# overview
Dr. Sato has a broad research background in circadian biology combined with growing knowledge in biochemistry, epigenetics, and metabolism. Especially during his second postdoctoral career in the laboratory of the late Paolo Sassone-Corsi at UCI, he has been tackling the question of how the circadian clock links to metabolic functions. Dr. Sato demonstrated the circadian control of metabolic pathways is reprogramed by aging, which is rescued by caloric restriction (Sato et al., Cell 2017). More recently, Dr. Sato investigated the time-dependent impact of exercise, revealing exercise at the early active phase (fasted phase) exerts robust metabolic responses in skeletal muscle (Sato et al., Cell Metab 2019) and illustrating the atlas of exercise metabolism unique to different exercise timing (Sato et al., Cell under revision). Lastly, Dr. Sato discovered a novel non-canonical role played by the circadian clock specific to pluripotent stem cells (Sato et al., in preparation). Taken together, his past/ongoing studies contribute to the accumulation of evidence underscoring a healthy lifestyle relied on biological clocks.

The goals of Sato lab will be to 1) achieve a fundamental understanding of the intertwined link between metabolism, epigenetics, and the circadian clock, and 2) establish translational interventions targeting the circadian clock system to promote human health by using molecular, biochemical, physiological, and bioinformatics approaches.

# keywords[]
Nuclear Receptor Subfamily 1, Group F, Member 1

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Nuclear Receptor Subfamily 1, Group D, Member 1

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Basic Helix-loop-helix Leucine Zipper Transcription Factors

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3214 Pharmacology And Pharmaceutical Sciences

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1.1 Normal Biological Development And Functioning

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3205 Medical Biochemistry And Metabolomics

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Reverse Transcriptase Polymerase Chain Reaction

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Nuclear Receptor Subfamily 1, Group D, Member 1

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Reverse Transcriptase Polymerase Chain Reaction

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Hypoxia-Inducible Factor 1, Alpha Subunit

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Circadian Rhythm Signaling Peptides And Proteins

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1.1 Normal Biological Development And Functioning

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1.1 Normal Biological Development And Functioning

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1.1 Normal Biological Development And Functioning

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6 Evaluation Of Treatments And Therapeutic Interventions

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Sterol Regulatory Element Binding Protein 1

# educationAndTraining[].organization.label
The University of Texas Southwestern Medical Center - (Dallas, Texas, United States)

# publications[].label
Synthesized glucocorticoid, dexamethasone regulates the expressions of -adrenoceptor and glucocorticoid receptor mRNAs but not proteins in slow-twitch soleus muscle of rats.

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Intracellular 2-adrenergic receptor signaling specificity in mouse skeletal muscle in response to single-dose 2-agonist clenbuterol treatment and acute exercise.

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Zinc-deficiency induced changes in the distribution of rat white blood cells.

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Different recovery responses from dietary zinc-deficiency in the distribution of rat granulocytes.

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Effects of dexamethasone on the expression of beta(1)-, beta (2)- and beta (3)-adrenoceptor mRNAs in skeletal and left ventricle muscles in rats.

# publications[].label
Circadian and epigenetic control of depression-like behaviors

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Acute effects of dihydrocapsaicin and capsaicin on the distribution of white blood cells in rats.

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Homer1a Undergoes Bimodal Transcriptional Regulation by CREB and the Circadian Clock.

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Effects of 2-Agonist Administration on Bacterial Phagocytosis by Splenic Macrophages in Mice

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NEU1 sialidase controls gene expression and secretion of IL-6 and MCP-1 through NF-B pathway in 3T3-L1 adipocytes.

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Age-related effects of fasting on ketone body production during lipolysis in rats.

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Rapid-acting antidepressants and the circadian clock.

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The effects of exercise on macrophage function

# publications[].publisher
The Japanese Society of Physical Fitness and Sports Medicine

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Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging.

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Metabolic elasticity: A new measure of age.

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Exercise timing influences multi-tissue metabolome and skeletal muscle proteome profiles in type 2 diabetic patients - A randomized crossover trial.

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First Total Syntheses of TetracenomycinsC and X.

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Oligomerised lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells.

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A circadian clock gene, Rev-erb, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.

# publications[].publisher
The American Association of Immunologists

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Dietary zinc-deficiency and its recovery responses in the thermogenesis of rats.

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The effects of exercise training on obesity-induced dysregulated expression of adipokines in white adipose tissue.

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Enhanced In Situ Spatial Proteomics by Effective Combination of MALDI Imaging and LC-MS/MS.

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Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR.

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Subacute Effects of Capsaicinoids on the Distribution of White Blood Cells in Rats

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Clenbuterol attenuates immobilization-induced atrophy of type II fibers in the fast- twitch extensor digitorum longus but not in the slow-twitch soleus muscle

# publications[].label
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis.

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Resilience to chronic stress is characterized by circadian brain-liver coordination

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Dose-dependent effects of diallyl disulfide on plasma glucose and free fatty acid levels in rats.

# publications[].label
Capsaicinoids-induced changes of plasma glucose, free fatty acid and glycerol concentrations in rats.

# publications[].label
Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida.

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Casted-immobilization downregulates glucocorticoid receptor expression in rat slow-twitch soleus muscle.

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Functional Roles of 2-Adrenergic Receptors in Skeletal Muscle Hypertrophy and Atrophy

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Muscle plasticity and -adrenergic receptors: adaptive responses of -adrenergic receptor expression to muscle hypertrophy and atrophy.

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Direct and indirect suppression of interleukin-6 gene expression in murine macrophages by nuclear orphan receptor REV-ERB.

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Effects of the beta2-agonist clenbuterol on beta1- and beta2-adrenoceptor mRNA expressions of rat skeletal and left ventricle muscles.

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Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis.

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Macrophage Meets the Circadian Clock: Implication of the Circadian Clock in the Role of Macrophages in Acute Lower Respiratory Tract Infection.

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Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression.

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Single administration effects of ethanol on the distribution of white blood cells in rats.

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2-agonist clenbuterol suppresses bacterial phagocytosis of splenic macrophages expressing high levels of macrophage receptor with collagenous structure.

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A Circadian Genomic Signature Common to Ketamine and Sleep Deprivation in the Anterior Cingulate Cortex.

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Effects of 2-agonists and exercise on 2-adrenergic receptor signaling in skeletal muscles

# publications[].publisher
The Japanese Society of Physical Fitness and Sports Medicine

# publications[].label
Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle.

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When Clocks Go Rogue: Circadian Rhythms and the Rise of Cancer.

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ETAS, an enzyme-treated asparagus extract, attenuates amyloid beta-induced cellular disorder in PC12 cells.

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Circadian Regulation of Metabolism: Commitment to Health and Diseases.

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The Effects of Long-term Exercise on Cerebral Function and the Maintenance of Concentration in the Elderly

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Lowering Effects of Allyl Isothiocyanate on the Number of Lymphocyte and Its Subsets in Rats

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Enzyme-treated Asparagus officinalis extract shows neuroprotective effects and attenuates cognitive impairment in senescence-accelerated mice.

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Effects of Resistance Exercise on Intramuscular Oxygenation and Muscle Fiber Composition

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Effect of exercise on HIF-1 and VEGF signaling

# publications[].publisher
The Japanese Society of Physical Fitness and Sports Medicine

# publications[].label
Acute and Subacute Effects of Dexamethasone on the Number of White Blood Cells in Rats

# publications[].label
Allyl isothiocyanate-induced changes in the distribution of white blood cells in rats.

# publications[].label
Effect of Circadian Rhythm on Clinical and Pathophysiological Conditions and Inflammation.

# publications[].label
Linking Depression to Epigenetics: Role of the Circadian Clock.

# publications[].label
Adaptive effects of the beta2-agonist clenbuterol on expression of beta2-adrenoceptor mRNA in rat fast-twitch fiber-rich muscles.

# publications[].label
Regular exercise improves inflammatory responses by resident or recruited macrophages against bacterial pathogens

# publications[].label
Your body has an internal clock that dictates when you eat, sleep and might have a heart attack  all based on time of day

# publications[].label
Dietary zinc-deficiency and its recovery responses in rat liver cytosolic alcohol dehydrogenase activities.

# publications[].label
Diallyl disulfide reduced dose-dependently the number of lymphocyte subsets and monocytes in rats.

# publications[].label
Folate-deficiency induced cell-specific changes in the distribution of lymphocytes and granulocytes in rats.

# publications[].label
The circadian clock CRY1 regulates pluripotent stem cell identity and somatic cell reprogramming.