# positions[].organizations[].parent[].label
College of Agriculture and Life Sciences

# positions[].organizations[].label
College of Agriculture and Life Sciences

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
3 Prevention Of Disease And Conditions, And Promotion Of Well-being

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
United States Dept. Of Health And Human Services

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
2.5 Research Design And Methodologies (aetiology)

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
3 Prevention Of Disease And Conditions, And Promotion Of Well-being

# keywords[]
United States Food And Drug Administration

# keywords[]
Oxidoreductases Acting On Ch-nh Group Donors

# educationAndTraining[].organization.label
Virginia Commonwealth University - (Richmond, Virginia, United States)

# educationAndTraining[].organization.label
Saint Joseph's University - (Philadelphia, Pennsylvania, United States)

# publications[].label
Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.

# publications[].label
Subchronic Tolerance Trials of Graded Oral Supplementation with Phenylalanine or Serine in Healthy Adults.

# publications[].label
Small ubiquitin-like modifier-1 (SUMO-1) modification of thymidylate synthase and dihydrofolate reductase.

# publications[].label
Bringing clarity to the role of MTHFR variants in neural tube defect prevention.

# publications[].label
Structure of a murine cytoplasmic serine hydroxymethyltransferase quinonoid ternary complex: evidence for asymmetric obligate dimers.

# publications[].label
Supplemental dietary folic acid has no effect on chromosome damage in erythrocyte progenitor cells of mice.

# publications[].label
Effects of disrupted serine hydroxymethyltransferase 1 (Shmt1) gene expression on motor function and myelin degeneration in vitamin B12 deficient mice

# publications[].label
Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men.

# publications[].label
The Effects of Folate Deficiency and Arsenic Exposure on Thymidylate Synthesis in Serine Hydroxymethyltransferase 1-Deficient Mouse Embryonic Fibroblasts

# publications[].label
Biomarkers of folate status in NHANES: a roundtable summary.

# publications[].label
New paradigms for nutrient control of genome translation.

# publications[].label
Mouse models to elucidate mechanisms of folate-related cancer pathologies.

# publications[].label
Folate supplementation in people with sickle cell disease.

# publications[].label
Human cytoplasmic serine hydroxymethyltransferase is an mRNA binding protein

# publications[].label
Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells.

# publications[].label
Provision of folic acid for reducing arsenic toxicity in arsenicexposed children and adults

# publications[].label
Neurobiology of eating behavior, nutrition, and health.

# publications[].label
Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Folate-mediated one-carbon metabolism and neural tube defects: balancing genome synthesis and gene expression.

# publications[].label
Nutrition and stem cell integrity in aging.

# publications[].label
Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Convergence of Genetic, Nutritional and Inflammatory Factors in Gastrointestinal Cancers

# publications[].label
Discussion: Folate and vitamin B<inf>12</inf> metabolism: Overview and interaction with riboflavin, vitamin B<inf>6</inf>, and polymorphisms

# publications[].label
Disruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice.

# publications[].label
Mthfd1 is a modifier of chemically induced intestinal carcinogenesis.

# publications[].label
Evidence for the accumulation of a stable intermediate in the nonenzymatic hydrolysis of 5,10-methenyltetrahydropteroylglutamate to 5-formyltetrahydropteroylglutamate.

# publications[].label
Strengthening national nutrition research: rationale and options for a new coordinated federal research effort and authority.

# publications[].label
The mitochondrial inner membrane protein MPV17 prevents uracil accumulation in mitochondrial DNA.

# publications[].label
Cloning, expression, and purification of 5,10-methenyltetrahydrofolate synthetase from Mus musculus.

# publications[].label
Time to Think About Nutrient Needs in Chronic Disease.

# publications[].label
Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males.

# publications[].label
General introduction: the role of science in identifying common ground in the debate on genetic modification of foods

# publications[].label
Addressing the Increased Expectations of Nutrition.

# publications[].label
Rapid Purification of the T-Protein of the Glycine Cleavage System from Rabbit Liver

# publications[].label
Nutritional regulation of epigenetic changes.

# publications[].label
Folate rescues vitamin B12 depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Nutrition and developmental biology--implications for public health.

