# positions[].organizations[].parent[].label
College of Agriculture and Life Sciences

# overview
Dr. Farnell's lab develops stem-cell-derived avian intestinal biobanks, including broilers, layers, and turkeys. This new technology has attracted interest and initiated collaboration from scientists around the world. This organoid culture will help us understand how host-pathogen interact, eventually leading us to identify potential intervention methods in poultry. It will also reduce the use of animal studies by saving billions of dollars for animal testing trials. It is a very useful drug and supplementary screening platform, including nutrient supplementary, immunomodulatory, and antibiotic alternatives. The avian intestinal organoid biobank was established, which will help reduce the number of animals used, implementing the principles of the 3Rs- replacement, refinement, and reduction of the use of animals in experiments

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
30 Agricultural, Veterinary And Food Sciences

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Growth Hormone Secretagogue Receptor (ghsr)

# publications[].label
Circadian regulation and function of voltage-dependent calcium channels in the suprachiasmatic nucleus.

# publications[].label
Evaluation of the Effects of Pre-Slaughter High-Frequency Electrical Stunning Current Intensities on Lipid Oxidative Stability and Antioxidant Capacity in the Liver of Yangzhou Goose (Anser cygnoides domesticus).

# publications[].label
Effects of developmental alcohol exposure on vasoactive intestinal polypeptide and voltage-dependent calcium channel expression in rat SCN and cerebellum.

# publications[].label
Competitive Exclusion of Intra-Genus Salmonella in Neonatal Broilers.

# publications[].label
Altered expression of lactate dehydrogenase and monocarboxylate transporter involved in lactate metabolism in broiler wooden breast.

# publications[].label
Distillers dried grains with soluble and enzyme inclusion in the diet effects broilers performance, intestinal health, and microbiota composition.

# publications[].label
Chicken-Specific Kinome Analysis of Early Host Immune Signaling Pathways in the Cecum of Newly Hatched Chickens Infected With Salmonella enterica Serovar Enteritidis.

# publications[].label
Long-term effects of neonatal alcohol exposure on photic reentrainment and phase-shifting responses of the activity rhythm in adult rats.

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Effects of prebiotics, probiotics, and their combination on growth performance, small intestine morphology, and resident Lactobacillus of male broilers.

# publications[].label
Myometrial effects of selective estrogen receptor modulators on estradiol-responsive gene expression are gene and cell-specific.

# publications[].label
Iron oxide nanozyme suppresses intracellular Salmonella Enteritidis growth and alleviates infection in vivo.

# publications[].label
Dietary Factors as Triggers of Low-Grade Chronic Intestinal Inflammation in Poultry.

# publications[].label
Bacitracin Supplementation as a Growth Promoter Down-Regulates Innate and Adaptive Cytokines in Broilers Intestines

# publications[].label
Estradiol and a selective estrogen receptor modulator affect steroid hormone receptor messenger RNA levels and turnover in explant cultures of sheep endometrium.

# publications[].label
Estradiol up-regulates estrogen receptor messenger ribonucleic acid in endometrial carcinoma (Ishikawa) cells by stabilizing the message.

# publications[].label
Effects of altered Clock gene expression on the pacemaker properties of SCN2.2 cells and oscillatory properties of NIH/3T3 cells.

# publications[].label
Neonatal alcohol exposure differentially alters clock gene oscillations within the suprachiasmatic nucleus, cerebellum, and liver of adult rats.

# publications[].label
Carbon Dioxide and Nitrogen Infused Compressed Air Foam for Depopulation of Caged Laying Hens.

# publications[].label
Effects of neonatal alcohol exposure on vasoactive intestinal polypeptide neurons in the rat suprachiasmatic nucleus.

# publications[].label
Novel Models for Chronic Intestinal Inflammation in Chickens: Intestinal Inflammation Pattern and Biomarkers.

# publications[].label
Effects of neonatal alcohol exposure on scn neurotransmitters involved in the light-dark regulation of circadian rhythms

# publications[].label
The effects of estradiol and selective estrogen receptor modulators on gene expression and messenger RNA stability in immortalized sheep endometrial stromal cells and human endometrial adenocarcinoma cells.

# publications[].label
Fructose induces inflammatory activation in macrophages and microglia through the nutrient-sensing ghrelin receptor.

# publications[].label
Effects of Bacillus subtilis and coccidial vaccination on cecal microbial diversity and composition of Eimeria-challenged male broilers.

# publications[].label
From crypts to enteroids: establishment and characterization of avian intestinal organoids.

# publications[].label
Novel model for chronic intestinal inflammation in chickens: (2) Immunologic mechanism behind the inflammatory response.

# publications[].label
Determination of Antimicrobial Resistance Patterns in Salmonella from Commercial Poultry as Influenced by Microbiological Culture and Antimicrobial Susceptibility Testing Methods.

# publications[].label
Depopulation of Caged Layer Hens with a Compressed Air Foam System.

# publications[].label
Evaluation of Alternative Euthanasia Methods of Neonatal Chickens.

# publications[].label
Neonatal alcohol-induced changes in circadian rhythm photoentrainment are coupled with alterations in glutamatergic input systems in the SCN

# publications[].label
Evaluation of Sodium Bisulfate on Reducing Salmonella Heidelberg Biofilm and Colonization in Broiler Crops and Ceca.

# publications[].label
Immortalized cell lines for real-time analysis of circadian pacemaker and peripheral oscillator properties.

# publications[].label
Developmental alcohol exposure alters light-induced phase shifts of the circadian activity rhythm in rats.

# publications[].label
Endometrial effects of selective estrogen receptor modulators (SERMs) on estradiol-responsive gene expression are gene and cell-specific.

# publications[].label
Use of a foaming disinfectant and cleaner to reduce aerobic bacteria on poultry transport coops

# publications[].label
Effect of Feeding a High Calcium: Phosphorus Ratio, Phosphorous Deficient Diet on Hypophosphatemic Rickets Onset in Broilers

# publications[].label
Unraveling frontiers in poultry health (part 1) - Mitigating economically important viral and bacterial diseases in commercial Chicken and Turkey production.

# researcherOn[].label
Enteric Diseases of Food Animals: Enhanced Prevention, Control and Food Safety

# researcherOn[].awardedBy.label
National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Characterize the Effects of Salmonella and Campylobacter on Gut-Brain Axis and Peripheral Circulation System in Broiler Chickens

# researcherOn[].awardedBy.label
Agricultural Research Service - (Washington D.C., District of Columbia, United States)

# streetAddress
Texas A&M University; Poultry Science; 2472 TAMU

# organizations[]
College of Agriculture and Life Sciences

# schools[]
College of Agriculture and Life Sciences