# positions[].organizations[].label
Center for Translational Research in Aging and Longevity

# overview
Chromatography and mass spectrometry of small molecules in applications related to research on human metabolism and nutrition.

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
1.1 Normal Biological Development And Functioning

# educationAndTraining[].organization.label
Johns Hopkins University - (Baltimore, Maryland, United States)

# publications[].label
Genetic mapping of quantitative trait loci governing longevity of Caenorhabditis elegans in recombinant-inbred progeny of a Bergerac-BO x RC301 interstrain cross.

# publications[].label
An iterative block-shifting approach to retention time alignment that preserves the shape and area of gas chromatography-mass spectrometry peaks.

# publications[].label
Metabolic Consequences of Supplemented Methionine in a Clinical Context.

# publications[].label
Enhanced anabolic capacity, but unchanged anabolic threshold in clinically-stable normal weight patients with chronic obstructive pulmonary disease

# publications[].label
Development of high-throughput HILIC-MS/MS methodology for plasma citrulline determination in multiple species

# publications[].label
Enhanced Splanchnic Extraction Of Nutritional Arginine And Lower Citrulline Production Play A Role In The Reduced Systemic Availability Of Arginine In The Early Recovery Phase Of Sepsis In The Pig

# publications[].label
MON-PP121: Skeletal Muscle Weakness in Chronic Obstructive Pulmonary Disease is Associated with Disturbances in Glutamate Related Metabolism

# publications[].label
Mutation induction in Escherichia coli WP2 uvrA by Cerenkov emission associated with 137Cs gamma irradiation.

# publications[].label
Mutagenic effects of 4-hydroxynonenal triacetate, a chemically protected form of the lipid peroxidation product 4-hydroxynonenal, as assayed in L5178Y/Tk+/- mouse lymphoma cells.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Protein Digestion, but Not Amino Acid Absorption, Is Compromised During Feeding in Chronic Obstructive Pulmonary Disease

# publications[].label
Comprehensive Metabolic Amino Acid Flux Analysis In Critically Ill Male And Female Patients

# publications[].label
Increased Amino Acid Turnover and Net Protein Breakdown but Preserved Muscle and Cognitive Function in Obese Middle-Age Adults

# publications[].label
-Hydroxy -Methylbutyric Acid (Hmb) Supplementation Stimulates Muscle Protein Synthesis In The Early Recovery Phase Of Sepsis In The Pig.

# publications[].label
Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin.

# publications[].label
Ten-fold extension of C. elegans longevity by mutations that also confer protection against oxidative and electrophilic stresses, but not hyperthermic stress

# publications[].label
-hydroxy -methylbutyric acid (hmb) supplementation reduced whole body protein breakdown in the early recovery phase of sepsis in the pig

# publications[].label
Altered Glutamate and Glutamine Kinetics in Autism Spectrum Disorder

# publications[].label
Total weight loss obtained after 2 weeks of very low caloric diet is strongly associated with baseline (net) protein catabolic and glutamine production rates

# publications[].label
Short-chain fatty acid production in accessible and inaccessible body pools as assessed by novel stable tracer pulse approach is reduced by aging independent of presence of COPD.

# publications[].label
Comprehensive metabolic flux analysis to explain skeletal muscle weakness in COPD.

# publications[].label
Unbiased chromosomal mapping of loci governing longevity in C. elegans.

# publications[].label
Sex Related Differences In Amino Acid Metabolism In Chronic Obstructive Pulmonary Disease

# publications[].label
Excessive nitrogen uptake by the liver limits the anabolic response to enteral amino acids intervention during early sepsis-recovery

# publications[].label
Ammonia, respiration, and longevity in nematodes: insights on metabolic regulation of life span from temporal rescaling.

# publications[].label
Changes in Whole-Body Amino Acid Metabolism in Response to 2 Weeks of the Very-Low Calorie Diet Are Not Affected by Gender

# publications[].label
Comparable Organ Protein Fractional Synthesis Rate of High and Low-Active Mice

# publications[].label
Anchor polymerase chain reaction display: a high-throughput method to resolve, score, and isolate dimorphic genetic markers based on interspersed repetitive DNA elements.

# publications[].label
Aging In Older Adults Induces Changes In Arginine And Glutamine Kinetics, Partly Independent of The Presence of Comorbidities

# publications[].label
Impact of -hydroxy--methylbutyrate (HMB) on muscle loss and protein metabolism in critically ill patients: A RCT.

# publications[].label
MON-PP282: Exhaled Concentration of Nitric Oxide (Feno) Does not Reflect the Upregulated Whole Body Nitric Oxide Synthesis in Patients with Chronic Obstructive Pulmonary Disease

# publications[].label
Activated whole-body arginine pathway in high-active mice.

# publications[].label
Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI).

# publications[].label
A narrow quantitative trait locus in C. elegans coordinately affects longevity, thermotolerance, and resistance to paraquat.

# publications[].label
Isoleucine supplementation for ten days does not modify protein and branched-chain amino acid turnover in type 2 diabetes

# publications[].label
Age-Specific Differences in Whole-Body Amino Acid Kinetics

# publications[].label
L-Citrulline Supplementation Stimulates De Novo Arginine Synthesis In The Early Recovery Phase Of Sepsis In The Pig

# publications[].label
Discrimination of primer 3'-nucleotide mismatch by taq DNA polymerase during polymerase chain reaction.

# publications[].label
Genetic loci modulating fitness and life span in Caenorhabditis elegans: categorical trait interval mapping in CL2a x Bergerac-BO recombinant-inbred worms.

# publications[].label
Metabolic phenotyping using kinetic measurements in young and older healthy adults.

# publications[].label
Protein fractional synthesis rates within tissues of high- and low-active mice.

# publications[].label
Correction: Protein fractional synthesis rates within tissues of high- and low-active mice.

# publications[].label
Application of gas chromatography-tandem mass spectrometry (GC/MS/MS) for the analysis of deuterium enrichment of water.

# publications[].label
High-active Mice Have Elevated Clearance Rate Of Bcaas Compared To Low-active Mice

# publications[].label
Females have a different metabolic response to critical illness, measured by comprehensive amino acid flux analysis.

# publications[].label
Remarkable longevity and stress resistance of nematode PI3K-null mutants.

# publications[].label
Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strains.

# publications[].label
NOVEL METHOD TO MEASURE FAT AND PROTEIN DIGESTION RATE AND THE ACUTE RESPONSE TO PANCREATIC ENZYME INTAKE IN PEDIATRIC AND ADULT PATIENTS WITH CYSTIC FIBROSIS

# publications[].label
Impaired whole-body arginine metabolism in type 2 diabetes

# publications[].label
Determination of -hydroxy--methylbutyrate concentration and enrichment in human plasma using chemical ionization gas chromatography tandem mass spectrometry.

# publications[].label
SUN-PP026: Reduced Protein Synthesis and Breakdown in Jejunal Mucosal Biopsies in a Live Bacteria Induced Hyperdynamic Sepsis Pig Model

# publications[].label
New advances in stable tracer methods to assess whole-body protein and amino acid metabolism.

# publications[].label
A Ketogenic Diet In Mice Reduces Cardiac Protein Synthesis Compared to a Western Diet

# publications[].label
Skeletal Muscle Weakness Is Associated with Specific Alterations in Amino Acid Metabolism in Patients with Chronic Obstructive Pulmonary Disease

# publications[].label
Comprehensive metabolic amino acid flux analysis in critically ill patients.

# publications[].label
Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo.

# publications[].label
Obesity- and sex-related metabolism of arginine and nitric oxide in adults.

# publications[].label
The pathogenesis of age-related bone loss in mice involves increased production of PPAR gamma-activating oxidized lipids derived from the lipoxygenase Alox15.

# publications[].label
Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants.

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Heart, Lung, and Blood Institute

# streetAddress
Texas A&M University; Health And Kinesiology; 4253 TAMU

# organizations[]
Center for Translational Research in Aging and Longevity

# organizations[]
Center for Translational Research in Aging and Longevity@en-US