# overview
Dr. Wu uses nanostructured materials and analytical tools to develop diagnostic techniques for medical applications. His laboratory recently focuses on understanding the influences of multivalency and cell membrane environment on pathogen-host cell recognition. The applications of his techniques include, infectious diseases screening, exploring cell membrane function, and targeted drug delivery.

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0306 Physical Chemistry (incl. Structural)

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0306 Physical Chemistry (incl. Structural)

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0306 Physical Chemistry (incl. Structural)

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Networking And Information Technology R&d (nitrd)

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Machine Learning And Artificial Intelligence

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3407 Theoretical And Computational Chemistry

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0306 Physical Chemistry (incl. Structural)

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

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Generation of view factors for RELAP5 using MCNP

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Quantitative surface-enhanced Raman spectroscopy for kinetic analysis of aldol condensation using Ag-Au core-shell nanocubes.

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Nanopore film based enrichment and quantification of low abundance hepcidin from human bodily fluids.

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Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine.

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Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles.

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Hetero-multivalent binding of cholera toxin subunit B with glycolipid mixtures.

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Enhancement of rate capability of a MHx electrode by Pd coating of active material

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Comparison of linear, nonlinear and semiparametric mixed-effects models for estimating HIV dynamic parameters

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Understanding the factors affecting the activation of alkane by Cp'Rh(CO)2 (Cp' = Cp or Cp*).

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Proceedings of the National Academy of Sciences

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INOR 1058-Kinetic C-H oxidative addition vs. thermodynamic C-X oxidative addition to Ir(I) and Rh(I) systems: A density functional theory study

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Cholera Toxin subunit B binding to heterogeneous gangliosides on cell mimicking surfaces

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Quality of Video Oriented Pricing Incentive for Mobile Video Offloading

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Institute of Electrical and Electronics Engineers (IEEE)

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Guiguzi, China's first treatise on rhetoric: A critical translation and commentary

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Twist1 promotes breast cancer invasion and metastasis by silencing Foxa1 expression

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Dual-cell culture system with identical culture environment for comparison of anti-cancer drug toxicity

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Increased dietary iron and radiation in rats promote oxidative stress, induce localized and systemic immune system responses, and alter colon mucosal environment.

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The role of multivalency and surface diffusion of glycolipid in lectin-glycolipid recognition

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Low-Cost and Simple Fabrication of Nanoplasmonic Paper for Coupled Chromatography Separation and Surface Enhanced Raman Detection.

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Silicon micro- and nanofabrication for medicine.

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Multi-functional SERS substrate: collection, separation, and identification of airborne chemical powders on a single device.

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Perfectly Alternating and Regioselective Copolymerization of Carbonyl Sulfide and Epoxides by Metal-Free Lewis Pairs.

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Membrane-protein binding measured with solution-phase plasmonic nanocube sensors.

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Myosin IIA modulates T cell receptor transport and CasL phosphorylation during early immunological synapse formation.

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Dual-pH Sensitive Charge-reversal Nanocomplex for Tumor-targeted Drug Delivery with Enhanced Anticancer Activity.

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Mapping potential energy landscapes on patterned surfaces using diffusing colloidal probe microscopy

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TWIST1 silences FOXA1 transcription to promote breast cancer progression

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American Association for Cancer Research (AACR)

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SPIE, the international society for optics and photonics

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Direct measurement of multi-dimensional and multi-body colloidal and surface interactions

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Hybrid PDE-kMC modeling approach to simulate multivalent lectin-glycan binding process

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PLMET: A Novel Pseudolikelihood-Based EM Test for Homogeneity in Generalilzed Exponential Tilt Mixture Models.

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Evaluation of hetero-multivalent lectin binding using a turbidity-based emulsion agglutination assay.

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A Prospective, Multi-institutional, Pathologist-Based Assessment of 4 Immunohistochemistry Assays for PD-L1 Expression in Non-Small Cell Lung Cancer.

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Quantification of circulating Mycobacterium tuberculosis antigen peptides allows rapid diagnosis of active disease and treatment monitoring.

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Proceedings of the National Academy of Sciences

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Mapping patterned potential energy landscapes with diffusing colloidal probes.

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Like-charge interactions between colloidal particles are asymmetric with respect to sign.

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Diffusing colloidal probes of protein and synthetic macromolecule interactions.

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Measurement and interpretation of particle-particle and particle-wall interactions in levitated colloidal ensembles.

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Hetero-Multivalent Targeted Liposomal Drug Delivery to Treat Pseudomonas aeruginosa Infections.

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Advancing Glycan Analysis: A New Platform Integrating SERS, Boronic Acids, and Machine Learning Algorithms

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Kinetic C-H oxidative addition vs thermodynamic C-X oxidative addition of chlorobenzene by a neutral Rh(I) system. A density functional theory study.

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HEAT TRANSFER IN A RIB AND PIN ROUGHENED ROTATING MULTI-PASS CHANNEL WITH HUB TURNING VANE AND TRAILING-EDGE SLOT EJECTION

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Lgr4 gene regulates corpus luteum maturation through modulation of the WNT-mediated EGFR-ERK signaling pathway.

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Direct measurements of ensemble particle and surface interactions on homogeneous and patterned substrates

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Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics.

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American Association for the Advancement of Science (AAAS)

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Antibody-free detection of Mycobacterium tuberculosis antigen using customized nanotraps.

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Direct measurement of single and ensemble average particle-surface potential energy profiles.

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Recent Developments in Drug Delivery for Treatment of Tuberculosis by Targeting Macrophages.

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Quantum optical immunoassay: upconversion nanoparticle-based neutralizing assay for COVID-19.

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Resonant effects in evanescent wave scattering of polydisperse colloids.

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Proximity within interphase chromosome contributes to the breakpoint distribution in radiation-induced intrachromosomal exchanges

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Kinetic Monte Carlo modeling of multivalent binding of CTB proteins with GM1 receptors

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Stochastic Modelling of CTB-receptor Binding Kinetics

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The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination.

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Af17 deficiency increases sodium excretion and decreases blood pressure.

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Hetero-Multivalent Binding of Lectin to Glycans on Cell Membranes

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Binding Cooperativity Matters: A GM1-Like Ganglioside-Cholera Toxin B Subunit Binding Study Using a Nanocube-Based Lipid Bilayer Array.

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Preparation of Two Types of Polymeric Micelles Based on Poly(-L-Malic Acid) for Antitumor Drug Delivery.

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Preparation of poly(-L-malic acid)-based charge-conversional nanoconjugates for tumor-specific uptake and cellular delivery.

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A new way to target bacteria: Hetero-multivalent binding of glycolipids to Pseudomonas aeruginosa

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Serum peptidomic biomarkers for pulmonary metastatic melanoma identified by means of a nanopore-based assay.

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Density functional theory on the larger active site models for [NiFe] hydrogenases: Two-state reactivity?

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Beneficial mutations for carotenoid production identified from laboratory-evolved Saccharomyces cerevisiae.

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Hetero-Multivalency of Pseudomonas aeruginosa Lectin LecA Binding to Model Membranes.

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Low molecular weight protein enrichment on mesoporous silica thin films for biomarker discovery.

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Elevated Adenosine Induces Placental DNA Hypomethylation Independent of A2B Receptor Signaling in Preeclampsia.

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Characterization of dynamic actin associations with T-cell receptor microclusters in primary T cells.

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Low molecular weight protein enrichment on mesoporous silica thin films for biomarker discovery

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Altered actin centripetal retrograde flow in physically restricted immunological synapses.

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Dynamic Modeling of Binding Kinetics Between GD1b Ganglioside and Cholera Toxin Subunit B

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

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Identification and functional analysis of two novel PAX9 mutations.

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The influence of heteromultivalency on lectin-glycan binding behavior.

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Combined Effects of Simulated Microgravity and Radiation Exposure on Osteoclast Cell Fusion

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An Integrated Numerical and Experimental Framework for Modeling of CTB and GD1b Ganglioside Binding Kinetics

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Specific ion-dependent attraction and phase behavior of polymer-coated colloids.

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Glycan detection based on Surface-enhanced Raman scattering and machine learning

# researcherOn[].label
Design of hetero-multivalent targeted liposome for combating intracellular Mycobacterium tuberculosis

# researcherOn[].awardedBy.label
National Institute of Allergy and Infectious Diseases - (Bethesda, Maryland, United States)

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A New Tool for the Analysis of Glycan Recognition in Lectin

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National Science Foundation - (Arlington, Virginia, United States)

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Microvesicle Isolation from Mycobacterium Tuberculosis Infected Macrophage using Multi-stage Microfluidic Channel

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National Institutes of Health - (Bethesda, Maryland, United States)

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Study the Interaction Between Lipopolysaccharide-Binding Protein and Immune Cell Membranes

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National Institutes of Health - (Bethesda, Maryland, United States)

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DHHS-NIH-National Institute of Allergy and Infectious Diseases

# streetAddress
Texas A&M University; Chemical Engineering; 3122 TAMU

# etdChairOf[].label
Krishnan, Pratik (2016-08). Quantifying Cooperative Binding of Cholera Toxin B with Gangliosides. Master's Thesis.