# positions[].organizations[].label
College of Veterinary Medicine and Biomedical Sciences

# positions[].organizations[].parent[].label
College of Agriculture and Life Sciences

# positions[].organizations[].parent[].label
College of Veterinary Medicine and Biomedical Sciences

# overview
The aryl hydrocarbon receptor (AhR) is a nuclear helix-loop-helix transcription factor which forms a ligand-induced nuclear heterodimer with the AhR nuclear translocator (Arnt) protein. Research in this laboratory is focused on the molecular mechanism of crosstalk between the AhR and estrogen receptor (ER) signaling pathways in which the AhR inhibits estrogen-induced gene expression. The antiestrogenic activities of some AhR agonists are also being developed as drugs for clinical treatment of breast and endometrial cancers in women. Research on estrogen-dependent gene expression in various cancer cell lines is focused on analysis of several gene promoters to determine the mechanisms of ERa and ERb action. This includes several genes that are activated through interactions of the ER with Sp1 protein and other DNA-bound transcription factors.

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 2

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Hypoxia-Inducible Factor 1, Alpha Subunit

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Vascular Endothelial Growth Factor Receptor-1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Cyclic AMP Response Element-Binding Protein

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 2

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Aryl Hydrocarbon Receptor Nuclear Translocator

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Specificity Protein (sp) Transcription Factors

# keywords[]
Suppressor Of Cytokine Signaling 3 Protein

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 2

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 2

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Cyclic AMP Response Element-Binding Protein

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Mechanistic Target Of Rapamycin Complex 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Basic Helix-loop-helix Leucine Zipper Transcription Factors

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Atp Binding Cassette Transporter, Subfamily B, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Insulin-like Growth Factor Binding Protein 4

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 2

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
United States Environmental Protection Agency

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
Aryl Hydrocarbon Receptor Nuclear Translocator

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 2

# keywords[]
Specificity Protein Transcription Factors (sp Tfs)

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
3407 Theoretical And Computational Chemistry

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
Aryl Hydrocarbon Receptor Nuclear Translocator

# keywords[]
Receptors, Vascular Endothelial Growth Factor

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Cyclic AMP Response Element-Binding Protein

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Cyclic AMP Response Element-Binding Protein

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Atp Binding Cassette Transporter, Subfamily B, Member 1

# keywords[]
Vascular Endothelial Growth Factor Receptor-1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Aryl Hydrocarbon Receptor Nuclear Translocator

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 2

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Aryl Hydrocarbon Receptor Nuclear Translocator

# keywords[]
Aryl Hydrocarbon Receptor Nuclear Translocator

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Atp Binding Cassette Transporter, Subfamily B, Member 1

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
Aryl Hydrocarbon Receptor Nuclear Translocator

# keywords[]
Myeloid Cell Leukemia Sequence 1 Protein

# keywords[]
Receptor, Platelet-derived Growth Factor Alpha

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 2

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 2

# keywords[]
Atp Binding Cassette Transporter, Subfamily B, Member 1

# keywords[]
Atp Binding Cassette Transporter, Subfamily B

# keywords[]
Single-Strand Specific DNA And RNA Endonucleases

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
Vascular Endothelial Growth Factor Receptor-1

# keywords[]
Aryl Hydrocarbon Receptor Nuclear Translocator

# keywords[]
Perinatal Period - Conditions Originating In Perinatal Period

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
Receptor, Fibroblast Growth Factor, Type 3

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Atp Binding Cassette Transporter, Subfamily B, Member 1

# keywords[]
Single-Strand Specific DNA And RNA Endonucleases

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 2

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 2

# keywords[]
Aryl Hydrocarbon Receptor Nuclear Translocator

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 2

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Self Nano-emulsifying Drug Delivery System

# keywords[]
Squamous Cell Carcinoma Of Head And Neck

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Aryl Hydrocarbon Receptor Nuclear Translocator

# keywords[]
United States Environmental Protection Agency

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 2

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 2

# keywords[]
United States Environmental Protection Agency

# keywords[]
Receptors, Transforming Growth Factor Beta

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# educationAndTraining[].organization.label
University of Oxford - (Oxford, Oxfordshire, United Kingdom)

# awardsAndHonors[].label
Distinguished Research Award of the Sigma Xi

# awardsAndHonors[].label
Association of Former Students University-Level Distinguished Achievement Award, The

# awardsAndHonors[].label
Association of Former Students University-Level Distinguished Achievement Award, The

# awardsAndHonors[].label
Association of Former Students University-Level Distinguished Achievement Award, The

# publications[].label
PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
PCBs and PBBs: biologic and toxic effects on C57BL/6J and DBA/2J inbred mice.

# publications[].label
INVITRO AHH INDUCTION BY POLYCHLORINATED BIPHENYL AND DIBENZOFURAN MIXTURES - ADDITIVE EFFECTS

# publications[].label
Methyl-substituted diindolylmethanes as inhibitors of estrogen-induced growth of T47D cells and mammary tumors in rats.

# publications[].label
Natural acetylenes. Part XXVI. Transformations of phenyl-polyacetylenes in the tubers of Dahlia hybrids

# publications[].label
Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells.

# publications[].label
Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex.

# publications[].label
Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
'Environmental factors and breast cancer' - Reply

# publications[].label
Stimulation of calcium uptake in cultured rat hippocampal neurons by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

# publications[].label
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways.

# publications[].label
Domains of estrogen receptor alpha (ERalpha) required for ERalpha/Sp1-mediated activation of GC-rich promoters by estrogens and antiestrogens in breast cancer cells.

# publications[].label
Endocrine disruptors and falling sperm counts: lessons learned or not!

# publications[].label
Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells.

# publications[].label
Is there an association between exposure to environmental estrogens and breast cancer?

# publications[].label
The comparative metabolism of halogenated biphenyls

# publications[].label
An enzyme-linked immunosorbent assay (ELISA) specific for antibodies to TNP-LPS detects alterations in serum immunoglobulins and isotype switching in C57BL/6 and DBA/2 mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.

# publications[].label
Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor.

# publications[].label
PHOTOLYSIS OF NITROPOLYCHLORODIBENZO-P-DIOXINS WITH BASE AS POTENTIAL METHODOLOGY FOR THE DESTRUCTION OF POLYCHLORINATED DIBENZO-P-DIOXINS

# publications[].label
Effects of chronic phthalate exposure on the kidney.

# publications[].label
BIOAVAILABILITY OF GRAIN AND SOIL-BORNE TRITIATED 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN (TCDD) ADMINISTERED TO LACTATING HOLSTEIN COWS

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Polychlorinated Biphenyls  Human Health Effects

# publications[].label
Inactivation of the orphan nuclear receptor NR4A1 contributes to apoptosis induction by fangchinoline in pancreatic cancer cells.

# publications[].label
Immunotoxicity of a reconstituted polynuclear aromatic hydrocarbon mixture in B6C3F1 mice.

# publications[].label
Polynuclear aromatic hydrocarbon carcinogens as antiestrogens in MCF-7 human breast cancer cells: role of the Ah receptor.

# publications[].label
Substituted polychlorinated dibenzofuran receptor binding affinities and aryl hydrocarbon hydroxylase induction potencies--a QSAR analysis.

# publications[].label
A novel diindolylmethane analog, 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) methane, inhibits the tumor necrosis factor-induced inflammatory response in primary murine synovial fibroblasts through a Nurr1-dependent mechanism.

# publications[].label
Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice.

# publications[].label
Investigation of macrophage polarization using bone marrow derived macrophages

# publications[].label
MECHANISM OF ACTION OF 2,3,7,8-TCDD AND 6-METHYL-1,3,8-TRICHLORODIBENZOFURAN (MCDF) AS ANTIESTROGENS IN THE FEMALE RAT

# publications[].label
Brewed Coffee and Its Components Act Through Orphan Nuclear Receptor 4A1 (NR4A1)

# publications[].label
Radioligand-dependent differences in the molecular properties of the mouse and rat hepatic aryl hydrocarbon receptor complexes.

# publications[].label
Identification of a motif within the 5' regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression.

# publications[].label
MECHANISM OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) MEDIATED DOWN-REGULATION OF ESTROGEN-RECEPTOR IN HUMAN BREAST-CANCER MCF-7 CELL-LINE

# publications[].label
Inhibition of pancreatic cancer Panc1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK.

# publications[].label
The ultraviolet absorption spectra of some chlorinated biphenyls.

# publications[].label
Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells.

# publications[].label
Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
FREE AND BOUND LIPIDS OF NEUROSPORA-CRASSA

# publications[].label
A comparison of the in vitro metabolism of biphenyl and 4-chlorobiphenyl by rat liver microsomes.

# publications[].label
Effects of hydroxylated polychlorinated biphenyls on mouse liver mitochondrial oxidative phosphorylation.

# publications[].label
Inhibition of estrogen-induced activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-7 human breast cancer and other cell lines transfected with vitellogenin A2 gene promoter constructs.

# publications[].label
Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cells.

# publications[].label
Further characterization and applications of the 4-chlorobiphenyl hydroxylase assay.

# publications[].label
Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment.

# publications[].label
Polychlorinated benzene and phenol congeners as inducers of rat hepatic drug-metabolizing enzymes in immature male Wistar rats.

# publications[].label
DEVELOPMENT AND VALIDATION OF INVITRO BIOASSAYS FOR 2,3,7,8-TCDD EQUIVALENTS

# publications[].label
Nuclear receptor-mediated transactivation through interaction with Sp proteins.

# publications[].label
The metabolism of chlorobiphenyls  A review

# publications[].label
Bromo and chlorobiphenyl metabolism: gas chromatography mass spectrometric identification of urinary metabolites and the effects of structure on their rates of excretion.

# publications[].label
NR4A1 Antagonists Inhibit 1-Integrin-Dependent Breast Cancer Cell Migration.

# publications[].label
COMPETITIVE-BINDING OF CHLORINATED AZOBENZENES AND AZOXYBENZENES TO THE AH RECEPTOR PROTEIN

# publications[].label
Nuclear receptor 4A1 (NR4A1) antagonists target PD-L1 in colon cancer.

# publications[].label
Mutagenic potential of binary mixtures of nitro-polychlorinated dibenzo-p-dioxins and related compounds.

# publications[].label
Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a.

# publications[].label
Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta.

# publications[].label
Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Failure of chloro-S-triazine-derived compounds to induce estrogenic responses in vivo and in vitro

# publications[].label
Induction of estradiol 2-hydroxylase activity in MCF-7 human breast cancer cells by pesticides and carcinogens.

# publications[].label
3,3'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and -independent prostate cancer cells.

# publications[].label
Immunosuppressive activity of polychlorinated biphenyl mixtures and congeners: nonadditive (antagonistic) interactions.

# publications[].label
Pharmacological Activators of the NR4A Nuclear Receptors Enhance LTP in a CREB/CBP-Dependent Manner.

# publications[].label
Orphan nuclear receptor 4A1 (NR4A1) and NR4A2 are endogenous regulators of CD71 and their ligands induce ferroptosis in breast cancer.

# publications[].label
Functional synergy between the transcription factor Sp1 and the estrogen receptor.

# publications[].label
Polychlorinated dibenzofurans: Environmental impact, toxicology, and risk assessment

# publications[].label
The nuclear orphan receptor NR4A1 regulates 1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists.

# publications[].label
Alteration of Oxytocin-Induced Calcium Oscillations in Clone 9 Cells by Toxin Exposure

# publications[].label
Competitive binding of 7-substituted-2,3-dichlorodibenzo-p-dioxins with human placental ah receptor--a QSAR analysis.

# publications[].label
Induction of rat hepatic microsomal cytochrome P-450 by 2,3',4,4',5,5'-hexachlorobiphenyl.

# publications[].label
Quantitative structure-activity relationships: analysis of interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2-substituted analogues with rat, mouse, guinea pig, and hamster cytosolic receptor.

# publications[].label
2- O -- D -galactopyranosylglycerol from Laurencia pinnatifida

# publications[].label
ChemInform Abstract: PHOTOCHEMISTRY OF BROMOBIPHENYLS, STERIC EFFECTS AND ELECTRON TRANSFER

# publications[].label
Mass spectra of fifteen chlorinated aromatic fungicides.

# publications[].label
Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines.

# publications[].label
[H-3] TETRACHLORODIBENZO-PARA-DIOXIN - AN EFFICIENT PHOTOAFFINITY LABEL FOR THE AH RECEPTOR

# publications[].label
Polybrominated dibenzo-p-dioxins and related compounds: quantitative in vivo and in vitro structure-activity relationships.

# publications[].label
The metabolism of chlorinated aromatic pollutants by the frog.

# publications[].label
Immunosuppressive and Monooxygenase Induction Activities of Highly Chlorinated Diphenyl Ether Congeners in C57BL/6 and DBA/2 Mice

# publications[].label
Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative.

# publications[].label
Biologic and toxic effects of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in the guinea pig. Quantitative structure-activity relationships.

# publications[].label
Polychlorinated biphenyl isomers and congeners as inducers of both 3-methylcholanthrene- and phenobarbitone-type microsomal enzyme activity.

# publications[].label
Bortezomib Targets Sp Transcription Factors in Cancer Cells.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effects on enzyme induction and immunotoxicity.

# publications[].label
Influences of different polychlorinated biphenyls on cytocidal, mitoinhibitory, and nodule-selecting activities of N-2-fluorenylacetamide in rat liver.

# publications[].label
SPORIDESMINS .17. ISOLATION OF SPORIDESMIN-H AND SPORIDESMIN-J

# publications[].label
Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements.

# publications[].label
Estrogen induces adenosine deaminase gene expression in MCF-7 human breast cancer cells: role of estrogen receptor-Sp1 interactions.

# publications[].label
Polychlorinated naphthalenes as hepatic microsomal enzyme inducers in the immature male rat.

# publications[].label
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17 beta-estradiol-induced glucose metabolism in MCF-7 human breast cancer cells: 13C nuclear magnetic resonance spectroscopy studies.

# publications[].label
Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists.

# publications[].label
Identification of toxic impurities in commercial diphenylamine.

# publications[].label
Halogen substituents at the 4- and 4'-positions of biphenyl: influence on hepatic function in the rat.

# publications[].label
Kinetics of the association of several tritiated polychlorinated dibenzo-p-dioxin and dibenzofuran congeners with hepatic cytosolic Ah receptor from the Wistar rat.

# publications[].label
Identification of a functional imperfect estrogen-responsive element in the 5'-promoter region of the human cathepsin D gene.

# publications[].label
Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay.

# publications[].label
Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self-renewal of colonic stem and progenitor cells.

# publications[].label
Regulation of constitutive gene expression through interactions of Sp1 protein with the nuclear aryl hydrocarbon receptor complex.

# publications[].label
Bis-Indoles as receptor ligands and novel anticancer agents

# publications[].label
Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs.

# publications[].label
Lipid and alkali extractable fatty acids from Mucor rouxii: effect of thermal changes in growth environment and age of cells.

# publications[].label
Targeting the aryl hydrocarbon receptor in stem cells to improve the use of food as medicine.

# publications[].label
The Metabolism of the Systemic Fungicide Carboxin (Vitavax) by Rhizopus japonicus

# publications[].label
Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma.

# publications[].label
Activation of COUP-TFI by a Novel Diindolylmethane Derivative.

# publications[].label
Effects of ligand structure on the in vitro transformation of the rat cytosolic aryl hydrocarbon receptor.

# publications[].label
Polychlorinated dibenzofurans as 2,3,7,8-TCDD antagonists: in vitro inhibition of monooxygenase enzyme induction.

# publications[].label
Gap junctions in myometrial cell cultures: evidence for modulation by cyclic adenosine 3':5'-monophosphate.

# publications[].label
Abstract 1149: Nuclear receptor 4A1 (NR4A1) antagonists target PD-L1 in colon cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR.

# publications[].label
HUMAN OVARIAN-CANCER CELLS - INTERACTION WITH TETRACHLORODIBENZO-P-DIOXIN (TCDD)

# publications[].label
Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors.

# publications[].label
Targeting apoptosis pathways in cancer--letter.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
CDODA-Me decreases specificity protein transcription factors and induces apoptosis in bladder cancer cells through induction of reactive oxygen species.

# publications[].label
Validation of bioassays for assessing the contamination of marine environments

# publications[].label
Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met.

# publications[].label
Immunosuppressive and monooxygenase induction activities of polychlorinated diphenyl ether congeners in C57BL/6N mice: quantitative structure-activity relationships.

# publications[].label
Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3.

# publications[].label
The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice.

# publications[].label
Environmental and dietary estrogens and human health: is there a problem?

# publications[].label
Natural acetylenes. Part XXXI. C 14 -tetrahydropyranyl and other polyacetylenes from the compositae Dahlia coccinea Cav. var. coccinea

# publications[].label
Aryl Hydrocarbon Receptor (AhR) Ligands as Selective AhR Modulators: Genomic Studies.

# publications[].label
Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3'-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells.

# publications[].label
Investigation of macrophage polarization using bone marrow derived macrophages.

# publications[].label
Targeting NR4A1 (TR3) in cancer cells and tumors.

# publications[].label
Uptake and distribution of chloronaphthalenes and their metabolites in pigs.

# publications[].label
An assessment of the effects of enzyme inducers on aryl hydrocarbon hydroxylase activity.

# publications[].label
Sex-dependent differences in the stress mitigating and antidepressant effects of selective aryl hydrocarbon receptor modulators.

# publications[].label
Bevacizumab/docetaxel association is more efficient than docetaxel alone in reducing breast and prostate cancer cell growth: a new paradigm for understanding the therapeutic effect of combined treatment.

# publications[].label
Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships.

# publications[].label
8.22 Estrogenic Endocrine Disruptors: Molecular Characteristics and Human Impacts

# publications[].label
Sporidesmins. Part IX. Isolation and structure of sporidesmin E

# publications[].label
Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer.

# publications[].label
Characterization of the H4IIE rat hepatoma cell bioassay for evaluation of environmental samples containing polynuclear aromatic hydrocarbons (PAHs).

# publications[].label
IDENTIFICATION AND ASSESSMENT OF POLYBROMINATED BIPHENYL (PBB) CONGENERS PRESENT IN THE COMMERCIAL FIRE RETARDANT, FIREMASTER BP-6

# publications[].label
The ion kinetic energy spectra of some chlorinated insecticides

# publications[].label
DETECTION OR TRACE LEVELS OF POLYETHYLENE-GLYCOL ETHER SURFACTANTS IN BIOLOGICAL TISSUES

# publications[].label
Abstract 4075: Tolfenamic Acid Inhibits Prostate Cancer Cells Growth and Tumor Development in Orthotopic Mice

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
The nonsteroidal anti-inflammatory drug tolfenamic acid inhibits BT474 and SKBR3 breast cancer cell and tumor growth by repressing erbB2 expression.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins.

# publications[].label
Polychlorinated biphenyls as phenobarbitone-type inducers of microsomal enzymes. Structure-activity relationships for a series of 2,4-dichloro-substituted congeners.

# publications[].label
1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife.

# publications[].label
Orphan nuclear receptor 4A1 (NR4A1) and novel ligands.

# publications[].label
Natural products and synthetic analogs as selective orphan nuclear receptor 4A (NR4A) modulators.

# publications[].label
Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells.

# publications[].label
Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action.

# publications[].label
Induction of drug-metabolizing enzymes by fractionated commercial polybrominated biphenyls (PBBs).

# publications[].label
Interaction of the aryl hydrocarbon receptor ligand 6-methyl-1,3,8-trichlorodibenzofuran with estrogen receptor alpha.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
ChemInform Abstract: POLYCHLORIERTE BIPHENYLE, DAS METABOLISCHE VERH. DER REINEN ISOMEREN IN TAUBEN, RATTEN UND BACHFORELLEN

# publications[].label
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on cell growth and the secretion of the estrogen-induced 34-, 52- and 160-kDa proteins in human breast cancer cells.

# publications[].label
Human exposure to endocrine-active chemicals: hazard assessment problems.

# publications[].label
Perfluorooctane Sulfonate (PFOS) and Related Compounds Induce Nuclear Receptor 4A1 (NR4A1)-Dependent Carcinogenesis.

# publications[].label
Inhibition of prolactin receptor gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 human breast cancer cells.

# publications[].label
Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
COMPARATIVE EFFECTS OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN (TCDD) AND PROGESTERONE ON ESTROGENIC RESPONSES IN RATS

# publications[].label
Hormonal regulation of lactate dehydrogenase-A through activation of protein kinase C pathways in MCF-7 breast cancer cells.

# publications[].label
INVITRO BIOASSAYS FOR TOXIC POLYCHLORINATED AZOBENZENES

# publications[].label
Toxicity and health effects of combustion byproducts

# publications[].label
INVITRO THERMAL INACTIVATION OF HEPATIC AH RECEPTORS FROM SEVERAL MAMMALIAN-SPECIES

# publications[].label
Synthesis and spectroscopic and gas chromatographic behavior of isomeric chlorinated terphenyls.

# publications[].label
Neonatal exposure to Aroclor 1254: effects on adult hepatic testosterone hydroxylase activities.

# publications[].label
Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).

# publications[].label
The metabolism of 4-chlorobiphenyl in the pig.

# publications[].label
Dual targeting of Nur77 and AMPK by isoalantolactone inhibits adipogenesis in vitro and decreases body fat mass in vivo.

# publications[].label
HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer.

# publications[].label
Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS).

# publications[].label
Cytochrome P-450-mediated metabolism of biphenyl and the 4-halobiphenyls.

# publications[].label
2,3,7,8-Tetrachlorodibenzo-p-dioxin as an antiestrogen: effect on rat uterine peroxidase activity.

# publications[].label
Investigation of macrophage polarization using bone marrow derived macrophages.

# publications[].label
UTILIZATION OF CULTURED CHICK-EMBRYO HEPATOCYTES AS INVITRO BIOASSAYS FOR POLYCHLORINATED-BIPHENYLS (PCBS) - QUANTITATIVE STRUCTURE-INDUCTION RELATIONSHIPS

# publications[].label
LIGAND-BINDING TO THE TCDD RECEPTOR - QUANTITATIVE STRUCTURE-ACTIVITY CORRELATIONS

# publications[].label
Methyl 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate is a peroxisome proliferator-activated receptor-gamma agonist that induces receptor-independent apoptosis in LNCaP prostate cancer cells.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
The mechanism of chlorobiphenyl metabolism.

# publications[].label
COMPARATIVE TOXICITIES OF THE POLYCHLORINATED DIBENZOFURAN (PCDF) AND BIPHENYL (PCB) MIXTURES WHICH PERSIST IN YUSHO VICTIMS

# publications[].label
Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.

# publications[].label
Hydrogen randomization between phenyl groups in the electron impact-induced fragmentation of substituted diphenylacetylenes

# publications[].label
Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells.

# publications[].label
Plant Alkaloid Tetrandrine Is a Nuclear Receptor 4A1 Antagonist and Inhibits Panc-1 Cell Growth In Vitro and In Vivo.

# publications[].label
The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53.

# publications[].label
Halogenated aryl hydrocarbon-induced suppression of the in vitro plaque-forming cell response to sheep red blood cells is not dependent on the Ah receptor.

# publications[].label
The Metabolism of the Systemic Fungicide Carboxin (Vitavax) by Rhizopus japonicus

# publications[].label
Tumors and DNA adducts in mice exposed to benzo[a]pyrene and coal tars: Implications for risk assessment

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Fragmentation pathways in electron impact mass spectra of methoxyhalobiphenyls.

# publications[].label
MODULATION OF CYTOCIDAL AND MITOINHIBITORY TOXICITY OF HEPATOCARCINOGENS IN RATS PRETREATED WITH DIFFERENT PURE PCBS AND OTHER INDUCERS

# publications[].label
Reconstituted halogenated hydrocarbon pesticide and pollutant mixtures found in human tissues: effects on the immature male Wistar rat after short-term exposure.

# publications[].label
Photochemical reactions of environmentally toxic substances (Dutch)

# publications[].label
Flavonoids kaempferol and quercetin are nuclear receptor 4A1 (NR4A1, Nur77) ligands and inhibit rhabdomyosarcoma cell and tumor growth.

# publications[].label
THE HANDBOOK OF ENVIRONMENTAL CHEMISTRY, VOL 1, PT A, VOL 2, PT A, VOL 3, PT A - HUTZINGER,O

# publications[].label
Ligand structure-dependent differences in activation of estrogen receptor alpha in human HepG2 liver and U2 osteogenic cancer cell lines.

# publications[].label
Nuclear receptor 4A1 (NR4A1) antagonists induce ROS-dependent inhibition of mTOR signaling in endometrial cancer.

# publications[].label
Polychlorinated biphenyls: synthesis of some individual chlorobiphenyls.

# publications[].label
Bis-Indole-Derived Nuclear Receptor 4A1 (NR4A1, Nur77) Ligands as Inhibitors of Endometriosis.

# publications[].label
A bioassay to measure energy metabolism in mouse colonic crypts, organoids, and sorted stem cells.

# publications[].label
3',4'-dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells.

# publications[].label
Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans.

# publications[].label
Toxicology of persistent organic pollutants

# publications[].label
Halogenated biphenyls as AHH inducers: effects of different halogen substituents.

# publications[].label
2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Isolation and characterization of variant benzo[a]pyrene-resistant T47D human breast-cancer cells.

# publications[].label
Inhibition of CYP1A1-dependent activity by the polynuclear aromatic hydrocarbon (PAH) fluoranthene.

# publications[].label
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells.

# publications[].label
BIOANALYSIS OF POLYCHLORINATED DIBENZOFURAN AND DIBENZO-P-DIOXIN MIXTURES IN FLY-ASH

# publications[].label
Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells.

# publications[].label
REACTIVE OXYGEN SPECIES AND COLORECTAL CANCER.

# publications[].label
Quantitative Structure-Activity Relationships: Analysis of Interactions of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and 2-Substituted Analogues with Rat, Mouse, Guinea Pig, and Hamster Cytosolic Receptor1

# publications[].label
Transforming Growth Factor /NR4A1-Inducible Breast Cancer Cell Migration and Epithelial-to-Mesenchymal Transition Is p38 (Mitogen-Activated Protein Kinase 14) Dependent.

# publications[].label
The synthesis and gas chromatographic properties of bromobiphenyls

# publications[].label
Effect of transient expression of the oestrogen receptor on constitutive and inducible CYP1A1 in Hs578T human breast cancer cells.

# publications[].label
In vitro thermal inactivation of hepatic Ah receptors from several mammalian species.

# publications[].label
Inhibition of pituitary tumor-transforming gene-1 in thyroid cancer cells by drugs that decrease specificity proteins.

# publications[].label
PCDD, PCDF, and PCB in farm-raised catfish from southeast United States--concentrations, sources, and CYP1A induction.

# publications[].label
POLYCHLORINATED DIPHENYL ETHERS - A REVIEW

# publications[].label
Structure-dependent Ah receptor agonist activities of chlorinated biphenylenes.

# publications[].label
Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c1c7.

# publications[].label
Interferon-tau activates multiple signal transducer and activator of transcription proteins and has complex effects on interferon-responsive gene transcription in ovine endometrial epithelial cells.

# publications[].label
Suppression of aberrant choroidal neovascularization through activation of the aryl hydrocarbon receptor.

# publications[].label
Mass spectra of aromatic and acetylenic compounds. Part VI. The electron impact-induced rearrangements of substituted phenylacetylenes

# publications[].label
Effects of interferon tau on short- and long-term activation of STAT proteins in immortalized ovine uterine luminal epithelial cells.

# publications[].label
Mammalian Biologic and Toxic Effects of PCBs

# publications[].label
Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.

# publications[].label
EFFECTS OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) AS AN ANTIESTROGEN IN MCF-7 HUMAN BREAST-CANCER CELLS

# publications[].label
The Structure-Dependent Effects of Heptachlorodibenzofuran Isomers in Male C57BL/6 Mice: Immunotoxicity and onooxygenase Enzyme Induction

# publications[].label
Aryl hydrocarbon receptor-mediated antiestrogenicity in MCF-7 cells: modulation of hormone-induced cell cycle enzymes.

# publications[].label
In vitro binding of sterols by extracts from Mucor rouxii cells grown under different environmental conditions.

# publications[].label
Induction of both cytochromes P-450 and P-448 by 2,3',4,4',5-pentabromobiphenyl, a component of fireMaster.

# publications[].label
The aryl hydrocarbon receptor is a tumor suppressor-like gene in glioblastoma.

# publications[].label
Modification of endocrine active potential by mixtures

# publications[].label
Indolo[3,2-b]carbazole: a dietary-derived factor that exhibits both antiestrogenic and estrogenic activity.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines.

# publications[].label
A new toxic metabolite of Pithomyces chartarum related to the sporidesmins

# publications[].label
HEAVY-ATOM EFFECTS IN PHOTOREACTIONS OF HALOGENATED AROMATIC-COMPOUNDS

# publications[].label
Diet-Host-Microbiota Interactions Shape Aryl Hydrocarbon Receptor Ligand Production to Modulate Intestinal Homeostasis.

# publications[].label
Environmental chemistry of flame retardants part I. Introduction and principles

# publications[].label
Metabolism and bacterial mutagenicity of binary mixtures of benzo(a)pyrene and polychlorinated aromatic hydrocarbons.

# publications[].label
Immunosuppressive activities of polychlorinated biphenyls in C57BL/6N mice: structure-activity relationships as Ah receptor agonists and partial antagonists.

# publications[].label
Sporidesmins. Part X. Synthesis of polysulphides by reaction of dihydrogen disulphide with disulphides and thiols

# publications[].label
2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN - RELATIONSHIP BETWEEN TOXICITY AND THE INDUCTION OF ARYL-HYDROCARBON HYDROXYLASE AND ORNITHINE DECARBOXYLASE

# publications[].label
Characterization of the aryl hydrocarbon receptor in the human C-4II cervical squamous carcinoma cell line.

# publications[].label
Endocrine disruptors and human health--is there a problem? An update.

# publications[].label
Benzo[a]pyrene-resistant MCF-7 human breast cancer cells. A unique aryl hydrocarbon-nonresponsive clone.

# publications[].label
Failure of Chloro-S-triazine-Derived Compounds to Induce Estrogen Receptor-Mediated Responses in Vivo and in Vitro

# publications[].label
Inactivation of the nuclear receptor TR3 as an important new drug target for treating RCC.

# publications[].label
Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC.

# publications[].label
Health Benefits of Coffee Consumption for Cancer and Other Diseases and Mechanisms of Action.

# publications[].label
Curcumin decreases specificity protein expression in bladder cancer cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
NR4A1 Ligands as Potent Inhibitors of Breast Cancer Cell and Tumor Growth.

# publications[].label
Ovine ill-thrift in Nova Scotia. 5. The production and toxicology of chetomin, a metabolite of chaetomium spp.

# publications[].label
Flavone and Hydroxyflavones Are Ligands That Bind the Orphan Nuclear Receptor 4A1 (NR4A1).

# publications[].label
Hydroxylated metabolites of chloronaphthalenes (Halowax 1031) in pig urine

# publications[].label
Metabolism of the systemic fungicide 2,5-dimethyl-3-furancarboxylic acid anilide (BAS 3191) by Rhizopus japonicus and related fungi.

# publications[].label
The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration.

# publications[].label
INTERSPECIES DIFFERENCES IN INVITRO THERMAL INACTIVATION OF UNLIGANDED HEPATIC AH-RECEPTOR

# publications[].label
Inhibition of tumor-necrosis-factor-alpha induced endothelial cell activation by a new class of PPAR-gamma agonists. An in vitro study showing receptor-independent effects.

# publications[].label
DNA damage induced by wood preserving waste extracts in vitro without metabolic activation, as assayed by 32P-postlabeling.

# publications[].label
Cooperative coactivation of estrogen receptor alpha in ZR-75 human breast cancer cells by SNURF and TATA-binding protein.

# publications[].label
A comparison of the mouse versus human aryl hydrocarbon (Ah) receptor complex: effects of proteolysis.

# publications[].label
p21 Expression Is Induced by Activation of Nuclear Nerve Growth Factor–Induced Bα (Nur77) in Pancreatic Cancer Cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Synergistic interactions of 2,3,7,8-TCDD and 2,2',4,4',5,5'-hexachlorobiphenyl in C57BL/6J and DBA/2J mice: role of the Ah receptor.

# publications[].label
Sporidesmins. 8. Ovine ill-thrift in Nova Scotia. 3. The characterisation of chetomin a toxic metabolite of Chaetomium cochliodes and Chaetomium globosum.

# publications[].label
Transcriptional activation of deoxyribonucleic acid polymerase alpha gene expression in MCF-7 cells by 17 beta-estradiol.

# publications[].label
Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins.

# publications[].label
Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective aryl hydrocarbon receptor modulator.

# publications[].label
Paralogues of porcine aromatase cytochrome P450: a novel hydroxylase activity is associated with the survival of a duplicated gene.

# publications[].label
Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements.

# publications[].label
Strong adsorption of Polychlorinated Biphenyls by processed montmorillonite clays: Potential applications as toxin enterosorbents during disasters and floods.

# publications[].label
Transcriptional activation of insulin-like growth factor-binding protein-4 by 17beta-estradiol in MCF-7 cells: role of estrogen receptor-Sp1 complexes.

# publications[].label
Alteration of oxytocin-induced calcium oscillations in clone 9 cells by toxin exposure.

# publications[].label
Hepatic microsomal enzyme induction by 2,2', 3,3', 4,4'- and 2,2', 3', 4,4', 5-hexachlorobiphenyl.

# publications[].label
Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach

# publications[].label
Analysis of chlorinated aromatic hydrocarbons by exhaustive chlorination: qualitative and structural aspects of the perchloro-derivatives of biphenyl, naphthalene, terphenyl, dibenzofuran, dibenzodioxin and DDE.

# publications[].label
Endocrine disruptors and human health: is there a problem.

# publications[].label
Involvement of Intestinal Epithelium Aryl Hydrocarbon Receptor Expression and 3, 3'-Diindolylmethane in Colonic Tertiary Lymphoid Tissue Formation.

# publications[].label
Bisphenol A and related endocrine disruptors.

# publications[].label
Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: characterization and mechanism of action.

# publications[].label
Antiestrogenic activities of alternate-substituted polychlorinated dibenzofurans in MCF-7 human breast cancer cells.

# publications[].label
Sex ratios at birth as monitors of endocrine disruption.

# publications[].label
A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Short chain fatty acids exhibit selective estrogen receptor downregulator (SERD) activity in breast cancer.

# publications[].label
Bis-Indole Derivatives as Dual Nuclear Receptor 4A1 (NR4A1) and NR4A2 Ligands.

# publications[].label
Broussochalcone A Is a Novel Inhibitor of the Orphan Nuclear Receptor NR4A1 and Induces Apoptosis in Pancreatic Cancer Cells.

# publications[].label
The effects of twenty-two organochlorine pesticides as inducers of the hepatic drug-metabolizing enzymes.

# publications[].label
Development validation and problems with the toxic equivalency factor approach for risk assessment of dioxins and related compounds.

# publications[].label
Kinetic models for association of 2,3,7,8-tetrachlorodibenzo-p-dioxin with the Ah receptor.

# publications[].label
Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase.

# publications[].label
Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition.

# publications[].label
6-substituted 3,4-benzocoumarins: a new structural class of inducers and inhibitors of CYP1A1-dependent activity.

# publications[].label
The effect of environment on the free and hydrosoluble sterols of Mucor rouxii.

# publications[].label
Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer.

# publications[].label
Endocrine disruptors - Effects on human health.

# publications[].label
Molecular biology of the Ah receptor and its role in carcinogenesis.

# publications[].label
Editorial overview: Risk assessment in toxicology

# publications[].label
Structure-activity relationships among mono- and dihydroxy flavones as aryl hydrocarbon receptor (AhR) agonists or antagonists in CACO2 cells.

# publications[].label
Small molecule tolfenamic acid inhibits PC-3 cell proliferation and invasion in vitro, and tumor growth in orthotopic mouse model for prostate cancer.

# publications[].label
Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum response factor in MCF-7 breast cancer cells.

# publications[].label
Male sexual development in "a sea of oestrogen".

# publications[].label
Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes.

# publications[].label
Estrogen Receptor (ER) Actions through Other Transcription Factor Sites

# publications[].label
Theranostic tumor homing nanocarriers for the treatment of lung cancer.

# publications[].label
ENHANCED ACTIVITY OF POLYNUCLEAR AROMATIC HYDROCARBON MIXTURES AS ARYL-HYDROCARBON (AH) RECEPTOR AGONISTS

# publications[].label
Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells.

# publications[].label
Polychlorinated dibenzo-p-dioxins: quantitative in vitro and in vivo structure-activity relationships.

# publications[].label
Correction to "Neuroprotective Efficacy and Pharmacokinetic Behavior of Novel Anti-Inflammatory Para-Phenyl Substituted Diindolylmethanes in a Mouse Model of Parkinson's Disease".

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
2,3,7,8-Tetrachlorodibenzo-p-dioxin reduces the number, size, and organelle content of Leydig cells in adult rat testes.

# publications[].label
Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs.

# publications[].label
AROCLOR 1254 AS A 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN ANTAGONIST IN MICE

# publications[].label
Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex.

# publications[].label
Effects of individual terphenyls and polychlorinated terphenyls on rat hepatic microsomal cytochrome P-450-dependent monooxygenases: structure-activity relationships.

# publications[].label
Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways.

# publications[].label
Aryl hydrocarbon (Ah) receptor-independent induction of Cyp1a2 gene expression by acenaphthylene and related compounds in B6C3F1 mice.

# publications[].label
HIGH RESOLUTION ISOMER-SPECIFIC PCB ANALYSIS.

# publications[].label
Timing of hydrogen randomization in substituted diphenyl acetylenes

# publications[].label
Mass spectra of some fungicidal organomercury compounds.

# publications[].label
Synergistic activity of polynuclear aromatic hydrocarbon mixtures as aryl hydrocarbon (Ah) receptor agonists.

# publications[].label
Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors.

# publications[].label
PROPERTIES OF EMULSIFIERS THAT ENHANCE REPLICATION OF VIRUSES IN CELL-CULTURES

# publications[].label
Atypical cytochrome P450 induction profiles in glomerular mesangial cells at the mRNA and enzyme level. Evidence for CYP1A1 and CYP1B1 expression and their involvement in benzo[a]pyrene metabolism.

# publications[].label
COMPARATIVE ARYL-HYDROCARBON HYDROXYLASE INDUCTION ACTIVITIES OF COMMERCIAL PCBS IN WISTAR RATS AND RAT HEPATOMA H-4-II-E-CELLS IN CULTURE

# publications[].label
Problems for risk assessment of endocrine-active estrogenic compounds

# publications[].label
INDUCTION OF TRANSIENT CELL-PROLIFERATION BY MANUFACTURED-GAS PLANT RESIDUE IN B6C3F1 MALE-MICE

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
miR-150 blocks MLL-AF9-associated leukemia through oncogene repression.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice.

# publications[].label
EXPOSURE OF KILLIFISH TO BENZO[A]PYRENE - COMPARATIVE METABOLISM, DNA ADDUCT FORMATION AND ARYL-HYDROCARBON (AH) RECEPTOR AGONIST ACTIVITIES

# publications[].label
Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: quantitative structure-activity relationships.

# publications[].label
Metabolism of chlorobiphenyls in the goat and cow.

# publications[].label
HALOGEN SUBSTITUENTS AT 4-POSITION AND 4'-POSITION OF BIPHENYL - INFLUENCE ON HEPATIC FUNCTION IN RAT

# publications[].label
The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons.

# publications[].label
Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Relative Sensitivities of 2,3,7,8-Tetrachlorodibenzo-                     p                     -dioxin-lnduced                     Cypla-1                     and                     Cypla-2                     Gene Expression and Immunotoxicity in Female B6C3F1 Mice

# publications[].label
Flavonoids are NR4A1 antagonists and target PAX3-FOXO1 and G9a in alveolar rhabdomyosarcoma cells.

# publications[].label
Inhibition of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumor growth by aryl hydrocarbon receptor agonists.

# publications[].label
Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: a review.

# publications[].label
Effects of developmental exposure to indole-3-carbinol or 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive potential of male rat offspring.

# publications[].label
Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB 155).

# publications[].label
Pesticide emulsifier actions on the cell to change viral replication

# publications[].label
Lipid composition of Chaetomium cochliodes: effect of media.

# publications[].label
The Toxicology Education Summit: building the future of toxicology through education.

# publications[].label
The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells.

# publications[].label
Carbidopa: a selective Ah receptor modulator (SAhRM).

# publications[].label
The Aryl Hydrocarbon Receptor (AhR) as a Drug Target for Cancer Chemotherapy.

# publications[].label
Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice.

# publications[].label
QUANTITATION OF HYMENOXON AND RELATED SESQUITERPENE LACTONES

# publications[].label
MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells.

# publications[].label
Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism.

# publications[].label
The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor B.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cells.

# publications[].label
Identification of 2,2,4,4,5,5-hexabromobiphenyl as the major component of flame retardant fireMaster BP-6

# publications[].label
Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells.

# publications[].label
Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol.

# publications[].label
Altered phenotypic characteristics of T47d human breast cancer cells after prolonged growth in estrogen-deficient medium.

# publications[].label
Binding of polynuclear aromatic hydrocarbons to the rat 4S cytosolic binding protein: structure-activity relationships.

# publications[].label
Isolation and biosynthesis of ergosta-5,7,9(11),22-tetraen-3-ol from Mucor rouxii

# publications[].label
2,3,4,4'-Pentachlorobiphenyl: differential effects on C57BL/6J and DBA/2J inbred mice.

# publications[].label
The metabolically mediated DNA damage and subsequent DNA repair by 4-chlorobiphenyl in Chinese hamster ovary cells.

# publications[].label
Protective Effects of Ghrelin on Fasting-Induced Muscle Atrophy in Aging Mice.

# publications[].label
Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: effects of di-ortho substitution.

# publications[].label
The mechanism of action of alpha-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.

# publications[].label
Composition and photochemistry of Iralec

# publications[].label
Photoaffinity labeling of the nuclear Ah receptor from mouse Hepa 1c1c7 cells using 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin.

# publications[].label
INVESTIGATION OF THE UTILITY OF VARIOUS MIXED AND HALOGENATED DIBENZO-PARA-DIOXINS, DIBENZOFURANS AND BIPHENYLS AS SURROGATE INTERNAL AND INJECTION STANDARDS

# publications[].label
3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters.

# publications[].label
Comparative in vitro and in vivo genotoxicities of 7H-benzo[c]fluorene, manufactured gas plant residue (MGP), and MGP fractions.

# publications[].label
Polychlorinated biphenyls: correlation between in vivo and in vitro quantitative structure-activity relationships (QSARs).

# publications[].label
PHOTOREACTIONS OF SIMPLE HALONAPHTHALENES IN SOLUTION

# publications[].label
INTRODUCTION OF A FUNCTIONAL HUMAN ESTROGEN-RECEPTOR RESTORES THE FUNCTION OF THE AH RECEPTOR IN THE HUMAN BREAST-CARCINOMA CELL-LINE MDA-MB-231

# publications[].label
Nonadditive interactive effects of polychlorinated biphenyl congeners in rats: role of the 2,3,7,8-tetrachlorodibenzo-p-dioxin receptor.

# publications[].label
Modulation of rat hepatic microsomal testosterone hydroxylases by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related toxic isostereomers.

# publications[].label
Orphan nuclear receptor transcription factors as drug targets.

# publications[].label
The in vitro metabolism of 2,2',4,4',5,5'-hexabromobiphenyl.

# publications[].label
Aryl hydrocarbon hydroxylase (AHH) induction by polybrominated biphenyls (PBBs): enchancement by photolysis.

# publications[].label
5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
MicroRNA-Specificity Protein (Sp) Transcription Factor Interactions and Significance in Carcinogenesis.

# publications[].label
Triazine dendrimers for drug delivery: Evaluation of solubilization properties, activity in cell culture, and in vivo toxicity of a candidate vehicle

# publications[].label
Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines

# publications[].label
Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: structure-activity rules.

# publications[].label
Flavonoids Kaempferol and Quercetin are Nuclear Receptor 4A1 (NR4A1, Nur77) Ligands and inhibit Rhabdomyosarcoma Cell and Tumor Growth

# publications[].label
INHIBITION OF ESTROGEN-INDUCED AND GROWTH FACTOR-INDUCED PROLIFERATION OF HUMAN BREAST-CANCER CELL-LINES BY TCDD - CHARACTERIZATION AND MECHANISTIC STUDIES

# publications[].label
Environmental estrogens: roles in male reproductive tract problems and in breast cancer.

# publications[].label
The bioactive compounds alpha-chaconine and gallic acid in potato extracts decrease survival and induce apoptosis in LNCaP and PC3 prostate cancer cells.

# publications[].label
POLYCHLORINATED DIBENZO-PARA-DIOXINS AND DIBENZOFURANS ASSOCIATED WITH WOOD-PRESERVING CHEMICAL SITES - BIOMONITORING WITH PINE NEEDLES

# publications[].label
3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5.

# publications[].label
Aroclor 1254 as an antagonist of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

# publications[].label
NR4A nuclear receptor expression in human macrophages mediates apoptosis and controls Mycobacterium tuberculosis growth.

# publications[].label
Effect of oxygen levels on the fatty acids and lipids of Mucor rouxii.

# publications[].label
THE EFFECTS OF THE DEGREE OF ORTHO CHLORO SUBSTITUTION ON THE PHARMACOKINETICS OF 5 HEXACHLOROBIPHENYLS IN THE RAT

# publications[].label
Abstract 3298: Diindolylmethane and its halogenated analogues induce autophagy in human prostate cancer cells via induction of the astrocyte-elevated gene-1 (AEG-1)

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells.

# publications[].label
Effect of diet and intestinal AhR expression on fecal microbiome and metabolomic profiles.

# publications[].label
Natural Products as Mechanism-based Anticancer Agents: Sp Transcription Factors as Targets.

# publications[].label
PHOTOCHEMISTRY OF BROMOBIPHENYLS - STERIC EFFECTS AND ELECTRON-TRANSFER

# publications[].label
Correction to Methyl 2-Cyano-3,12-dioxooleana-1, 9-dien-28-oate Decreases Specificity Protein Transcription Factors and Inhibits Pancreatic Tumor Growth: Role of MicroRNA-27a

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
PHOTO-DECOMPOSITION OF A COMMERCIAL POLYBROMINATED BIPHENYL FIRE RETARDANT - HIGH-RESOLUTION GAS-CHROMATOGRAPHIC ANALYSIS

# publications[].label
Gas chromatographic/mass spectrometric analysis of specific isomers of polychlorodibenzofurans.

# publications[].label
Isomerically pure bromobiphenyl congeners and hepatic mono-oxygenase activities in the rat: influence of position and degree of bromination.

# publications[].label
Induction of both 3-methylcholanthrene- and phenobarbitone-type microsomal enzyme activity by a single polychlorinated biphenyl isomer.

# publications[].label
The ion kinetic energy and mass spectra of the isomeric mono- and di-chloronaphthalenes

# publications[].label
The ion kinetic energy and mass spectra of isomeric methyl indoles

# publications[].label
Aryl hydrocarbon (Ah) nonresponsiveness in estrogen receptor-negative MDA-MB-231 cells is associated with expression of a variant arnt protein.

# publications[].label
THE INVITRO METABOLISM OF BENZO[A]PYRENE BY POLYCHLORINATED AND POLYBROMINATED BIPHENYL INDUCED RAT HEPATIC-MICROSOMAL MONOOXYGENASES

# publications[].label
Effects of cycloheximide on the induction of CYP1A1 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in three human breast cancer cell lines.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Constitutive and Aroclor 1254-induced hepatic glutathione S-transferase, peroxidase and reductase activities in genetically inbred mice.

# publications[].label
Co-induction of cytochrome P-450 isozymes in rat liver by 2,4,5,2',4',5'-hexachlorobiphenyl or 3-methoxy-4-aminoazobenzene

# publications[].label
Abstract 629: Flavonoids are NR4A1 antagonists and target PAX3-FOXO1 and G9a in alveolar rhabdomyosarcoma cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Methyl 2-cyano-3,11-dioxo-18-olean-1,12-dien-30-oate (CDODA-Me), a derivative of glycyrrhetinic acid, functions as a potent angiogenesis inhibitor.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization.

# publications[].label
1,1-Bis(3-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease -radiation-induced survivin in colon and pancreatic cancer cells

# publications[].label
Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents.

# publications[].label
Estrogen-induced c-fos protooncogene expression in MCF-7 human breast cancer cells: role of estrogen receptor Sp1 complex formation.

# publications[].label
RADIOLIGAND-DEPENDENT PROPERTIES OF THE AH-RECEPTOR FROM RAT AND MOUSE HEPATIC CYTOSOL

# publications[].label
Abstract B101: Inactivation of the orphan nuclear receptor TR3 induces ER stress-mediated apoptosis by increasing ROS production in pancreatic cancer cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Characterization and Biological Potency of Mono- to Tetra-Halogenated Carbazoles.

# publications[].label
Sterol content and polyene antibiotic resistance in isolates of Candida krusei, Candida parakrusei, and Candida tropicalis.

# publications[].label
Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation.

# publications[].label
PHOTOCHEMISTRY OF CHLORINATED BIPHENYLS IN ISO-OCTANE SOLUTION

# publications[].label
The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
POLYCHLORINATED BIPHENYLS (PCBs) AS INDUCERS OF THE HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYMES - EFFECTS OF STRUCTURE ON ACTIVITY

# publications[].label
Photochemical degradation of di- and octachlorodibenzofuran.

# publications[].label
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.

# publications[].label
Potent inhibition of breast cancer by bis-indole-derived nuclear receptor 4A1 (NR4A1) antagonists.

# publications[].label
Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK).

# publications[].label
The Effects of betulinic acid on microRNA-27a regulated target genes in MDA-MB-231 breast cancer cells

# publications[].label
Potency of combined estrogenic pesticides.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum.

# publications[].label
Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds.

# publications[].label
ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy.

# publications[].label
Chemopreventive effects of tolfenamic acid against esophageal tumorigenesis in rats.

# publications[].label
Inhibition of insulin-like growth factor-I responses in MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.

# publications[].label
Comparative influences of different PB-type and 3-MC-type polychlorinated biphenyl-induced phenotypes on cytocidal hepatotoxicity of bromobenzene and acetaminophen.

# publications[].label
Bis-Indole-Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells.

# publications[].label
6-METHYL-1,3,8-TRICHLORODIBENZOFURAN (MCDF) AS A 2,3,7,8-TCDD ANTAGONIST IN C57BL/6 MICE

# publications[].label
CHARACTERIZATION OF 6-METHYL-1,3,8-TRICHLORODIBENZOFURAN (MCDF) AS A 2,3,7,8-TCDD ANTAGONIST IN MALE-RATS - INDUCTION OF MONOOXYGENASES

# publications[].label
Estrogen and aryl hydrocarbon responsiveness of ECC-1 endometrial cancer cells.

# publications[].label
Cigarette Smoking and Estrogen-Related Cancer.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
SYNTHESIS AND IDENTIFICATION OF HIGHLY TOXIC POLYBROMINATED BIPHENYLS IN THE FIRE RETARDANT FIREMASTER BP-6

# publications[].label
Problems for risk assessment of endocrine-active estrogenic compounds.

# publications[].label
Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in ApcS580/+; KrasG12D/+ Mice.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
ASSESSING AROMATIC HYDROCARBON EXPOSURE IN ANTARCTIC FISH CAPTURED NEAR PALMER AND MCMURDO STATIONS, ANTARCTICA

# publications[].label
Role of the 4-5S binding protein in the induction of aryl hydrocarbon hydroxylase in the rat.

# publications[].label
The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis.

# publications[].label
Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer.

# publications[].label
ANALYSIS OF PCBs USING SPECIFIC ISOMER HIGH RESOLUTION CAPILLARY GAS CHROMATOGRAPHY.

# publications[].label
High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome.

# publications[].label
Failure of chloro-S-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro.

# publications[].label
Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line.

# publications[].label
Activation of adenosine deaminase in MCF-7 cells through IGF-estrogen receptor alpha crosstalk.

# publications[].label
Crosstalk between estrogen receptor alpha and the aryl hydrocarbon receptor in breast cancer cells involves unidirectional activation of proteasomes.

# publications[].label
Symposium on mechanisms of action of naturally occurring anticarcinogens.

# publications[].label
Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
4-chlorobiphenyl metabolism: the effects of chemical inducers.

# publications[].label
Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways.

# publications[].label
Dual nuclear receptor 4A1 (NR4A1/NR4A2) ligands inhibit glioblastoma growth and target TWIST1

# publications[].label
Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Competitive binding to the cytosolic 2,3,7,8-tetrachlorodibenzo-p-dioxin receptor. Effects of structure on the affinities of substituted halogenated biphenyls--a QSAR analysis.

# publications[].label
:Endocrine Disruptors and Human Health : Is There a Problem?(21)

# publications[].label
Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors.

# publications[].label
The metabolism of brominated aromatic compounds

# publications[].label
Editor's Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling.

# publications[].label
Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
High passage T47D human breast cancer cells: altered endocrine and 2,3,7,8-tetrachlorodibenzo-p-dioxin responsiveness.

# publications[].label
Comparative Potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in Male Wistar RatsAssessment of the Toxic Equivalency Factor (TEF) Approach for Polychlorinated Biphenyls (PCBs)

# publications[].label
A NOVEL NUCLEAR RECEPTOR 4A1 (NR4A1) ANTAGONISTS ATTENUATES T-CELL EXHAUSTION IN COLORECTAL CANCER

# publications[].label
THE EFFECTS OF RECEPTOR ANTAGONISTS ON THE AHH INDUCTION ACTIVITY OF 2,3,7,8-TCDD IN C57BL/6 AND DBA/2 MICE - 1,3,6,8-TETRACHLORODIBENZOFURAN

# publications[].label
Clinical correlates of environmental endocrine disruptors.

# publications[].label
6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities.

# publications[].label
Induction of glutathione S-transferases in genetically inbred male mice by dietary ethoxyquin hydrochloride.

# publications[].label
Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells.

# publications[].label
Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors.

# publications[].label
Organochlorine residues and breast cancer

# publications[].label
Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1.

# publications[].label
Toxicological and pathophysiological roles of reactive oxygen and nitrogen species.

# publications[].label
HIGHLIGHTS OF PENTACYCLIC TRITERPENES IN THE CANCER SETTING

# publications[].label
1,1-Bis (3'-indolyl)-1-(p-substitutedphenyl)methane compounds inhibit lung cancer cell and tumor growth in a metastasis model.

# publications[].label
The utility of the microsomal 4-chlorobiphenyl hydroxylase enzyme assay in distinguishing between phenobarbitone- and 3-methylcholanthrene-induced microsomal monooxygenases.

# publications[].label
Mass spectrometric studies on methyl ether derivatives of sterols.

# publications[].label
Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach.

# publications[].label
EFFECTS OF SUBSTITUENT STRUCTURE ON BINDING TO THE TCDD RECEPTOR - A QSAR ANALYSIS

# publications[].label
Correction for Hedrick et al., "NR4A1 Antagonists Inhibit 1-Integrin-Dependent Breast Cancer Cell Migration".

# publications[].label
Polychlorinated biphenyls: metabolic behavior of pure isomers in pigeons, rats, and brook trout.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Health effects and risk assessment of halogenated aromatic hydrocarbons

# publications[].label
KINETICS OF THE ASSOCIATION OF SEVERAL TRITIATED PCDD AND PCDF CONGENERS WITH THE CYTOSOLIC AH RECEPTOR FROM THE SPRAGUE-DAWLEY RAT

# publications[].label
Sporidesmins. XII. Isolation and structure of sporidesmin G, a naturally-occuring 3,6-epitetrahiopiperazine-2,5-dione.

# publications[].label
Estrogen-dependent regulation of ornithine decarboxylase in breast cancer cells through activation of nongenomic cAMP-dependent pathways.

# publications[].label
Sublethal detoxification responses to contaminant exposure associated with offshore production platforms

# publications[].label
MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells.

# publications[].label
Biomarker sensitivity for polynuclear aromatic hydrocarbon contamination in two marine fish species collected in Galveston Bay, Texas

# publications[].label
Abstract 236: Nuclear receptor 4A1 ligands target T-cell exhaustion in colorectal cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Studies on the relationship between estrogen receptor content, glutathione S-transferase pi expression, and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and drug resistance in human breast cancer cells.

# publications[].label
Hexachlorobenzene and substituted pentachlorobenzenes (X-C6Cl5) as inducers of hepatic cytochrome P-450-dependent mono-oxygenases.

# publications[].label
AN ANIMAL-MODEL OF HEMODIALYSIS INDUCED POLYCYSTIC KIDNEY-DISEASE (PKD)

# publications[].label
A Chalcone Synthase-Like Bacterial Protein Catalyzes Heterocyclic C-Ring Cleavage of Naringenin to Alter Bioactivity Against Nuclear Receptors in Colonic Epithelial Cells

# publications[].label
Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.

# publications[].label
The effects of organochlorine pesticides as inducers of testosterone and benzo[a]pyrene hydroxylases.

# publications[].label
Minireview: role of orphan nuclear receptors in cancer and potential as drug targets.

# publications[].label
Metabolism of 4-chlorobiphenyl by lichens.

# publications[].label
Synthesis, biologic and toxic effects of the major 2,3,7,8-tetrachlorodibenzo-p-dioxin metabolites in the rat.

# publications[].label
Role of SP transcription factors in hormone-dependent modulation of genes in MCF-7 breast cancer cells: microarray and RNA interference studies.

# publications[].label
Other Industrial Pollutants and Natural Toxins

# publications[].label
SWEDISH DIOXIN SURVEY - DETERMINATION OF 2,3,7,8-TCDD TOXIC EQUIVALENT FACTORS FOR SOME POLYCHLORINATED-BIPHENYLS AND NAPHTHALENES USING BIOLOGICAL TESTS

# publications[].label
Pharmacokinetic and pharmacodynamic evaluation of novel dual channel spray dried enteric coated self-emulsifying capsules for anti-cancer agents in dogs.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
alpha-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation.

# publications[].label
CHARACTERIZATION OF THE HUMAN AH RECEPTOR

# publications[].label
Editorial Expression of Concern: Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer.

# publications[].label
Failure of Chloro-s-triazine-Derived Compounds to Induce Estrogenic Responses in Vivo and in Vitro

# publications[].label
Induction of Cyp1a-1 and Cyp1a-2 gene expression by a reconstituted mixture of polynuclear aromatic hydrocarbons in B6C3F1 mice.

# publications[].label
Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells.

# publications[].label
Cytotoxicity and aromatase (CYP19) activity modulation by organochlorines in human placental JEG-3 and JAR choriocarcinoma cells.

# publications[].label
Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
In Vitro Methods for Characterizing Chemical Interactions with Steroid Hormone Receptors

# publications[].label
NR4A1 Acts as a Nutrient Sensor That Inhibits the Effects of Aging.

# publications[].label
Aryl Hydrocarbon Receptor (AhR) Signaling in Colonic Cells and Tumors.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds.

# publications[].label
Induction of endoplasmic reticulum-induced stress genes in Panc-1 pancreatic cancer cells is dependent on Sp proteins.

# publications[].label
Therapeutic applications of NSAIDS in cancer: special emphasis on tolfenamic acid.

# publications[].label
Benzyl Isothiocyanate (BITC) Induces Reactive Oxygen Species-dependent Repression of STAT3 Protein by Down-regulation of Specificity Proteins in Pancreatic Cancer.

# publications[].label
Tolfenamic Acid Increases EGR-1 Expression through a PKC/ERK Dependent Pathway in Human Colorectal Cancer Cells

# publications[].label
Cell context-dependent differences in the induction of E2F-1 gene expression by 17 beta-estradiol in MCF-7 and ZR-75 cells.

# publications[].label
MASS AND ION KINETIC-ENERGY SPECTRA OF SOME CHLORINATED DIBENZO-PARA-DIOXINS

# publications[].label
Influences of various xenobiotic inducers on cytocidal toxicity of lasiocarpine and senecionine in primary cultures of rat hepatocytes.

# publications[].label
Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice.

# publications[].label
Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target.

# publications[].label
Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression.

# publications[].label
Comparative32P-postlabeling analysis of exogenous and endogenous DNA adducts in mouse skin exposed to a wood-preserving waste extract, a complex mixture of polycyclic and polychlorinated chemicals

# publications[].label
Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells.

# publications[].label
2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibition of 17 beta-estradiol-induced increases in rat uterine epidermal growth factor receptor binding activity and gene expression.

# publications[].label
Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives.

# publications[].label
Potency of combined estrogenic pesticides: Synergy between synthetic oestrogens?

# publications[].label
The Role of the Aryl Hydrocarbon Receptor (AhR) and Its Ligands in Breast Cancer.

# publications[].label
Der Arylhydrocarbon Rezeptor als neue Zielscheibe zur Behandlung des Pankreaskarzinoms

# publications[].label
1,1-Bis(3'-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells.

# publications[].label
Organ-specific effects of long term feeding of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 1,2,3,7,8-pentachlorodibenzo-p-dioxin on I-compounds in hepatic and renal DNA of female Sprague-Dawley rats.

# publications[].label
VALIDATION OF IN VITRO BIOASSAYS FOR 2,3,7,8-TCDD EQUIVALENTS

# publications[].label
Role of estrogen receptor (ER) alpha in insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells.

# publications[].label
Aryl hydrocarbon receptor (AhR) activation decreases severity of laser-induced choroidal neovascular lesions (CNV)

# publications[].label
Neonatal phenobarbital imprinting of rat hepatic microsomal testosterone hydroxylations.

# publications[].label
Immunotoxic potencies of polychlorinated biphenyl (PCB), dibenzofuran (PCDF) and dibenzo-p-dioxin (PCDD) congeners in C57BL/6 and DBA/2 mice.

# publications[].label
Erratum to: Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target.

# publications[].label
INTERACTIONS OF 2,3,7,8-TCDD AND PCB MIXTURES CONGENERS - IMMUNOTOXICITY STUDIES

# publications[].label
Betulinic Acid Targets YY1 and ErbB2 through Cannabinoid Receptor-Dependent Disruption of MicroRNA-27a:ZBTB10 in Breast Cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
INTERACTIVE EFFECTS OF FOS WITH THE AH RECEPTOR IN WILD-TYPE MOUSE HEPATOMA-CELLS

# publications[].label
Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice.

# publications[].label
Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species-Dependent Targeting of Specificity Protein Transcription Factors.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer.

# publications[].label
FireMaster BP-6: fractionation, metabolic and enzyme induction studies.

# publications[].label
EFFECTS OF CHLORINATED PHENOLS ON RAT EMBRYONIC AND HEPATIC MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION

# publications[].label
DNA binding properties of the Ah receptor in wild-type and variant mouse hepatoma cells.

# publications[].label
LETHAL VIRUS-EMULSIFIER-SOLVENT INTERACTION - INVIVO AND INVITRO STUDIES

# publications[].label
Role of estrogen receptor/Sp1 complexes in estrogen-induced heat shock protein 27 gene expression.

# publications[].label
POLYCHLORINATED DIBENZO-P-DIOXINS AND DIBENZOFURANS - A BIOANALYTICAL APPROACH

# publications[].label
The metabolism of 4'chloro-4-biphenylol in the rat.

# publications[].label
Ring-substituted analogs of 3,3'-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and -independent prostate cancer cells.

# publications[].label
Modulation of protooncogene expression in rat aortic smooth muscle cells by benzo[a]pyrene.

# publications[].label
Abstract 2428: NR4A1 ligands inhibits PSPC1 regulated EMT and stemness markers in breast, lung and liver cancer cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 17 beta-estradiol in MCF-7 human breast cancer cells.

# publications[].label
Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept.

# publications[].label
Ultra-flexible nanocarriers for enhanced topical delivery of a highly lipophilic antioxidative molecule for skin cancer chemoprevention.

# publications[].label
Effect of ligand structure on formation and DNA binding properties of the transformed rat cytosolic aryl hydrocarbon receptor.

# publications[].label
Do environmental estrogens play a role in development of breast cancer in women and male reproductive problems?

# publications[].label
Development of gel staining techniques for detecting the secretion of procathepsin D (52-kDa protein) in MCF-7 human breast cancer cells.

# publications[].label
Co-induction of cytochrome P-450 isozymes in rat liver by 2,4,5,2',4',5'-hexachlorobiphenyl or 3-methoxy-4-aminoazobenzene.

# publications[].label
Development and validation of bioassays for polychlorinated dibenzo-p-dioxins and dibenzofurans.

# publications[].label
Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action.

# publications[].label
Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity.

# publications[].label
Inhibition of bladder tumor growth by 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes: a new class of peroxisome proliferator-activated receptor gamma agonists.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids.

# publications[].label
Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins.

# publications[].label
NR4A1 inhibition synergizes with ibrutinib in killing mantle cell lymphoma cells.

# publications[].label
Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Chemoprevention of skin cancer with 1,1-Bis (3'-indolyl)-1-(aromatic) methane analog through induction of the orphan nuclear receptor, NR4A2 (Nurr1).

# publications[].label
Mutagenic potential of binary and complex mixtures using different enzyme induction systems.

# publications[].label
Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells.

# publications[].label
Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures.

# publications[].label
Inhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists.

# publications[].label
Bardoxolone Methyl and a Related Triterpenoid Downregulate cMyc Expression in Leukemia Cells.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Synthesis of the Octa- and nonachlorobiphenyl isomers and congeners and their quantitation in commercial polychlorinated biphenyls and identification in human breast milk.

# publications[].label
Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer.

# publications[].label
Differential time course of induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by Aroclor 1254.

# publications[].label
Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation.

# publications[].label
Electron-donor-acceptor complexing reagents in the analysis of pesticides. V. The analysis of pesticide decomposition products via electron-donor-acceptor complexes; photolysis of methoxychlor.

# publications[].label
Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor.

# publications[].label
Evaluation of Spray BIO-Max DIM-P in Dogs for Oral Bioavailability and in Nu/nu Mice Bearing Orthotopic/Metastatic Lung Tumor Models for Anticancer Activity.

# publications[].label
Nuclear receptor 4A1 as a drug target for breast cancer chemotherapy

# publications[].label
Estrogen regulation of transferrin gene expression in MCF-7 human breast cancer cells.

# publications[].label
Substituent and H/D randomization in the mass spectra of substituted diphenylacetylenic compounds

# publications[].label
Alteration of oxytocin-induced calcium oscillations in Clone 9 cells by toxin exposure

# publications[].label
EFFECTS OF STRUCTURE ON THE ACTIVITY OF POLYBROMINATED BIPHENYLS (PBB) AS MICROSOMAL-ENZYME INDUCERS

# publications[].label
Structure-dependent activation of endoplasmic reticulum stress_mediated apoptosis in pancreatic cancer by 1,1-bis(3-indoly)-1-(p_substituted phenyl)methanes (Molecular Cancer Therapeutics (2008) 7, (3363-3372))

# publications[].label
Limitations of the toxic equivalency factor approach for risk assessment of TCDD and related compounds.

# publications[].label
Binding of polychlorinated biphenyls classified as either phenobarbitone-, 3-methylcholanthrene- or mixed-type inducers to cytosolic Ah receptor.

# publications[].label
Microbial demethylation and debutynylation of four phenylurea herbicides

# publications[].label
2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN AS AN ANTIPROLIFERATIVE AGENT IN HUMAN BREAST-CANCER CELLS - EFFECTS ON INSULIN-INDUCED CELL-PROLIFERATION

# publications[].label
Regulation of cytochrome P-450p by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture and in vivo.

# publications[].label
Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.

# publications[].label
EFFECTS OF ALLOGENIC SERUM ON THE IN-VITRO IMMUNE-RESPONSE - AH RECEPTOR STRUCTURE-IMMUNOTOXICITY RELATIONSHIPS

# publications[].label
Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins.

# publications[].label
Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells.

# publications[].label
Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease.

# publications[].label
Cadmium's disguise dupes the estrogen receptor.

# publications[].label
Comparative estrogenic activity of wine extracts and organochlorine pesticide residues in food

# publications[].label
Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes.

# publications[].label
Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors.

# publications[].label
Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms.

# publications[].label
Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1.

# publications[].label
Polychlorinated dibenzofurans (PCDFs): correlation between in vivo and in vitro structure-activity relationships.

# publications[].label
Estrogen does not inhibit 2,3,7, 8-tetrachlorodibenzo-p-dioxin-mediated effects in MCF-7 and Hepa 1c1c7 cells.

# publications[].label
Exhaustive Chlorination as a Technique in the Analysis of Aromatic Hydrocarbons

# publications[].label
Development of selective aryl hydrocarbon receptor modulators for treatment of breast cancer.

# publications[].label
Toxic equivalency factor approach for risk assessment of combustion byproducts

# publications[].label
Flavonoids: structure-function and mechanisms of action and opportunities for drug development.

# publications[].label
AN ANIMAL-MODEL OF HEMODIALYSIS-INDUCED POLYCYSTIC KIDNEY-DISEASE (PKD)

# publications[].label
Inhibition of the 17 beta-estradiol-induced and constitutive expression of the cellular protooncogene c-fos by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the female rat uterus.

# publications[].label
Effects of Aroclor 1254-induced rat liver S-9 fraction on benzo[a]pyrene-mediated DNA damage and benzo[a]pyrene metabolism in cultured human skin fibroblasts.

# publications[].label
Omeprazole Inhibits Glioblastoma Cell Invasion and Tumor Growth.

# publications[].label
Reduced Leydig cell volume and function in adult rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin without a significant effect on spermatogenesis.

# publications[].label
The effect of growth environment on the chloroform-methanol and alkali-extractable cell wall and cytoplasm lipid levels of Mucor rouxii.

# publications[].label
Association of ARNT splice variants with estrogen receptor-negative breast cancer, poor induction of vascular endothelial growth factor under hypoxia, and poor prognosis.

# publications[].label
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.

# publications[].label
Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Synergistic effects of methyl 2-cyano-3,11-dioxo-18beta-olean-1,-12-dien-30-oate and erlotinib on erlotinib-resistant non-small cell lung cancer cells.

# publications[].label
Synthesis and aryl hydrocarbon receptor binding properties of radiolabeled polychlorinated dibenzofuran congeners.

# publications[].label
X -Ray crystallographic determination of the stereochemistry of the tetrathio-bridge in sporidesmin G

# publications[].label
Lipid-based oral delivery systems for skin deposition of a potential chemopreventive DIM derivative: characterization and evaluation.

# publications[].label
Immunosuppressive Activity of Polychiorinated Biphenyl Mixtures and Congeners: Nonadditive (Antagonistic) Interactions

# publications[].label
Halogenated aromatic hydrocarbon-induced suppression of the plaque-forming cell response in B6C3F1 splenocytes cultured with allogenic mouse serum: Ah receptor structure activity relationships.

# publications[].label
The biologic and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in chickens.

# publications[].label
DNA damage induced in mouse tissues by organic wood preserving waste extracts as assayed by 32P-postlabeling.

# publications[].label
Alkyl polychlorinated dibenzofurans and related compounds as antiestrogens in the female rat uterus: structure-activity studies.

# publications[].label
Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis.

# publications[].label
Mithramycin A inhibits myeloid cell leukemia-1 to induce apoptosis in oral squamous cell carcinomas and tumor xenograft through activation of Bax and oligomerization.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Evaluation of self-emulsified DIM-14 in dogs for oral bioavailability and in Nu/nu mice bearing stem cell lung tumor models for anticancer activity.

# publications[].label
The Aryl Hydrocarbon Receptor is a repressor of colorectal cancer development induced by high-fat diet in mice.

# publications[].label
Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors.

# publications[].label
Chemically induced polycystic kidney disease.

# publications[].label
COMPARATIVE-ANALYSIS OF POLYCHLORINATED DIBENZO-P-DIOXIN AND DIBENZOFURAN CONGENERS IN GREAT-LAKES FISH EXTRACTS BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY AND INVITRO ENZYME-INDUCTION ACTIVITIES

# publications[].label
Is there an association between exposure to environmental estrogens and breast cancer?

# publications[].label
POLYCHLORINATED BIPHENYL (PCB) CONGENERS AS 2,3,7,8-TCDD ANTAGONISTS - TERATOGENICITY STUDIES

# publications[].label
The ion kinetic energy spectra of isomeric chlorobenzenes and polychlorinated biphenyls (PCB'S)

# publications[].label
Development of bioassays and approaches for the risk assessment of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related compounds

# publications[].label
MP45-02 CDODA-ME DECREASES SPECIFICITY PROTEIN TRANSCRIPTION FACTORS AND INDUCES APOPTOSIS IN BLADDER CANCER CELLS THROUGH INDUCTION OF REACTIVE OXYGEN SPECIES

# publications[].label
Dopamine is an aryl hydrocarbon receptor agonist.

# publications[].label
Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoic acid in MCF-7 human breast cancer cells.

# publications[].label
Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells.

# publications[].label
In situ and in vitro photoaffinity labeling of the nuclear aryl hydrocarbon receptor from transformed rodent and human cell lines.

# publications[].label
ChemInform Abstract: NATUERLICHE ACETYLENE 31. MITT. C(14)TETRAHYDROPYRANYL UND ANDERE POLYACETYLENE AUS DAHLIA COCCINEA CAV. VAR. COCCINEA

# publications[].label
MASS AND ION KINETIC ENERGY SPECTRA OF THE CHLORINATED ANILINES.

# publications[].label
Expression of Prooncogenic Nuclear Receptor 4A (NR4A)-Regulated Genes 1-Integrin and G9a Inhibited by Dual NR4A1/2 Ligands.

# publications[].label
Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins.

# publications[].label
SYNTHESIS, BIOLOGIC AND TOXIC PROPERTIES OF 2,3,7,8-TCDD METABOLITES

# publications[].label
Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure-Activity Relationships.

# publications[].label
Influence of cell proliferation on initiating activity of pure polychlorinated biphenyls and complex mixtures in resistant hepatocyte in vivo assays for carcinogenicity.

# publications[].label
POLYBROMINATED AND CHLORINATED DIBENZO-PARA-DIOXINS - SYNTHESIS BIOLOGIC AND TOXIC EFFECTS AND STRUCTURE-ACTIVITY-RELATIONSHIPS

# publications[].label
Interactions between hormones and chemicals in breast cancer.

# publications[].label
Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors.

# publications[].label
Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.

# publications[].label
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats.

# publications[].label
Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes.

# publications[].label
Colored Potato Bioactive Compounds Suppress Proliferation and Induce Apoptosis in Both Androgen-Dependent and - Independent Prostate Cancer Cell Lines

# publications[].label
Estrogenic Endocrine Disruptors: Molecular Characteristics and Human Impacts

# publications[].label
Chlorobiphenylols. Thin-layer chromatography and colour reactions of some hydroxylated chlorobiphenyls.

# publications[].label
Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast cancer cells.

# publications[].label
Transcriptional activation of estrogen-induced gene expression through estrogen receptor Sp1 complexes.

# publications[].label
Novel coumarins as potential anticarcinogenic agents.

# publications[].label
17beta-estradiol (E2) induces cdc25A gene expression in breast cancer cells by genomic and non-genomic pathways.

# publications[].label
Characterization of the molecular and structural properties of the transformed and nuclear aryl hydrocarbon (Ah) receptor complexes by proteolytic digestion.

# publications[].label
1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
PCB isomers and congeners: induction of aryl hydrocarbon hydroxylase and ethoxyresorufin O-deethylase enzyme activities in rat hepatoma cells.

# publications[].label
Structure-dependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats.

# publications[].label
ANALYSIS OF AN AROMATIC SOLVENT USED IN A FOREST SPRAY PROGRAM

# publications[].label
PCDDs and Related Compounds: Metabolism and Biochemistry

# publications[].label
EFFECT OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) ON SPERMATOGENESIS AND LEYDIG-CELL VOLUME IN ADULT-RATS

# publications[].label
Erratum: X-Ray crystallographic determination of the stereochemistry of the tetrathio-bridge in sporidesmin G (J.C.S. Chem. Comm. (1973), (554))

# publications[].label
[H-3] 2,3,7,8-TETRACHLORODIBENZOFURAN (TCDF)-SYNTHESIS AND CHARACTERIZATION AS A RADIOLIGAND FOR THE AH RECEPTOR

# publications[].label
PCBs: structure-function relationships and mechanism of action.

# publications[].label
ANALYSIS OF ORGANOCHLORINE METABOLITES IN CRUDE EXTRACTS BY HIGH-RESOLUTION PHOTOPLATE MASS-SPECTROMETRY

# publications[].label
Compensatory Expression of Nur77 and Nurr1 Regulates NF-B-Dependent Inflammatory Signaling in Astrocytes.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis.

# publications[].label
A Chalcone Synthase-like Bacterial Protein Catalyzes Heterocyclic C-Ring Cleavage of Naringenin to Alter Bioactivity Against Nuclear Receptors in Colonic Epithelial Cells.

# publications[].label
The origin, fate, and health effects of combustion by-products: a research framework.

# publications[].label
Human chorionic gonadotropin protects Leydig cell function against 2,3,7,8-tetrachlorodibenzo-p-dioxin in adult rats: role of Leydig cell cytoplasmic volume.

# publications[].label
DIOXINS AND FURANS IN THE ENVIRONMENT: EVALUATING TOXICOLOGICAL RISK FROM DIFFERENT SOURCES BY MULTI-CRITERIA ANALYSIS.

# publications[].label
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor.

# publications[].label
POSSIBLE INTERRELATIONSHIP BETWEEN TCDD AND INTERLEUKIN-1 AS ANTIPROLIFERATIVE AGENTS IN HUMAN BREAST-CANCER CELLS

# publications[].label
Transcriptional activation of rat creatine kinase B by 17beta-estradiol in MCF-7 cells involves an estrogen responsive element and GC-rich sites.

# publications[].label
The metabolism of higher chlorinated benzene isomers.

# publications[].label
Bis-indole-derived NR4A1 antagonists inhibit colon tumor and splenic growth and T-cell exhaustion.

# publications[].label
ChemInform Abstract: NATURAL ACETYLENES. PART XLIX. POLYACETYLENES FROM DAHLIA SCAPIGERA (A. DIETR.) LINK AND OTTO VAR. SCAPIGERA F. SCAPIGERA AND SOME DAHLIA HYBRIDS

# publications[].label
2-Phenylphenanthridinone and related compounds: aryl hydrocarbon receptor agonists and suicide inactivators of P4501A1.

# publications[].label
Chlorine randomization between phenyl groups in the electron impact-induced fragmentation of polychlorinated biphenyls

# publications[].label
The in vitro metabolism, macromolecular binding and bacterial mutagenicity of 4-chloribiphenyl, a model PCB substrate.

# publications[].label
RISK ASSESSMENT OF PCDDS AND PCDFS BASED ON INVITRO AND INVIVO BIOASSAYS

# publications[].label
TIME COURSE OF INDUCTION BY AROCLOR 1254 OF THREE FORMS OF CYTOCHROME-P-450 AND EPOXIDE HYDROLASE (EH) IN RAT-LIVER MICROSOMES

# publications[].label
Toxicity of 3,3',4,4'- and 2,2',5,5'-tetrabromobiphenyl: correlation of activity with aryl hydrocarbon hydroxylase induction and lack of protection by antioxidants.

# publications[].label
Comparative 32P-postlabeling analysis of exogenous and endogenous DNA adducts in mouse skin exposed to a wood-preserving waste extract, a complex mixture of polycyclic and polychlorinated chemicals.

# publications[].label
Relative sensitivities of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced Cyp1a-1 and Cyp1a-2 gene expression and immunotoxicity in female B6C3F1 mice.

# publications[].label
DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs.

# publications[].label
Preparation of cis and transd3alkenoic acids

# publications[].label
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.

# publications[].label
VIRAL INTERACTION WITH PESTICIDE EMULSIFIERS INVIVO

# publications[].label
Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach

# publications[].label
ChemInform Abstract: ISOLATION AND SYNTHESIS OF E24ETHYLIDENE5LANOST8EN3YL ACETATE

# publications[].label
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase.

# publications[].label
MOLECULAR-PROPERTIES OF CYTOSOLIC AND NUCLEAR TCDD RECEPTOR COMPLEXES FROM MOUSE HEPATOMA-CELL LINES

# publications[].label
Contamination of agricultural products by halogenated biphenyls.

# publications[].label
Binding of metyrapone to dithionite-reduced cytochrome P-450 from rats treated with xenobiotics.

# publications[].label
Metabolism of aflatoxin B1 by rat hepatic microsomes induced by polyhalogenated biphenyl congeners.

# publications[].label
PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene.

# publications[].label
SYNTHESIS AND CHARACTERIZATION OF 22 PURIFIED POLYCHLORINATED DIBENZOFURAN CONGENERS

# publications[].label
Ah receptor-independent induction of CYP1A2 gene expression in genetically inbred mice.

# publications[].label
Estrogen- and antiestrogen-responsiveness of HEC1A endometrial adenocarcinoma cells in culture.

# publications[].label
Mechanism of action of alpha-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells.

# publications[].label
Absence of positive co-operativity in the binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to its cytosolic receptor protein.

# publications[].label
Naringenin: a weakly estrogenic bioflavonoid that exhibits antiestrogenic activity.

# publications[].label
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on insulin-induced responses in MCF-7 human breast cancer cells.

# publications[].label
Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists.

# publications[].label
Transcriptional activation of thymidylate synthase by 17beta-estradiol in MCF-7 human breast cancer cells.

# publications[].label
MODULATION OF HEPATIC 2,3,7,8-TCDD CYTOSOLIC RECEPTOR LEVELS BY PCBS AND ORGANOCHLORINE POLLUTANTS

# publications[].label
Effect of tolfenamic acid on canine cancer cell proliferation, specificity protein (sp) transcription factors, and sp-regulated proteins in canine osteosarcoma, mammary carcinoma, and melanoma cells.

# publications[].label
Organochlorine exposure and risk for breast cancer.

# publications[].label
Interleukin-24 (IL24) Is Suppressed by PAX3-FOXO1 and Is a Novel Therapy for Rhabdomyosarcoma.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Reactive Oxygen Species (ROS)-Inducing Triterpenoid Inhibits Rhabdomyosarcoma Cell and Tumor Growth through Targeting Sp Transcription Factors.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
CF3DODA-Me induces apoptosis, degrades Sp1, and blocks the transformation phase of the blebbishield emergency program.

# publications[].label
Hydroxylated polychlorinated Biphenyls (PCBs) and Organochlorine Pesticides as Potential Endocrine Disruptors

# publications[].label
GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds.

# publications[].label
Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer.

# publications[].label
Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
POLYCHLORINATED-BIPHENYLS - CONGENER-SPECIFIC ANALYSIS OF A COMMERCIAL MIXTURE AND A HUMAN-MILK EXTRACT

# publications[].label
METABOLISM OF P,P'-ISOMERS OF DDT COMPOUNDS IN PIG

# publications[].label
Non-dioxin-like AhR ligands in a mouse peanut allergy model.

# publications[].label
Ovine ill-thrift in Nova Scotia. 4. The survival at low oxygen partial pressure of fungi isolated from the contents of the ovine rumen.

# publications[].label
Ring-DIMs induce mitochondrial dysfunction and ER stress in human prostate cancer cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Coactivation of estrogen receptor alpha (ER alpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150).

# publications[].label
Dietary -Tocopherol-Rich Mixture Inhibits Estrogen-Induced Mammary Tumorigenesis by Modulating Estrogen Metabolism, Antioxidant Response, and PPAR.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Aflatoxin B1 metabolism in the rat: polyhalogenated biphenyl enhanced conversion to aflatoxin M1.

# publications[].label
STRUCTURE-DEPENDENT REDUCTION IN DNA I-COMPOUND ADDUCTS BY POLYCHLORINATED DIBENZOFURANS IN FEMALE SPRAGUE-DAWLEY RAT-LIVER

# publications[].label
Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements.

# publications[].label
Sporidesmins. Part XI. The reaction of triphenylphosphine with epipolythiodioxopiperazines

# publications[].label
Halogenated aromatic hydrocarbons suppress CA1 field excitatory postsynaptic potentials in rat hippocampal slices.

# publications[].label
Detection of the ergosterol and episterol isomers lichesterol and fecosterol in nystatin-resistant mutants of Neurospora crassa.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation.

# publications[].label
Reviews in biochemical toxicology Vol. V. E. Hodgson, J. R. Bend, and R. M. Philpot, Editors, Elsevier Biomedical, New York, 1983.415 pp, $60.00 (U.S.)

# publications[].label
Potent induction of rat liver microsomal, drug-metabolizing enzymes by 2,3,3',4,4',5-hexabromobiphenyl, a component of fireMaster.

# publications[].label
Template-free fabrication of vertically-aligned polymer nanowire array on the flat-end tip for quantifying the single living cancer cells and nanosurface interaction

# publications[].label
The effects of ortho chloro substituents on the retention of PCB isomers in rat, rabbit, Japanese quail, guinea pig and trout.

# publications[].label
The metabolism of 2,2,4,45,5-hexachlorobiphenyl by rabbits, rats and mice

# publications[].label
Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.

# publications[].label
Neonatal modulation of adult rat hepatic microsomal benzo[a]pyrene hydroxylase activities by Aroclor 1254 or phenobarbital.

# publications[].label
Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells.

# publications[].label
Natural acetylenes. Part XXIII. A C 18 polyacetylenic keto-aldehyde related to falcarinone from an Umbellifer ( Pastinaca sativa L.)

# publications[].label
Polychlorinated biphenyls as a classic case of environmental pollution (Dutch)

# publications[].label
THE EFFECTS OF RECEPTOR MODULATORS ON THE AHH INDUCTION ACTIVITY OF 2,3,7,8-TCDD IN C57BL/6 AND DBA/2 MICE

# publications[].label
Induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by a series of 4'-substituted-2,3,4,5-tetrachlorobiphenyls.

# publications[].label
Transcriptional activation of cathepsin D gene expression by growth factors.

# publications[].label
CHLORINATED TRANS STILBENES - COMPETITIVE-BINDING TO THE AH RECEPTOR, INDUCTION OF CYTOCHROME-P-450 MONOOXYGENASE ACTIVITY AND PARTIAL 2,3,7,8-TCDD ANTAGONISM

# publications[].label
Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
3,3'-Diindolylmethane and 1,4-dihydroxy-2-naphthoic acid prevent chronic mild stress induced depressive-like behaviors in female mice.

# publications[].label
Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells.

# publications[].label
Erratum: 3,3'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and-independent prostate cancer cells.

# publications[].label
Natural Products in the Prevention of Metabolic Diseases: Lessons Learned from the 20th KAST Frontier Scientists Workshop.

# publications[].label
Endocrine disruption: Relevance of experimental studies in female animals to human studies

# publications[].label
Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells.

# publications[].label
In vitro metabolism of 4-chlorobiphenyl by control and induced rat liver microsomes.

# publications[].label
Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes.

# publications[].label
Biphasic modulation of protein kinase C (PKC) activity by polychlorinated dibenzo-p-dioxins (PCDDs) in serum-deprived rat aortic smooth muscle cells.

# publications[].label
Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells.

# publications[].label
DETERMINATION OF 2,3,7,8-TCDD TOXIC EQUIVALENT FACTORS (TEFS) - SUPPORT FOR THE USE OF THE INVITRO AHH INDUCTION ASSAY

# publications[].label
Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells.

# publications[].label
Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review).

# publications[].label
Role of the Aryl Hydrocarbon Receptor (AhR) in Mediating the Effects of Coffee in the Colon.

# publications[].label
Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions.

# publications[].label
The Histone Methyltransferase Gene G9A Is Regulated by Nuclear Receptor 4A1 in Alveolar Rhabdomyosarcoma Cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Single-cell RNA Sequencing Reveals How the Aryl Hydrocarbon Receptor Shapes Cellular Differentiation Potency in the Mouse Colon.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation

# publications[].label
Octachloronaphthalene induction of hepatic microsomal aryl hydrocarbon hydroxylase activity in the immature male rat.

# publications[].label
Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells.

# publications[].label
Chemospheric evaluation - Toxic equivalency factors do not predict the acute toxicities of dioxins in rats - Comment

# publications[].label
NR4A1 ligands inhibits PSPC1 regulated EMT and stemness markers in breast, lung and liver cancer cells.

# publications[].label
Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways.

# publications[].label
Characterization of the aryl hydrocarbon receptor and aryl hydrocarbon responsiveness in human ovarian carcinoma cell lines.

# publications[].label
Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs.

# publications[].label
DEVELOPMENT, VALIDATION AND LIMITATIONS OF TOXIC EQUIVALENCY FACTORS

# publications[].label
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on I-compounds in hepatic DNA of Sprague-Dawley rats: sex-specific effects and structure-activity relationships.

# publications[].label
Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin.

# publications[].label
Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target.

# publications[].label
Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells.

# publications[].label
Immunosuppressive effects of highly chlorinated biphenyls and diphenyl ethers on T-cell dependent and independent antigens in mice.

# publications[].label
Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth.

# publications[].label
Eburicol, lichesterol, ergosterol, and obtusifoliol from polyene antibiotic-resistant mutants of Candida albicans.

# publications[].label
Chapter 52 Toxicity Equivalents and Their Use in Hazard and Risk Assessment

# publications[].label
Applications of the in vitro aryl hydrocarbon hydroxylase induction assay for determining "2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents": pyrolyzed brominated flame retardants.

# publications[].label
Nanotechnology systems for drug delivery, multi-modal targeting and imaging of tumors

# publications[].label
Citrus limonoids induce apoptosis and inhibit the proliferation of pancreatic cancer cells.

# publications[].label
Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens.

# publications[].label
Mechanism of benzo[a]pyrene-induced Cyp1a-1 gene expression in mouse Hepa 1c1c7 cells: role of the nuclear 6 s and 4 s proteins.

# publications[].label
Autophagy inhibition improves the chemotherapeutic efficacy of cruciferous vegetable-derived diindolymethane in a murine prostate cancer xenograft model.

# publications[].label
The role of xenoestrogenic compounds in the development of breast cancer.

# publications[].label
17 beta-Estradiol-mediated growth inhibition of MDA-MB-468 cells stably transfected with the estrogen receptor: cell cycle effects.

# publications[].label
A general method for the preparation of tritiated polychlorobiphenyls of high specific activity: 2,2',5,5'-tetrachlorobiphenyl-(3H) and 2,2',4,4',5,5'-hexachlorobiphenyl-(3H).

# publications[].label
Avian metabolism of halogenated biphenyls.

# publications[].label
Induction of cytochrome P450-dependent monooxygenase activities in rat hepatoma H-4-IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: mechanistic studies using radiolabeled congeners.

# publications[].label
The mass spectra of polychlorinated biphenyls.

# publications[].label
Erratum: The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53

# publications[].label
The p38 MAPK pathway is critical for 5,5'-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells.

# publications[].label
Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL/6 mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related congeners: mechanistic studies.

# publications[].label
GC/MS STUDIES OF SPECIFIC CONGENERS OF POLYCHLORODIBENZOFURANS.

# publications[].label
Nuclear receptor 4A2 (NR4A2) is a druggable target for glioblastomas.

# publications[].label
Comments on ''Developmental neurotoxicity of PCBs in humans: What do we know and where do we go from here?'' Reply

# publications[].label
Estrogen-induced retinoic acid receptor alpha 1 gene expression: role of estrogen receptor-Sp1 complex.

# publications[].label
Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum.

# publications[].label
Dietary and environmental estrogens and antiestrogens and their possible role in human disease.

# publications[].label
Inhibition of carcinogen-induced rat mammary tumor growth and other estrogen-dependent responses by symmetrical dihalo-substituted analogs of diindolylmethane.

# publications[].label
Comparative hazards: Chemicals in the environment are the largest risk to human health

# publications[].label
STEROLS OF THREE LICHEN SPECIES - LOBARIA-PULMONARIA, LOBARIA-SCROBICULATA AND USNEA-LONGISSIMA

# publications[].label
APPLICATIONS OF THE INVITRO AHH INDUCTION BIOASSAY FOR DETERMINING 2,3,7,8-TCDD EQUIVALENTS - PYROLYZED FLAME-RETARDANT MIXTURES

# publications[].label
CONGENER-SPECIFIC EFFECTS OF DIOXINS ON NEURAL CELLS

# publications[].label
A Chalcone Synthase-Like Bacterial Protein Catalyzes Heterocyclic C-Ring Cleavage of Naringenin to Alter Bioactivity Against Nuclear Receptors in Colonic Epithelial Cells

# publications[].label
Preparation, gas chromatographic behavior, and spectroscopic properties of hydroxylated chlorobiphenyls.

# publications[].label
Environmental levels and toxicological potencies of a novel mixed halogenated carbazole

# publications[].label
Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines.

# publications[].label
Mass Spectra of the Hydroxyindole-3-carboxylic Acids and the Hydroxyskatoles

# publications[].label
Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses.

# publications[].label
Omeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway.

# publications[].label
Sp transcription factor family and its role in cancer.

# publications[].label
The need for cellular, biochemical, and mechanistic studies.

# publications[].label
THE EFFECTS OF CYTOSOLIC RECEPTOR MODULATION ON THE AHH-INDUCING ACTIVITY OF 2,3,7,8-TCDD

# publications[].label
Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity.

# publications[].label
7-SUBSTITUTED-2,3-DICHLORODIBENZO-PARA-DIOXINS AS COMPETITIVE LIGANDS FOR THE AH RECEPTOR - QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS (QSARS) AND A COMPARISON OF HUMAN RECEPTOR WITH AH RECEPTOR FROM RODENTS

# publications[].label
Activation of Genes by Nuclear Receptor/Specificity Protein (Sp) Interactions in Cancer.

# publications[].label
Dual Targeting of Orphan Nuclear Receptors NR4A1 and NR4A2 for Non-Hormonal Endometriosis Therapy.

# publications[].label
Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10.

# publications[].label
Transcription factor Sp1, also known as specificity protein 1 as a therapeutic target.

# publications[].label
MDM2 regulates estrogen receptor  and estrogen responsiveness in breast cancer cells.

# publications[].label
TOXIC EQUIVALENCY FACTORS FOR DIOXIN-LIKE PCBS - REPORT ON A WHO-ECEH AND IPCS CONSULTATION, DECEMBER 1993

# publications[].label
Organochlorine residues and breast cancer.

# publications[].label
PCBS AS MICROSOMAL-ENZYME INDUCERS - STRUCTURE-ACTIVITY RULES

# publications[].label
The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis.

# publications[].label
Identification of estrogen-induced genes downregulated by AhR agonists in MCF-7 breast cancer cells using suppression subtractive hybridization.

# publications[].label
Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent.

# publications[].label
Effects of polychlorinated dibenzofurans on compounds in hepatic DNA of female Sprague-Dawley rats: structure dependence and mechanistic considerations.

# publications[].label
ROLE OF THE AH RECEPTOR IN MEDIATING THE DOWN REGULATION OF UTERINE AND HEPATIC ESTROGEN-RECEPTOR LEVELS IN RATS

# publications[].label
TISSUE DISTRIBUTION AND CLEARANCE OF AEROTEX 3470, AN AROMATIC HYDROCARBON SOLVENT

# publications[].label
Effects of sesquiterpene lactones on mitochondrial oxidative phosphorylation.

# publications[].label
DETECTION OF ENZYME-INDUCTION BY RAT-LIVER MICROSOMES PREPARED BY ISOELECTRIC PRECIPITATION

# publications[].label
Effects of substituents on the cytosolic receptor-binding avidities and aryl hydrocarbon hydroxylase induction potencies of 7-substituted 2,3-dichlorodibenzo-p-dioxins. A quantitative structure-activity relationship analysis.

# publications[].label
Developing Lipid Nanoparticle-Based siRNA Therapeutics for Hepatocellular Carcinoma Using an Integrated Approach

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
COMPARATIVE METABOLISM OF HALOGENATED BIPHENYLS

# publications[].label
Toxicological and pathophysiological roles of reactive oxygen and nitrogen species (vol 276, pg 85, 2010)

# publications[].label
Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition.

# publications[].label
Enhanced virus replication in mammalian cells exposed to commercial emulsifiers.

# publications[].label
The comparative biologic and toxic potencies of polychlorinated biphenyls and polybrominated biphenyls.

# publications[].label
Growth inhibitory and antimitogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in T47D human breast cancer cells.

# publications[].label
7-Methyl-7-hexadecenoic acid: isolation from lipids of the ocean sunfish Mola mola (Linnaeus) 1758.

# publications[].label
Structure-dependent activation of gene expression by bis-indole and quinoline-derived activators of nuclear receptor 4A2.

# publications[].label
The in vitro hydroxylation of 4'-chloro-4-biphenylol by a mushroom tyrosinase preparation.

# publications[].label
AGFD 243-Potential of citrus limonoids in pancreatic cancer prevention

# publications[].label
Analysis of benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line.

# publications[].label
Comparative kinetic study of the binding between 2,3,7,8-tetrachlorodibenzo-p-dioxin and related ligands with the hepatic Ah receptors from several rodent species.

# publications[].label
Piperlongumine Induces Reactive Oxygen Species (ROS)-Dependent Downregulation of Specificity Protein Transcription Factors.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Intestinal epithelium aryl hydrocarbon receptor is involved in stress sensitivity and maintaining depressive symptoms.

# publications[].label
Evidence for the mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant mouse Hepa 1c1c7 cells.

# publications[].label
Cellular and genetic basis for suppression of cytotoxic T cell generation by haloaromatic hydrocarbons.

# publications[].label
Aryl hydrocarbon receptor (AHR)-active pharmaceuticals are selective AHR modulators in MDA-MB-468 and BT474 breast cancer cells.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes.

# publications[].label
Aryl hydrocarbon hydroxylase induction and its relationship to the toxicity of halogenated aryl hydrocarbons

# publications[].label
Metabolism of the systemic fungicides 2-methylbenzanilide and 2-chlorobenzanilide by Rhizopus japonicus

# publications[].label
Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner.

# publications[].label
Identification of metabolic dechlorination of highly chlorinated biphenyl in rabbit.

# publications[].label
Comparative potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in male Wistar rats--assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs).

# publications[].label
BACTERIAL MUTAGENICITY OF SOIL EXTRACTS FROM A BIOREMEDIATION FACILITY TREATING WOOD-PRESERVING WASTE

# publications[].label
1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes inhibit growth, induce apoptosis, and decrease the androgen receptor in LNCaP prostate cancer cells through peroxisome proliferator-activated receptor gamma-independent pathways.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Development of an in vitro model for investigating the formation of the nuclear Ah receptor complex in mouse Hepa 1c1c7 cells.

# publications[].label
Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.

# publications[].label
MASS-SPECTROMETRY OF POLYCYCLIC AROMATIC-HYDROCARBONS BY LINKED-SCAN STUDIES OF METASTABLE IONS

# publications[].label
Carcinogenicity of benzo[a]pyrene and manufactured gas plant residues in infant mice.

# publications[].label
Lysosomal membrane labilization by DDT, DDE and polychlorinated biphenyls (PCB).

# publications[].label
COMPARATIVE CAPILLARY GC/MS OF STANDARD SOLUTIONS OF CHLORINATED BIPHENLYS.

# publications[].label
Regulation of vascular endothelial growth factor receptor-2 expression in pancreatic cancer cells by Sp proteins.

# publications[].label
TOXICOLOGICAL SIGNIFICANCE OF NON-ORTHO-SUBSTITUTED, MONO-ORTHO-SUBSTITUTED AND DI-ORTHO-SUBSTITUTED POLYCHLORINATED-BIPHENYLS IN OYSTERS FROM GALVESTON AND TAMPA BAYS

# publications[].label
Identification of a toxic impurity in commercial diphenylamine.

# publications[].label
Nuclear receptor 4A (NR4A) family - orphans no more.

# publications[].label
Absorption and biological activity of phytochemical-rich extracts from aai (Euterpe oleracea Mart.) pulp and oil in vitro.

# publications[].label
Identification of 4-chloro-4'-hydroxybiphenyl and 4,4'-dichloro-3-hydroxybiphenyl as metabolites of 4-chloro- and 4,4'-dichlorobiphenyl fed to rats.

# publications[].label
Identification of 3'-methoxy-4'-nitroflavone as a pure aryl hydrocarbon (Ah) receptor antagonist and evidence for more than one form of the nuclear Ah receptor in MCF-7 human breast cancer cells.

# publications[].label
RESVERATROL BINDS NUCLEAR RECEPTOR 4A1 (NR4A1) AND ACTS AS AN NR4A1 ANTAGONIST IN LUNG CANCER CELLS.

# publications[].label
VAPOR-PRESSURE MEASUREMENTS ON HALOGENATED DIBENZO-PARA-DIOXINS AND DIBENZOFURANS - AN EXTENDED DATA SET FOR A CORRELATION METHOD

# publications[].label
Methods for the study of metabolism of toxic and persistent chemicals in aquatic organisms as exemplified by chloronaphthalene

# publications[].label
Transcriptional activation of transforming growth factor alpha by estradiol: requirement for both a GC-rich site and an estrogen response element half-site.

# publications[].label
The Role of Self-Nanoemulsifying Drug Delivery Systems of CDODA-Me in Sensitizing Erlotinib-Resistant Non-Small Cell Lung Cancer.

# publications[].label
Immunosuppressive and monooxygenase induction activities of highly chlorinated diphenyl ether congeners in C57BL/6 and DBA/2 mice.

# publications[].label
Toxicological significance of non-, mono- and di-ortho-substituted polychlorinated biphenyls in oysters from galveston and tampa bays

# publications[].label
CXCL11-CXCR3 Axis Mediates Tumor Lymphatic Cross Talk and Inflammation-Induced Tumor, Promoting Pathways in Head and Neck Cancers.

# publications[].label
Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT.

# publications[].label
POLYCHLORINATED DIBENZO-PARA-DIOXINS AND RELATED-COMPOUNDS - SOURCES, ENVIRONMENTAL DISTRIBUTION AND RISK ASSESSMENT

# publications[].label
The effect of 6-nitro-1,3,8-trichlorodibenzofuran as a partial estrogen in the female rat uterus.

# publications[].label
Transcriptional activation of genes by 17 beta-estradiol through estrogen receptor-Sp1 interactions.

# publications[].label
The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Halogenated hydrocarbons and aryl hydrocarbons identified in human tissues

# publications[].label
Targeting Lineage-Specific Functions of NR4A1 for Cancer Immunotherapy.

# publications[].label
Effects of structure on binding to the 2,3,7,8-TCDD receptor protein and AHH induction--halogenated biphenyls.

# publications[].label
Novel diindolylmethane derivatives based NLC formulations to improve the oral bioavailability and anticancer effects in triple negative breast cancer.

# publications[].label
Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors.

# publications[].label
Hydroxylated Chalcones as Aryl Hydrocarbon Receptor Agonists: Structure-Activity Effects.

# publications[].label
Vascular endothelial growth factor receptor-2 expression is down-regulated by 17beta-estradiol in MCF-7 breast cancer cells by estrogen receptor alpha/Sp proteins.

# publications[].label
IMMUNOMODULATION BY TARGETING PDL-1 IN COLON CANCER USING NUCLEAR RECEPTOR 4A1 (NR4A1) ANTAGONISTS

# publications[].label
HALOGENATED HYDROCARBONS IN HUMAN-TISSUE - BIOLOGIC AND TOXIC EFFECTS

# publications[].label
A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation.

# publications[].label
Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

# publications[].label
VALIDATION OF THE AHH INDUCTION BIOASSAY FOR THE DETERMINATION OF 2,3,7,8-TCDD TOXIC EQUIVALENTS

# publications[].label
Male sexual development in "a sea of oestrogen".

# publications[].label
Ah receptor ligands and their impacts on gut resilience: structure-activity effects.

# publications[].label
Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells.

# publications[].label
Inhalation delivery of a novel diindolylmethane derivative for the treatment of lung cancer.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
The detection of enzyme induction by rat liver microsomes prepared by isoelectric precipitation.

# publications[].label
17 beta-estradiol- and 4-hydroxytamoxifen-induced transactivation in breast, endometrial and liver cancer cells is dependent on ER-subtype, cell and promoter context.

# publications[].label
The structure-dependent effects of heptachlorodibenzofuran isomers in male C57BL/6 mice: immunotoxicity and monooxygenase enzyme induction.

# publications[].label
Development of bioassays and approaches for the risk assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.

# publications[].label
Lethal interaction of ubiquitous insecticide carriers with virus.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Human Contamination of the Marine Environment-Arthur Harbor and McMurdo Sound, Antarctica.

# publications[].label
3,3'4,4'-Tetrachlorobiphenyl exhibits antiestrogenic and antitumorigenic activity in the rodent uterus and mammary cells and in human breast cancer cells.

# publications[].label
Retention times and electron-capture detector responses of some individual chlorobiphenyls.

# publications[].label
Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells.

# publications[].label
KINETICS OF THE INTERACTION BETWEEN 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN AND THE AH RECEPTOR PROTEIN

# publications[].label
Metabolism of bromobenzenes in the rabbit.

# publications[].label
Endocrine Screening Methods Workshop report: detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms.

# publications[].label
Environmental chemistry of PCB - replacement compounds II. Photochemical properties of alkylchlorobiphenyls

# publications[].label
EFFECTS OF 2,3,7,8-TCDD AND RELATED-COMPOUNDS ON THE LEVELS OF AGE-DEPENDENT I-SPOT DNA ADDUCTS IN THE LIVER OF FEMALE AND MALE SPRAGUE-DAWLEY RATS

# publications[].label
Regulation of KiSS-1 metastasis suppressor gene expression in breast cancer cells by direct interaction of transcription factors activator protein-2alpha and specificity protein-1.

# publications[].label
Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs).

# publications[].label
Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins.

# publications[].label
Pharmacokinetic evaluation and in vitro-in vivo correlation (IVIVC) of novel methylene-substituted 3,3' diindolylmethane (DIM).

# publications[].label
The cytochrome P-450-mediated metabolism of biphenyl and the 4-halobiphenyls.

# publications[].label
High-resolution PCB analysis: synthesis and chromatographic properties of all 209 PCB congeners.

# publications[].label
Dioxin as an Environmental Pollutant and Its Role in Breast Cancer

# publications[].label
Characterization of calcium oscillations in normal and benzo[a]pyrene-treated clone 9 cells.

# publications[].label
CORRELATION BETWEEN BIOASSAY-DERIVED P4501A1 INDUCTION ACTIVITY AND CHEMICAL-ANALYSIS OF CLAM (LATERNULA-ELLIPTICA) EXTRACTS FROM MCMURDO SOUND, ANTARCTICA

# publications[].label
PROPERTIES OF THE 2,3,7,8-TCDD RECEPTOR - A QSAR APPROACH

# publications[].label
NATURAL ACETYLENES .49. POLYACETYLENES FROM DAHLIA-SCAPIGERA (A DIETR) LINK AND OTTO VAR SCAPIGERA-F-SCAPIGERA AND SOME DAHLIA HYBRIDS

# publications[].label
Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
HUMAN BREAST-CANCER CELL-LINES AS MODELS FOR INVESTIGATING THE EFFECTS OF 2,3,7,8-TCDD AND RELATED-COMPOUNDS

# publications[].label
Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Nurr1 in Glial Cells as a Disease-Modifying Target for Parkinson's Disease

# publications[].label
miR-150 regulates obesity-associated insulin resistance by controlling B cell functions.

# publications[].label
Isolation and characterization of variant benzo[a]pyrene-resistant T47D human breast-cancer cells

# publications[].label
Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems.

# publications[].label
LETHAL INTERACTION OF INSECTICIDE CARRIERS WITH VIRUS

# publications[].label
A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro.

# publications[].label
Aflatoxin B1 hydroxylation by the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450.

# publications[].label
Potentiation of CYP1A1 gene expression in MCF-7 human breast cancer cells cotreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 12-O-tetradecanoylphorbol-13-acetate.

# publications[].label
MicroRNA-223 is a crucial mediator of PPAR-regulated alternative macrophage activation.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Estrogenic and antiestrogenic activities of 16alpha- and 2-hydroxy metabolites of 17beta-estradiol in MCF-7 and T47D human breast cancer cells.

# publications[].label
Endocrine disrupting chemicals research program of the U.S. Environmental Protection Agency: summary of a peer-review report.

# publications[].label
TGF-Induced Lung Cancer Cell Migration Is NR4A1-Dependent.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
The in vitro metabolism of benzo[a]pyrene by polychlorinated and polybrominated biphenyl induced rat hepatic microsomal monooxygenases.

# publications[].label
Orphan Nuclear Receptor 4A1 (NR4A1) and NR4A2are Endogenous Regulators of CD71 and TheirLigands Induce Ferroptosis in Breast Cancer.

# publications[].label
BINDING OF SUBSTITUTED ARYL HYDROCARBONS TO THE AH RECEPTOR - A QSAR ANALYSIS

# publications[].label
Induction of 16alpha-/2-hydroxyestrone metabolite ratios in MCF-7 cells by pesticides, carcinogens, and antiestrogens does not predict mammary carcinogens.

# publications[].label
3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM.

# publications[].label
A Bis-Indole-Derived NR4A1 Antagonist Induces PD-L1 Degradation and Enhances Antitumor Immunity.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Comparative activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and progesterone as antiestrogens in the female rat uterus.

# publications[].label
Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors.

# publications[].publisher
American Association for Cancer Research (AACR)

# researcherOn[].label
Texas A&M Center for Environmental Health Research

# researcherOn[].awardedBy.label
National Institute of Environmental Health Sciences - (Durham, North Carolina, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Environmental Health Sciences

# researcherOn[].label
Role of Aryl Hydrocarbon Receptor in Microbiota-Colon Stem Cell Interactions

# researcherOn[].awardedBy.label
National Institute of Environmental Health Sciences - (Durham, North Carolina, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Environmental Health Sciences

# researcherOn[].label
A Novel Approach for Targeting Pediatric Sarcoma

# researcherOn[].label
Micrornas As Targets for Colon Cancer Chemotherapy

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Molecular Mechanisms and Application of Ah Receptor - Microrna Interactions

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Aryl Hydrocarbon Receptor Mediated Modulation of Colorectal Cancer by Microbiota Metabolites

# researcherOn[].awardedBy.label
Cancer Prevention and Research Institute of Texas - (Austin, Texas, United States)

# researcherOn[].label
Cytosolic Ah Receptor:  Mechanism of Action

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Nutrition, Biostatistics and Bioinformatics Training Grant

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Dietary Flavonoids-Microbiota-Ah Receptor Interactions in the Gut

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Center for Complementary and Alternative Medicine

# researcherOn[].label
Diet induced modifications of microbiota metabolites in colon tumorigenesis

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M University; Vet Med - Physiology & Pharmacology; 4466 TAMU

# organizations[]
College of Veterinary Medicine and Biomedical Sciences

# organizations[]
College of Agriculture and Life Sciences

# organizations[]
"College of Veterinary Medicine and Biomedical Sciences"@en-US

# schools[]
College of Agriculture and Life Sciences

# schools[]
College of Veterinary Medicine and Biomedical Sciences

# schools[]
"College of Veterinary Medicine and Biomedical Sciences"@en-US

# inTheNews[].label
Texas A&M Announces 2020 Distinguished Achievement Award Recipients

# etdChairOf[].label
Li, Xiangrong (2005-05). Hormonal activation of genes through nongenomic pathways by estrogen and structurally diverse estrogenic compounds. Doctoral Dissertation.

# etdChairOf[].label
Guthrie, Aaron S 1987- (2012-12). Phenethyl Isothiocyanate (PEITC) Decreases Specficity Protein (SP) Tanscription Factors through an ROS-dependent Mechanism. Master's Thesis.

# etdChairOf[].label
Pathi, Satya (2012-08). Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Colon Cancer. Doctoral Dissertation.

# etdChairOf[].label
Chintharlapalli, Sudhakar Reddy (2003-05). New mechanism-based anticancer drugs that act as orphan nuclear receptor agonists. Doctoral Dissertation.

# etdChairOf[].label
Wu, Fei (2007-12). Comparative activation of estrogen receptor alpha (er alpha) by endocrine disruptors. Doctoral Dissertation.

# etdChairOf[].label
Zhang, Shu (2007-12). Role of estrogen receptor alpha (ER alpha) insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells. Doctoral Dissertation.

# etdChairOf[].label
Higgins, Kelly Jean (2007-09). Regulation of vascular endothelial growth factor receptor-2 in pancreatic and breast cancer cells by Sp proteins. Doctoral Dissertation.

# etdChairOf[].label
Lee, Jeong Eun (2004-12). Mechanisms of aryl hydrocarbon receptor and estrogen receptor action in breast cancer cells. Doctoral Dissertation.

# etdChairOf[].label
Hou, Tim Yu-Tien (2014-12). n-3 Polyunsaturated Fatty Acids Alter Mouse CD4+ T Cell Activation by Modifying the Lipid Bilayer Properties. Doctoral Dissertation.

# etdChairOf[].label
Sreevalsan, Sandeep (2013-05). Molecular Mechanisms of Cannabinoids as Anti-cancer Agents. Doctoral Dissertation.

# etdChairOf[].label
Partridge, Charles Randal (2007-04). Identification and molecular characterization of novel genomic targets in oxidant-induced vascular injury. Doctoral Dissertation.

# etdChairOf[].label
Kim, KyoungHyun (2004-08). Domain analysis for estrogen receptor/Sp1-mediated transactivation and detection of estrogen receptor/Sp1 protein interactions in living cells. Doctoral Dissertation.

# etdChairOf[].label
Nemec, Matthew James (2016-08). Polyphenolics from Mango (Mangifera Indica L.) Suppress Breast Cancer Ductal Carcinoma In Situ Proliferation Both In Vitro And In Vivo: Potential Role of the IGFR-1-AKT-AMPK-mTOR-Signaling Axis. Doctoral Dissertation.

# etdChairOf[].label
York, Melissa Dawn (2007-08). 1,1-bis(3-indolyl)-1-(p-substitutedphenyl) methanes induce apoptosis and inhibit renal cell carcinoma growth. Master's Thesis.

# etdChairOf[].label
Hosako, Hiromi (2009-05). The role of p53 in normal development and teratogen-induced apoptosis and birth defects in mouse embryos. Doctoral Dissertation.

# etdChairOf[].label
Khan, Shaheen Munawar Ali (2007-04). Mechanisms of hormonal regulation of CAD gene expression and inhibition by Aryl hydrocarbon receptor agonist in human breast cancer cells. Doctoral Dissertation.

# etdChairOf[].label
Li, Xi (2014-05). Mechanism of Action of Sulindac and Diindolylmethane Analogs as Anticancer Agents. Doctoral Dissertation.

# etdChairOf[].label
Wu, Qian (2005-12). Mechanisms of coactivation of estrogen receptor alpha (ER alpha)- and ER alpha/Sp-mediated gene transactivation by vitamin D receptor interacting protein 205 (DRIP205) in breast cancer cells. Doctoral Dissertation.

# etdChairOf[].label
Lacey, Alexandra Dianne (2017-08). NR4A1 Antagonists Target the Oncogenic PAX3-FOXO1A Gene and Induce Interleukin -24 in Rhabdomyosarcoma (RMS). Doctoral Dissertation.

# etdChairOf[].label
Papineni, Sabitha (2009-05). New synthetic derivatives of triterpenoids in the treatment of cancer. Doctoral Dissertation.

# etdChairOf[].label
Scott, Maya Millicent (2005-05). Canine hepatic slices as a model for studying drug toxicity and metabolism. Doctoral Dissertation.

# etdChairOf[].label
Chadalapaka, Gayathri (2013-03). Mechanism Based Anticancer Drugs that Degrade Sp Transcription Factors. Doctoral Dissertation.

# etdChairOf[].label
Chen, Chien-Cheng (2009-06). Mechanisms of transcriptional activation of estrogen responsive genes in breast cancer cells. Doctoral Dissertation.

# etdChairOf[].label
Cheng, Yating (2016-12). The Role of Long Noncoding RNAs in Cancer and Microbiota-derived Aryl Hydrocarbon Receptor Ligands. Doctoral Dissertation.

# etdChairOf[].label
Hedrick, Erik Duane (2016-12). Diindolylmethane Analogs as Novel NR4A1 Antagonists and as a Novel Class of Anticancer Agents and Sp Transcription Factors as Nononcogene Addiction Genes That Are Targets of ROS Inducing Agents. Doctoral Dissertation.

# etdChairOf[].label
Liu, Xinyi (2011-08). Mechanistic Investigation of Tolfenamic Acid, Betulinic Acid, and Aspirin in Anti-Cancer Therapy. Doctoral Dissertation.

# etdChairOf[].label
Jutooru, Indira Devi (2011-08). New Mechanism Based Anticancer Drugs for Treatment of Pancreatic and Bladder Cancers. Doctoral Dissertation.

# etdChairOf[].label
Ramachandran Nair Vasanthakum, Vijayalekshmi (2014-08). Mechanisms of Action of Metformin as an Anti-cancer Agent. Doctoral Dissertation.

# etdChairOf[].label
Kotha, Leela (2006-12). Inhibition of breast and prostate cancer cell growth by 3,3'-diindolylmethane and related compounds. Doctoral Dissertation.

# etdChairOf[].label
Vanderlaag, Kathryn Elisabeth (2007-05). Mechanisms of growth inhibition induced by methylene-substituted and ring-substituted dims in breast cancer cells. Doctoral Dissertation.

# etdChairOf[].label
Lee, Wan-Ru (2006-12). Mechanisms of hormonal activation of Cdc25A and coactivation of estrogen receptor alpha by protein inhibitor of activated STAT3 (PIAS3). Doctoral Dissertation.