publications[].label
Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone.

# publications[].label
Rosiglitazone induces decreases in bone mass and strength that are reminiscent of aged bone.

# publications[].label
Parathyroid Hormone Related Protein (PTHrP)

# publications[].label
Two-incision versus one-incision repair for distal biceps tendon rupture: a cadaveric study.

# publications[].label
Antagonism of oestrogen action in human breast and endometrial cells in vitro: potential novel antitumour agents.

# publications[].label
Parathyroid hormone-related protein: a novel gene product.

# publications[].label
1,25-dihydroxyvitamin D3 and breast cancer.

# publications[].label
Proteomic technologies for the study of osteosarcoma.

# publications[].label
FREQUENCY OF 1,25-DIHYDROXY VITAMIN-D3 RECEPTOR IN HUMAN-BREAST CANCER

# publications[].label
Investigation of the regulation of bone mass by mechanical loading: from quantitative cytochemistry to gene array

# publications[].label
Histidine at position 5 is the specificity ''switch'' between two parathyroid hormone receptor subtypes

# publications[].label
Bone anabolism in multiple myeloma patients treated with bortezomib

# publications[].label
The discovery of new biomarkers for the diagnosis of osteoporosis: Is SELDI the answer?

# publications[].label
Increased levels of IL-8 are associated with bone loss in primary hyperparathyroidism.

# publications[].label
Histidine at position 5 is the specificity "switch" between two parathyroid hormone receptor subtypes.

# publications[].label
STRUCTURAL-ANALYSIS OF CALCITONIN CDNA PREPARED FROM HUMAN-LUNG CANCER-CELLS

# publications[].label
New insights into interactions between the human PTH/PTHrP receptor and agonist/antagonist binding

# publications[].label
Interleukin-1 and tumor necrosis factor antagonists attenuate ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Effect of glutamine on radiation morbidity in breast conservaton therapy is associated with a novel protein marker.

# publications[].label
Low bone turnover and low bone density in a cohort of adults with Down syndrome.

# publications[].label
Engineering bone phenotypes in domestic animals: Unique resources for enhancing musculoskeletal research.

# publications[].label
Imaging the vasculature by microCT; ain't no bones about it.

# publications[].label
Skeletal toxicity associated with chronic ethanol exposure in a rat model using total enteral nutrition.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
The effects of rhFGF2/sTNF-Rl on bone formation during distraction osteogenesis in ZDF rats.

# publications[].label
1,25-(OH)2DIHYDROXYVITAMIN-D3 RECEPTORS IN PRIMARY AND CULTURED HUMAN CANCER-CELLS

# publications[].label
Treatment of subperiosteal abscesses in children: is drainage of the intramedullary canal required?

# publications[].label
The human PTH2 receptor: binding and signal transduction properties of the stably expressed recombinant receptor.

# publications[].label
ISOLATION AND CHARACTERIZATION OF NOVEL ADHESION MOLECULES - EVIDENCE FOR CADHERINS IN OSTEOBLASTS

# publications[].label
Re-Mineralization of Large Pelvic Lytic Lesions By CT Imaging in Patients with Multiple Myeloma: The Arkansas Experience

# publications[].label
Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, Activin and Inhibin.

# publications[].label
Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease.

# publications[].label
Repression of multiple myeloma growth and preservation of bone with combined radiotherapy and anti-angiogenic agent.

# publications[].label
Osteoprotegrin and the bone homing and colonization potential of breast cancer cells.

# publications[].label
Glutamate signalling regulates skeletogenesis and bone growth.

# publications[].label
Neuropathy profiling in streptozotocin-rat models of diabetes and pre-diabetes

# publications[].label
Glutamate signaling in bone: A role in mechanosensing, bone formation and bone resorption.

# publications[].label
In vivo regulation of Zif268 messenger RNA expression by 17 beta-estradiol in the rat uterus.

# publications[].label
RoBo-1, a novel member of the urokinase plasminogen activator receptor/CD59/Ly-6/snake toxin family selectively expressed in rat bone and growth plate cartilage.

# publications[].label
N-TERMINAL PTH/PTHRP PEPTIDES INHIBIT CELL-PROLIFERATION IN A RECEPTOR NUMBER-DEPENDENT AND CAMP-DEPENDENT FASHION IN CELLS STABLY EXPRESSING THE HUMAN PTH/PTHRP RECEPTOR

# publications[].label
The best of both worlds - managing the cancer, saving the bone.

# publications[].label
Oral glutamine reduces radiation morbidity in breast conservation surgery.

# publications[].label
Microarchitecture and mechanical properties of the human scaphoid

# publications[].label
Exploiting the tear proteome for the diagnosis of breast cancer

# publications[].label
PARATHYROID HORMONE-RELATED PROTEIN OF CANCER - A NOVEL GENE-PRODUCT WITH A PTH PROTOPE

# publications[].label
The metastatic phenotype of MDA-MB-231 human breast cancer cells.

# publications[].label
Probing the bimolecular interactions of parathyroid hormone and the human parathyroid hormone/parathyroid hormone-related protein receptor. 2. Cloning, characterization, and photoaffinity labeling of the recombinant human receptor.

# publications[].label
Functional characterization of N-methyl-D-aspartic acid-gated channels in bone cells.

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M University; College Of Veterinary Medicine; 4461 TAMU

# schools[]
School of Veterinary Medicine and Biomedical Sciences