# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
6 Evaluation Of Treatments And Therapeutic Interventions

# educationAndTraining[].organization.label
University of Leeds - (Leeds, United Kingdom)

# educationAndTraining[].organization.label
University of the West Indies - (Bridgetown, Barbados)

# publications[].label
Chromosomal Resistance to Metronidazole in Clostridioides difficile can be Mediated By Epistasis Between Iron Homeostasis and Oxidoreductases

# publications[].label
Chemical genetic analysis of enoxolone inhibition of Clostridioides difficile toxin production reveals adenine deaminase and ATP synthase as antivirulence targets.

# publications[].label
A simple in vitro PK/PD model system to determine time-kill curves of drugs against Mycobacteria.

# publications[].label
Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity.

# publications[].label
Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections.

# publications[].label
N-substituted 3-acetyltetramic acid derivatives as antibacterial agents.

# publications[].label
Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review.

# publications[].label
Fidaxomicin resistance in Clostridioides difficile: a systematic review and predictive modeling with RNA polymerase binding sites.

# publications[].label
Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.

# publications[].label
Rifamycin Resistance in Clostridium difficile Is Generally Associated with a Low Fitness Burden.

# publications[].label
Systems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation.

# publications[].label
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

# publications[].label
Action of nitroheterocyclic drugs against Clostridium difficile.

# publications[].label
The structure-activity relationship of urea derivatives as anti-tuberculosis agents.

# publications[].label
Design, synthesis and microbiological evaluation of ampicillin-tetramic acid hybrid antibiotics.

# publications[].label
The Integrity of Heme Is Essential for Reproducible Detection of Metronidazole-Resistant Clostridioides difficile by Agar Dilution Susceptibility Tests.

# publications[].label
The isoleucyl-tRNA synthetase mutation V588F conferring mupirocin resistance in glycopeptide-intermediate Staphylococcus aureus is not associated with a significant fitness burden.

# publications[].label
In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis.

# publications[].label
Evaluation of Fusobacterium nucleatum Enoyl-ACP Reductase (FabK) as a Narrow-Spectrum Drug Target.

# publications[].label
Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections.

# publications[].label
Constitutive expression of the cryptic vanGCd operon promotes vancomycin resistance in Clostridioides difficile clinical isolates.

# publications[].label
The Clostridium difficile proline racemase is not essential for early logarithmic growth and infection.

# publications[].label
In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy.

# publications[].label
Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents.

# publications[].label
Solid-Phase Synthesis and Antibacterial Activity of Cyclohexapeptide Wollamide B Analogs.

# publications[].label
380. A molecular epidemiological exploration of reduced vancomycin susceptibility in Clostridioides difficile

# publications[].label
Genetic Mechanisms of Vancomycin Resistance in Clostridioides difficile: A Systematic Review.

# publications[].label
Pharmacophore Modeling, Synthesis, and Antibacterial Evaluation of Chalcones and Derivatives.

# publications[].label
Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis.

# publications[].label
Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.

# publications[].label
Surveillance of Clostridioides difficile Antimicrobial Resistance in the United States.

# publications[].label
Structural studies of pterin-based inhibitors of dihydropteroate synthase.

# publications[].label
Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections.

# publications[].label
Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing.

# publications[].label
Mode of action and bactericidal properties of surotomycin against growing and nongrowing Clostridium difficile.

# publications[].label
Gastrointestinal localization of metronidazole by a lactobacilli-inspired tetramic acid motif improves treatment outcomes in the hamster model of Clostridium difficile infection.

# publications[].label
Small-Molecule Inhibition of the C. difficile FAS-II Enzyme, FabK, Results in Selective Activity.

# publications[].label
Epidemic Clostridioides difficile Ribotype 027 Lineages: Comparisons of Texas Versus Worldwide Strains.

# publications[].label
Prospects for flavonoid and related phytochemicals as nature-inspired treatments for Clostridium difficile infection.

# publications[].label
Chromosomal Resistance to Metronidazole in Clostridioides difficile Can Be Mediated by Epistasis between Iron Homeostasis and Oxidoreductases.

# publications[].label
The membrane as a target for controlling hypervirulent Clostridium difficile infections.

# publications[].label
Reduced vancomycin susceptibility in Clostridioides difficile is associated with specific ribotypes

# publications[].label
The Fatty Acid Synthesis Protein Enoyl-ACP Reductase II (FabK) is a Target for Narrow-Spectrum Antibacterials for Clostridium difficile Infection.

# publications[].label
Analysis of mupirocin resistance and fitness in Staphylococcus aureus by molecular genetic and structural modeling techniques.

# publications[].label
NF-B inhibitors, unique -pyranol--lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462.

# publications[].label
The licorice metabolite enoxolone attenuates Clostridioides difficile pathophysiology by corrupting its metabolic and toxin production networks

# publications[].label
Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria.

# publications[].label
The Membrane as a Novel Target Site for Antibiotics to Kill Persisting Bacterial Pathogens

# publications[].label
A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents.

# publications[].label
Ebselen Exhibits Antimicrobial Activity Against Clostridioides difficile By Disrupting Redox Associated Metabolism

# publications[].label
Chemical modulation of the biological activity of reutericyclin: a membrane-active antibiotic from Lactobacillus reuteri.

# publications[].label
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.

# publications[].label
710. Increased Clinical Failure Rates Associated with Reduced Metronidazole Susceptibility in Clostridioides difficile

# publications[].label
The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection.

# publications[].label
The Ferrous Iron Transporter FeoB1 is Essential for Clostridioides difficile Toxin Production and Pathogenesis in Mice

# publications[].label
In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) Inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy.

# publications[].label
New -lactam - Tetramic acid hybrids show promising antibacterial activities.

# publications[].label
Reduced Susceptibility to Metronidazole Is Associated With Initial Clinical Failure in Clostridioides difficile Infection.

# publications[].label
401. Rigor and Reproducibility of Clostridioides difficile susceptibility testing

# publications[].label
840. Clinical Failure Rates Associated with Hemin-induced Metronidazole Resistance in Clostridioides difficile

# publications[].label
Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

# publications[].label
Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile.

# publications[].label
Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead.

# publications[].label
Mechanisms and impact of antimicrobial resistance in Clostridioides difficile.

# publications[].label
Reutericyclin and related analogues kill stationary phase Clostridium difficile at achievable colonic concentrations.

# publications[].label
The microbiome-restorative potential of ibezapolstat for the treatment of Clostridioides difficile infection is predicted through variant PolC-type DNA polymerase III in Lachnospiraceae and Oscillospiraceae.

# publications[].label
Secondary metabolites from Bacillus amyloliquefaciens isolated from soil can kill Burkholderia pseudomallei.

# researcherOn[].label
High Throughput Screening for Non-antibiotic inhibitors of Clostridium difficile Pathophysiology

# researcherOn[].awardedBy.label
National Institute of Allergy and Infectious Diseases - (Bethesda, Maryland, United States)

# researcherOn[].label
Decoding the clinical impact of the recent evolution of metronidazole resistance on Clostridium difficile infection

# researcherOn[].awardedBy.label
National Institute of Allergy and Infectious Diseases - (Bethesda, Maryland, United States)

# researcherOn[].label
Manipulation of Host Complement by Clostridium Difficile Spores - an Immune Evasion Strategy

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
NIH/NIAID/Texas A&M Health Science Center

# researcherOn[].label
Investigation of the FAS-II Enzyme, FabK, as a Druggable Target in Clostridium difficile

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Relationships Among Metronidazole Resistance, Pharmacodynamics and Treatment Outcomes in Clostridium Difficile Infection

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine