# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
Mechanical forces are well known to activate various cell signaling pathways, particularly those involving ion channel activation. My recent research in cardiovascular and neuronal systems focuses on several key areas: (1) identifying ion channels activated by mechanical stress; (2) investigating ion channels modulated by integrins; (3) elucidating how integrin-mediated signaling pathways influence ion channel function and mechanotransduction under both physiological and pathological conditions; and (4) studying epilepsy, neurosteroids, and the development of new therapeutic drugs.

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
1.1 Normal Biological Development And Functioning

# educationAndTraining[].organization.label
Texas A&M Health Science Center - (College Station, Texas, United States)

# publications[].label
Cardiac Myosin Binding Protein C Regulates Cross-bridge Kinetics to Affect Diastolic Function

# publications[].label
Sex Differences in Organophosphate Model of Benzodiazepine-Refractory Status Epilepticus and Neuronal Damage.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Frequency Dependent Phosphorylation of Cardiac Myosin Binding Protein-C Mediates Acceleration of Myocardial Relaxation to Support Normal Diastolic Function

# publications[].label
Atomic Force Microscopy Protocol for Measurement of Membrane Plasticity and Extracellular Interactions in Single Neurons in Epilepsy.

# publications[].label
Exercise-Induced Changes in Mechanotransduction Improve Myocardial Function in a Porcine Model of Chronic Occlusion

# publications[].label
Impairments in the intrinsic contractility of mesenteric collecting lymphatics in a rat model of metabolic syndrome.

# publications[].label
Integrins as receptor targets for neurological disorders.

# publications[].label
Novel role for vinculin in ventricular myocyte mechanics and dysfunction.

# publications[].label
Application of Atomic Force Microscopy Measurements on Cardiovascular Cells

# publications[].label
Myosin Binding Protein C is Essential for Beta-adrenergic Mediated Acceleration of Cardiac Relaxation

# publications[].label
Stay-at-home and face mask policy intentions inconsistent with incidence and fatality during the US COVID-19 pandemic.

# publications[].label
Effects of histamine on electrophysiological properties and triggered activity in guinea pig papillary muscles.

# publications[].publisher
JR PROUS SA APARTADO DE CORREOS 540, 08080 BARCELONA, SPAIN

# publications[].label
TNF mediated regulation of myosin light chain 20 phosphorylation in lymphatic muscle

# publications[].label
Neuroprotectant Activity of Novel Water-Soluble Synthetic Neurosteroids on Organophosphate Intoxication and Status Epilepticus-induced Long-term Neurological Dysfunction, Neurodegeneration and Neuroinflammation.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Cardiomyocyte contractile status is associated with differences in fibronectin and integrin interactions.

# publications[].label
Role of the central alpha-receptors in the modulation of carotid sinus reflex of rats

# publications[].label
Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.

# publications[].label
Inconsistent with the Intent of Public Health Strategies on Incidence Rates and Case-Fatality Ratio between States with Extra Stay-at-Home and Mandating Face Masks Orders and States Only Following CDC Recommendations During COVID-19 Pandemic in the US

# publications[].label
Kindling Models of Epileptogenesis for Developing Disease-Modifying Drugs for Epilepsy.

# publications[].label
Perturbation of Tropomyosin Amino Acid Residues Binding to Actin at the "Off" State of Tropomyosin Increase Cardiac Muscle Dynamics

# publications[].label
Characterization of stretch-activated cation current in coronary smooth muscle cells.

# publications[].label
Experimental Models of Gulf War Illness, a Chronic Neuropsychiatric Disorder in Veterans.

# publications[].label
A Comprehensive and Advanced Mouse Model of Post-Traumatic Epilepsy with Robust Spontaneous Recurrent Seizures.

# publications[].label
Stay-at-home and face mask policies intentions inconsistent with incidence and fatality during US COVID-19 pandemic

# publications[].label
Potentiation of large conductance, Ca2+-activated K+ (BK) channels by alpha5beta1 integrin activation in arteriolar smooth muscle.

# publications[].label
Sodium azide dilates coronary arterioles via activation of inward rectifier K+ channels and Na+-K+-ATPase.

# publications[].label
Integrin receptor activation triggers converging regulation of Cav1.2 calcium channels by c-Src and protein kinase A pathways.

# publications[].label
Integrins and mechanotransduction of the vascular myogenic response.

# publications[].label
Mechanical Properties of the Interaction between Fibronectin and Integrins on Diabetic Cardiomyocytes

# publications[].label
A Comprehensive Stereology Method for Quantitative Evaluation of Neuronal Injury, Neurodegeneration, and Neurogenesis in Brain Disorders.

# publications[].label
Epigenetic Histone Deacetylases Activity Assay in the Brain and Peripheral Organ Tissues.

# publications[].label
Coordinated regulation of vascular Ca2+ and K+ channels by integrin signaling.

# publications[].label
Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C During Increased Pacing Frequency or 1-Adrenergic Stimulation.

# publications[].label
Fibronectin-Induced Mechanotransduction Mediated by alpha (5) beta (1) Integrin Requires Calcium and Vinculin in Mouse Cardiomyocytes

# publications[].label
Regulation of ion channels by protein tyrosine phosphorylation.

# publications[].label
Modulation of calcium current in arteriolar smooth muscle by alphav beta3 and alpha5 beta1 integrin ligands.

# publications[].label
Fibronectin increases the force production of mouse papillary muscles via 51 integrin.

# publications[].label
Neurosteroid mitigation of developmental neurological dysfunction, long-term epileptic biomarkers, chronic neuroinflammation, and neurodegeneration in a pediatric rat model of organophosphate exposure.

# publications[].label
A Pediatric Rat Model of Organophosphate-Induced Refractory Status Epilepticus: Characterization of Long-term Epileptic Seizure Activity, Neurological Dysfunction and Neurodegeneration.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Estrous cycle regulation of extrasynaptic -containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Fibronectin Increases Mouse Cardiac Contractility via Alpha (5) Beta (1) Integrin

# publications[].label
Regulation of ion channels by integrins.

# publications[].label
Phosphorylation of Myosin Binding Protein C Contributes to the Force-Frequency Response and Beta-Adrenergic Enhancement of Cardiac Contraction

# publications[].label
Abstract 19552: Exercise-Induced Changes in Mechanotransduction Improve Myocardial Function in a Porcine Model of Chronic Occlusion

# publications[].label
Magnetic resonance imaging analysis of long-term neuropathology after exposure to the nerve agent soman: correlation with histopathology and neurological dysfunction.

# publications[].label
Abstract 1580: Phosphorylation of Myosin Binding Protein C Contributes to the Force-Frequency Response and Beta-Adrenergic Enhancement of Cardiac Contraction

# publications[].label
Perimenstrual-like hormonal regulation of extrasynaptic -containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity.

# publications[].label
Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman

# publications[].label
Regulation of the L-type calcium channel by alpha 5beta 1 integrin requires signaling between focal adhesion proteins.

# publications[].label
Long-term changes in neuroimaging markers, cognitive function and psychiatric symptoms in an experimental model of Gulf War Illness.

# publications[].label
Alpha5beta1 integrin engagement increases large conductance, Ca2+-activated K+ channel current and Ca2+ sensitivity through c-src-mediated channel phosphorylation.

# publications[].label
Integrins as unique receptors for vascular control.

# publications[].label
alpha(4)beta(1) Integrin activation of L-type calcium channels in vascular smooth muscle causes arteriole vasoconstriction.

# publications[].label
Mechanical properties of the interaction between fibronectin and alpha 5 beta 1-integrin on cardiomyocytes studied by atomic force microscopy

# publications[].label
Fibronectin improves the impaired calcium signaling and myofilament activation in diabetic cardiomyocytes

# publications[].label
Histamine-induced early afterdepolarizations and triggered activity in guinea-pig papillary muscles

# publications[].label
Cardiac Myosin Binding Protein-C Phosphorylation Modulates Relaxation in Myocardium

# publications[].label
Application of atomic force microscopy measurements on cardiovascular cells.

# streetAddress
Texas A&M Health Science Center; Neuroscience & Experimental Therapeutics; 1359 TAMUS

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine