# positions[].organizations[].label
College of Veterinary Medicine and Biomedical Sciences

# positions[].organizations[].label
School of Veterinary Medicine and Biomedical Sciences

# overview
My laboratory has an active research portfolio funded by the National Institutes of Health and the US EPA with a focus on the mechanisms of action of environmental toxicants and the genetic determinants of the susceptibility to toxicant-induced injury. Through a combination of in vivo animal studies and experiments that utilize cellular and molecular models, we aim to better understand why certain chemicals cause cancer or organ damage in rodents and whether humans in general, or any susceptible sub-population in particular, are at risk from similar exposures.

The main focus of our inter-disciplinary research is on improving the linkages between exposures and adverse health effects Specifically, we develop innovative experimental methods and computational tools which enable analysis of data across multiple dimensions including SNPs, -omic endpoints, multiple chemicals and traditional toxicity phenotypes.

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
Drug-Related Side Effects And Adverse Reactions

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Receptors, Tumor Necrosis Factor, Type I

# keywords[]
Alternatives To Animal Testing < In Vitro And Alternatives

# keywords[]
Drug-Related Side Effects And Adverse Reactions

# keywords[]
Drug-Related Side Effects And Adverse Reactions

# keywords[]
Drug-Related Side Effects And Adverse Reactions

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
Effective Concentration At 50% Of The Maximum Response

# keywords[]
Drug-Related Side Effects And Adverse Reactions

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
United States Environmental Protection Agency

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Squamous Cell Carcinoma Of Head And Neck

# keywords[]
Von Hippel-Lindau Tumor Suppressor Protein

# keywords[]
Drug-Related Side Effects And Adverse Reactions

# keywords[]
Receptors, Tumor Necrosis Factor, Type I

# keywords[]
Drug-Related Side Effects And Adverse Reactions

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
DNA-(Apurinic Or Apyrimidinic Site) Lyase

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Networking And Information Technology R&d

# keywords[]
Nonalcoholic Fatty Liver Disease (nafld)

# keywords[]
United States Environmental Protection Agency

# keywords[]
Drug-Related Side Effects And Adverse Reactions

# keywords[]
Consensus Development Conferences, Nih As Topic

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Drug-Related Side Effects And Adverse Reactions

# keywords[]
Intracellular Signaling Peptides And Proteins

# educationAndTraining[].organization.label
Bogomolets National Medical University - (Kiev, Ukraine)

# educationAndTraining[].organization.label
University of North Carolina at Chapel Hill - (Chapel Hill, North Carolina, United States)

# publications[].label
Relationships between constituents of energy drinks and beating parameters in human induced pluripotent stem cell (iPSC)-Derived cardiomyocytes.

# publications[].label
Indoor air pollutants and health in the United Arab Emirates.

# publications[].label
Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice.

# publications[].label
Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor.

# publications[].label
Kupffer cell nadph oxidase plays an important role in early alcohol-induced liver injury in mice

# publications[].label
Intracellular Expression of TOA Lowers Glucose Production

# publications[].label
WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase.

# publications[].label
Sustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-alpha, but not NADPH oxidase.

# publications[].label
Computational toxicology: realizing the promise of the toxicity testing in the 21st century.

# publications[].label
Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects.

# publications[].label
Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review.

# publications[].label
Endothelial cells contain a glycine-gated chloride channel.

# publications[].label
Addressing human variability in next-generation human health risk assessments of environmental chemicals.

# publications[].label
Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel.

# publications[].label
Introduction to mammalian genome special issue: the combined role of genetics and environment relevant to human disease outcomes.

# publications[].label
Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension.

# publications[].label
Oxidative DNA damage: New approaches to a very old problem.

# publications[].label
The role of Kupffer cell oxidant production in early ethanol-induced liver disease.

# publications[].label
Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice.

# publications[].label
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis.

# publications[].label
Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches.

# publications[].label
Glycine accelerates recovery from alcohol-induced liver injury.

# publications[].label
Severe liver and kidney injury in mouse models of acute-on-chronic alcoholic hepatitis

# publications[].label
Risk Characterization and Probabilistic Concentration-Response Modeling of Complex Environmental Mixtures Using New Approach Methodologies (NAMs) Data from Organotypic in Vitro Human Stem Cell Assays.

# publications[].label
Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Expression of base excision DNA repair genes as a biomarker of oxidative DNA damage.

# publications[].label
Testing the efficacy of broad-acting sorbents for environmental mixtures using isothermal analysis, mammalian cells, and H. vulgaris.

# publications[].label
Analysis of per- and polyfluoroalkyl substances in Houston Ship Channel and Galveston Bay following a large-scale industrial fire using ion-mobility-spectrometry-mass spectrometry.

# publications[].label
Assessment of biological responses of EpiAirway 3-D cell constructs versus A549 cells for determining toxicity of ambient air pollution.

# publications[].label
FastMap: fast eQTL mapping in homozygous populations.

# publications[].label
Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells.

# publications[].label
Experimental pharmacogenetic approaches to understanding toxic responses in populations

# publications[].label
Tissue-Engineered Bone Tumor as a Reproducible Human in Vitro Model for Studies of Anticancer Drugs.

# publications[].label
Modeling liver-related adverse effects of drugs using knearest neighbor quantitative structure-activity relationship method.

# publications[].label
Prediction of human population responses to toxic compounds by a collaborative competition.

# publications[].label
The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning.

# publications[].label
Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism.

# publications[].label
Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice.

# publications[].label
Methyl deficiency, alterations in global histone modifications, and carcinogenesis

# publications[].label
Sex-specific differences in genotoxic and epigenetic effects of 1,3-butadiene among mouse tissues.

# publications[].label
Grouping of UVCB substances with new approach methodologies (NAMs) data.

# publications[].label
Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making.

# publications[].label
Protective effect of Juzen-taiho-to on hepatocarcinogenesis is mediated through the inhibition of Kupffer cell-induced oxidative stress.

# publications[].label
Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice.

# publications[].label
Role of Kupffer cells and NF kappa B in peroxisome proliferator-induced cell proliferation.

# publications[].label
Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration-QTc Relationships.

# publications[].label
In memoriam: Ronald G. Thurman (1941-2001).

# publications[].label
Re: 'Application of the key characteristics of carcinogens in cancer hazard evaluation': response to Goodman, Lynch and Rhomberg.

# publications[].label
Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.

# publications[].label
Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA).

# publications[].label
Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents.

# publications[].label
Concordance between sites of tumor development in humans and in experimental animals for 111 agents that are carcinogenic to humans.

# publications[].label
Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity.

# publications[].label
The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.

# publications[].label
Conducting environmental health research in the Arabian Middle East: lessons learned and opportunities.

# publications[].label
Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice.

# publications[].label
Rapid Characterization of Emerging Per- and Polyfluoroalkyl Substances in Aqueous Film-Forming Foams Using Ion Mobility Spectrometry-Mass Spectrometry.

# publications[].label
In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances.

# publications[].label
Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver.

# publications[].label
A systematic approach for identifying and presenting mechanistic evidence in human health assessments.

# publications[].label
Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha.

# publications[].label
Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma.

# publications[].label
The Impact of Novel Assessment Methodologies in Toxicology on Green Chemistry and Chemical Alternatives.

# publications[].label
Temporal and spatial analysis of per and polyfluoroalkyl substances in surface waters of Houston ship channel following a large-scale industrial fire incident.

# publications[].label
Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis.

# publications[].label
Histopathological and Molecular Signatures of a Mouse Model of Acute-on-Chronic Alcoholic Liver Injury Demonstrate Concordance With Human Alcoholic Hepatitis.

# publications[].label
Impaired Ras membrane association and activation in PPARalpha knockout mice after partial hepatectomy.

# publications[].label
Effects of polymorphisms in alcohol metabolism and oxidative stress genes on survival from head and neck cancer.

