# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
Our research interests are directed towards understanding the complex mechanisms which regulate the expression of specific gene sequences in development. We have focused our studies upon the factors that influence the smooth muscle component of the developing gastrointestinal (G.I.) tract. It has been shown that smooth muscle cells are predominantly derived from mesodermal precursor cells, however the factors regulating the selection of the smooth muscle myogenic pathway is not well defined.

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Receptor, Platelet-Derived Growth Factor Beta

# educationAndTraining[].organization.label
Baylor College of Medicine - (Houston, Texas, United States)

# educationAndTraining[].organization.label
Vanderbilt University - (Nashville, Tennessee, United States)

# educationAndTraining[].organization.label
University of Houston - (Houston, Texas, United States)

# awardsAndHonors[].label
Faculty Early Career Development (CAREER) Program

# publications[].label
PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution.

# publications[].label
Structure and expression of a calcium-binding protein gene contained within a calmodulin-regulated protein kinase gene.

# publications[].label
Molecular cloning of testicular 20 alpha-hydroxysteroid dehydrogenase: identity with aldose reductase.

# publications[].label
Regulation of organ development by the NKX-homeodomain factors: an NKX code.

# publications[].label
Smooth muscle-specific gene delivery in the vasculature based on restriction of DNA nuclear import.

# publications[].label
Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function.

# publications[].label
Analysis of Centrosome Replication Events in Mammalian Cells

# publications[].label
Discovery of vascular Rho kinase (ROCK) inhibitory peptides.

# publications[].label
The developmentally regulated expression of serum response factor plays a key role in the control of smooth muscle-specific genes.

# publications[].label
The use of synthetic oligodeoxyribonucleotides in the examination of calmodulin gene and protein structure and function.

# publications[].label
The domain of brain beta-spectrin responsible for synaptic vesicle association is essential for synaptic transmission.

# publications[].label
Erythrocyte Spectrin Is An E2 Ubiquitin Conjugating Enzyme.

# publications[].label
Perturbation of the calmodulin system in transformed cells.

# publications[].label
The smooth muscle gamma-actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor.

# publications[].label
ORGANIZATION AND EXPRESSION OF THE CHICKEN ACTIN MULTIGENE FAMILY DURING MYOGENESIS

# publications[].label
Corrigendum to brain  erthroid spectrin: identification, compartmentalization, and  spectrin associations [Brain Res. 663 (1994) 223236] (BRES 10639)

# publications[].label
Molecular characterization and distribution of the opioid growth factor receptor (OGFr) in mouse.

# publications[].label
S100A1 and S100B expression and target proteins in type I diabetes.

# publications[].label
The identification and sequence of the actin-binding domain of human red blood cell beta-spectrin.

# publications[].label
Brain beta spectrin isoform 235 (Spnb-2) maps to mouse chromosome 11.

# publications[].label
Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development.

# publications[].label
Isolation of a rat S100 alpha cDNA and distribution of its mRNA in rat tissues.

# publications[].label
The smooth muscle gamma-actin gene is androgen responsive in prostate epithelia.

# publications[].label
Characterization of bacterial artificial chromosome transgenic mice expressing mCherry fluorescent protein substituted for the murine smooth muscle alpha-actin gene.

# publications[].label
Immunohistochemical localization of cadherin and catenin adhesion molecules in the murine growth plate.

# publications[].label
Developmental expression of brain beta-spectrin isoform messenger RNAs.

# publications[].label
Differential regulation of chromogranin B/secretogranin I and secretogranin II by forskolin in PC12 cells.

# publications[].label
Smooth muscle gamma-actin promoter regulation by RhoA and serum response factor signaling.

# publications[].label
Brain alpha erythroid spectrin: identification, compartmentalization, and beta spectrin associations.

# publications[].label
Isolation and characterization of six different chicken actin genes.

# publications[].label
Molecular cloning and expression of the chicken smooth muscle gamma-actin mRNA.

# publications[].label
Transient Transgenics: An Efficient Method to Identify Gene Regulatory Elements.

# publications[].label
Promoter methylation is associated with the age-dependent loss of N-cadherin in the rat kidney.

# publications[].label
Autoepitope mapping of the centrosome autoantigen PCM-1 using scleroderma sera with anticentrosome autoantibodies.

# publications[].label
Identification of mRNA encoding homeobox proteins hox b4 and Hox b5 in developing chicken gizzard tissues

# publications[].label
Intronic DNA elements regulate androgen-dependent expression of the murine Nkx3.1 gene.

# publications[].label
Role of MCP-1 in tumor necrosis factor-alpha-induced endothelial dysfunction in type 2 diabetic mice.

# publications[].label
Localization of autoepitopes on the PCM-1 autoantigen using scleroderma sera with autoantibodies against the centrosome.

# publications[].label
The complete amino acid sequence for brain  spectrin ( fodrin): relationship to globin sequences (Mol. brain Res. 18 (1993)_87-99) (BRESM 70581) (PII:0169-328X(93)90176-P)

# publications[].label
Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells.

# publications[].label
Cell-specific transcription of the smooth muscle gamma-actin gene requires both positive- and negative-acting cis elements.

# publications[].label
Calmodulin and calmodulin-regulated protein kinases as transducers of intracellular calcium signals.

# publications[].label
Smooth muscle hyperplasia due to loss of smooth muscle -actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-.

# publications[].label
Exclusion of two candidate genes, Spnb-2 and Dcd, for the wobbler spinal muscular atrophy gene on proximal mouse chromosome 11.

# publications[].label
Spectrin's key role in synaptic transmission

# publications[].label
Structural organization, DNA sequence, and expression of the calmodulin gene.

# publications[].label
Erratum: The complete amino acid sequence for brain  spectrin ( fo;drin): Relationship to globin sequences (Molecular Brain Research (1993) (87-99))

# publications[].label
Synergistic immunologic targets for the treatment of prostate cancer.

# publications[].label
The bagpipe homolog Nkx3.2 is an important factor in the specification of bone and intestinal tract mesoderm

# publications[].label
COUP-TFII is essential for radial and anteroposterior patterning of the stomach.

# publications[].label
Transforming growth factor-beta induction of smooth muscle cell phenotpye requires transcriptional and post-transcriptional control of serum response factor.

# publications[].label
New concepts concerning prostate cancer screening.

# publications[].label
Erratum: The complete amino acid sequence for brain  spectrin ( fodrin): Relationship to globin sequences (Molecular Brain Research, 18 (1993) (87-99))

# publications[].label
Cell-specific nuclear import of plasmid DNA.

# publications[].label
Identification of a mouse brain beta-spectrin cDNA and distribution of its mRNA in adult tissues.

# publications[].label
Erythrocyte spectrin is an E2 ubiquitin conjugating enzyme.

# publications[].label
Structural and functional analysis of domains mediating interaction between the bagpipe homologue, Nkx3.1 and serum response factor.

# publications[].label
Expression of an Nkx3.1-CRE gene using ROSA26 reporter mice.

# publications[].label
Processing of high molecular weight ovalbumin and ovomucoid precursor RNAs to messenger RNA.

# publications[].label
Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein.

# publications[].label
Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene.

# publications[].label
Spectrin's chimeric E2/E3 enzymatic activity.

# publications[].label
Prolactin granulogenesis is associated with increased secretogranin expression and aggregation in the Golgi apparatus of GH4C1 cells.

# publications[].label
The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences.

# publications[].label
Identification of an amelin isoform located in axons.

# streetAddress
Texas A&M Health Science Center; Medical Physiology; 1114 TAMUS

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine