# overview
My lab investigates the roles of early inflammation in tissue damage and wound healing following spinal cord injury. We employ genetic and pharmacological methods to study how immune receptors (e.g. L-selectin) and signaling pathways alter the accumulation and activation of early arriving immune cells, predominantly neutrophils. We are also developing new three-dimensional imaging strategies to characterize inflammation and tissue damage after spinal cord injury. Utilizing tissue clearing techniques and lightsheet microscopy, we can visualize the spatiotemporal effects of spinal cord injury in a manner previously unachievable with traditional imaging modalities. With the knowledge gained from these studies, we aim to develop novel neuroprotective strategies to reduce inflammatory damage and improve long-term recovery for the spinal cord injured patient.

# keywords[]
Physical Injury - Accidents And Adverse Effects

# keywords[]
1.1 Normal Biological Development And Functioning

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Physical Injury - Accidents And Adverse Effects

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Physical Injury - Accidents And Adverse Effects

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3102 Bioinformatics And Computational Biology

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Stem Cell Research - Nonembryonic - Non-human

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5 Development Of Treatments And Therapeutic Interventions

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Stem Cell Research - Nonembryonic - Human

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Stem Cell Research - Embryonic - Non-human

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4201 Allied Health And Rehabilitation Science

# keywords[]
Physical Injury - Accidents And Adverse Effects

# keywords[]
Physical Injury - Accidents And Adverse Effects

# keywords[]
Physical Injury - Accidents And Adverse Effects

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Stem Cell Research - Embryonic - Non-human

# keywords[]
Physical Injury - Accidents And Adverse Effects

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
1.1 Normal Biological Development And Functioning

# educationAndTraining[].organization.label
University of Utah - (Salt Lake City, Utah, United States)

# educationAndTraining[].organization.label
Washington University in St. Louis - (St Louis, Missouri, United States)

# publications[].label
Early Targeting of L-Selectin on Leukocytes Promotes Recovery after Spinal Cord Injury, Implicating Novel Mechanisms of Pathogenesis.

# publications[].label
Semi-automated counting of axon regeneration in poly(lactide co-glycolide) spinal cord bridges.

# publications[].label
Hydrophobic and Hydrogel-Based Methods for Passive Tissue Clearing.

# publications[].label
Generation of v2a interneurons from mouse embryonic stem cells.

# publications[].label
Developmental stage of transplanted neural progenitor cells influences anatomical and functional outcomes after spinal cord injury in mice.

# publications[].label
Lifetime analysis of mdx skeletal muscle reveals a progressive pathology that leads to myofiber loss.

# publications[].label
Role of EZH2 in Uterine Gland Development.

# publications[].label
Combination therapies in the CNS: engineering the environment.

# publications[].label
L-selectin shedding regulates functional recovery and neutrophil clearance following spinal cord injury in a sex-dependent manner.

# publications[].label
Spleen tyrosine kinase facilitates neutrophil activation and worsens long-term neurologic deficits after spinal cord injury.

# publications[].label
Dichotomous Branching of Human Fetal Lung Demonstrated with Light Sheet Fluorescence Microscopy.

# publications[].label
Mature neutrophils promote long-term functional recovery after spinal cord injury in a sex-dependent manner

# publications[].label
Passive clearing and 3D lightsheet imaging of the intact and injured spinal cord in mice

# publications[].label
Three Photon Excited Image Scanning Microscopy for in-Depth Super-Resolution Studies of Biological Samples

# publications[].label
Tissue-engineered fibrin scaffolds containing neural progenitors enhance functional recovery in a subacute model of SCI.

# publications[].label
Three-dimensional imaging of the developing human fetal urogenital-genital tract: Indifferent stage to male and female differentiation.

# publications[].label
Systematic analysis of federal funding for spinal cord injury research.

# publications[].label
Rapid and efficient optical tissue clearing for volumetric imaging of the intact and injured spinal cord in mice

# publications[].label
Imaging the developing human external and internal urogenital organs with light sheet fluorescence microscopy.

# publications[].label
V2a neurons restore diaphragm function in mice following spinal cord injury.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Differentiation of V2a interneurons from human pluripotent stem cells.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
A new method for generating high purity motoneurons from mouse embryonic stem cells.

# publications[].label
Navigating the Light-Sheet Image Analysis Software Landscape: Concepts for Driving Cohesion From Data Acquisition to Analysis.

# publications[].label
Direct reprogramming of mouse fibroblasts to cardiomyocyte-like cells using Yamanaka factors on engineered poly(ethylene glycol) (PEG) hydrogels.

# publications[].label
Recombinant human DNase treatment mitigates extracellular trap mediated damage and improves long-term recovery after spinal cord injury in male mice.

# publications[].label
Sex-dependent effects of peptidylarginine deiminases on neutrophil function and long-term outcomes after spinal cord injury.

# publications[].label
Survival, Differentiation, and Migration of High-Purity Mouse Embryonic Stem Cell-derived Progenitor Motor Neurons in Fibrin Scaffolds after Sub-Acute Spinal Cord Injury.

# publications[].label
L-selectin shedding affects bacterial clearance in the lung: a new regulatory pathway for integrin outside-in signaling.

# publications[].label
Circulating neutrophil activation in dogs with naturally occurring spinal cord injury secondary to intervertebral disk herniation.

# publications[].publisher
American Veterinary Medical Association (AVMA)

# publications[].label
Lightsheet fluorescence microscopy of branching human fetal kidney.

# publications[].label
Functional synaptic connectivity of engrafted spinal cord neurons with locomotor circuitry in the injured spinal cord.

# publications[].label
Transgenic enrichment of mouse embryonic stem cell-derived progenitor motor neurons.

# publications[].label
Reducing neuroinflammation by delivery of IL-10 encoding lentivirus from multiple-channel bridges.

# publications[].label
Passive Clearing and 3D Lightsheet Imaging of the Intact and Injured Spinal Cord in Mice.

# researcherOn[].label
Evaluating neutrophil extracellular traps in spinal cord injury

# researcherOn[].awardedBy.label
Craig H Neilsen Foundation - (Los Angeles, California, United States)