# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
My major research goals are to understand the molecular pathophysiology and develop novel therapeutic strategies for epilepsy, with an emphasis on neurosteroids and GABA inhibition in the brain. Neurosteroids are steroids synthesized locally within the brain that rapidly change neural excitability by non-genomic mechanisms, principally via postsynaptic GABAA receptors that play critical role in epilepsy. Current work in his lab is focused on uncovering molecular mechanisms of neurosteroids in epilepsy and brain disorders, and testing the efficacy of mechanism-based, rationale therapeutic strategies for epilepsy and epileptogenesis. Reddy lab is utilizing multidisciplinary approaches such as pharmacological, molecular, electrophysiological (patch-clamp), mass spectrometry, and transgenic mouse models in research projects.

# keywords[]
Physical Injury - Accidents And Adverse Effects

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
6 Evaluation Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
Perinatal Period - Conditions Originating In Perinatal Period

# keywords[]
6 Evaluation Of Treatments And Therapeutic Interventions

# keywords[]
Attention Deficit Hyperactivity Disorder (ADHD)

# keywords[]
Attention Deficit Disorder With Hyperactivity

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
6 Evaluation Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
6 Evaluation Of Treatments And Therapeutic Interventions

# keywords[]
6 Evaluation Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# educationAndTraining[].organization.label
Panjab University - (Chandigarh, Chandigarh, India)

# educationAndTraining[].organization.label
Panjab University - (Chandigarh, Chandigarh, India)

# educationAndTraining[].organization.label
National Institute of Neurological Disorders and Stroke - (Bethesda, Maryland, United States)

# awardsAndHonors[].label
Association of Former Students University-Level Distinguished Achievement Award, The

# awardsAndHonors[].label
NATA Award of Excellence in Drug Discovery

# awardsAndHonors[].label
Enhancing Development and Generating Excellence in Scholarship (EDGES) Fellow

# publications[].label
Cardioprotective actions of ace inhibitors on ischemic myocardium: An overview

# publications[].label
Prognosis of Epileptic Seizure Event Onsets Using Random Survival Forests

# publications[].label
Development of multidrug resistance protein inhibitors

# publications[].label
Advances and Challenges in Experimental Models of Post-traumatic Epilepsy for Therapeutic Interventions #

# publications[].label
Possible role of nitric oxide in the nootropic and antiamnesic effects of neurosteroids on aging- and dizocilpine-induced learning impairment.

# publications[].label
Molecular, physiological and behavioral characterization of the heterozygous Df[h15q13]/+ mouse model associated with the human 15q13.3 microdeletion syndrome.

# publications[].label
The optimization of TaqMan real-time RT-PCR assay for transcriptional profiling of GABA-A receptor subunit plasticity.

# publications[].label
Neuroimaging Biomarkers of Experimental Epileptogenesis and Refractory Epilepsy.

# publications[].label
Sex and estrous cycle-dependent changes in neurosteroid and benzodiazepine effects on food consumption and plus-maze learning behaviors in rats.

# publications[].label
Progress and Challenges in Developing Medical Countermeasures for Chemical, Biological, Radiological, and Nuclear Threat Agents (Special Issue on Medical Countermeasures -Commentary).

# publications[].label
Epigenetic Histone Deacetylases Activity Assay in the Brain and Peripheral Organ Tissues.

# publications[].label
Novel Drugs and Biologics of 2016: A Boom for Neurodrugs in the Pipelin

# publications[].label
Losartan, a nonpeptide angiotensin-II receptor antagonist, inhibits iron-dependent lipid peroxidation in murine ventricular membranes

# publications[].label
Novel New Drug Approvals in 2011: A Succinct Analysis of Drug Discovery Trends in the United States

# publications[].label
Development of Neurosteroid-Based Novel Psychotropic Drugs

# publications[].label
Efficacy of the FDA-approved cannabidiol on the development and persistence of temporal lobe epilepsy and complex focal onset seizures.

# publications[].label
The neuroendocrine basis of sex differences in epilepsy.

# publications[].label
The clinical potentials of endogenous neurosteroids.

# publications[].label
Animal behavioral models for testing antianxiety agents.

# publications[].label
An enigmatic role of tonic inhibition in gabapentin therapy.

# publications[].label
Catamenial Epilepsy: Discovery of an Extrasynaptic Molecular Mechanism for Targeted Therapy

# publications[].label
Chapter 21 Molecular mechanisms of sex differences in epilepsy

# publications[].label
The Novel Drugs of 2014 Record Approvals for Niche Markets

# publications[].label
Neurosteroids as endogenous regulators of seizure susceptibility and use in the treatment of epilepsy.

# publications[].label
Novel oral colon-specific drug delivery systems for pharmacotherapy of peptide and nonpeptide drugs.

# publications[].label
Neurosteroids for the potential protection of humans against organophosphate toxicity.

# publications[].label
Magnetic resonance imaging analysis of long-term neuropathology after exposure to the nerve agent soman: correlation with histopathology and neurological dysfunction.

# publications[].label
PROGESTERONEDERIVED NEUROSTEROID 3ALPHAHYDROXY 5ALPHAPREGNAN20ONE INHIBITS SPONTANEOUS RECURRENT SEIZURES IN A RAT MODEL OF TEMPORAL LOBE EPILEPSY

# publications[].label
NEUROACTIVE STEROID THERAPY OF STATUS EPILEPTICUS IN EPILEPSY RATS

# publications[].label
Cannabidiol Therapy for Refractory Epilepsy and Seizure Disorders.

# publications[].label
Effect of Neurosteroid Withdrawal on Hippocampal GABAA Receptor 4Subunit Expression in Female Mice

# publications[].label
G proteins: Molecular targets for drug action

# publications[].label
Captopril and lisinopril inhibits iron-dependent lipid peroxidation in murine ventricular membranes

# publications[].label
Role of <inf>2/3</inf>-specific GABA-A receptor isoforms in the development of hippocampus kindling epileptogenesis

# publications[].label
Sigma (sigma1) receptor mediated anti-depressant-like effects of neurosteroids in the Porsolt forced swim test.

# publications[].label
Neurosteroid replacement therapy for catamenial epilepsy.

# publications[].label
Neurostereology protocol for unbiased quantification of neuronal injury and neurodegeneration.

# publications[].label
Neurosteroid Influences on Neuronal Excitability

# publications[].label
Differential anesthetic activity of ketamine and the GABAergic neurosteroid allopregnanolone in mice lacking progesterone receptor a and B subtypes

# publications[].label
Development of neurosteroid-based novel psychotropic drugs.

# publications[].label
Clinical Pharmacology of Modern Antiepileptic Drugs

# publications[].label
A mouse kindling model of perimenstrual catamenial epilepsy.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Atomic Force Microscopy Protocol for Measurement of Membrane Plasticity and Extracellular Interactions in Single Neurons in Epilepsy.

# publications[].label
Zinc reduces antiseizure activity of neurosteroids by selective blockade of extrasynaptic GABA-A receptor-mediated tonic inhibition in the hippocampus.

# publications[].label
Zinc Selectively Blocks Neurosteroid-Sensitive Extrasynaptic GABAA Receptors in the Hippocampus.

# publications[].label
Neuroendocrine aspects of catamenial epilepsy.

# publications[].label
Effects of long-term hydralazine treatment on myocardial structure and expression of myosin isogenes in cardiac pressure overload in rats.

# publications[].label
Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability.

# publications[].label
Clinical Potential of Neurosteroids for CNS Disorders.

# publications[].label
Neurosteroid mitigation of developmental neurological dysfunction, long-term epileptic biomarkers, chronic neuroinflammation, and neurodegeneration in a pediatric rat model of organophosphate exposure.

# publications[].label
GENDER DIFFERENCES IN ANTISEIZURE SENSITIVITY OF NEUROSTEROIDS IN THE PILOCARPINE MODEL OF STATUS EPILEPTICUS

# publications[].label
Neurosteroid coadministration prevents development of tolerance and augments recovery from benzodiazepine withdrawal anxiety and hyperactivity in mice.

# publications[].label
Hippocampal neurodegeneration, spontaneous seizures, and mossy fiber sprouting in the F344 rat model of temporal lobe epilepsy.

# publications[].label
Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
ANTIEPILEPTOGENIC ACTIVITY OF PROGESTERONE IN WILD-TYPE AND PROGESTERONE RECEPTOR KNOCKOUT MICE

# publications[].label
Effect of Neurosteroid Withdrawal on Spontaneous Recurrent Seizures in a Rat Model of Catamenial Epilepsy

# publications[].label
The Novel Drugs of 2015  An Extraordinary Growth of Innovative Pharmaceuticals

# publications[].label
Assessment of nootropic and amnestic activity of centrally acting agents

# publications[].label
Neuroendocrine aspects of improving sleep in epilepsy.

# publications[].label
Differential anxiolytic effects of neurosteroids in the mirrored chamber behavior test in mice.

# publications[].label
Newer antithrombotic drugs for prophylaxis of myocardial infarction and stroke

# publications[].label
Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself.

# publications[].label
Role of nitric oxide mechanism in the nootropic and antiamnesic effects of neurosteroids on aging and dizocilpine-induced learning impairment

# publications[].label
Catamenial Epilepsy: Discovery of an Extrasynaptic Molecular Mechanism for Targeted Therapy.

# publications[].label
Is Prenatal Valproate Exposure a Risk Factor for Autism

# publications[].label
Therapeutic and clinical foundations of cannabidiol therapy for difficult-to-treat seizures in children and adults with refractory epilepsies.

# publications[].label
Funding opportunities in biomedical sciences and preparing a successful grant application

# publications[].label
Isobolographic analysis of adjunct antiseizure activity of the FDA-approved cannabidiol with neurosteroids and benzodiazepines in adult refractory focal onset epilepsy.

# publications[].label
Comparative antioxidant effects of beta-adrenoceptor blockers, calcium antagonists and U-74500A against iron-dependent lipid peroxidation in murine ventricular microsomal membranes.

# publications[].label
Current pharmacotherapy of attention deficit hyperactivity disorder.

# publications[].label
Measuring Histone Deacetylase Inhibition in the Brain.

# publications[].label
Sex Differences in Neurological Diseases

# publications[].label
Mass spectrometric assay and physiological-pharmacological activity of androgenic neurosteroids.

# publications[].label
Chronic neurosteroid treatment prevents the development of morphine tolerance and attenuates abstinence behavior in mice.

# publications[].label
Do oral contraceptives increase epileptic seizures?

# publications[].label
Cellular and Molecular Mechanisms of Neuroinflammation in Epilepsy

# publications[].label
Erratum to: Neurosteroid interactions with synaptic and extrasynaptic GABAA receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability

# publications[].label
Neurosteroids: endogenous role in the human brain and therapeutic potentials.

# publications[].label
Atomic force microscopy investigations of fibronectin and 51-integrin signaling in neuroplasticity and seizure susceptibility in experimental epilepsy.

# publications[].label
Involvement of neurosteroid mechanism in the adrenocorticotrophin-induced behavioral effects in rats

# publications[].label
Ovarian cycle-related effects of neurosteroids on GABA-A receptor-mediated phasic and tonic currents in the hippocampus

# publications[].label
The pathophysiological and pharmacological basis of current drug treatment of migraine headache.

# publications[].label
Antisense oligonucleotides: A new class of potential anti-aids and anticancer drugs

# publications[].label
Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.

# publications[].label
Clinical efficacy and safety of cannabidiol for pediatric refractory epilepsy indications: A systematic review and meta-analysis.

# publications[].label
The Utility of Cannabidiol in the Treatment of Refractory Epilepsy.

# publications[].label
Current drug shortages in the United States

# publications[].label
Clinical pharmacokinetic interactions between antiepileptic drugs and hormonal contraceptives.

# publications[].label
Neuropharmacology of centrally acting antihypertensive drugs

# publications[].label
Role of GABA-A and mitochondrial diazepam binding inhibitor receptors in the anti-stress activity of neurosteroids in mice.

# publications[].label
Midazolam as an anticonvulsant antidote for organophosphate intoxication--A pharmacotherapeutic appraisal.

# publications[].label
Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman

# publications[].label
Cellular and molecular biology of cardiac hypertrophy

# publications[].label
Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3alpha-androstanediol and 17beta-estradiol.

# publications[].label
Reversal of benzodiazepine inverse agonist FG 7142-induced anxiety syndrome by neurosteroids in mice.

# publications[].label
Differential anesthetic activity of ketamine and the GABAergic neurosteroid allopregnanolone in mice lacking progesterone receptor A and B subtypes.

# publications[].label
Recent Advances in Hormonal Contraceptives for Women

# publications[].label
Patch-clamp recording and analysis of GABA-gated chloride currents in acutely dissociated hippocampal neurons from adult mice

# publications[].label
A Comparative Toxidrome Analysis of Human Organophosphate and Nerve Agent Poisonings Using Social Media.

# publications[].tags
16 Peace, Justice and Strong Institutions

# publications[].label
Chapter 12 Sex Differences in Neurological Diseases

# publications[].label
NeurosteroidsEndogenous Regulators of Seizure Susceptibility and Role in the Treatment of Epilepsy

# publications[].label
Protective Activity of Novel Hydrophilic Synthetic Neurosteroids on Organophosphate Status Epilepticus-induced Chronic Epileptic Seizures, Non-Convulsive Discharges, High-Frequency Oscillations and Electrographic Ictal Biomarkers.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Therapeutic Basis of Generic Substitution of Antiseizure Medications.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Experimental Models of Gulf War Illness, a Chronic Neuropsychiatric Disorder in Veterans.

# publications[].label
PHARMACOKINETIC-PHARMACODYNAMIC COMPARISON OF GANAXOLONE IN NORMAL RATS AND IN A RAT MODEL OF CATAMENIAL EPILEPSY

# publications[].label
Sex Differences in Organophosphate Model of Benzodiazepine-Refractory Status Epilepticus and Neuronal Damage.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Clinical Overview of Innovative New Drug Approvals in 2017

# publications[].label
Neurosteroid withdrawal model of perimenstrual catamenial epilepsy.

# publications[].label
Perimenstrual-like hormonal regulation of extrasynaptic -containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity.

# publications[].label
Neurosteroid replacement therapy for catamenial epilepsy, postpartum depression and neuroendocrine disorders in women.

# publications[].label
Chapter 20 Advances in targeted therapy of organophosphate neurotoxicity and chemical warfare nerve agents

# publications[].label
Steroid Hormones and Sex Differences in Seizure Susceptibility

# publications[].label
PR-independent neurosteroid regulation of 2-GABA-A receptors in the hippocampus subfields.

# publications[].label
Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.

# publications[].label
Contusion brain damage in mice for modelling of post-traumatic epilepsy with contralateral hippocampus sclerosis: Comprehensive and longitudinal characterization of spontaneous seizures, neuropathology, and neuropsychiatric comorbidities.

# publications[].label
Potential mechanisms of neurosteroid-induced attenuation of morphine tolerance and dependence

# publications[].label
Anti-free radical and cardioprotective drugs in ischemic myocardial injury

# publications[].label
A Pediatric Rat Model of Organophosphate-Induced Refractory Status Epilepticus: Characterization of Long-Term Epileptic Seizure Activity, Neurologic Dysfunction and Neurodegeneration.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Role of brain renin-angiotensin system in the regulation of cerebral circulation and ischaemia

# publications[].label
Long-term changes in neuroimaging markers, cognitive function and psychiatric symptoms in an experimental model of Gulf War Illness.

# publications[].label
GABA-A Receptors Mediate Tonic Inhibition and Neurosteroid Sensitivity in the Brain.

# publications[].label
Neurosteroid Replacement Therapy for Catamenial Epilepsy

# publications[].label
Brain structural and neuroendocrine basis of sex differences in epilepsy.

# publications[].label
Pharmacology of endogenous neuroactive steroids.

# publications[].label
Neuroendocrinological aspects of epilepsy: important issues and trends in future research.

# publications[].label
Catamenial-like seizure exacerbation in mice with targeted ablation of extrasynaptic GABA-a receptors in the brain.

# publications[].label
Neurocysticercosis as an infectious acquired epilepsy worldwide.

# publications[].label
Newer thrombolytic drugs for acute myocardial infarction.

# publications[].label
Neuroprotectant Activity of Novel Water-Soluble Synthetic Neurosteroids on Organophosphate Intoxication and Status Epilepticus-Induced Long-Term Neurological Dysfunction, Neurodegeneration, and Neuroinflammation.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Long-term Neuropsychiatric Developmental Defects after Neonatal Organophosphate Exposure: Mitigation by Synthetic Neurosteroids.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
New Drugs of 2012: A Concise Overview of the NMEs and Trends for Innovative Brand Market in the United States

# publications[].label
Building evidence on therapeutic efficacy and innovative mechanisms of cannabinoids in neurological disorders.

# publications[].label
A Comprehensive Stereology Method for Quantitative Evaluation of Neuronal Injury, Neurodegeneration, and Neurogenesis in Brain Disorders.

# publications[].label
Role of hormones and neurosteroids in epileptogenesis.

# publications[].label
Estrous cycle regulation of extrasynaptic -containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
A Pharma Heroic Act that Wasn't Ignored Written and Published by Dr Bobby George

# publications[].label
Seizure facilitating activity of the oral contraceptive ethinyl estradiol.

# publications[].label
A resurging boom in new drugs for epilepsy and brain disorders.

# publications[].label
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.

# publications[].label
Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model.

# publications[].label
Seizure resistance of progesterone receptor knockout mice

# publications[].label
Neurosteroids: Biosynthesis, Molecular Mechanisms, and Neurophysiological Functions in the Human Brain

# publications[].label
Response to: 'Birth control in epilepsy: we need to know more'.

# publications[].label
Method of treating organophosphate intoxication by administration of neurosteroids

# publications[].label
Neurosteroids as Novel Anticonvulsants for Refractory Status Epilepticus and Medical Countermeasures for Nerve Agents: A 15-Year Journey to Bring Ganaxolone from Bench to Clinic.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Isobolographic Analysis of Antiseizure Activity of the GABA Type A Receptor-Modulating Synthetic Neurosteroids Brexanolone and Ganaxolone with Tiagabine and Midazolam.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
A Comprehensive and Advanced Mouse Model of Post-Traumatic Epilepsy with Robust Spontaneous Recurrent Seizures.

# publications[].label
Antiseizure Activity of Midazolam in Mice Lacking -Subunit Extrasynaptic GABA(A) Receptors.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Antiepileptogenic and Antiepileptic Activity of Progesterone in the Rapid Kindling Model in PRKO Mice

# publications[].label
Method of treating organophosphate intoxication by administration of neurosteroids

# publications[].label
Chapter 62 Perimenstrual Seizures and Neurosteroid Withdrawal

# publications[].label
Does Stress Trigger Seizures? Evidence from Experimental Models.

# publications[].label
Resurgence of cannabinoid phytopharmaceuticals in USA

# publications[].label
Proconvulsant effects of neurosteroids pregnenolone sulfate and dehydroepiandrosterone sulfate in mice.

# publications[].label
Enhanced anticonvulsant activity of ganaxolone following neurosteroid withdrawal in a rat model of catamenial epilepsy.

# publications[].label
Anesthetic effects of progesterone are undiminished in progesterone receptor knockout mice.

# publications[].label
Pharmacotherapy of male erectile dysfunction with sildenafil

# publications[].label
Kindling Models of Epileptogenesis for Developing Disease-Modifying Drugs for Epilepsy.

# publications[].label
3-Methyl-Neurosteroid Analogs Are Preferential Positive Allosteric Modulators and Direct Activators of Extrasynaptic -Subunit -Aminobutyric Acid Type A Receptors in the Hippocampus Dentate Gyrus Subfield.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Clinical Pharmacology of Current Antiepileptic Drugs

# publications[].label
Pharmacy Quiz GPAT Pharmacy Competitive Exams

# publications[].label
Finasteride inhibits the disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis.

# publications[].label
The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Role of neurosteroids in catamenial epilepsy.

# publications[].label
Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Current Drug Shortages in the United States

# publications[].label
Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic GABA(A) Receptors.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Role of cardiac renin-angiotensin system in the development of pressure-overload left ventricular hypertrophy in rats with abdominal aortic constriction.

# publications[].label
Neurosteroids and infantile spasms: the deoxycorticosterone hypothesis.

# publications[].label
Development and persistence of limbic epileptogenesis are impaired in mice lacking progesterone receptors.

# publications[].label
Molecular mechanisms of sex differences in epilepsy and seizure susceptibility in chemical, genetic and acquired epileptogenesis.

# publications[].label
Progress and Challenges in Developing Medical Countermeasures for Chemical, Biological, Radiological, and Nuclear Threat Agents.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Neuroprotective effects of neurosteroids against hypoxic-neurotoxicity in naive and benzodiazepine inverse agonist FG 7142-treated mice

# publications[].label
Protective effects of gabaergic neurosteroids in a rat model of chronic temporal lobe epilepsy

# publications[].label
HORMONES AND GENDER | Steroid Hormones and Sex Differences in Seizure Susceptibility

# publications[].label
Ovarian CycleRelated Neurosteroid Regulation of GABAA Receptor Subunit Plasticity in the Hippocampus Subfields

# publications[].label
Role of anticonvulsant and antiepileptogenic neurosteroids in the pathophysiology and treatment of epilepsy.

# publications[].label
Protective Efficacy and Potency of Neuroactive Steroids and Benzodiazepines in the Amygdala Kindling Model of Epilepsy

# publications[].label
Novel drugs and new chemical entities in 2013

# publications[].label
Effect of Progesterone on Hippocampal GABAA Receptor Subunit Expression in Mice Lacking PRs

# publications[].label
Anxiolytic activity of progesterone in progesterone receptor knockout mice.

# publications[].label
Sex differences in the anticonvulsant activity of neurosteroids.

# publications[].label
Preclinical and clinical behavioral paradigms for testing drugs that affect learning and memory processes.

# publications[].label
The role of neurosteroids in the pathophysiology and treatment of catamenial epilepsy.

# publications[].label
Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy.

# publications[].label
Newer GABAergic agents for pharmacotherapy of infantile spasms.

# publications[].label
Neurosteroid Compounds And Methods For Their Preparation And Use In Treating Central Nervous System Disorders

# publications[].label
Experimental and Clinical Biomarkers for Progressive Evaluation of Neuropathology and Therapeutic Interventions for Acute and Chronic Neurological Disorders.

# publications[].label
Pharmacy Quiz - A Handbook for Pharmacy Competitive Exams

# publications[].label
Behavioral Assays for Comprehensive Evaluation of Cognitive and Neuropsychiatric Comorbidities of Traumatic Brain Injury and Chronic Neurological Disorders.

# publications[].label
Neurosteroids: A new class of neuromodulators

# publications[].label
An Overview of Novel Drugs and New Chemical Entities in 2013

# publications[].label
Inhibition of neuronal nitric oxide synthase (n-cNOS) reverses the corticotrophin-induced behavioral effects in rats.

# publications[].label
Experimental models of status epilepticus and neuronal injury for evaluation of therapeutic interventions.

# publications[].label
Neurosteroids and their role in sex-specific epilepsies.

# publications[].label
Novel New Drug Approvals in 2011: A Succinct Analysis of Drug Discovery Trends in the United States

# publications[].label
The role of GABA-A and mitochondrial diazepam-binding inhibitor receptors on the effects of neurosteroids on food intake in mice.

# publications[].label
Antiperoxidative effects of platelet activating factor antagonists against iron-dependent lipid peroxidation in murine ventricular membranes.

# publications[].label
Preclinical and clinical pharmacology of brexanolone (allopregnanolone) for postpartum depression: a landmark journey from concept to clinic in neurosteroid replacement therapy.

# publications[].label
Pathophysiological basis and promise of experimental therapies for Gulf War Illness, a chronic neuropsychiatric syndrome in veterans.

# publications[].label
Integrins as receptor targets for neurological disorders.

# publications[].label
Extrasynaptic -aminobutyric acid type A receptor-mediated sex differences in the antiseizure activity of neurosteroids in status epilepticus and complex partial seizures.

# publications[].label
Genetic and Molecular Regulation of Extrasynaptic GABA-A Receptors in the Brain: Therapeutic Insights for Epilepsy.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Special Section on Medical Countermeasures, From Bench to Battlefield: Translating Experimental Therapies for Effective Combat Against Chemical Threats-Editorial.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Neuroendocrine insights into neurosteroid therapy for postpartum depression.

# publications[].label
Tiagabine: A potent antiepileptic drug with selective GABA uptake inhibitory effect

# publications[].label
Signalling mechanisms of cardiac hypertrophy

# publications[].label
Role of Neurosteroidogenic Pathways in the Antiseizure Activity of Midazolam in the 6Hz and Kindling Models of Epilepsy

# publications[].label
The Pharmacological Basis of Cannabis Therapy for Epilepsy.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Neurosteroid withdrawal regulates GABA-A receptor 4-subunit expression and seizure susceptibility by activation of progesterone receptor-independent early growth response factor-3 pathway.

# publications[].label
Chapter 4 Neurosteroids Biosynthesis, Molecular Mechanisms, and Neurophysiological Functions in the Human Brain

# publications[].label
Atomic force microscopy study of ECM-integrin modulation of neuroplasticity in the hippocampal dentate granule cells in epilepsy

# publications[].label
Disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis.

# publications[].label
Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions?

# publications[].label
The effects of neurosteroids on acquisition and retention of a modified passive-avoidance learning task in mice.

# publications[].label
SGLT2 Inhibitors: A New Generation of Antidiabetic Drugs

# publications[].label
Epigenetic Histone Deacetylation Inhibition Prevents the Development and Persistence of Temporal Lobe Epilepsy.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Epigenetic interventions for epileptogenesis: A new frontier for curing epilepsy.

# researcherOn[].label
Epigenetic Attenuation of Long-Term Effects of Nerve Agents

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Neurological Disorders and Stroke

# researcherOn[].label
Novel pediatric anticonvulsants for nerve agents

# researcherOn[].awardedBy.label
National Institute of Neurological Disorders and Stroke - (Bethesda, Maryland, United States)

# researcherOn[].label
Neurosteroid Treatment for OP Intoxication

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Neurological Disorders and Stroke

# researcherOn[].label
Epigenetic mechanisms of post-traumatic epilepsy

# researcherOn[].awardedBy.label
United States Army - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
DOD-Army-Medical Research and Materiel Command

# researcherOn[].label
Neurosteroid Therapy for Gulf War Illness

# researcherOn[].awardedBy.label
United States Army - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
U.S. Army Medical Research Acquisition Activity

# streetAddress
Texas A&M Health Science Center; Neuroscience & Experimental Therapeutics; 1359 TAMUS

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine

# inTheNews[].label
Texas A&M Professor Honored With Lifetime Achievement Award

# inTheNews[].label
Texas A&M University Announces 2020 EDGES Fellows

# inTheNews[].label
NRI Pharma Scientist Wins Lifetime Gold Medal Award

# inTheNews[].label
NRI professor discovers new therapy for epilepsy brain disease

# inTheNews[].label
Chancellor's Award for Texas A&M Professor Samba Reddy

# inTheNews[].label
X-Grants Program Provides Funding for Eight Interdisciplinary Projects

# inTheNews[].label
Texas A&M Announces 2020 Distinguished Achievement Award Recipients

# inTheNews[].label
Texas A&M Neuroscientists Discover New Therapy For Refractory Epilepsy

# inTheNews[].label
Targeted mitigation strategies for halting COVID-19 hotspots

# etdChairOf[].label
Jones, Daniel K (2016-05). Neuroprotection Therapy for Traumatic Brain Injury. Master's Thesis.

# etdChairOf[].label
Carver, Chase M (2015-04). Role of Delta Subunit-Containing GABAA Receptors in Hippocampus Tonic Inhibition and Epileptogenesis within Transgenic Mouse Models. Doctoral Dissertation.