# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
Mechanical forces are known to stimulate a number of cell signaling pathways, including those initiated by or resulting in ion channel activation. My recent research in cardiovascular and neuronal systems focuses on: (1) Which ion channels are activated by mechanical stress; (2) Which ion channels are modulated by integrins; (3) How integrin-mediated signaling pathways modulate ion channel function and mechanotransduction in physiological and pathological conditions; (4) Epilepsy study, Neurosteroids and New Drug Development.

# keywords[]
1.1 Normal Biological Development And Functioning

# educationAndTraining[].organization.label
Texas A&M Health Science Center - (College Station, Texas, United States)

# publications[].label
Cardiac Myosin Binding Protein C Regulates Cross-bridge Kinetics to Affect Diastolic Function

# publications[].label
Frequency Dependent Phosphorylation of Cardiac Myosin Binding Protein-C Mediates Acceleration of Myocardial Relaxation to Support Normal Diastolic Function

# publications[].label
Atomic Force Microscopy Protocol for Measurement of Membrane Plasticity and Extracellular Interactions in Single Neurons in Epilepsy.

# publications[].label
Exercise-Induced Changes in Mechanotransduction Improve Myocardial Function in a Porcine Model of Chronic Occlusion

# publications[].label
Impairments in the intrinsic contractility of mesenteric collecting lymphatics in a rat model of metabolic syndrome.

# publications[].label
Integrins as receptor targets for neurological disorders.

# publications[].label
Novel role for vinculin in ventricular myocyte mechanics and dysfunction.

# publications[].label
Application of Atomic Force Microscopy Measurements on Cardiovascular Cells

# publications[].label
Myosin Binding Protein C is Essential for Beta-adrenergic Mediated Acceleration of Cardiac Relaxation

# publications[].label
Stay-at-home and face mask policy intentions inconsistent with incidence and fatality during the US COVID-19 pandemic.

# publications[].label
Effects of histamine on electrophysiological properties and triggered activity in guinea pig papillary muscles.

# publications[].publisher
JR PROUS SA APARTADO DE CORREOS 540, 08080 BARCELONA, SPAIN

# publications[].label
TNF mediated regulation of myosin light chain 20 phosphorylation in lymphatic muscle

# publications[].label
Cardiomyocyte contractile status is associated with differences in fibronectin and integrin interactions.

# publications[].label
Role of the central alpha-receptors in the modulation of carotid sinus reflex of rats

# publications[].label
Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.

# publications[].label
Inconsistent with the Intent of Public Health Strategies on Incidence Rates and Case-Fatality Ratio between States with Extra Stay-at-Home and Mandating Face Masks Orders and States Only Following CDC Recommendations During COVID-19 Pandemic in the US

# publications[].label
Perturbation of Tropomyosin Amino Acid Residues Binding to Actin at the "Off" State of Tropomyosin Increase Cardiac Muscle Dynamics

# publications[].label
Characterization of stretch-activated cation current in coronary smooth muscle cells.

# publications[].label
Experimental Models of Gulf War Illness, a Chronic Neuropsychiatric Disorder in Veterans.

# publications[].label
A Comprehensive and Advanced Mouse Model of Post-Traumatic Epilepsy with Robust Spontaneous Recurrent Seizures.

# publications[].label
Stay-at-home and face mask policies intentions inconsistent with incidence and fatality during US COVID-19 pandemic

# publications[].label
Potentiation of large conductance, Ca2+-activated K+ (BK) channels by alpha5beta1 integrin activation in arteriolar smooth muscle.

# publications[].label
Sodium azide dilates coronary arterioles via activation of inward rectifier K+ channels and Na+-K+-ATPase.

# publications[].label
Integrin receptor activation triggers converging regulation of Cav1.2 calcium channels by c-Src and protein kinase A pathways.

# publications[].label
Integrins and mechanotransduction of the vascular myogenic response.

# publications[].label
Mechanical Properties of the Interaction between Fibronectin and Integrins on Diabetic Cardiomyocytes

# publications[].label
Coordinated regulation of vascular Ca2+ and K+ channels by integrin signaling.

# publications[].label
Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C During Increased Pacing Frequency or 1-Adrenergic Stimulation.

# publications[].label
Fibronectin-Induced Mechanotransduction Mediated by alpha (5) beta (1) Integrin Requires Calcium and Vinculin in Mouse Cardiomyocytes

# publications[].label
Regulation of ion channels by protein tyrosine phosphorylation.

# publications[].label
Modulation of calcium current in arteriolar smooth muscle by alphav beta3 and alpha5 beta1 integrin ligands.

# publications[].label
Fibronectin increases the force production of mouse papillary muscles via 51 integrin.

# publications[].label
Estrous cycle regulation of extrasynaptic -containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Fibronectin Increases Mouse Cardiac Contractility via Alpha (5) Beta (1) Integrin

# publications[].label
Regulation of ion channels by integrins.

# publications[].label
Phosphorylation of Myosin Binding Protein C Contributes to the Force-Frequency Response and Beta-Adrenergic Enhancement of Cardiac Contraction

# publications[].label
Magnetic resonance imaging analysis of long-term neuropathology after exposure to the nerve agent soman: correlation with histopathology and neurological dysfunction.

# publications[].label
Abstract 1580: Phosphorylation of Myosin Binding Protein C Contributes to the Force-Frequency Response and Beta-Adrenergic Enhancement of Cardiac Contraction

# publications[].label
Perimenstrual-like hormonal regulation of extrasynaptic -containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity.

# publications[].label
Regulation of the L-type calcium channel by alpha 5beta 1 integrin requires signaling between focal adhesion proteins.

# publications[].label
Long-term changes in neuroimaging markers, cognitive function and psychiatric symptoms in an experimental model of Gulf War Illness.

# publications[].label
Alpha5beta1 integrin engagement increases large conductance, Ca2+-activated K+ channel current and Ca2+ sensitivity through c-src-mediated channel phosphorylation.

# publications[].label
Integrins as unique receptors for vascular control.

# publications[].label
alpha(4)beta(1) Integrin activation of L-type calcium channels in vascular smooth muscle causes arteriole vasoconstriction.

# publications[].label
Mechanical properties of the interaction between fibronectin and alpha 5 beta 1-integrin on cardiomyocytes studied by atomic force microscopy

# publications[].label
Fibronectin improves the impaired calcium signaling and myofilament activation in diabetic cardiomyocytes

# publications[].label
Histamine-induced early afterdepolarizations and triggered activity in guinea-pig papillary muscles

# publications[].label
Cardiac Myosin Binding Protein-C Phosphorylation Modulates Relaxation in Myocardium

# publications[].label
Application of atomic force microscopy measurements on cardiovascular cells.

# streetAddress
Texas A&M Health Science Center; Neuroscience & Experimental Therapeutics; 1359 TAMUS

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine