# positions[].organizations[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
My research includes studying the cellular immune response of target leukocytes to cytomegalovirus infection in the fetal-placental unit and also the mechanism of CMV deafness of the developing fetus in utero. I also have a long term interest in the relationship of cancer to viral infections and will investigate the potential link of CMV and other herpesviruses to specific types of cancer.

# keywords[]
Receptor, Platelet-derived Growth Factor Alpha

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Receptor, Platelet-derived Growth Factor Alpha

# educationAndTraining[].organization.label
University of California, Davis - (Davis, California, United States)

# educationAndTraining[].organization.label
University of California, Berkeley - (Berkeley, California, United States)

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# publications[].label
Endothelial Cell Infection by Guinea Pig Cytomegalovirus Is a Lytic or Persistent Infection Depending on Tissue Origin but Requires Viral Pentamer Complex and pp65 Tegument Protein.

# publications[].label
Requirements for guinea pig cytomegalovirus tropism and antibody neutralization on placental amniotic sac cells.

# publications[].label
Neutralizing antibodies to gB based CMV vaccine requires full length antigen but reduced virus neutralization on non-fibroblast cells limits vaccine efficacy in the guinea pig model.

# publications[].label
Accelerated photobleaching of a cyanine dye in the presence of a ternary target DNA, PNA probe, dye catalytic complex: a molecular diagnostic.

# publications[].label
Glycoprotein B (gB) vaccines adjuvanted with AS01 or AS02 protect female guinea pigs against cytomegalovirus (CMV) viremia and offspring mortality in a CMV-challenge model.

# publications[].label
Cytomegalovirus antivirals and development of improved animal models.

# publications[].label
Relative sensitivity and specificity of agar gel immunodiffusion, enzyme immunosorbent assay, and immunoblotting for detection of anti-bovine leukemia virus antibodies in cattle.

# publications[].label
A trimeric capable gB CMV vaccine provides limited protection against a highly cell associated and epithelial tropic strain of cytomegalovirus in guinea pigs.

# publications[].label
Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV.

# publications[].label
Humans have antibodies reactive with Bovine leukemia virus.

# publications[].label
The guinea pig as a relevant preclinical model in the rat race for a vaccine against congenital cytomegalovirus infection.

# publications[].label
Analysis of the essential nature of viral proteins considered to be important target antigens against CMV in candidate vaccine strategies in the guinea pig model

# publications[].label
Emergence of antiviral resistance during oral valganciclovir treatment of an infant with congenital cytomegalovirus (CMV) infection.

# publications[].label
A LIVE, ATTENUATED CMV VACCINE PROTECTS AT THE PLACENTAL-FETAL INTERFACE IN THE GUINEA PIG MODEL OF CONGENITAL CMV INFECTION

# publications[].label
A novel replication impaired virus vaccine strategy is effective against congenital cytomegalovirus infection

# publications[].label
An Attenuated CMV Vaccine with a Deletion in Tegument Protein GP83 (pp65 Homolog) Protects against Placental Infection and Improves Pregnancy Outcome in a Guinea Pig Challenge Model.

# publications[].label
A Fully Protective Congenital CMV Vaccine Requires Neutralizing Antibodies to Viral Pentamer and gB Glycoprotein Complexes but a pp65 T-Cell Response Is Not Necessary.

# publications[].label
Bovine leukemia virus in human breast tissues

# publications[].label
Vaccine Therapy for Cytomegalovirus Induced Hearing Loss

# publications[].label
Convalescent Immunity to Guinea Pig Cytomegalovirus Induces Limited Cross Strain Protection against Re-Infection but High-Level Protection against Congenital Disease.

# publications[].label
Expression of the human cytomegalovirus UL97 gene in a chimeric guinea pig cytomegalovirus (GPCMV) results in viable virus with increased susceptibility to ganciclovir and maribavir.

# publications[].label
A live guinea pig cytomegalovirus vaccine deleted of three putative immune evasion genes is highly attenuated but remains immunogenic in a vaccine/challenge model of congenital cytomegalovirus infection.

# publications[].label
Macrophage inflammatory proteins in cytomegalovirus-related inner ear injury.

# publications[].label
Intravaginal cytomegalovirus (CMV) challenge elicits maternal viremia and results in congenital transmission in a guinea pig model.

# publications[].label
Detection of cytomegalovirus DNA in dried blood spots of Minnesota infants who do not pass newborn hearing screening.

# publications[].label
Cross Strain Protection against Cytomegalovirus Reduces DISC Vaccine Efficacy against CMV in the Guinea Pig Model.

# publications[].label
Analysis of the nucleotide sequence of the guinea pig cytomegalovirus (GPCMV) genome.

# publications[].label
Complete cross strain protection against congenital cytomegalovirus infection requires a vaccine encoding key antibody (gB) and T-cell (immediate early 1 protein) viral antigens.

# publications[].label
Inhibition of chemokine-induced chemotaxis of monkey leukocytes by mu-opioid receptor agonists.

# publications[].label
Guinea pig cytomegalovirus protective T cell antigen GP83 is a functional pp65 homolog for innate immune evasion and pentamer dependent virus tropism.

# publications[].label
Protein kinase inhibitors of the quinazoline class exert anti-cytomegaloviral activity in vitro and in vivo.

# publications[].label
Absence of bovine leukosis virus in semen of seropositive bulls.

# publications[].label
Severe clinical deterioration in a preterm twin following discordant transmission of cytomegalovirus via breast milk

# publications[].label
Bovine leukemia virus DNA in human breast tissue.

# publications[].publisher
Centers for Disease Control and Prevention (CDC)

# publications[].label
The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting.

# publications[].label
Cytomegalovirus UL128 homolog mutants that form a pentameric complex produce virus with impaired epithelial and trophoblast cell tropism and altered pathogenicity in the guinea pig.

# publications[].label
Chapter 37 Human Herpesviruses and Animal Models

# publications[].label
A Novel Non-Replication-Competent Cytomegalovirus Capsid Mutant Vaccine Strategy Is Effective in Reducing Congenital Infection.

# publications[].label
An attenuated cytomegalovirus vaccine with a deletion of a viral chemokine gene is protective against congenital CMV transmission in a guinea pig model.

# publications[].label
A Homolog Pentameric Complex Dictates Viral Epithelial Tropism, Pathogenicity and Congenital Infection Rate in Guinea Pig Cytomegalovirus.

# publications[].label
Viral Glycoprotein Complex Formation, Essential Function and Immunogenicity in the Guinea Pig Model for Cytomegalovirus.

# publications[].label
Guinea pig cytomegalovirus trimer complex gH/gL/gO uses PDGFRA as universal receptor for cell fusion and entry.

# publications[].label
Inclusion of the Viral Pentamer Complex in a Vaccine Design Greatly Improves Protection against Congenital Cytomegalovirus in the Guinea Pig Model.

# publications[].label
Differential expression of bovine MHC class II antigens identified by monoclonal antibodies.

# publications[].label
Bovine cytokine expression during different phases of bovine leukemia virus infection.

# publications[].label
Correction: Viral Glycoprotein Complex Formation, Essential Function and Immunogenicity in the Guinea Pig Model for Cytomegalovirus.

# publications[].label
Antiviral and vaccine strategies against cytomegalovirus: Current therapies and future directions

# researcherOn[].label
Placental Trophoblast Infection and TLR Mediated Response to Congenital CMV

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# researcherOn[].label
Development of an Effective DISC Vaccine Strategy Against Congenital CMV

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# researcherOn[].label
CMV Pentameric Complex Based Vaccine Strategies for Prevention of Congenital CMV

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-Eunice Kennedy Shriver National Institute of Child Health & Human Development

# streetAddress
Texas A&M Health Science Center; 8447 Riverside Parkway; MREB2 3209, MPIM

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine