# overview
As a bioengineer, I have a broad background in biomedical science and engineering, with specific training and expertise in novel biomaterials design/fabrication, controlled protein release, and the use of stem cells for bone, dental and other tissues repair and regeneration. Some of the our current research projects include:

1. Development of novel biomimetic materials/scaffolds for dental and craniofacial tissue regeneration.

2. Development of controlled drug/growth factor delivery system

3. Development of bio-inspired platform to explore cell-material interactions in three-dimension (3D).

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
3403 Macromolecular And Materials Chemistry

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Bone Morphogenetic Protein Receptors, Type I

# keywords[]
3403 Macromolecular And Materials Chemistry

# educationAndTraining[].organization.label
Tsinghua University - (Beijing, Beijing, China)

# educationAndTraining[].organization.label
Tsinghua University - (Beijing, Beijing, China)

# educationAndTraining[].organization.label
University of Michigan-Ann Arbor - (Ann Arbor, Michigan, United States)

# publications[].label
Nano-fibrous gelatin/apatite composite scaffolds for bone tissue engineering

# publications[].label
The odontogenic differentiation of human dental pulp stem cells on nanofibrous poly(L-lactic acid) scaffolds in vitro and in vivo.

# publications[].label
Advancing biomaterials of human origin for tissue engineering.

# publications[].label
Surface modification of biodegradable poly(-hydroxy acids) scaffolds for tissue engineering

# publications[].label
The effect of scaffold architecture on odontogenic differentiation of human dental pulp stem cells.

# publications[].label
E7-Conjugated Bio-Inspired Microspheres as a Biological Barrier for Guided Tissue Regeneration.

# publications[].label
Pyrophosphate inhibits periodontal ligament stem cell differentiation and mineralization through MAPK signaling pathways.

# publications[].label
Nanofibers Regulate Single Bone Marrow Stem Cell Osteogenesis via FAK/RhoA/YAP1 Pathway.

# publications[].label
Designing a Mucoadhesive ChemoPatch to Ablate Oral Dysplasia for Cancer Prevention.

# publications[].label
Injectable scaffolds: Preparation and application in dental and craniofacial regeneration.

# publications[].label
The nanofibrous architecture of poly(L-lactic acid)-based functional copolymers.

# publications[].label
Surface engineering of nano-fibrous biodegradable poly(L-lactic acid) scaffolds for tissue engineering

# publications[].label
Pharmacokinetic Model Analysis of Supralingual, Oral and Intravenous Deliveries of Mycophenolic Acid.

# publications[].label
The enhancement of human embryonic stem cell osteogenic differentiation with nano-fibrous scaffolding.

# publications[].label
Complete pulpodentin complex regeneration by modulating the stiffness of biomimetic matrix.

# publications[].label
Cell-matrix and cell-cell interactions of human gingival fibroblasts on three-dimensional nanofibrous gelatin scaffolds.

# publications[].label
Pulsatile release of parathyroid hormone from an implantable delivery system.

# publications[].label
Dental Pulp Stem Cell Polarization: Effects of Biophysical Factors.

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Multifunctional polyplex micelles for efficient microRNA delivery and accelerated osteogenesis.

# publications[].label
Immunomodulatory ECM-like Microspheres for Accelerated Bone Regeneration in Diabetes Mellitus.

# publications[].label
Efficiently engineered cell sheet using a complex of polyethylenimine-alginate nanocomposites plus bone morphogenetic protein 2 gene to promote new bone formation.

# publications[].label
Enhancing osteogenic differentiation of mouse embryonic stem cells by nanofibers.

# publications[].label
3D Maskless Micropatterning for Regeneration of Highly Organized Tubular Tissues.

# publications[].label
Pulp regeneration in a full-length human tooth root using a hierarchical nanofibrous microsphere system.

# publications[].label
Nanofibrous Membrane Promotes and Sustains Vascular Endothelial Barrier Function.

# publications[].label
Development of channeled nanofibrous scaffolds for oriented tissue engineering.

# publications[].label
Osteoclasts in bone regeneration under type 2 diabetes mellitus.

# publications[].label
Delivering Multifunctional Peptide-Conjugated Gene Carrier/miRNA-218 Complexes from Monodisperse Microspheres for Bone Regeneration.

# publications[].label
Functional microspheres for tissue regeneration.

# publications[].label
Erbium:Yttrium Aluminum Garnet Laser-Activated Sodium Hypochlorite Irrigation: A Promising Procedure for Minimally Invasive Endodontics.

# publications[].label
Quantitative characterizations of the Sharpey's fibers of rat molars.

# publications[].label
Author Correction: Tissue clearing of both hard and soft tissue organs with the PEGASOS method

# publications[].label
Tissue Engineering with Nano-Fibrous Scaffolds.

# publications[].label
Determination of Oxaliplatin by a UHPLC-MS/MS Method: Application to Pharmacokinetics and Tongue Tissue Distribution Studies in Rats.

# publications[].label
Determination and validation of mycophenolic acid by a UPLC-MS/MS method: Applications to pharmacokinetics and tongue tissue distribution studies in rats.

# publications[].label
Dentinal mineralization is not limited in the mineralization front but occurs along with the entire odontoblast process.

# publications[].label
Gli1+ Periodontal Mesenchymal Stem Cells in Periodontitis.

# publications[].label
Hierarchical Nanofibrous Microspheres with Controlled Growth Factor Delivery for Bone Regeneration.

# publications[].label
Functionalized synthetic biodegradable polymer scaffolds for tissue engineering.

# publications[].label
Biomimetic Tubular Matrix Induces Periodontal Ligament Principal Fiber Formation and Inhibits Osteogenic Differentiation of Periodontal Ligament Stem Cells.

# publications[].label
Nano-Structured Gelatin/Bioactive Glass Hybrid Scaffolds for the Enhancement of Odontogenic Differentiation of Human Dental Pulp Stem Cells.

# publications[].label
Bioactive injectable aggregates with nanofibrous microspheres and human dental pulp stem cells: A translational strategy in dental endodontics.

# publications[].label
Efficacy of Different Solvents for Achieving Patency in Teeth Obturated Using Bioceramic Sealer.

# publications[].label
Cell polarization: From epithelial cells to odontoblasts.

# publications[].label
Induction of osteoblast differentiation phenotype on poly(L-lactic acid) nanofibrous matrix.

# publications[].label
Bioactive mono-dispersed nanospheres with long-term antibacterial effects for endodontic sealing.

# publications[].label
Biomimetic engineering of nanofibrous gelatin scaffolds with noncollagenous proteins for enhanced bone regeneration.

# publications[].label
Regeneration of Dentin-Pulp Complex Using Biophysical Cues

# publications[].label
Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering.

# publications[].label
Gelatin-based Injectable hydrogels for Enhanced Angiogenesis

# publications[].label
Resveratrol represses tumor necrosis factor /c-Jun N-terminal kinase signaling via autophagy in human dental pulp stem cells.

# publications[].label
Multifunctional peptide-conjugated nanocarriers for pulp regeneration in a full-length human tooth root.

# publications[].label
Response of human embryonic stem cell-derived mesenchymal stem cells to osteogenic factors and architectures of materials during in vitro osteogenesis.

# publications[].label
Nanofibrous hollow microspheres self-assembled from star-shaped polymers as injectable cell carriers for knee repair.

# publications[].label
Formation of Nanofibrous Matrices, Three-Dimensional Scaffolds, and Microspheres: From Theory to Practice.

# publications[].label
Porogen-induced surface modification of nano-fibrous poly(L-lactic acid) scaffolds for tissue engineering.

# publications[].label
Nanostructured polymer scaffolds for tissue engineering and regenerative medicine

# publications[].label
Long-acting PFI-2 small molecule release and multilayer scaffold design achieve extensive new formation of complex periodontal tissues with unprecedented fidelity.

# publications[].label
Recent advances in periodontal regeneration: A biomaterial perspective.

# publications[].label
ECM-mimicking nanofibrous matrix coaxes macrophages toward an anti-inflammatory phenotype: Cellular behaviors and transcriptome analysis.

# publications[].label
Polymeric scaffolds for bone tissue engineering.

# publications[].label
Enhanced osteogenic healing process of rat tooth sockets using a novel simvastatin-loaded injectable microsphere-hydrogel system.

# publications[].label
Nanofibrous Tubular Three-Dimensional Platform for Single Dental Pulp Stem Cell Polarization.

# publications[].label
Nanostructured polymer scaffolds for tissue engineering and regenerative medicine.

# publications[].label
The influence of three-dimensional nanofibrous scaffolds on the osteogenic differentiation of embryonic stem cells.

# publications[].label
Immunomodulatory ECM-like nanofibrous microspheres for accelerated bone regeneration in diabetes mellitus

# publications[].label
Tissue clearing of both hard and soft tissue organs with the PEGASOS method

# publications[].label
Injectable gelatin derivative hydrogels with sustained vascular endothelial growth factor release for induced angiogenesis.

# publications[].label
Chondrogenesis and osteogenesis are one continuous developmental and lineage defined biological process.

# publications[].label
Modulating macrophage responses to promote tissue regeneration by changing the formulation of bone extracellular matrix from filler particles to gel bioscaffolds.

# publications[].label
Chondrogenic and osteogenic differentiations of human bone marrow-derived mesenchymal stem cells on a nanofibrous scaffold with designed pore network.

# publications[].label
Bactericidal Effect of Strong Acid Electrolyzed Water against Flow Enterococcus faecalisBiofilms.

# publications[].label
Phase separation, pore structure, and properties of nanofibrous gelatin scaffolds.

# publications[].label
Generation and control of multiple solitons under the influence of parameters

# publications[].label
Cell-Matrix Interactions and Signal Transduction

# publications[].label
Tissue Regeneration: 3D Maskless Micropatterning for Regeneration of Highly Organized Tubular Tissues (Adv. Healthcare Mater. 3/2018)

# publications[].label
Bio-Inspired Micropatterned Platforms Recapitulate 3D Physiological Morphologies of Bone and Dentinal Cells.

# publications[].label
Surface modification of interconnected porous scaffolds.

# publications[].label
In Situ Synthesis and Self-Assembly of Peptide-PEG Conjugates: A Facile Method for the Construction of Fibrous Hydrogels.

# publications[].label
Endodontic release system for apexification with calcium hydroxide microspheres.

# researcherOn[].label
Chemoablation of high-risk oral premalignant lesions for sustained cancer prevention

# researcherOn[].awardedBy.label
Cancer Prevention and Research Institute of Texas - (Austin, Texas, United States)

# researcherOn[].label
Nanofibrous hollow microspheres for bone regeneration

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Regeneration of tubular vascularized pulpodentin complex

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Novel Pharmacotherapeutic Bioadhesive Patch for Oral Ulcerations

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
MINE-MS for horizontal bone loss treatment

# researcherOn[].awardedBy.label
National Institute of Dental and Craniofacial Research - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.label
National Institute of Dental and Craniofacial Research - (Bethesda, Maryland, United States)

# researcherOn[].label
Small molecule microenvironment design for craniofacial bone regeneration

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Dental and Craniofacial Research

# streetAddress
Texas A&M University College of Dentistry; Biomedical Sciences; 3302 Gaston Avenue

# etdChairOf[].label
Arora, Akshi (2014-04). Synthesis and Characterization of Novel Fluorescent Injectable Micro-Carriers for Tissue Regeneration. Master's Thesis.

# etdChairOf[].label
Ahuja, Neelam (2017-05). Development of a Demineralized Dentin Matrix Hydrogel for Dental Pulp Regeneration. Master's Thesis.