# positions[].organizations[].parent[].label
College of Agriculture and Life Sciences

# overview
Dr. Zhang's long-term goal is to decode genetic events and molecular interactions of biological processes, and rigorously represent the complex molecular behaviors with mathematical models. We use advanced high-throughput technology and robust stochastic models to obtain the systematic picture of a biological process. Multiple types of omics data, such as microarray, RNA-seq, ChIP-seq, lipidomics and proteomics are collected through innovative study designs in animals and humans, and are modeled for integrative analysis. Using embryonic mouse as a model system, one of our current focuses is to untangle the spatial and dynamic gene-gene interaction networks during heart development, and illustrate how environmental factors introduce adverse molecular changes and morphological defects. We are also investigating the transgenerational epigenetic variations carried from overweight mother to the offspring, and how the change of lifestyles would prevent childhood obesity.

# keywords[]
High Resolution Time Of Flight Mass Spectrometry

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Intercellular Signaling Peptides And Proteins

# educationAndTraining[].organization.label
Kansas State University - (Manhattan, Kansas, United States)

# educationAndTraining[].organization.label
Kansas State University - (Manhattan, Kansas, United States)

# publications[].label
Differential expression of cancer associated proteins in breast milk based on age at first full term pregnancy.

# publications[].label
Effects of dietary calorie restriction or exercise on the PI3K and Ras signaling pathways in the skin of mice.

# publications[].label
An integrative analysis of DNA methylation and RNA-Seq data for human heart, kidney and liver.

# publications[].label
Comparative analysis of de novo transcriptome assembly.

# publications[].label
Short and long term gene expression variation and networking in human proximal tubule cells when exposed to cadmium.

# publications[].label
Series of randomized complete block experiments with non-normal data

# publications[].label
Differential expression of cancer-related proteins in paired breast milk samples from women with breast cancer.

# publications[].label
Genomic signatures and gene networking: challenges and promises.

# publications[].label
The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance.

# publications[].label
Determination of trans-resveratrol and its metabolites in rat serum using liquid chromatography with high-resolution time of flight mass spectrometry.

# publications[].label
Interaural level difference-dependent gain control and synaptic scaling underlying binaural computation.

# publications[].label
ABT-869, a multitargeted receptor tyrosine kinase inhibitor, reduces tumor microvascularity and improves vascular wall integrity in preclinical tumor models.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation.

# publications[].label
Serum Mllerian inhibiting substance levels are lower in premenopausal women with breast precancer and cancer.

# publications[].label
Family history of breast cancer predicts breastmilk protein expression.

# publications[].label
A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium.

# publications[].label
Gene set analysis for longitudinal gene expression data.

# publications[].label
Methylation and miRNA effects of resveratrol on mammary tumors vs. normal tissue.

# publications[].label
Effects of dietary calorie restriction or exercise on the PI3K and Ras signaling pathways in the skin of mice (Journal of Biological Chemistry (2007) 282, (28025-28035))

# publications[].label
Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.

# publications[].label
In ovo exposure to cadmium causes right ventricle hyperplasia due to cell proliferation of cardiomyocytes.

# publications[].label
Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation.

# publications[].label
Effects of prenatal low protein and postnatal high fat diets on visceral adipose tissue macrophage phenotypes and IL-6 expression in Sprague Dawley rat offspring.

# publications[].label
Comparative analysis of de novo transcriptome assembly

# publications[].label
A hidden Markov model-based algorithm for identifying tumour subtype using array CGH data.

# publications[].label
Offspring NAFLD liver phospholipid profiles are differentially programmed by maternal high-fat diet and maternal one carbon supplement.

# publications[].label
Differential expression of cancer-associated proteins in breastmilk.

# publications[].label
Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation.

# publications[].label
From genes to networks: in systematic points of view.

# publications[].label
The current trend of genomics research for human diseases.

# publications[].label
Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer.

# publications[].label
Proteins and carbohydrates in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy.

# publications[].label
Exosomal miRNAs in nipple aspirate fluid and breast cancer

# publications[].label
Polyunsaturated fatty acid content may be increased in the milk of women with pregnancy-associated breast cancer.

# publications[].label
Comparison of RNA-seq and microarray-based models for clinical endpoint prediction.

# publications[].label
A short-term transition from a high-fat diet to a normal-fat diet before pregnancy exacerbates female mouse offspring obesity.

# publications[].label
An algorithm for classifying tumors based on genomic aberrations and selecting representative tumor models.

# publications[].label
Overexpression of IL-10 in C2D macrophages promotes a macrophage phenotypic switch in adipose tissue environments.

# publications[].label
The unique C- and N-terminal sequences of Metallothionein isoform 3 mediate growth inhibition and Vectorial active transport in MCF-7 cells.

# publications[].label
Prediction of the number of activated genes in multiple independent Cd(+2)- and As(+3)-induced malignant transformations of human urothelial cells (UROtsa).

# publications[].label
Microarray analysis of gene expression patterns in human proximal tubule cells over a short and long time course of cadmium exposure.

# publications[].label
Activity and structural comparisons of solution associating and monomeric channel-forming peptides derived from the glycine receptor m2 segment.

# publications[].label
Slit/Robo signaling mediates spatial positioning of spiral ganglion neurons during development of cochlear innervation.

# researcherOn[].label
A poly-omic study of the molecular mechanisms underlying maternal diet interventions for offspring obesity and NAFLD

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M Health Science Center; IBT - Cedp - Dashwood; 1201 TAMUS

# schools[]
College of Agriculture and Life Sciences