# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Hfpef, Heart Failure With Preserved Ejection Fraction

# keywords[]
3sa, Mutated 3 Serines To 3 alanines To Mimic Hypophosphorylated Cardiac Myosin Binding Protein-c (s273a, S282a, And S302a)

# keywords[]
3sd, Mutated 3 Serines To 3 aspartic Acids To Mimic Phosphorylated Cmybp-c (s273d, S282d, And S302d)

# keywords[]
Cmybp-c, Cardiac Myosin Binding Protein-c

# educationAndTraining[].organization.label
University of Florida - (Gainesville, Florida, United States)

# educationAndTraining[].organization.label
Cornell University - (Ithaca, New York, United States)

# educationAndTraining[].organization.label
Lehigh University - (Bethlehem, Pennsylvania, United States)

# awardsAndHonors[].label
Member of the Academy of Distinguished Medical Educators

# publications[].label
Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection.

# publications[].label
Histamine effects on endothelial cell fibronectin interaction studied by atomic force microscopy.

# publications[].label
Extracellular matrix effect on RhoA signaling modulation in vascular smooth muscle cells.

# publications[].label
Chronic but not acute treatment with antidepressants enhances the electroconvulsive seizure response in rats.

# publications[].label
Increased vascular smooth muscle cell stiffness: a novel mechanism for aortic stiffness in hypertension.

# publications[].label
Reduction of intraocular pressure in glaucomatous dogs by a new cholinergic drug.

# publications[].label
RhoA-induced cytoskeletal tension controls adaptive cellular remodeling to mechanical signaling.

# publications[].label
Combined effects of autoregulation and vasoconstrictors on hindquarters vascular resistance.

# publications[].label
Cardiac histamine: a mediator in search of a function

# publications[].label
Characterization of a conditional bosR mutant in Borrelia burgdorferi.

# publications[].label
Inhibition of guinea pig ileum contractions mediated by a class of histamine receptor resembling the H3 subtype.

# publications[].label
Effects of acute and chronic ethanol treatment on pre- and postsynaptic responses to baclofen in rat hippocampus.

# publications[].label
Overexpression of MMP-7 Increases Collagen 1A2 in the Aging Kidney.

# publications[].label
Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi.

# publications[].label
Cardiomyocyte contractile status is associated with differences in fibronectin and integrin interactions.

# publications[].label
Temporal analysis of vascular smooth muscle cell elasticity and adhesion reveals oscillation waveforms that differ with aging.

# publications[].label
GABAergic miniature postsynaptic currents in septal neurons show differential allosteric sensitivity after binge-like ethanol exposure.

# publications[].label
Pressor responses to central injection of H2 antagonists not caused by GABA blockade.

# publications[].label
Hypoxia and extracellular matrix proteins influence angiogenesis and lymphangiogenesis in mouse embryoid bodies.

# publications[].label
Protective action of cimetidine against ouabain-induced pressor effects, arrhythmias, and lethality in guinea pigs.

# publications[].label
Atomic force microscope studies demonstrate increased vascular smooth muscle cell stiffness associated with aging

# publications[].label
Chronic nicotine induces growth retardation in neonatal rat pups.

# publications[].label
Influence of cell stiffness on adhesion force between 51 integrin and fibronectin in intact cells using atomic force microscopy

# publications[].label
Potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats.

# publications[].label
Ischemia-induced cleavage of cadherins in NRK cells is not sufficient for beta-catenin transcriptional activity.

# publications[].label
Effects of intraventricular histamine and H2 receptor antagonists on intraocular pressure.

# publications[].label
Micro RNA clusters in maternal plasma are associated with preterm birth and infant outcomes.

# publications[].label
Mechanical Properties of the Interaction between Fibronectin and Integrins on Diabetic Cardiomyocytes

# publications[].label
Time-dependent changes in smooth muscle cell stiffness and focal adhesion area in response to cyclic equibiaxial stretch.

# publications[].label
Modulation of mechanical properties of the interactions between fibronectin and alpha(5)beta(1)-integrin on cardiomyocytes

# publications[].label
Effects of prostaglandins on intraocular pressure recovery rate in rabbits.

# publications[].label
Coordination of fibronectin adhesion with contraction and relaxation in microvascular smooth muscle.

# publications[].label
Reinventing Biostatistics Education for Basic Scientists.

# publications[].label
Nonlinear analysis of partial dopamine agonist effects on cAMP in C6 glioma cells.

# publications[].label
Transforming growth factor-beta signaling in hypertensive remodeling of porcine aorta.

# publications[].label
Selective regulation of cytoskeletal tension and cell-matrix adhesion by RhoA and Src.

# publications[].label
Comparison of contractile responses of the guinea pig ileum longitudinal muscle to ethanol and GABAA agonists.

# publications[].label
Analysis of stimulus-response chains using nonlinear dynamics.

# publications[].label
Acculturation Predicts Negative Affect and Shortened Telomere Length.

# publications[].label
Vascular smooth muscle cells: Key players in arterial aging

# publications[].label
Inhibition of Mast Cell-Derived Histamine Decreases Human Cholangiocarcinoma Growth and Differentiation via c-Kit/Stem Cell Factor-Dependent Signaling.

# publications[].label
Loss of smooth muscle -actin effects on mechanosensing and cell-matrix adhesions.

# publications[].label
Mechanical properties of the interaction between fibronectin and alpha5beta1-integrin on vascular smooth muscle cells studied using atomic force microscopy.

# publications[].label
Borrelia burgdorferi alters its gene expression and antigenic profile in response to CO2 levels.

# publications[].label
Temporal Dynamics of the Rat Thoracic Duct Contractility in the Presence of Imposed Flow.

# publications[].label
Cytoskeletal tension modulates cellular responses to mechanical stimuli

# publications[].label
Borrelia burgdorferi spatiotemporal regulation of transcriptional regulator bosR and decorin binding protein during murine infection.

# publications[].label
Analysis of receptors mediating histamine-induced decrease of ventricular fibrillation threshold in the guinea pig heart

# publications[].label
Structural equation modeling highlights the potential of Kim-1 as a biomarker for chronic kidney disease.

# publications[].label
Regional atherosclerotic plaque properties in ApoE-/- mice quantified by atomic force, immunofluorescence, and light microscopy.

# publications[].label
EFFECTS OF ETHANOL ON GABA-A AND GABA-B RESPONSES IN THE GUINEA-PIG ILEUM

# publications[].label
Short communication: vascular smooth muscle cell stiffness as a mechanism for increased aortic stiffness with aging.

# publications[].label
Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity.

# publications[].label
EFFECTS OF A FALSE CHOLINERGIC TRANSMITTER ON A NEUROMUSCULAR-JUNCTION, A SYMPATHETIC-GANGLION AND A POSTGANGLIONIC PARASYMPATHETIC NEUROEFFECTOR JUNCTION

# publications[].label
Integrins and regulation of the microcirculation: from arterioles to molecular studies using atomic force microscopy.

# publications[].label
Effect of Tensile Stress on Smooth Muscle Cells

# publications[].label
Synergistic interaction between histamine and ouabain on ventricular fibrillation threshold.

# publications[].label
Effect of ethanol dependence on GABAA antagonist-induced seizures and agonist-stimulated chloride uptake.

# publications[].label
Stimulus amplification, efficacy, and the operational model. Part II--ternary complex occupancy mechanisms.

# publications[].label
Chaotic behavior of the coronary circulation.

# publications[].label
Influence of inflammatory cytokines in integrin-mediated vasodilation.

# publications[].label
Stimulus amplification, efficacy, and the operational model. Part I--binary complex occupancy mechanisms.

# publications[].label
Mechanically Induced Cell Signaling Stimulates Real-Time Cytoskeleton Remodeling

# publications[].label
Effects of environmental levels of cadmium, lead and mercury on human renal function evaluated by structural equation modeling.

# publications[].label
Studies of action mechanism of antiglaucoma drugs with a newly developed cat model.

# publications[].label
Reduction of ventricular fibrillation threshold by histamine: resolution into separate H1- and H2-mediated components.

# publications[].label
The cardiac pharmacology of tiotidine (LCL 125, 211): a new histamine H2-receptor antagonist.

# publications[].label
Binge ethanol exposure delays development of GABAergic miniature postsynaptic currents in septal neurons.

# publications[].label
Dysrhythmias caused by histamine release in guinea pig and human hearts.

# publications[].label
The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete.

# publications[].label
Ranitidine potentiates ileum contractions caused by GABA and electrical stimulation.

# publications[].label
Usefulness of Released Cardiac Myosin Binding Protein-C as a Predictor of Cardiovascular Events.

# publications[].label
Sample entropy analysis of cervical neoplasia gene-expression signatures.

# publications[].label
Vascular Smooth Muscle Contractile Function Declines With Age in Skeletal Muscle Feed Arteries.

# publications[].label
Intervertebral disk mineralization in progressive ankylosis mice.

# publications[].label
Vasoactive agonists exert dynamic and coordinated effects on vascular smooth muscle cell elasticity, cytoskeletal remodelling and adhesion.

# publications[].label
In Vivo Imaging Demonstrates That Borrelia burgdorferi ospC Is Uniquely Expressed Temporally and Spatially throughout Experimental Infection.

# publications[].label
Mg2+ modulates integrin-extracellular matrix interaction in vascular smooth muscle cells studied by atomic force microscopy.

# publications[].label
Effect of cytoskeletal tension on vascular smooth muscle cell adhesion.

# publications[].label
Influence of inflammatory cytokines in integrin-mediated vasodilation.

# publications[].label
Modulation of Integrin-Extracellular Matrix Adhesions by RhoA and Src

# publications[].label
A method for normalizing drug responses to enhance reliability of parametric statistical tests.

# publications[].label
ANALYSIS OF RECEPTORS MEDIATING HISTAMINE-INDUCED DECREASE OF VENTRICULAR-FIBRILLATION THRESHOLD IN THE GUINEA-PIG HEART

# publications[].label
Effect of N-demethylated carbachol (DMC) on canine intraocular pressure (IOP), pupil size, outflow facility, and isolated iris and ciliary muscles

# publications[].label
Central control of intraocular pressure.

# publications[].label
Aging Alters Functional Properties of Cell-Matrix Adhesions in Vascular Smooth Muscle Cells

# publications[].label
Selective measurement and manipulation of adhesion forces between cancer cells and bone marrow endothelial cells using atomic force microscopy.

# publications[].label
Histamine mediation of nicotine effects on postganglionic sympathetic neuroeffector junctions.

# publications[].label
Structural equation modeling identifies markers of damage and function in the aging male Fischer 344 rat.

# publications[].label
Effects of N-demethylated carbachol on iris and ciliary muscles.

# publications[].label
alpha(4)beta(1) Integrin activation of L-type calcium channels in vascular smooth muscle causes arteriole vasoconstriction.

# publications[].label
Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Age-RelatedCardiac Dysfunction: Hope for Better Aging?

# publications[].label
miR-24 Inhibition Increases Menin Expression and Decreases Cholangiocarcinoma Proliferation.

# publications[].label
CHOLINERGIC PROPERTIES OF N-DEMETHYLATED CARBACHOL (DMC), A POTENTIAL OCULAR HYPOTENSIVE AGENT

# researcherOn[].label
Exercise Training-Enhanced Reactive Oxygen Species as Protective Mechanisms in the Coronary Microcirculation

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Heart, Lung, and Blood Institute

# streetAddress
Texas A&M Health Science Center; Medical Physiology; 1114 TAMUS