# publications[].label
Folate nutrition and blood-brain barrier dysfunction.

# publications[].label
Molecular cloning, characterization, and regulation of the human mitochondrial serine hydroxymethyltransferase gene.

# publications[].label
Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.

# publications[].label
Cell cycle regulation of folate-mediated one-carbon metabolism.

# publications[].label
p53 Disruption Increases Uracil Accumulation in DNA and Leads to Folic Acid Nonresponsive Neural Tube Defects in Mice

# publications[].label
Consensus Measures of Diet for Genomewide Association Studies of GeneNutrient Interactions in Health and Disease

# publications[].label
Biomarkers of Nutrition for Development-Folate Review.

# publications[].label
Nutrition and its role in human evolution.

# publications[].label
Nutrition research to affect food and a healthy life span.

# publications[].label
Proposals for Upper Limits of Safe Intake for Methionine, Histidine, and Lysine in Healthy Humans.

# publications[].label
Bringing individuality to public health recommendations

# publications[].label
Regulation of de novo purine biosynthesis by methenyltetrahydrofolate synthetase in neuroblastoma.

# publications[].label
Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies.

# publications[].label
Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function.

# publications[].label
Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview.

# publications[].label
p53 Disruption Increases Uracil Accumulation in DNA of Murine Embryonic Fibroblasts and Leads to Folic Acid-Nonresponsive Neural Tube Defects in Mice.

# publications[].label
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.

# publications[].label
The Roles of SUMO in Metabolic Regulation.

# publications[].label
Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study.

# publications[].label
Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.

# publications[].label
Pyridoxal phosphate inhibits dynamic subunit interchange among serine hydroxymethyltransferase tetramers.

# publications[].label
High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5.

# publications[].label
Deoxyuracil in DNA and disease: Genomic signal or managed situation?

# publications[].label
Lincoln's Biodefense Strategy: Protecting the Agricultural Base.

# publications[].label
Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc. Implications for inhibition of DNA replication.

# publications[].label
Biomarkers of vitamin B-12 status in NHANES: a roundtable summary.

# publications[].label
Genetic and epigenetic contributions to human nutrition and health: managing genome-diet interactions.

# publications[].label
Genetic variation: Effect on nutrient utilization and metabolism

# publications[].label
Mthfs is an Essential Gene in Mice and a Component of the Purinosome.

# publications[].label
Purification and properties of a folate-catabolizing enzyme.

# publications[].label
A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis.

# publications[].label
Heavy chain ferritin enhances serine hydroxymethyltransferase expression and de novo thymidine biosynthesis.

# publications[].label
Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway.

# publications[].label
No association between cSHMT genotypes and the risk of breast cancer in the Nurses' Health Study.

# publications[].label
Securing the future of nutritional sciences through integrative graduate education.

# publications[].label
Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency.

# publications[].label
Human cytoplasmic serine hydroxymethyltransferase is an mRNA binding protein.

# publications[].label
Identifying the role of genomic uracil in folate deficiency

# publications[].label
Diffraction grade crystals of Escherichia coli serine hydroxymethyltransferase.

# publications[].label
Dietary and genetic manipulations of folate metabolism differentially affect neocortical functions in mice.

# publications[].label
DTYMK is an essential gene in mice and heterozygosity does not cause neural tube defects.

# publications[].label
Folate supplementation in people with sickle cell disease.

# publications[].label
Sensitizing cancer cells: is it really all about U?

# publications[].label
De novo Thymidylate Biosynthesis and dUTPase Interact in DNA Synthesis

# publications[].label
Relationship between dopamine-stimulated phospholipid methylation and the single-carbon folate pathway.

# publications[].label
Primary structure and tetrahydropteroylglutamate binding site of rabbit liver cytosolic 5,10-methenyltetrahydrofolate synthetase.

# publications[].label
Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice.

# publications[].label
Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene.

# publications[].label
5,10-Methenyltetrahydrofolate synthetase activity is increased in tumors and modifies the efficacy of antipurine LY309887.

# publications[].label
Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells.

# publications[].label
Influence of human genetic variation on nutritional requirements.

# publications[].label
Modeling cellular compartmentation in one-carbon metabolism.

# publications[].label
A UV-responsive internal ribosome entry site enhances serine hydroxymethyltransferase 1 expression for DNA damage repair.

# publications[].label
Arsenic Exposure Alters Folate Metabolism Causing Genomic Instability and Neural Tube Defects in a Dose-Dependent Manner

# publications[].label
The Role of Serine Hydroxymethyltransferase and Methylene-Tetrahydrofolate Dehydrogenase in Genome Stability

# publications[].label
Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects.

# publications[].label
Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA.

# publications[].label
Escherichia coli serine hydroxymethyltransferase. The role of histidine 228 in determining reaction specificity.

# publications[].label
Lack of catalytic activity of a murine mRNA cytoplasmic serine hydroxymethyltransferase splice variant: evidence against alternative splicing as a regulatory mechanism.

# publications[].label
Emerging concepts on the role of epigenetics in the relationships between nutrition and health.

# publications[].label
Nutrition research to affect food and a healthy lifespan.

# publications[].label
PhenX: a toolkit for interdisciplinary genetics research.

# publications[].label
Murine cysteine dioxygenase gene: structural organization, tissue-specific expression and promoter identification.

# publications[].label
Haploinsufficiency of cytosolic serine hydroxymethyltransferase in the Smith-Magenis syndrome.

# publications[].label
MTHFD1 regulates nuclear de novo thymidylate biosynthesis and genome stability.

# publications[].label
Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis.

# publications[].label
Mimosine is a cell-specific antagonist of folate metabolism.

# publications[].label
Nutrition research to affect food and a healthy life span.

# publications[].label
Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults.

# publications[].label
Physiology of folate and vitamin B<inf>12</inf> in health and disease

# publications[].label
Molecular and genetic considerations for long-term nutrition interventions

# publications[].label
The 5-formyltetrahydrofolate futile cycle reduces pathway stochasticity in an extended hybrid-stochastic model of folate-mediated one-carbon metabolism.

# publications[].label
More Nutrition Precision, Better Decisions for the Health of Our Nation.

# publications[].label
Identifying the role of genomic uracil in folate deficiency

# publications[].label
Late-life dietary folate restriction reduces biosynthetic processes without compromising healthspan in mice.

# publications[].label
Integrating themes, evidence gaps, and research needs identified by workshop on iron screening and supplementation in iron-replete pregnant women and young children.

# publications[].label
The Roles of SUMO in Metabolic Regulation

# publications[].label
The Role of Brain Barriers in Maintaining Brain Vitamin Levels.

# publications[].label
Deoxyuracil in DNA in health and disease.

# publications[].label
Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis.

# publications[].label
Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop.

# publications[].label
Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Vitamins in the prevention of human diseases

# publications[].label
A ferritin-responsive internal ribosome entry site regulates folate metabolism.

# publications[].label
Dietary Uridine Decreases Tumorigenesis in the ApcMin/+ Model of Intestinal Cancer.

# publications[].label
Evidence that 5-formyltetrahydropteroylglutamate has a metabolic role in one-carbon metabolism.

# publications[].label
Structural comparison of the human mitochondrial and cytoplasmic serine hydroxymethyltransferase genes.

# publications[].label
Mechanism of the internal ribosome entry site-mediated translation of serine hydroxymethyltransferase 1.

# publications[].label
Food systems: Healthy diet sustains the environment too.

# publications[].label
Effects of Cellular Glycine on Cell Proliferation

# publications[].label
Dietary folic acid protects against genotoxicity in the red blood cells of mice.

# publications[].label
Celebrating 40 Years of the Annual Review of Nutrition.

# publications[].label
Unprocessed Red Meat and Processed Meat Consumption: Dietary Guideline Recommendations From the Nutritional Recommendations (NutriRECS) Consortium.

# publications[].label
Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice.

# publications[].label
Dietary uridine supplementation decreases tumor number in Apc(Min/+) mice (829.11)

# publications[].label
Best practices in nutrition science to earn and keep the public's trust.

# publications[].label
Polymorphisms in serine hydroxymethyltransferase 1 and methylenetetrahydrofolate reductase interact to increase cardiovascular disease risk in humans.

# publications[].label
Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice.

# publications[].label
BEST PRACTICES FROM THE ASN COMMITTEE ON PUBLIC TRUST

# streetAddress
Texas A&M AgriLife Research; Vice Chancellor of Agriculture - Management; 2147 TAMUS

# organizations[]
College of Agriculture and Life Sciences

# schools[]
College of Agriculture and Life Sciences

# inTheNews[].label
Texas A&M Slaps Back at Harvard Critics of Its Beef-Industry-Backed Research

# inTheNews[].label
Texas A&M AgriLife Creates 'Murder Hornet' Task Force

# inTheNews[].label
Promising study offers hope for Menkes disease treatment

# inTheNews[].label
Disease triangle' indicates COVID-19 peak isn't the end

# inTheNews[].label
AgriLife biochemist Libo Shan named EDGES Fellow

# inTheNews[].label
A closer look at agriculture market interruptions during COVID-19

# inTheNews[].label
COVID-19 Relief for Farmers and Ranchers

# inTheNews[].label
Texas A&M, Blinn College, team up to open workforce training complex in Bryan

# inTheNews[].label
Texas A&M corn breeder named Blavatnik award finalist

# inTheNews[].label
Study Shows 'Organic' Wounds Improve Produce

# inTheNews[].label
Urban agriculture and nutritious food production

# inTheNews[].label
Texas A&M leader, nationally recognized entomologist dies

# inTheNews[].label
Texas A&M AgriLife expands statewide water commitment

# inTheNews[].label
AgriLife Joins FAO Roundtable to discuss enhancing food systems

# inTheNews[].label
Texas A&M System receives grassland revitalization grant

# inTheNews[].label
Texas A&M College of Agriculture and Life Sciences departments restructured

# inTheNews[].label
Meat factories are shutting down across the country: Will there be a shortage of food?

# inTheNews[].label
COVID-19 erases two decades of food security gains

# inTheNews[].label
New study shows 'organic' wounds improve produce

# inTheNews[].label
Texas' agricultural losses from pandemic could reach $8 billion

# inTheNews[].label
Opinion: Why we need precision nutrition now

# inTheNews[].label
AgriLife Expands Statewide Water Commitment

# inTheNews[].label
Texas A&M AgriLife celebrates Feed the Future anniversary

# inTheNews[].label
Texas A&M, Harvard Scientists Feud Over Controversial Red and Processed Meat Study

# inTheNews[].label
Texas A&M Researcher Creating Better Corn Yields, Quality On Less Land

# inTheNews[].label
Death Of Former Texas A&M System Chancellor, Bush Library Director, And Nationally Recognized Entomologist Perry Adkisson

# inTheNews[].label
Seven Texas A&M Faculty Members Awarded With University Distinguished Professorships

# inTheNews[].label
Live demonstrations highlight Texas A&M beef short course

# inTheNews[].label
Opinion: Modernizing agriculture is key to fighting coronavirus crisis

# inTheNews[].label
Texas A&M University System, Blinn College dedicate new workforce complex

# inTheNews[].label
Investment in nutrition research needed at federal level

# inTheNews[].label
Study: COVID-19 Economic Impact $2.5 Trillion Loss in Goods, Services

# inTheNews[].label
Texas A&M AgriLife maps out Texas' working lands

# inTheNews[].label
Murder hornet task force mobilized by Texas A&M AgriLife

# inTheNews[].label
AgriLife Extension assists Texans in production agriculture

# inTheNews[].label
New report estimates Texas' agricultural losse from pandemic could be $6-8 billion

# inTheNews[].label
Stopping SARS-CoV-2 along the farm-to-plate supply chain