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"overview" : "Our research group is actively characterizing the biosynthetic genes of this pathway, which involves a variety of techniques and strategies including: cloning and overexpression of genes, disruption/knockout of genes, enzymology, as well as chemical synthesis/isotopic labeling studies. Functional characterization of the genes of the pathway will not only shed light on the mechanism of azabicycle formation but will also pave the way for genetic engineering of the pathway and the development of new therapeutic methodologies.
We have also been investigating the biosynthesis and cellular effects of cycloterpenals and their derivatives. Cycloretinal (all-trans retinal dimer), a representative member of this family of natural products is attributed to causing age-related macular degeneration (AMD). AMD is the leading cause of blindness in adults over the age of 50 that can lead to the loss of central vision. One of the most common early characteristic features of AMD (the dry form) is the accumulation of yellow deposits in the eye called drusen. A more severe form of the disease, the wet form, is characterized by neovascularization (abnormal blood vessel formation). Our research group aims to study the role of beta-lactoglobulin in cycloretinal synthesis in the eye as an environmental (dietary), non-genetic contributor of AMD. This involves tracking BLG in the eye, monitoring the formation of cycloretinal, and elucidating the mechanism of cycloretinal formation. Research strategies include: chemical synthesis, enzymology, fluorescence/confocal microscopy, PET imaging, dual modality OCT/fluorescence lifetime imaging.",
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"Chemotaxis", "Hawaii", "Azabicyclo Compounds", "Naphthalenes", "Glycopeptides", "Epoxy Compounds", "Molecular Structure", "Time Factors", "Peptides", "Dipeptides", "Intercellular Signaling Peptides And Proteins", "Streptomyces", "Naphthalenes", "Cross-Linking Reagents", "Carrier Proteins", "Peptides", "Anti-Bacterial Agents", "Escherichia Coli", "Intercellular Signaling Peptides And Proteins", "Bacterial Proteins", "Lipofuscin", "Peroxidases", "Macular Degeneration", "Chromatography, High Pressure Liquid", "Humans", "Kinetics", "Tandem Mass Spectrometry", "Sulfhydryl Compounds", "Bacterial Proteins", "Biosynthetic Pathways", "Naphthalenes", "Epoxy Compounds", "Metabolomics", "Polyketides", "Genes, Bacterial", "Peptide Synthases", "Streptomyces", "Peptides", "Polyketide Synthases", "3405 Organic Chemistry", "34 Chemical Sciences", "Animals", "Cells, Cultured", "Dose-Response Relationship, Drug", "Cerebral Cortex", "Oligonucleotide Array Sequence Analysis", "Chromatography, High Pressure Liquid", "Keratinocytes", "Mice", "Female", "Ginkgo Biloba", "Reverse Transcriptase Polymerase Chain Reaction", "Plant Extracts", "Time Factors", "Hippocampus", "Gene Expression", "Humans", "Azabicyclo Compounds", "Glycopeptides", "Biological Products", "Bridged Bicyclo Compounds, Heterocyclic", "Molecular Structure", "Peptides", "Dipeptides", "Intercellular Signaling Peptides And Proteins", "DNA", "Azabicyclo Compounds", "Naphthalenes", "Glycopeptides", "Acetone", "Molecular Structure", "Peptides", "Dipeptides", "Intercellular Signaling Peptides And Proteins", "Antineoplastic Agents", "Aldehydes", "Spectrometry, Mass, Electrospray Ionization", "Dimerization", "Proline", "Magnetic Resonance Spectroscopy", "Receptors, AMPA", "Cerebral Cortex", "Prealbumin", "Brain", "Growth Hormone", "Hippocampus", "Microtubule-Associated Proteins", "Oligonucleotide Array Sequence Analysis", "Female", "Mice", "Transcription, Genetic", "Animals", "Plants, Medicinal", "Ginkgo Biloba", "Halomonadaceae", "Biotin", "Genomic Library", "Species Specificity", "Flow Cytometry", "DNA", "Polymerase Chain Reaction", "Nitriles", "Bacteria", "Jurkat Cells", "Biochemistry", "Humans", "Cyclohexenes", "Microbial Sensitivity Tests", "Anti-Infective Agents", "Drug Screening Assays, Antitumor", "Quinazolines", "Molecular Structure", "Ketones", "Lysine", "Enzyme Inhibitors", "Aldehydes", "Alkenes", "Biocatalysis", "Carbon-carbon Lyases", "Lactoglobulins", "Animals", "Cyclization", "Cattle", "Multifunctional Enzymes", "Hydrophobic And Hydrophilic Interactions", "Glycopeptides", "Streptomyces", "Bacterial Proteins", "Glutamates", "Kinetics", "Antineoplastic Agents", "Dipeptides", "Biosynthetic Pathways", "Catalytic Domain", "Intercellular Signaling Peptides And Proteins", "Naphthalenes", "Peptides", "Azabicyclo Compounds", "Magnetic Resonance Spectroscopy", "Culture Media", "Streptomyces", "Time Factors", "Peptides", "Fermentation", "Bacteriological Techniques", "Naphthalenes", "Reference Standards", "Intercellular Signaling Peptides And Proteins", "Molecular Conformation", "Lactoglobulins", "Lipofuscin", "Mutation, Missense", "Macular Degeneration", "Mutagenesis, Site-Directed", "Catalysis", "Amino Acid Substitution", "Humans", "Rare Diseases", "Streptomyces", "Naphthalenes", "Molecular Structure", "Catalysis", "Peptides", "Intercellular Signaling Peptides And Proteins", "Antineoplastic Agents", "RNA", "Gene Expression Profiling", "Constriction", "Oligonucleotide Array Sequence Analysis", "Gene Expression", "Myocardial Infarction", "Fibrosis", "Animals", "Ventricular Remodeling", "Male", "Myocardium", "Mice, Inbred C57BL", "Cardiomegaly", "Mice", "Reverse Transcriptase Polymerase Chain Reaction", "Heart Ventricles", "Caproates", "Autoradiography", "Fatty Acid Synthases", "Electrophoresis, Polyacrylamide Gel", "Sulfhydryl Compounds", "Aflatoxin B1", "Anthraquinones", "Coenzyme A", "Multienzyme Complexes", "Aspergillus", "Chromatography, High Pressure Liquid", "NADP", "Sterigmatocystin", "Oxygenases", "Anthraquinones", "Cytochrome P-450 Enzyme System", "Transformation, Genetic", "Aspergillus Nidulans", "Polyketide Synthases", "Streptomyces", "Glycopeptides", "Protein Structure, Tertiary", "Bacterial Proteins", "Antineoplastic Agents", "Retinaldehyde", "Lactoglobulins", "Milk", "Rabbits", "Magnetic Resonance Spectroscopy", "Animals", "Cattle", "Humans", "Dimethyl Furan-2,4-dicarboxylate", "Cryptic Metabolite", "Non-ribosomal Peptide Synthetase Module", "Genetic Knockout", "Natural Products", "Streptomyces", "DNA Damage", "Aminoglycosides", "Antibiotics, Antineoplastic", "Transcription, Genetic", "Enediynes", "Saccharomyces Cerevisiae", "Oligonucleotide Array Sequence Analysis", "Anti-Bacterial Agents", "Gene Expression Regulation, Fungal", "Cell Cycle", "Nuclear Proteins", "Mice, Inbred C57BL", "Ginkgo Biloba", "Neuronal Plasticity", "Hippocampus", "Mice", "Animals", "Male", "Aging", "Plant Extracts", "In Vitro Techniques", "Synaptic Transmission", "Intercellular Signaling Peptides And Proteins", "Naphthalenes", "Reverse Transcriptase Polymerase Chain Reaction", "Cell Cycle", "DNA, Fungal", "Antineoplastic Agents", "DNA Primers", "Saccharomyces Cerevisiae", "DNA Damage", "Transcription, Genetic", "Alkylation", "Peptides", "Base Sequence", "Fatty Acid Synthases", "Aflatoxin B1", "Multienzyme Complexes", "Oxidation-Reduction", "Catalysis", "Hydrolysis", "Protein Binding" ],
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