# positions[].organizations[].parent[].label
School of Veterinary Medicine and Biomedical Sciences

# overview
We are studying transcriptional regulation and the genomics of the mammary gland and the role of epigenetic events during mammary gland development and lactation. We use various genomics approaches to mammary gland biology and my laboratory has been using ChIP-seq, DNase-seq, ATAC-seq and other epigenomic approaches to determine chromosomal states at different developmental time points to determine the role of epigenetic regulation in mammary gland development and understand gene regulation in the mammary gland in general. We use transgenic mouse models to study gene regulation in mammary gland development and lactation.

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
Receptor, Transforming Growth Factor-beta Type I

# keywords[]
Breastfeeding, Lactation And Breast Milk

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
Breastfeeding, Lactation And Breast Milk

# keywords[]
1.5 Resources And Infrastructure (underpinning)

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
Baylor College of Medicine - (Houston, Texas, United States)

# educationAndTraining[].organization.label
Leiden University - (Leiden, Netherlands)

# educationAndTraining[].organization.label
Leiden University - (Leiden, Netherlands)

# publications[].label
Adjustment of RNASeq data for the effect of highly abundant transcripts: a case study in milk production (622.4)

# publications[].label
Integration of prolactin and glucocorticoid signaling at the beta-casein promoter and enhancer by ordered recruitment of specific transcription factors and chromatin modifiers.

# publications[].label
Epigenetics in mammary gland biology and cancer.

# publications[].label
Genetic variation in sensitivity to estrogens and breast cancer risk.

# publications[].label
From genes to milk: genomic organization of the mammary transcriptome

# publications[].label
Physical map and localization of the human casein gene locus.

# publications[].label
Epigenetic modifications and chromatin loop organization explain the different expression profiles of the Tbrg4, WAP and Ramp3 genes.

# publications[].label
Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress.

# publications[].label
Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution.

# publications[].label
High-level expression of bovine alpha s1-casein in milk of transgenic mice.

# publications[].label
The genome sequence of taurine cattle: a window to ruminant biology and evolution.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Epigenetic modifications in 3D: nuclear organization of the differentiating mammary epithelial cell.

# publications[].label
Multispecies comparison of the casein gene loci and evolution of casein gene family.

# publications[].label
In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1.

# publications[].label
TRIENNIAL LACTATION SYMPOSIUM: Nutrigenomics in dairy cows.

# publications[].label
Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptome.

# publications[].label
From genes to milk: genomic organization and epigenetic regulation of the mammary transcriptome.

# publications[].label
Lessons from the bovine genome: implications for human nutrition and research.

# publications[].label
The epigenetic landscape of mammary gland development and functional differentiation.

# publications[].label
Autophagy regulates functional differentiation of mammary epithelial cells.

# publications[].label
Structure and expression of the mouse casein gene locus.

# publications[].label
PER2 regulation of mammary gland development.

# publications[].label
Transforming growth factor beta signaling and decidual integrity in mice.

# publications[].label
Noncanonical role of singleminded-2s in mitochondrial respiratory chain formation in breast cancer.

# publications[].label
EZH2 and Endometrial Cancer Development: Insights from a Mouse Model.

# publications[].label
Sitespecific evolution of casein proteins

# publications[].label
Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit Is Required for Uterine Epithelial Integrity.

# publications[].label
Lactation and neonatal nutrition: defining and refining the critical questions.

# publications[].label
Adenovirus-Cre-mediated recombination in mammary epithelial early progenitor cells.

# publications[].label
The International Milk Genomics Consortium Web Portal

# publications[].label
Organization of the bovine casein gene locus.

# publications[].label
Epigenetic modifications unlock the milk protein gene loci during mouse mammary gland development and differentiation.

# publications[].label
ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition.

# publications[].label
Multispecies comparative analysis of a mammalian-specific genomic domain encoding secretory proteins.

# publications[].label
Expression analysis of the individual bovine beta-, alpha s2- and kappa-casein genes in transgenic mice.

# publications[].label
Lactogenic hormonal induction of long distance interactions between beta-casein gene regulatory elements.

# publications[].label
Lactation Biology Symposium: the long-term impact of epigenetics and maternal influence on the neonate through milk-borne factors and nutrient status.

# publications[].label
In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci.

# publications[].label
The chromatin landscape of the casein gene locus.

# publications[].label
The bovine lactation genome: insights into the evolution of mammalian milk.

# publications[].label
Short-term administration of rhGH increases markers of cellular proliferation but not milk protein gene expression in normal lactating women.

# publications[].label
Functional genomics of cattle through integration of multi-omics data

# publications[].label
A noncoding RNA is a potential marker of cell fate during mammary gland development.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
SIM2s directed Parkin-mediated mitophagy promotes mammary epithelial cell differentiation.

# publications[].label
G-NEST: a gene neighborhood scoring tool to identify co-conserved, co-expressed genes.

# researcherOn[].label
TGF-BETA Signaling in Endometrial Cell Function and Dysfunction

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-Eunice Kennedy Shriver National Institute of Child Health & Human Development

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-Eunice Kennedy Shriver National Institute of Child Health & Human Development

# researcherOn[].label
Characterization Of Cis-Regulatory Elements Associated With Mammary Gland Function

# researcherOn[].awardedBy.label
United States Department of Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
USDA-National Institute of Food And Agriculture

# streetAddress
Texas A&M University; Veterinary Integrative Biosciences; 4458 TAMU

# organizations[]
School of Veterinary Medicine and Biomedical Sciences

# schools[]
School of Veterinary Medicine and Biomedical Sciences