# preferredTitle
Professor and Presidential Impact Fellow

# positions[].organizations[].parent[].label
College of Agriculture and Life Sciences

# overview
The long-term goal of Dr. Wu's research program is to elucidate the mechanisms underlying the pathogenesis of obesity and overnutrition-associated metabolic diseases including insulin resistance, diabetes, and fatty liver disease so that novel dietary and/or pharmacological approaches can be developed for preventing and/or treating metabolic diseases. Using molecular, cellular, and integrative approaches, the Wu lab is focused on investigating the interaction between metabolism and inflammation.

# keywords[]
Atp Binding Cassette Transporter, Subfamily G, Member 1

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
Sterol Regulatory Element Binding Protein 1

# keywords[]
Atp Binding Cassette Transporter, Subfamily B

# keywords[]
Sterol Regulatory Element Binding Protein 1

# keywords[]
Chemical And Drug Induced Liver Injury, Chronic

# keywords[]
Cyclic Amp-dependent Protein Kinase Type Ii

# keywords[]
Hypoxia-Inducible Factor 1, Alpha Subunit

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Atp Binding Cassette Transporter, Subfamily B

# keywords[]
Severe Coronavirus Disease 2019; Mortality; Diabetes; Fasting Blood Glucose

# keywords[]
Sterol Regulatory Element Binding Protein 1

# keywords[]
Atp Binding Cassette Transporter, Subfamily B

# keywords[]
Sterol Regulatory Element Binding Protein 1

# keywords[]
Nonalcoholic Fatty Liver Disease (nafld)

# keywords[]
Atp Binding Cassette Transporter, Subfamily B

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Sterol Regulatory Element Binding Protein 2

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Atp Binding Cassette Transporter, Subfamily B

# keywords[]
NLR Family, Pyrin Domain-Containing 3 Protein

# keywords[]
Atp Binding Cassette Transporter, Subfamily B

# educationAndTraining[].organization.label
Peking University - (Beijing, Beijing, China)

# awardsAndHonors[].label
ADK regulation of fat metabolism and insulin sensitivity

# publications[].label
Chicken embryos as a potential new model for early onset type I diabetes.

# publications[].label
Ablation of Myeloid ADK (Adenosine Kinase) Epigenetically Suppresses Atherosclerosis in ApoE-/- (Apolipoprotein E Deficient) Mice.

# publications[].label
Disruption of inducible 6-phosphofructo-2-kinase impairs the suppressive effect of PPAR activation on diet-induced intestine inflammatory response.

# publications[].label
Metabolites of microbiota response to tryptophan and intestinal mucosal immunity: A therapeutic target to control intestinal inflammation.

# publications[].label
Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis.

# publications[].label
Editorial: The relationship between sarcopenia and metabolic diseases: Its formation mechanism and intervention means.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression.

# publications[].label
Berberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue Inflammation in Mice with Diet-induced Obesity.

# publications[].label
p16 INK4A drives nonalcoholic fatty liver disease phenotypes in high fat diet fed mice through biliary E2F1/FOXO1/IGF-1 signaling.

# publications[].label
SCFAs alleviated steatosis and inflammation in mice with NASH induced by MCD

# publications[].label
mtDNA RELEASED BY CHOLANGIOCYTES PROMOTES STING ACTIVATION AND FIBROTIC REACTION

# publications[].label
A role of PFKFB3/iPFK2 in the regulation of neuronal glycolysis and food intake

# publications[].label
Amelioration of Ductular Reaction by Stem Cell Derived Extracellular Vesicles in MDR2 Knockout Mice via Lethal-7 microRNA.

# publications[].label
Not performing an OGTT results in underdiagnosis, inadequate risk assessment and probable cost increases of (pre)diabetes in Han Chinese over 40 years: a population-based prospective cohort study

# publications[].label
Glycolysis in the control of blood glucose homeostasis

# publications[].label
Interaction with PFK-/FBP-2 is essential to glucokinase molecular physiology.

# publications[].label
Osr1 Regulates Macrophage-mediated Liver Inflammation in Nonalcoholic Fatty Liver Disease Progression.

# publications[].label
INFLUENCES OF EXPOSURE TO GULF WAR ILLNESS-RELATED CHEMICALS ON GUT DYSBIOSIS AND HEPATIC CLEARANCE OF TRANSLOCATED PATHOBIONTS IN AGING ASSOCIATED CHRONIC LIVER INJURIES

# publications[].label
Regulation of adipose tissue inflammation by adenosine 2A receptor in obese mice.

# publications[].label
Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1.

# publications[].label
The Apelin-Apelin Receptor Axis Triggers Cholangiocyte Proliferation and Liver Fibrosis During Mouse Models of Cholestasis.

# publications[].label
Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression.

# publications[].label
Investigation of in vivo fatty acid metabolism in AFABP/aP2(-/-) mice.

# publications[].label
Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis.

# publications[].label
Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.

# publications[].label
Alteration of FXR phosphorylation and sumoylation in liver in the development of adult catch-up growth.

# publications[].label
INHIBITION OF THE SUBSTANCE P/NEUROKININ RECEPTOR (SP/NK1R) AXIS AMELIORATES LIVER PHENOTYPES IN A MODEL OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)

# publications[].label
miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury.

# publications[].publisher
Ovid Technologies (Wolters Kluwer Health)

# publications[].label
A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation.

# publications[].label
A role for inducible 6-phosphofructo-2-kinase in the control of neuronal glycolysis.

# publications[].label
Ginsenoside Rb1 Alleviates Oxidative Low-Density Lipoprotein-Induced Vascular Endothelium Senescence via the SIRT1/Beclin-1/Autophagy Axis.

# publications[].label
A Role for Palmitoleate in Regulating Macrophage Activation

# publications[].label
[Adenovirus mediated expression of interleukin 12 regulating hepatitis C virus E2 gene immunization-induced immune response].

# publications[].label
Ginsenoside Rb1 prevents H2O2-induced HUVEC senescence by stimulating sirtuin-1 pathway.

# publications[].label
miR-1934, downregulated in obesity, protects against low-grade inflammation in adipocytes.

# publications[].label
Ginsenoside Rb1 Protects Human Umbilical Vein Endothelial Cells against High Glucose-Induced Mitochondria-Related Apoptosis through Activating SIRT3 Signalling Pathway.

# publications[].label
Effects of a high fat diet and Metformin on skeletal muscle membrane proteins and fiber size in young mice

# publications[].label
7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice.

# publications[].label
Blocking Nuclear Factor-Kappa B Protects against Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice.

# publications[].label
Increasing fructose 2,6-bisphosphate overcomes hepatic insulin resistance of type 2 diabetes.

# publications[].label
Cre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A.

# publications[].label
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis.

# publications[].label
Mice lacking adenosine 2A receptor reveal increased severity of MCD-induced NASH.

# publications[].label
Knockout of -calcitonin gene-related peptide attenuates cholestatic liver injury by differentially regulating cellular senescence of hepatic stellate cells and cholangiocytes.

# publications[].label
[Expression of glycoprotein hepatitis C virus in mammalian cell and application of purified protein for detection of antibody against E2 in hepatitis C patients].

# publications[].label
Deleting Gata4 in hepatocytes promoted the progression of NAFLD via increasing steatosis and apoptosis, and desensitizing insulin signaling.

# publications[].label
Dietary fiber-derived short-chain fatty acids: A potential therapeutic target to alleviate obesity-related nonalcoholic fatty liver disease.

# publications[].label
Involvement of PFKFB3/iPFK2 in the suppressive effect of rosiglitazone on diet-induced intestine inflammatory response

# publications[].label
Regulation of Cellular Senescence by miR-34a in Alcoholic Liver Injury.

# publications[].label
Paternal hyperglycemia induces transgenerational inheritance of susceptibility to hepatic steatosis in rats involving altered methylation on Ppar promoter.

# publications[].label
AMP-activated protein kinase 1 protects against diet-induced insulin resistance and obesity. Diabetes 2012;61:3114-3125.

# publications[].label
Platelet IB kinase- deficiency increases mouse arterial neointima formation via delayed glycoprotein Ib shedding.

# publications[].label
Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation.

# publications[].label
FGF1 Signaling Modulates Biliary Injury and Liver Fibrosis in the Mdr2-/- Mouse Model of Primary Sclerosing Cholangitis.

# publications[].label
Tannerella forsythia and coating color on the tongue dorsum, and fatty food liking associate with fat accumulation and insulin resistance in adult catch-up fat.

# publications[].label
Molecular Mechanisms Linking Risk Factors to Cholangiocarcinoma Development.

# publications[].label
A novel mechanism for the insulin-sensitizing effect of leucine in adipocytes

# publications[].label
Knockout of microRNA-21 attenuates alcoholic hepatitis through the VHL/NF-B signaling pathway in hepatic stellate cells.

# publications[].label
MELATONIN BINDS MT1 TO IMPROVE THE PHENOTYPES OF PRIMARY SCLEROSING CHOLANGITIS (PSC) THROUGH CLOCK GENES/MIR-200B/MASPIN/GST SIGNALING

# publications[].label
Cholangiocarcinoma: bridging the translational gap from preclinical to clinical development and implications for future therapy.

# publications[].label
Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes.

# publications[].label
Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Is Associated with Increased Intestinal Inflammation.

# publications[].label
Disruption of Myeloid Cell-Specific PFKFB3 Exacerbates Diet-Induced Hepatic Steatosis and Inflammation in Mice

# publications[].label
Enhancing hepatic glycolysis reduces obesity: differential effects on lipogenesis depend on site of glycolytic modulation.

# publications[].label
Knock-out (KO) of Secretin (Sct) Reduces Biliary Senescence, Ductular Reaction, Liver Inflammation, Steatosis and Fibrosis in Mice Fed High-Fat Diet (HFD) through Changes in the miRNA-125b/VEGF-A Axis.

# publications[].label
Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation.

# publications[].label
Disruption of inducible 6-phosphofructo-2-kinase ameliorates diet-induced adiposity but exacerbates systemic insulin resistance and adipose tissue inflammatory response.

# publications[].label
Biliary Epithelial Senescence in Liver Disease: There Will Be SASP.

# publications[].label
Endothelial adenosine kinase deficiency ameliorates diet-induced insulin resistance.

# publications[].label
Mini review: STING activation during non-alcoholic fatty liver disease.

# publications[].label
Ghrelin Alleviates Experimental Ulcerative Colitis in Old Mice and Modulates Colonocyte Metabolism via PPAR Pathway.

# publications[].label
STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease.

# publications[].label
DISRUPTION OF ADENOSINE 2A RECEPTOR EXACERBATES MCD-INDUCED NASH PHENOTYPE IN MICE

# publications[].label
The Choline Metabolite TMAO Inhibits NETosis and Promotes Placental Development in GDM of Humans and Mice.

# publications[].label
Estimating genome coverage of lepidopteran BAC libraries by screening with single copy probes

# publications[].label
Regulation of glycolysis-role of insulin.

# publications[].label
MicroRNA-223 Regulates Macrophage Polarization and Protects Mice from Diet-Induced Insulin Resistance and Adipose Tissue Inflammation

# publications[].label
Deletion of pancreatic -cell adenosine kinase improves glucose homeostasis in young mice and ameliorates streptozotocin-induced hyperglycaemia.

# publications[].label
Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice using in vivo (13)C NMR measurements of hepatic carbohydrate metabolism.

# publications[].label
PROLONGED ADMINISTRATION OF MELATONIN AMELIORATES BILIARY AND LIVER PHENOTYPES IN THE FEMALE MDR2-/- MOUSE MODEL OF PRIMARY SCLEROSING CHOLANGITIS

# publications[].label
Palmitoleate Supplementation Dissociates Liver Inflammatory Response from Hepatic Steatosis in Mice

# publications[].label
Myeloid cell-specific disruption of Period1 and Period2 exacerbates diet-induced inflammation and insulin resistance.

# publications[].label
Bisphenol A promotes hyperuricemia via activating xanthine oxidase

# publications[].label
Comparison between homologies of E2/NS1 gene from genotype III Chinese isolates of hepatitis C virus and that from reported isolates.

# publications[].label
Paternal hyperglycemia in rats exacerbates the development of obesity in offspring

# publications[].label
Functional Role of the Secretin/Secretin Receptor Signaling During Cholestatic Liver Injury.

# publications[].label
[Changes in gamma-amino-butyric acid and N-methyl-D-aspartic acid receptor-gated currents from freshly isolated hippocampal CA1 pyramidal neurons of hepatic encephalopathy rats].

# publications[].label
Dysregulated Autophagy in Hepatocytes Promotes Bisphenol A-Induced Hepatic Lipid Accumulation in Male Mice.

# publications[].label
Downregulation of p16 Decreases Biliary Damage and Liver Fibrosis in the Mdr2/ Mouse Model of Primary Sclerosing Cholangitis.

# publications[].label
Insulin sensitizers improve the GLP-1 secretion and the amount of intestinal L cells on high-fat-diet-induced catch-up growth.

# publications[].label
A role for PFKFB3/iPFK2 in metformin suppression of adipocyte inflammatory responses.

# publications[].label
Perturbation of glucose flux in the liver by decreasing F26P2 levels causes hepatic insulin resistance and hyperglycemia.

# publications[].label
Liver-specific deletion of microRNA-34a alleviates ductular reaction and liver fibrosis during experimental cholestasis.

# publications[].label
PRKAA1/AMPK1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis.

# publications[].label
Advances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD.

# publications[].label
Fasting Glucose Level Is a Predictor of Mortality in Patients with COVID-19 Independent of Diabetes History

# publications[].label
A role of PFKFB3/iPFK2 in the regulation of high fat diet-induced inflammation and metabolic responses

# publications[].label
Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway.

# publications[].label
miR-196b-5p-enriched extracellular vesicles from tubular epithelial cells mediated aldosterone-induced renal fibrosis in mice with diabetes.

# publications[].label
Indole supplementation ameliorates MCD-induced NASH in mice.

# publications[].label
Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity.

# publications[].label
PFKFB3 Control of Cancer Growth by Responding to Circadian Clock Outputs.

# publications[].label
Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis.

# publications[].label
Ketogenic Diets and Cardio-Metabolic Diseases.

# publications[].label
Adipose tissue inflammation and systemic insulin resistance in mice with diet-induced obesity is possibly associated with disruption of PFKFB3 in hematopoietic cells.

# publications[].label
KNOCKOUT OF BILIARY NEUROKININ 1 RECEPTOR (NK1R) AMELIORATES LIVER PHENOTYPES IN ALCOHOL ASSOCIATED LIVER DISEASE (ALD)

# publications[].label
Endotoxin-induced liver injury and changes in the levels of plasma tumor necrosis factor-alpha and interleukin-6 in rabbits.

# publications[].label
Palmitoleate induces hepatic steatosis but suppresses liver inflammatory response in mice.

# publications[].label
Temporal effects of peroxisome proliferator-activated receptor. activation on macrophage inflammatory responses

# publications[].label
DOWNREGULATION OF STIMULATOR OF INTERFERON GENES (STING) DECREASES BILIARY SENESCENCE AND LIVER FIBROSIS IN CHOLESTATIC MICE THROUGH A DECREASE EXPRESSION OF tmiR24-3p/MELATONIN/AANAT/PER1 SIGNALING.

# publications[].label
Metformin and metabolic diseases: a focus on hepatic aspects.

# publications[].label
A long-term maternal diet transition from high-fat diet to normal fat diet during pre-pregnancy avoids adipose tissue inflammation in next generation.

# publications[].label
Endothelial PFKFB3 plays a critical role in angiogenesis.

# publications[].label
Prolonged administration of a secretin receptor antagonist inhibits biliary senescence and liver fibrosis in Mdr2 -/- mice.

# publications[].label
Gut Microbiota and Metagenomic Advancement in Digestive Disease.

# publications[].label
Metformin ameliorates diet-induced hepatic steatosis and inflammation without altering adipose phenotype

# publications[].label
A long-term maternal diet intervention is necessary to avoid the obesogenic effect of maternal high-fat diet in the offspring.

# publications[].label
STING EXPRESSION IN MONOCYTE-DERIVED MACROPHAGES IS ASSOCIATED WITH THE PROGRESSION OF LIVER INFLAMMATION AND FIBROSIS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE

# publications[].label
Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: beyond its allosteric effects on glycolytic and gluconeogenic enzymes.

# publications[].label
Recent Advances in Adipose Tissue Dysfunction and Its Role in the Pathogenesis of Non-Alcoholic Fatty Liver Disease.

# publications[].label
Gly482Ser mutation impairs the effects of peroxisome proliferator-activated receptor  coactivator-1 on decreasing fat deposition and stimulating phosphoenolpyruvate carboxykinase expression in hepatocytes.

# publications[].label
Dysbiosis in gastrointestinal pathophysiology: Role of the gut microbiome in Gulf War Illness.

# publications[].label
Metabolic Regulation of Adipose Tissue Inflammation and Systemic Insulin Sensitivity: A Role for PFKFB3 in Macrophage Polarization

# publications[].label
THE BILIARY SECRETIN/SECRETIN RECEPTOR (SCT/SR)/MIR-125b AXIS REGULATES HEPATIC STEATOSIS AND LIVER ANGIOGENESIS IN NONALCOHOLIC FATTY LIVER DISEASE (NAFLD)

# publications[].label
Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2-/- mouse model of primary sclerosing cholangitis (PSC).

# publications[].label
Fish Oil Feeding Modulates the Expression of Hepatic MicroRNAs in a Western-Style Diet-Induced Nonalcoholic Fatty Liver Disease Rat Model.

# publications[].label
Inactivation of the adenosine A2A receptor protects apolipoprotein E-deficient mice from atherosclerosis.

# publications[].label
Exacerbation of NAFLD in both HFD-fed Mice and MCD-fed Mice by Adenosine 2A Receptor Deficiency

# publications[].label
Antibody response to E2 glycoprotein induced in mice by immunization with plasmid DNA containing sequence derived from a Chinese genotype III/2a isolate of hepatitis C virus.

# publications[].label
Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity.

# publications[].label
Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis.

# publications[].label
HUMAN LIVER MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES REDUCE LIVER FIBROSIS THROUGH INHIBITION OF p53-MIR-34a AXIS IN ALD

# publications[].label
Aquaporin-11 control of testicular fertility markers in Syrian hamsters.

# publications[].label
Bisphenol A promotes hepatic lipid deposition involving Kupffer cells M1 polarization in male mice

# publications[].label
Macronutrients Differentially Regulate PFKFB3 Expression and Increase Inflammation in Intestinal Epithelial Cells

# publications[].label
Involvement of inducible 6-phosphofructo-2-kinase in the anti-diabetic effect of peroxisome proliferator-activated receptor gamma activation in mice.

# publications[].label
[Effects of reducing injection on plasma TNF-alpha and IL-6 levels in rabbits with endotoxin-induced DIC].

# publications[].label
The Pathogenesis of Nonalcoholic Fatty Liver Disease: Interplay between Diet, Gut Microbiota, and Genetic Background.

# publications[].label
Combined cereal and pulse flavonoids show enhanced bioavailability by downregulating phase II metabolism and ABC membrane transporter function in Caco-2 model.

# publications[].label
BILIARY SENESCENCE REGULATES NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) PHENOTYPES BY E2F1/FOXO1/IGF-1 SIGNALING

# publications[].label
[Cloning and sequencing of E2/NS1 gene from a Chinese genotype III isolate of hepatitis C virus].

# publications[].label
Knockout of the Tachykinin Receptor 1 in the Mdr2-/- (Abcb4-/-) Mouse Model of Primary Sclerosing Cholangitis Reduces Biliary Damage and Liver Fibrosis.

# publications[].label
Adipocyte PFKFB3 overexpression protects mice from diet-induced adipose tissue inflammation and systemic insulin resistance

# publications[].label
Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity.

# publications[].label
Ectopic Overexpression of PPAR2 in the Heart Determines Differences in Hypertrophic Cardiomyopathy After Treatment With Different Thiazolidinediones in a Mouse Model of Diabetes.

# publications[].label
Targeted overexpression of inducible 6-phosphofructo-2-kinase in adipose tissue increases fat deposition but protects against diet-induced insulin resistance and inflammatory responses.

# publications[].label
Hepatocyte Adenosine Kinase Promotes Excessive Fat Deposition and Liver Inflammation.

# publications[].label
AMP-activated protein kinase 1 protects against diet-induced insulin resistance and obesity.

# publications[].label
Endothelial dysfunction in pathological processes of chronic liver disease during aging.

# publications[].label
Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia.

# publications[].label
Dietary effects on A2AR expression in liver and adipose tissues: A role for A2AR in protecting against inflammation and insulin resistance in obesity

# publications[].label
Adenosine receptor A2A deficiency in leukocytes increases arterial neointima formation in apolipoprotein E-deficient mice.

# publications[].label
CMHX008, a novel peroxisome proliferator-activated receptor  partial agonist, enhances insulin sensitivity in vitro and in vivo.

# publications[].label
Inactivation of endothelial adenosine A2A receptors protects mice from cerebral ischaemia-induced brain injury.

# publications[].label
CMHX008, a PPAR partial agonist, enhances insulin sensitivity with minor influences on bone loss.

# publications[].label
Indole Alleviates Diet-Induced Hepatic Steatosis and Inflammation in a Manner Involving Myeloid Cell 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3.

# publications[].label
Glucagon regulates hepatic mitochondrial function and biogenesis through FOXO1.

# publications[].label
PFKFB3/iPFK2 links nutrient metabolism and overnutrition-associated adipocyte inflammatory response through controlling oxidative stress

# publications[].label
Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice.

# publications[].label
KNOCKOUT OF SECRETIN RECEPTOR (SR) AMELIORATES LIVER PHENOTYPES IN A MOUSE MODEL OF ALCOHOL ASSOCIATED LIVER DISEASE (ALD)

# publications[].label
Glucose and Palmitate Differentially Regulate PFKFB3/iPFK2 and Inflammatory Responses in Mouse Intestinal Epithelial Cells.

# publications[].label
FREE FATTY ACIDS-INDUCED ACTIVATION OF THE ALPHA-CALCITONIN GENE-RELATED PEPTIDE (ACGRP)/CALCITONIN RECEPTOR-LIKE RECEPTOR (CRLR)/RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 (RAMP1) AXIS REGULATES MIR-125B EXPRESSION VIA TLR4 IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)

# publications[].label
Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2-/- mice by diminishing senescence of cholangiocytes.

# publications[].label
The Secretin/Secretin Receptor Axis Modulates Ductular Reaction and Liver Fibrosis through Changes in Transforming Growth Factor-1-Mediated Biliary Senescence.

# publications[].label
Reduction of hepatic glucose production as a therapeutic target in the treatment of diabetes.

# publications[].label
TARBP2 promotes tumor angiogenesis and metastasis by destabilizing antiangiogenic factor mRNAs.

# publications[].label
Pinealectomy or Prolonged Light Exposure Exacerbates Biliary Proliferation and Senescence and Liver Fibrosis in Bile Duct Ligated (BDL) Rats Via Decreased Biliary Melatonin Synthesis.

# researcherOn[].label
PFKFB3 control of adipocyte-macrophage crosstalk in obesity

# researcherOn[].awardedBy.label
National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Novel role for adenosine kinase in the control of hepatic gluconeogenesis

# researcherOn[].awardedBy.label
American Diabetes Association - (Alexandria, Virginia, United States)

# researcherOn[].label
Protective role of adenosine 2A receptor in NAFLD

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
ADK Regulation of Fat Metabolism and Insulin Sensitivity

# researcherOn[].awardedBy.label
National Institute of Diabetes and Digestive and Kidney Diseases - (Bethesda, Maryland, United States)

# researcherOn[].label
Metabolic regulation of adipocyte-macrophage crosstalk in obesity

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Mechanisms for synergistic interactions of combined cereal flavones and legume 3-hydroxyflavones against inflammation

# researcherOn[].awardedBy.label
United States Department of Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
USDA-National Institute of Food And Agriculture

# streetAddress
Texas A&M University; Nutrition; 2253 TAMU

# schools[]
College of Agriculture and Life Sciences

# inTheNews[].label
Veggie compound fights fatty liver disease

# inTheNews[].label
Natural Compound In Vegetables Helps Fight Fatty Liver Disease

# inTheNews[].label
Natural compound in vegetables helps fight fatty liver disease

# etdChairOf[].label
Qi, Ting (2015-08). Involvement of PFKFB3/iPFK2 in Beneficial Effects of Metformin on 3T3-L1 Adipocytes and Temporal Effects of Pioglitazone on Adipocytes. Master's Thesis.

# etdChairOf[].label
Woo, Shih Lung (2016-08). Beneficial Effects of Metformin in Diet-Induced Obesity Associated Non-Alcoholic Fatty Liver Disease. Doctoral Dissertation.

# etdChairOf[].label
Guo, Ting (2015-05). Beneficial Effects of Berberine on Nonalcoholic Fatty Liver Disease (NAFLD). Master's Thesis.

# etdChairOf[].label
Halim, Vera (2012-02). Involvement of PFKFB3/iPFK2 in the Effects of Leucine and n-3 PUFA in Adipocytes. Master's Thesis.

# etdChairOf[].label
Guo, Xin (2013-04). A Role for PFKFB3/IPFK2 in Overnutrition-Associated Adipose Tissue and Intestine Inflammatory Responses and Insulin Resistance. Doctoral Dissertation.

# etdChairOf[].label
Botchlett, Rachel Erin (2015-11). Nutrient Regulation of PFKFB3/iPFK2 and Its Role in Regulating Diet-Induced Inflammation in Intestinal Epithelial Cells. Doctoral Dissertation.