# publications[].label
Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains.

# publications[].label
Role of Kupffer cells in peroxisome proliferator-induced hepatocyte proliferation.

# publications[].label
Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice.

# publications[].label
Using quantitative high-throughput screening (qHTS) results as biological descriptors to assist quantitative structure activity relationship (QSAR) modeling of rat acute toxicity

# publications[].label
Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1,3-butadiene in male C57BL/6J mice.

# publications[].label
Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene.

# publications[].label
ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice.

# publications[].label
Metabolomic analysis of urine and liver after chronic alcohol treatment in C57BL/6j mice

# publications[].label
Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators.

# publications[].label
Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice.

# publications[].label
Phthalates rapidly increase reactive oxygen species in vivo

# publications[].label
Temporal correlation of histopathological changes and markers of oxidative DNA damage with gene expression in a choline deficient model of hepatocellular carcinoma

# publications[].label
Endothelial cells have a glycine-gated chloride channel

# publications[].label
Standardizing global gene expression analysis between laboratories and across platforms.

# publications[].label
Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity.

# publications[].label
Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities.

# publications[].label
Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse.

# publications[].label
Effects of pirfenidone in acute and sub-chronic liver fibrosis, and an initiation-promotion cancer model in the mouse.

# publications[].label
Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis.

# publications[].label
Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage.

# publications[].label
Reply to: "The autophagic response to alcohol toxicity: the missing layer".

# publications[].label
Delivery of the Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats.

# publications[].label
Conditional Toxicity Value (CTV) Predictor: An In Silico Approach for Generating Quantitative Risk Estimates for Chemicals.

# publications[].label
Swift increase in alcohol metabolism (SIAM): understanding the phenomenon of hypermetabolism in liver.

# publications[].label
Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription.

# publications[].label
In vitro screening for population variability in toxicity of pesticide-containing mixtures.

# publications[].label
Tolerance and sensitization to endotoxin in Kupffer cells caused by acute ethanol involve interleukin-1 receptor-associated kinase.

# publications[].label
Genomic profiling in nuclear receptor-mediated toxicity.

# publications[].label
Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers.

# publications[].label
Characterization of population variability of 1,3-butadiene derived protein adducts in humans and mice.

# publications[].label
ACUTE-ON-CHRONIC MODEL OF ALCOHOLIC HEPATITIS IN THE MOUSE

# publications[].label
Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene in Cytochrome P450 2E1 Knockout and Humanized Transgenic Mice.

# publications[].label
Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.

# publications[].label
SAFEGUI: resampling-based tests of categorical significance in gene expression data made easy.

# publications[].label
The microRNA profile is altered in fibrosis-associated hepatocarcinogenesis in mice

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene.

# publications[].label
Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.

# publications[].label
Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects.

# publications[].label
Cardiovascular Effects of Polychlorinated Biphenyls and Their Major Metabolites.

# publications[].label
Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Computational Toxicology: From Data to Analyses to Applications

# publications[].label
Temporal chemical composition changes in water below a crude oil slick irradiated with natural sunlight.

# publications[].label
Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice.

# publications[].label
Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms.

# publications[].label
Development of an intragastric enteral model in the mouse: studies of alcohol-induced liver disease using knockout technology.

# publications[].label
miR-1247 blocks SOX9-mediated regeneration in alcohol- and fibrosis-associated acute kidney injury in mice.

# publications[].label
In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model.

# publications[].label
Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: An update of a systematic literature review.

# publications[].label
High-content high-throughput assays for characterizing the viability and morphology of human iPSC-derived neuronal cultures.

# publications[].label
Trichloroethylene: Mechanistic, epidemiologic and other supporting evidence of carcinogenic hazard.

# publications[].label
IARC monographs: 40 years of evaluating carcinogenic hazards to humans.

# publications[].label
Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet.

# publications[].label
Development of an Ion Mobility Spectrometry-Orbitrap Mass Spectrometer Platform.

# publications[].label
Model systems and organisms for addressing inter- and intra-species variability in risk assessment.

# publications[].label
Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver.

# publications[].label
Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen.

# publications[].label
Oxidative stress occurs in perfused rat liver at low oxygen tension by mechanisms involving peroxynitrite.

# publications[].label
Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse.

# publications[].label
Phthalates rapidly increase production of reactive oxygen species in vivo: role of Kupffer cells.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Environmental exposures due to natural disasters.

# publications[].label
Empirical evaluation of data transformations and ranking statistics for microarray analysis.

# publications[].label
Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis.

# publications[].label
Computational tools for discovery and interpretation of expression quantitative trait loci.

# publications[].label
Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma.

# publications[].label
A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability.

# publications[].label
Editorial overview of the special issue on genomic toxicology epigenetics.

# publications[].label
Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling.

# publications[].label
Characterization of copy number alterations in a mouse model of fibrosis-associated hepatocellular carcinoma reveals concordance with human disease.

# publications[].label
Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Epigenetic Changes in C57BL/6J Mice Induced by Short-Term Exposure to 1,3-Butadiene by Inhalation

# publications[].label
NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Toxicity reference database (ToxRefDB) to develop predictive toxicity models and prioritize compounds for future toxicity testing

# publications[].label
A tiered, Bayesian approach to estimating of population variability for regulatory decision-making.

# publications[].label
Editor's Highlight: Comparative Dose-Response Analysis of Liver and Kidney Transcriptomic Effects of Trichloroethylene and Tetrachloroethylene in B6C3F1 Mouse.

# publications[].label
Hazard and risk characterization of 56 structurally diverse PFAS using a targeted battery of broad coverage assays using six human cell types.

# publications[].label
Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice.

# publications[].label
Evaluating Ion Mobility Data Acquisition, Calibration, and Processing for Small Molecules: A Cross-Platform Assessment of Drift Tube and Traveling Wave Methodologies.

# publications[].label
Long-Term Combinatorial Exposure to Trichloroethylene and Inorganic Arsenic in Genetically Heterogeneous Mice Results in Renal Tubular Damage and Cancer-Associated Molecular Changes.

# publications[].label
Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS).

# publications[].label
gQTL: A Web Application for QTL Analysis Using the Collaborative Cross Mouse Genetic Reference Population.

# publications[].label
Protective effect of glycine on renal injury induced by ischemia-reperfusion in vivo.

# publications[].label
The peroxisome proliferator WY-14,643 triggers an increase in parenchymal cell proliferation: Role of Kupffer cells and NF-kappa B.

# publications[].label
IN UTERO EXPOSURE TO ALCOHOL INDUCES REPROGRAMMING OF MAMMARY DEVELOPMENT AND TUMOR RISK IN MMTV-ERBB-2 TRANSGENIC MICE

# publications[].label
Predictive power of oxidative stress biomarkers in patients with HCV-associated hepatocellular carcinoma

# publications[].label
Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells.

# publications[].label
Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors.

# publications[].label
Functional heterogeneity of the kupffer cell population is involved in the mechanism of gadolinium chloride in rats administered endotoxin.

# publications[].label
Susceptibility to alcohol-induced liver injury is independent of changes in metabolism and inflammation pathways

# publications[].label
A human population-based organotypic in vitro model for cardiotoxicity screening.

# publications[].label
Alcohol-induced free radicals in mice: direct toxicants or signaling molecules?

# publications[].label
Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet.

# publications[].label
MicroRNA expression in the livers of inbred mice.

# publications[].label
Time course investigation of PPARalpha- and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression.

# publications[].label
Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity.

# publications[].label
Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease.

# publications[].label
Oy Vey! A Comment on "Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships Outperforming Animal Test Reproducibility".

# publications[].label
The effect of DNA damaging agents on gene expression of DNA repair glycosylases in human and mouse fibroblasts

# publications[].label
Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse.

# publications[].label
Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development.

# publications[].label
A Comparative Analysis of Analytical Techniques for Rapid Oil Spill Identification.

# publications[].label
METHYLATION FREQUENCY OF P16, SOCS-1, RASSF1A, APC AND GSTP1 PROMOTERS IN TUMOROUS, NON-TUMOROUS AND METASTATIC LIVER TUMOR SAMPLES FROM HCV-POSITIVE PATIENTS WITH HCC IN JAPAN

# publications[].label
Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity.

# publications[].label
Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study.

# publications[].label
Toxicogenetics: population-based testing of drug and chemical safety in mouse models.

# publications[].label
Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches.

# publications[].label
Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma.

# publications[].label
Analysis of reproducibility and robustness of OrganoPlate 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs.

# publications[].label
In vitro models for liver toxicity testing.

# publications[].label
Using new methodologies for a better understanding of the health impacts of petroleum substances

# publications[].label
Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver.

# publications[].label
The role of hepatocyte and Kupffer cell derived free radicals in peroxisome proliferator induced carcinogenesis

# publications[].label
Acetaminophen-induced acute liver injury in HCV transgenic mice.

# publications[].label
TRANSLATIONAL STUDY IDENTIFIES NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) AS A POTENTIAL MEDIATOR OF LIVER INJURY AND FIBROGENESIS IN ALCOHOLIC HEPATITIS

# publications[].label
Expression of base excision repair enzymes in rat and mouse liver is induced by peroxisome proliferators and is dependent upon carcinogenic potency.

# publications[].label
Towards a better consideration of the interindividual variability in chemical risk assessment

# publications[].label
High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells.

# publications[].label
Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat.

# publications[].label
Sex-specific gene expression in the BXD mouse liver.

# publications[].label
Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry.

# publications[].label
PPARalpha-dependent induction of liver microsomal esterification of estradiol and testosterone by a prototypical peroxisome proliferator.

# publications[].label
Application of Ion Mobility Spectrometry-Mass Spectrometry for Compositional Characterization and Fingerprinting of a Library of Diverse Crude Oil Samples.

# publications[].label
Oxidative stress occurs in perfused rat liver under hypoxic conditions via mechanisms involving peroxynitrite.

# publications[].label
THE UNITED ARAB EMIRATES (UAE) INDOOR AIR, HEALTH, AND NUTRITION STUDY

# publications[].label
Inhibition of chronic rejection of aortic allografts by dietary glycine.

# publications[].label
Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model.

# publications[].label
Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver.

# publications[].label
Glycine as a potent anti-angiogenic nutrient for tumor growth.

# publications[].label
Supporting computational systems science: Genomic analysis tool federations using aspects and AOP

# publications[].label
miRNA as population variability-independent biomarkers of toxicity

# publications[].label
Gender differences in early alcohol-induced liver injury: role of CD14, NF-kappaB, and TNF-alpha.

# publications[].label
Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate.

# publications[].label
Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses.

# publications[].label
WY-14 643 rapidly activates nuclear factor kappaB in Kupffer cells before hepatocytes.

# publications[].label
Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization.

# publications[].label
Application of the key characteristics of carcinogens in cancer hazard identification.

# publications[].label
Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies?

# publications[].label
Alcohol consumption and ethyl carbamate.

# publications[].label
An empirical Bayes approach for multiple tissue eQTL analysis.

# publications[].label
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.

# publications[].label
Comparative Analysis of the Physiological and Transport Functions of Various Sources of Renal Proximal Tubule Cells Under Static and Fluidic Conditions in PhysioMimix{trade mark, serif} T12 Platform.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics.

# publications[].label
Intra- and Inter-Species Variability in Urinary N7-(1-Hydroxy-3-buten-2-yl)guanine Adducts Following Inhalation Exposure to 1,3-Butadiene.

# publications[].label
Glycine: a new anti-inflammatory immunonutrient.

# publications[].label
Gene Expression and DNA Methylation Alterations in the Glycine N-Methyltransferase Gene in Diet-Induced Nonalcoholic Fatty Liver Disease-Associated Carcinogenesis.

# publications[].label
In vitro screening for population variability in chemical toxicity

# publications[].label
Ebselen prevents early alcohol-induced liver injury in rats.

# publications[].label
DNA damage by peroxynitrite characterized with DNA repair enzymes.

# publications[].label
Baseline data for distribution of contaminants by natural disasters: results from a residential Houston neighborhood during Hurricane Harvey flooding.

# publications[].label
Oxidative DNA damage: New approaches to a very old problem.

# publications[].label
Analytical chemistry solutions to hazard evaluation of petroleum refining products.

# publications[].label
Co-regulation of primary mouse hepatocyte viability and function by oxygen and matrix.

# publications[].label
Software Tools to Facilitate Systematic Review Used for Cancer Hazard Identification.

# publications[].label
INCIDENCE OF AFLATOXIN B1-INDUCED HEPATIC TUMORS IS INCREASED IN HEPATITIS VIRUS C TRANSGENIC MICE AS COMPARED TO WILD TYPE C57BL/6J STRAIN

# publications[].label
INDOOR AIR EXPOSURES AND HEALTH IN THE UNITED ARAB EMIRATES (UAE).

# publications[].label
ADULT EXPOSURE TO ALCOHOL PROMOTES MAMMARY TUMOR DEVELOPMENT IN MMTV-ERBB-2 TRANSGENIC MICE THROUGH ACTIVATION OF ER, AKT AND ERK1/2 SIGNALING

# publications[].label
Characterizing PFAS hazards and risks: a human population-based in vitro cardiotoxicity assessment strategy.

# publications[].label
Distinct patterns of gene expression in hepatocellular carcinomas and adjacent non-cancerous, cirrhotic liver tissues in rats fed a choline-deficient, L-amino acid-defined diet.

# publications[].label
Replication and narrowing of gene expression quantitative trait loci using inbred mice.

# publications[].label
A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives.

# publications[].label
Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.

# publications[].label
Erratum: Prediction of human population responses to toxic compounds by a collaborative competition

# publications[].label
Heading down the wrong pathway: on the influence of correlation within gene sets.

# publications[].label
Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip.

# publications[].label
SYSTEMS BIOLOGY ANALYSIS OF GENETIC AND ENVIRONMENTAL DETERMINANTS OF TOXICITY

# publications[].label
High-Content Assay Multiplexing for Muscle Toxicity Screening in Human-Induced Pluripotent Stem Cell-Derived Skeletal Myoblasts.

# publications[].label
Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma.

# publications[].label
Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates.

# publications[].label
Cardiotoxicity Hazard and Risk Characterization of ToxCast Chemicals Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Multiple Donors.

# publications[].label
Genome-level analysis of genetic regulation of liver gene expression networks.

# publications[].label
Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse.

# publications[].label
Editor's Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism.

# publications[].label
A Novel Mouse Model of Acute-on-Chronic Cholestatic Alcoholic Liver Disease: A Systems Biology Comparison With Human Alcoholic Hepatitis.

# publications[].label
ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence.

# publications[].label
A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents.

# publications[].label
Integrative approaches for predicting in vivo effects of chemicals from their structural descriptors and the results of short-term biological assays.

# publications[].label
High-Content Assay Multiplexing for Toxicity Screening in Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Hepatocytes.

# publications[].label
Air Pollutant Patterns and Human Health Risk following the East Palestine, Ohio, Train Derailment.

# publications[].label
PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice.

# publications[].label
Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators.

# publications[].label
An integrative method for identification and prioritization of constituents of concern in produced water from onshore oil and gas extraction.

# publications[].label
Toxico-cheminformatics and QSPR modeling of the carcinogenic potency database

# publications[].label
Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation.

# publications[].label
ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models.

# publications[].label
Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene.

# publications[].label
Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation.

# publications[].label
Informing Hazard Identification and Risk Characterization of Environmental Chemicals by Combining Transcriptomic and Functional Data from Human-Induced Pluripotent Stem-Cell-Derived Cardiomyocytes.

# publications[].label
Genetic and epigenetic determinants of inter-individual variability in responses to toxicants.

# publications[].label
Optimal Chemical Grouping and Sorbent Material Design by Data Analysis, Modeling and Dimensionality Reduction Techniques.

# publications[].label
From "weight of evidence" to quantitative data integration using multicriteria decision analysis and Bayesian methods.

# publications[].label
Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage.

# publications[].label
Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data.

# publications[].label
Erratum: Prediction of human population responses to toxic compounds by a collaborative competition.

# publications[].label
Chronic ethanol increases adeno-associated viral transgene expression in rat liver via oxidant and NFkappaB-dependent mechanisms.

# publications[].label
Selenium-containing compounds protect DNA from single-strand breaks caused by peroxynitrite.

# publications[].label
A Bayesian Method for Population-wide Cardiotoxicity Hazard and Risk Characterization Using an In Vitro Human Model.

# publications[].label
WY-14,643 rapidly activates the nuclear factor kappa B in non-parenchymal cells.

# publications[].label
A new approach method for characterizing inter-species toxicodynamic variability.

# publications[].label
The role of microRNAs in the development and progression of chemical-associated cancers.

# publications[].label
Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis.

# publications[].label
Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes.

# publications[].label
Comparative analysis of Rapid Equilibrium Dialysis (RED) and solid phase micro-extraction (SPME) methods for In Vitro-In Vivo extrapolation of environmental chemicals.

# publications[].label
Development of an animal model of chronic alcohol-induced pancreatitis in the rat.

# publications[].label
Toxico-cheminformatics and QSPR modeling of the carcinogenic potency database

# publications[].label
GENETIC BACKGROUND-INDEPENDENT AND -DEPENDENT PATHWAYS IN ALCOHOL-INDUCED LIVER INJURY

# publications[].label
The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat.

# publications[].label
The Genotype-Tissue Expression (GTEx) project.

# publications[].label
Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice.

# publications[].label
Allopurinol prevents early alcohol-induced liver injury in rats.

# publications[].label
Effects of ethylene oxide and ethylene inhalation on DNA adducts, apurinic/apyrimidinic sites and expression of base excision DNA repair genes in rat brain, spleen, and liver.

# publications[].label
The Next Generation of Risk Assessment Multi-Year Study-Highlights of Findings, Applications to Risk Assessment, and Future Directions.

# publications[].label
High-Content Assay Multiplexing for Vascular Toxicity Screening in Induced Pluripotent Stem Cell-Derived Endothelial Cells and Human Umbilical Vein Endothelial Cells.

# publications[].label
Environmental impacts of Hurricane Florence flooding in eastern North Carolina: temporal analysis of contaminant distribution and potential human health risks.

# publications[].label
Glycine and uridine prevent D-galactosamine hepatotoxicity in the rat: role of Kupffer cells.

# publications[].label
Methyl deficiency, alterations in global histone modifications, and carcinogenesis.

# publications[].label
Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury.

# publications[].label
Cytochrome p450 2E1, but not NADPH oxidase is required for ethanol-induced DNA damage and upregulation of DNA repair genes in mouse liver.

# publications[].label
In vitro screening for population variability in chemical toxicity.

# publications[].label
A mouse model of alcoholic liver fibrosis-associated acute kidney injury identifies key molecular pathways.

# publications[].label
Risk Characterization of Environmental Samples Using In Vitro Bioactivity and Polycyclic Aromatic Hydrocarbon Concentrations Data.

# publications[].label
Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis.

# publications[].label
Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene.

# publications[].label
Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury.

# publications[].label
Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity.

# publications[].label
Grouping of Petroleum Substances as Example UVCBs by Ion Mobility-Mass Spectrometry to Enable Chemical Composition-Based Read-Across.

# publications[].label
Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs.

# publications[].label
GENE EXPRESSION IN NON-TUMORAL LIVER TISSUE AND RISK OF RECURRENCE OF HEPATOCELLULAR CARCINOMA IN HEPATITIS C VIRUS-POSITIVE SUBJECTS

# publications[].label
Curated Data In - Trustworthy In Silico Models Out: The Impact of Data Quality on the Reliability of Artificial Intelligence Models as Alternatives to Animal Testing.

# publications[].label
Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows.

# publications[].label
Editorial overview of the special issue on application of tissue chips in toxicology.

# publications[].label
Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity.

# publications[].label
Standardizing benchmark dose calculations to improve science-based decisions in human health assessments.

# publications[].label
Questioning Existing Cancer Hazard Evaluation Standards in the Name of Statistics.

# publications[].label
NADPH oxidase is the source of oxidants for activation of NF-kappa B by the peroxisome proliferator WY-14,613 (WY)

# publications[].label
Adiponectin lowers glucose production by increasing SOGA.

# publications[].label
Chemistry-Wide Association Studies (CWAS): A Novel Framework for Identifying and Interpreting Structure-Activity Relationships.

# publications[].label
Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.

# publications[].label
Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population.

# publications[].label
Prediction of binding affinity and efficacy of thyroid hormone receptor ligands using QSAR and structure-based modeling methods.

# publications[].label
Characterization of the variability in the extent of nonalcoholic fatty liver induced by a high-fat diet in the genetically diverse Collaborative Cross mouse model.

# publications[].label
Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice.

# publications[].label
Adenoviral gene delivery can inactivate Kupffer cells: role of oxidants in NF-kappaB activation and cytokine production.

# publications[].label
SPECTRUM OF HNF1A SOMATIC MUTATIONS IN HEPATOCELLULAR ADENOMA DIFFERS FROM THAT IN MODY3 PATIENTS AND SUGGESTS GENOTOXIC DAMAGE

# publications[].label
Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma.

# researcherOn[].awardedBy.label
Environmental Protection Agency - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Chromatin regions, genes and pathways that confer susceptibility to chemical-induced DNA damage

# researcherOn[].awardedBy.label
National Institute of Environmental Health Sciences - (Durham, North Carolina, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Environmental Health Sciences

# researcherOn[].label
TEX-VAL: Texas A&M Tissue Chip Validation Center

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
TEX-VAL: Texas A&M Tissue Chip Validation Consortium

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Nonalcoholic steatohepatitis as a potential contributor to individual susceptibility to tetrachloroethylene-associated toxicity

# researcherOn[].awardedBy.label
National Institute of Environmental Health Sciences - (Durham, North Carolina, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Environmental Health Sciences

# researcherOn[].label
IMSD at Texas A&M University:  Initiative for Maximizing Student Diversity in Biomedical Sciences

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of General Medical Science

# researcherOn[].label
Texas A&M Center for Environmental Health Research

# researcherOn[].awardedBy.label
National Institute of Environmental Health Sciences - (Durham, North Carolina, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Environmental Health Sciences

# researcherOn[].label
Carolina Center for Computational Toxicology:  Experimental and Computational Tools for NexGen Safety

# researcherOn[].awardedBy.label
Environmental Protection Agency - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Center for Translational Environmental Health Research

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.label
Environmental Protection Agency - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Regulatory Science in Environmental Health and Toxicology

# researcherOn[].awardedBy.label
National Institute of Environmental Health Sciences - (Durham, North Carolina, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Environmental Health Sciences

# researcherOn[].label
Comprehensive Tools and Models for Addressing Exposure to Mixtures During Environmental Emergency-Related Contamination Events

# researcherOn[].awardedBy.label
National Institute of Environmental Health Sciences - (Durham, North Carolina, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Environmental Health Sciences

# researcherOn[].label
Cardiotoxicity Adverse Outcome Pathway Center: Organotypic Culture Model and In Vitro-to-In Vivo Extrapolation for High-Throughput Hazard, Dose-Response and Variability Assessments

# researcherOn[].awardedBy.label
Environmental Protection Agency - (Washington D.C., District of Columbia, United States)

# streetAddress
Texas A&M University; Veterinary Integrative Biosciences; 4458 TAMU

# organizations[]
College of Veterinary Medicine and Biomedical Sciences

# organizations[]
School of Veterinary Medicine and Biomedical Sciences

# inTheNews[].label
New Pandemic Vulnerability Index dashboard maps global spread of COVID-19

# inTheNews[].label
Tay Gavin Erickson Lecture Series: 'When Disaster Strikes: Response, Research, and Recovery'

# inTheNews[].label
Texas A&M Announces 2020 Distinguished Achievement Award Recipients

# etdChairOf[].label
Lewis, Lauren Anne (2019-12). Inter-Individual Variability in DNA Damage and Epigenetic Effects in Response to 1,3-Butadiene. Doctoral Dissertation.

# etdChairOf[].label
Wilson, Melinda R (2016-08). Data Integration and Visualization for Transparent Communication in Read-Across: a Glycol Ether Case Study. Master's Thesis.