# positions[].organizations[].parent[].label
School of Veterinary Medicine and Biomedical Sciences

# overview
Research in my lab focuses on male-female differences in normal cardiovascular function, and in the development of various diseases, including hypertension, coronary artery disease, and stroke, and the roles of the sex hormones in these male-female differences in cardiovascular disease. A major topic of study in my lab is the so-called "estrogen paradox" which reveals protective effects of this female sex hormone in younger women and animals, but deleterious effects in older females.

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Sexual Dimorphism In Blood Pressure And Metabolism

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
University of Arizona - (Tucson, Arizona, United States)

# educationAndTraining[].organization.label
University of Tennessee Health Science Center - (Memphis, Tennessee, United States)

# educationAndTraining[].organization.label
San Diego State University - (San Diego, California, United States)

# educationAndTraining[].organization.label
San Diego State University - (San Diego, California, United States)

# publications[].label
Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation.

# publications[].label
Systemic hypotensive effects of testosterone are androgen structure-specific and neuronal nitric oxide synthase-dependent.

# publications[].label
Immunoreactive plasma arginine vasotocin (P(AVT)) in the putative diabetes insipidus domestic fowl

# publications[].label
Osmotic and volemic regulation of plasma arginine vasotocin in conscious domestic fowl.

# publications[].label
Hypothalamo-pituitary-adrenal axis dynamics: do apples and oranges increase our understanding of the hypothalamo-pituitary-adrenal axis in illness?

# publications[].label
Angiotensin II receptors in the fowl aorta.

# publications[].label
Contributions of glomerular and tubular mechanisms to antidiuresis in conscious domestic fowl

# publications[].label
Antihypertensive responses of vasoactive androgens in an in vivo experimental model of preeclampsia.

# publications[].label
Inhibiting long chain fatty Acyl CoA synthetase increases basal and agonist-stimulated NO synthesis in endothelium.

# publications[].label
Indomethacin enhances reactivity to vasopressin in normotensive and hypertensive rats, while PGE2 receptor blockade only attenuates reactivity in normotensive rats.

# publications[].label
Sympathy for the devil: the role of thromboxane in the regulation of vascular tone and blood pressure.

# publications[].label
Predicting mortality from sepsis: is protein C a true crystal ball?

# publications[].label
Angiotensin II vascular receptors in the domestic fowl

# publications[].label
Contributions of glomerular and tubular mechanisms to antidiuresis in conscious domestic fowl.

# publications[].label
Acute exercise attenuates phenylephrine-induced contraction of rabbit isolated aortic rings.

# publications[].label
Testosterone-induced relaxation of rat thoracic aorta: Structural specificity of androgen analog effects on vascular smooth muscle (VSM) and endothelium (ENDO)

# publications[].label
Gender differences in the expression of heat shock proteins: the effect of estrogen.

# publications[].label
Hypogonadal hypertension in male Sprague-Dawley rats is renin-angiotensin system-dependent: role of endogenous androgens.

# publications[].label
Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel.

# publications[].label
The mechanism of activation of G-protein coupled estrogen receptor induced coronary artery smooth muscle relaxation

# publications[].label
Effects of age and sex on cerebrovascular function in the rat middle cerebral artery.

# publications[].label
Angiotensin II (AII)-induced natriuresis in anesthetized domestic fowl

# publications[].label
Cardiovascular and metabolic actions of the androgens: Is testosterone a Janus-faced molecule?

# publications[].label
Contributions of glomerular and tubular mechanisms to antidiuresis in conscious domestic fowl.

# publications[].label
Testosterone-induced relaxation of rat thoracic aorta involves vascular smooth muscle (VSM) K+ channel activation

# publications[].label
Sexual dimorphism in vasopressin-induced contraction of rat aorta.

# publications[].label
Contributions of glomerular and tubular mechanisms to antidiuresis in conscious domestic fowl

# publications[].label
Antihypertensive effects of androgens in conscious, spontaneously hypertensive rats.

# publications[].label
Selective Estrogen Receptor Agonists Enhance Blood Pressure, Thromboxane and Prostacyclin in Aortic CoarctationInduced Hypertensive Female Rats

# publications[].label
Estrogen replacement restores flow-induced vasodilation in coronary arterioles of aged and ovariectomized rats.

# publications[].label
Regulation of plasma antidiuretic hormone in the dehydrated kangaroo rat (Dipodomys spectabilis M.).

# publications[].label
Testosterone-induced vasorelaxation of porcine coronary artery involves K+ channel activation

# publications[].label
Age and estrogendependent effects on cerebrovascular reactivity: shifting from beneficial to detrimental (1069.6)

# publications[].label
G protein-coupled estrogen receptor 1 mediates relaxation of coronary arteries via cAMP/PKA-dependent activation of MLCP.

# publications[].label
Sexual dimorphism in renal vascular reactivity to ang1otensin in spontaneously hypertensive rats: Effects of gonadectomy and estrogen replacement

# publications[].label
The activation of G protein-coupled estrogen receptor induces relaxation via cAMP as well as potentiates contraction via EGFR transactivation in porcine coronary arteries.

# publications[].label
Effects of estrogen on cerebrovascular function: age-dependent shifts from beneficial to detrimental in small cerebral arteries of the rat.

# publications[].label
Testosterone-induced relaxation of rat aorta is androgen structure specific and involves K+ channel activation.

# publications[].label
Androgen-receptor defect abolishes sex differences in nitric oxide and reactivity to vasopressin in rat aorta.

# publications[].label
The occurrence of nephrogenic diabetes insipidus in domestic fowl.

# publications[].label
Regional differences in the vasorelaxing effects of testosterone and its 5-reduced metabolites in the canine vasculature.

# publications[].label
Activation of G protein-coupled estrogen receptor fine-tunes age-related decreased vascular activities in the aortae of female and male rats.

# publications[].label
Estrogen enhances contractile responses of rat aorta by upregulating expression of cyclooxygenase-2 and thromboxame synthase

# publications[].label
Effects of arginine and antioxidant vitamins on pulmonary artery reactivity to phenylephrine in the broiler chicken.

# publications[].label
Osmotic regulation of plasma arginine vasotocin (PAVT) in conscious domestic fowl

# publications[].label
Activation of G-protein-coupled estrogen receptor (GPER) inhibits coronary artery smooth muscle cell proliferation

# publications[].label
Regulation of plasma arginine vasotocin in conscious water-deprived domestic fowl.

# publications[].label
Effects of melatonin on water metabolism and renal function in male Syrian hamsters (Mesocricetus auratus).

# publications[].label
Sex Differences in Sepsis Survival Involve Effects of Gonadal Steroid Hormones

# publications[].label
Angiotensin II vascular receptors in fowl aorta: binding specificity and modulation by divalent cations and guanine nucleotides.

# publications[].label
Inhibiting long-chain fatty acyl CoA synthetase does not increase agonist-induced release of arachidonate metabolites from human endothelial cells.

# publications[].label
Estrogen potentiates vasopressin-induced contraction of female rat aorta by enhancing cyclooxygenase-2 and thromboxane function.

# publications[].label
Exercise training enhances flow-induced vasodilation in skeletal muscle resistance arteries of aged rats: role of PGI2 and nitric oxide.

# publications[].label
Hypogonadal Hypertension in Male SpragueDawley Rats Is Reversed by Testosterone Replacement Therapy, which Suppresses ReninAngiotensin System Expression

# publications[].label
Testosterone causes direct relaxation of rat thoracic aorta.

# publications[].label
Kallistatin is a potent new vasodilator.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
SEX DIFFERENCES IN CONSTRICTOR RESPONSES TO BERAPROST IN RAT MESENTERIC ARTERIOLES: ROLES OF THROMBOXANE VS. PGE2 PROSTANOID RECEPTORS

# publications[].label
Mesenteric vascular responses to vasopressin during development of DOCA-salt hypertension in male and female rats.

# publications[].label
Do androgens play a beneficial role in the regulation of vascular tone? Nongenomic vascular effects of testosterone metabolites.

# publications[].label
Hypogonadal Hypertension In Male SpragueDawley Rats Is Reversed By Testosterone and its Genomically Inactive Metabolite 5Dihydrotestosterone

# publications[].label
Effects of arginine vasotocin (AVT) infusion on glomerular filtration rate (GFR) in conscious domestic fowl

# publications[].label
Sexual dimorphism in prostanoid-potentiated vascular contraction: roles of endothelium and ovarian steroids.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Corticosteroid Therapy in Sepsis: When Is a Good Thing Too Much of a Good Thing?

# publications[].label
Sex differences in nitric oxide-mediated attenuation of vascular reactivity to vasopressin are abolished by gonadectomy.

# publications[].label
Correction: Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation

# publications[].label
Reply to "Letter to the Editor: 'Understanding the WHI gap"'

# publications[].label
Temperature maintenance and CO2 concentration in a swarm cluster of honey bees, Apis mellifera.

# publications[].label
Sex differences in extracellular and intracellular calcium-mediated vascular reactivity to vasopressin in rat aorta.

# publications[].label
Long-term tamoxifen (TMX)-treatment enhances endothelium-dependent nitric oxide (NO) and constrictor prostanoid (PG) function in female rat aorta

# publications[].label
Activation of G protein-coupled estrogen receptor 1 induces coronary artery relaxation via Epac/Rap1-mediated inhibition of RhoA/Rho kinase pathway in parallel with PKA.

# publications[].label
Role of endothelium in sexual dimorphism in vasopressin-induced contraction of rat aorta.

# publications[].label
Estrogen potentiates constrictor prostanoid function in female rat aorta by upregulation of cyclooxygenase-2 and thromboxane pathway expression.

# publications[].label
G proteincoupled estrogen receptor mediates relaxation of coronary arteries via cAMP/PKAdependent activation of MLCP (1065.14)

# publications[].label
Angiotensin II binding sites in aortic endothelium of domestic fowl.

# publications[].label
HypotestosteronemiaInduced Hypertension in Male SpragueDawley Rats is Reversed by Testosterone Replacement Therapy, Which is a NonGenomic, EstrogenIndependent Effect

# publications[].label
Seasonal changes in the water metabolism of woodrats.

# publications[].label
Impact of aging vs. estrogen loss on cardiac gene expression: estrogen replacement and inflammation.

# publications[].label
Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle.

# publications[].label
Testosterone-induced relaxation of coronary arteries: activation of BKCa channels via the cGMP-dependent protein kinase.

# publications[].label
Nongenomic androgen-induced vasorelaxation is structurally-specific and involves vascular smooth muscle K+ channel activation via nitric oxide-cyclic-gmp pathway

# streetAddress
Texas A&M University; Vet Med - Physiology & Pharmacology; 4466 TAMU

# schools[]
School of Veterinary Medicine and Biomedical Sciences

# inTheNews[].label
Faculty Senate Presents Award To Provost Carol A. Fierke And Team

# inTheNews[].label
Texas A&M announces pause on merit raises for faculty, staff

# inTheNews[].label
Committee Announced to Find Next President of Texas A&M

# etdChairOf[].label
Baltzer, Wendy Irene (2005-02). The role of constrictor prostanoids in the development of aortic  coarctation-induced hypertension in male and female rats. Doctoral Dissertation.

# etdChairOf[].label
Osborn, Pamela (2014-01). The Relative Contributions of COX-1 and COX-2 to Vascular Biosynthesis of Prostacyclin and Thromboxane. Master's Thesis.

# etdChairOf[].label
Deer, Rachel Renee (2013-07). Physiological Factors that Modulate Vascular Function: States of Endothelial Dysfunction and Therapeutic Interventions. Doctoral Dissertation.

# etdChairOf[].label
Sellers, Minga Miown (2009-05). The role of estrogen receptors in the contribution of constrictor prostanoids to aortic  coarctation-induced hypertension. Doctoral Dissertation.

# etdChairOf[].label
Li, Min (2004-09). Constrictor prostanoid-potentiated vascular contraction: regulation of endothelial and vascular smooth muscle mechanism by estrogen. Doctoral Dissertation.