# positions[].label
Associate Director, Institute for Regenerative Medicine

# overview
Dr. Ashok K. Shetty's laboratory is interested in developing clinically applicable strategies efficacious for enhancing brain function after injury, disease, or aging. The central areas of investigation are focused on:

o Mechanisms by which intranasally administered stem cell-derived extracellular vesicles (EVs) promote neuroprotection, neuroregeneration, neural plasticity, and alleviate neuroinflammation. The sources of EVs include human bone marrow mesenchymal stem cells (hMSCs), and human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSCs), astrocytes, and microglia. The model systems include traumatic brain injury (TBI), closed head injury (CHI), Aging, Alzheimer's disease (AD) and temporal lobe epilepsy (TLE).

o Mechanisms by which transplanted human neural stem cells or human GABA-ergic precursor cells derived from hiPSCs promote brain repair, and alleviate spontaneous seizures, and cognitive and mood impairments in prototypes of SE, TLE, and TBI.

o Elucidating mechanisms of brain dysfunction and chronic neuroinflammation in prototypes of Gulf War Illness. Developing therapeutic strategies to alleviate neuroinflammation, systemic inflammation, and cognitive and mood impairments in models of GWI.

o Developing clinically feasible strategies for improving brain function in aging and AD models via stimulation of endogenous neural stem cells using drugs and biologics.

Dr. Shetty has received continuous extramural research funding as PI for >25 years from sources such as the NIH, DOD, Dept of Veterans Affairs (VA), and industry. These include seven R01 grant awards and an R21 grant award from the NIH; seven CDMRP grant awards from the DOD; five Merit Grant awards and two Research Career Scientist Awards from the VA; and two industry grants. He has also served as Co-I of 8 other DOD grants. Grants from the NIH, DOD, and industry fund Dr. Shetty's current research. Dr. Shetty has authored 181 peer-reviewed publications (147 as senior/first author) and edited a book on Neural Stem Cells in Health and Disease. His work has appeared in many prestigious and high-impact journals. Dr. Shetty has received >17,000 citations for his publications with an h-index of 64. Dr. Shetty has the distinction of serving on two NIH Study Sections and one VA study section as a Chartered Member. Besides, he has served as a member of many other study section panels of the NIH, DOD, VA, and Maryland State Stem Cell Research Fund. Dr. Shetty is Co-Editor-in-Chief of the journal, Aging & Disease and Associate Editor of 6 Neuroscience journals. He is also a Member of the Editorial Board of many prestigious journals, including The Journal of Extracellular Vesicles, Aging Cell, and Stem Cells. Dr. Shetty is a Fellow of the American Society for Neural Transplantation and Repair. Dr. Shetty received the Senior Research Excellence Award in 2021 from the TAMU College of Medicine and is among the "World's Top 2% Scientists" across all scientific fields.

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
NLR Family, Pyrin Domain-Containing 3 Protein

# keywords[]
Stem Cell Research - Embryonic - Non-human

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
Alzheimer's Disease Including Alzheimer's Disease Related Dementias (ad/adrd)

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
NLR Family, Pyrin Domain-Containing 3 Protein

# keywords[]
Human Induced Pluripotent Stem (hips) Cells

# keywords[]
Neural Stem Cell-derived Extracellular Vesicles

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
Bone Marrow-derived Mesenchymal Stem Cells

# keywords[]
Human Mesenchymal Stem Cell-derived Extracellular Vesicles

# keywords[]
NLR Family, Pyrin Domain-Containing 3 Protein

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Cyclic AMP Response Element-Binding Protein

# keywords[]
Chemical And Drug Induced Liver Injury, Chronic

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
6 Evaluation Of Treatments And Therapeutic Interventions

# keywords[]
Glial-cell Line Derived Neurotrophic Factor

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
Stem Cell Research - Umbilical Cord Blood/ Placenta

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell

# keywords[]
Glial Cell Line-Derived Neurotrophic Factor

# educationAndTraining[].organization.label
All India Institute of Medical Sciences - (New Delhi, India)

# publications[].label
Fetal nigral transplants in the lateral ventricle of adult rats. A long-term morphological study.

# publications[].label
Mood and memory deficits in a model of Gulf War illness are linked with reduced neurogenesis, partial neuron loss, and mild inflammation in the hippocampus.

# publications[].label
Intranasal Administration of MSC-Derived Exosomes Modulate Status Epilepticus Induced Abnormal Plasticity of Newly Born Neurons and Microglial Activation in the Hippocampus

# publications[].label
Prolonged Low-Level Inflammation Due to Exposure to Gulf War Illness Related Chemicals Increases Susceptibility to Cholestatic Liver Injury by Enhancing CD11b(+) Macrophage/Monocyte Infiltration into the Liver

# publications[].label
Predictable chronic mild stress improves mood, hippocampal neurogenesis and memory.

# publications[].label
Nestin expression in hippocampal astrocytes after injury depends on the age of the hippocampus.

# publications[].label
Neural stem cell- and neurogenesis-related gene expression profiles in the young and aged dentate gyrus.

# publications[].label
Stem/progenitor cell proliferation factors FGF-2, IGF-1 and VEGF exhibit early decline in the hippocampus during aging

# publications[].label
Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are We There Yet?

# publications[].label
Chronic temporal lobe epilepsy is associated with severely declined dentate neurogenesis in the adult hippocampus.

# publications[].label
Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells.

# publications[].label
Extracellular Vesicles as Therapeutics for Brain Injury and Disease.

# publications[].label
Selective laser-activated lesioning of prelabeled fetal hippocampal grafts by intracellular photolytic chromophore.

# publications[].label
Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness.

# publications[].label
Emerging Anti-Aging Strategies - Scientific Basis and Efficacy.

# publications[].label
Neural stem cell derived extracellular vesicles: Attributes and prospects for treating neurodegenerative disorders.

# publications[].label
Enhanced production and dendritic growth of new dentate granule cells in the middle-aged hippocampus following intracerebroventricular FGF-2 infusions.

# publications[].label
Glutamic acid decarboxylase-67-positive hippocampal interneurons undergo a permanent reduction in number following kainic acid-induced degeneration of ca3 pyramidal neurons.

# publications[].label
Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies.

# publications[].label
Potential of GABA-ergic cell therapy for schizophrenia, neuropathic pain, and Alzheimer's and Parkinson's diseases.

# publications[].label
Chronobiology of limbic seizures: Potential mechanisms and prospects of chronotherapy for mesial temporal lobe epilepsy.

# publications[].label
Enduring survival of new neurons born at early post-status epilepticus and during chronic epilepsy in the rat dentate gyrus

# publications[].label
Protective effects of gabaergic neurosteroids in a rat model of chronic temporal lobe epilepsy

# publications[].label
Grafted Subventricular Zone Neural Stem Cells Display Robust Engraftment and Similar Differentiation Properties and Form New Neurogenic Niches in the Young and Aged Hippocampus.

# publications[].label
Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus.

# publications[].label
Fetal hippocampal CA3 cell grafts enriched with fibroblast growth factor-2 exhibit enhanced neuronal integration into the lesioned aging rat hippocampus in a kainate model of temporal lobe epilepsy.

# publications[].label
Incorporation of embryonic CA3 cell grafts into the adult hippocampus at 4-months after injury: effects of combined neurotrophic supplementation and caspase inhibition.

# publications[].label
Combined pre- and postnatal ethanol exposure alters the development of Bergmann glia in rat cerebellum.

# publications[].label
IN OCULO DIFFERENTIATION OF EMBRYONIC NEOCORTEX INTO RETINA IN ADULT-RAT

# publications[].label
Gulf War Illness-related Chemicals Increase Hepatic Steatosis and Enhance Chronic Ethanol-induced Liver Damage in Mice

# publications[].label
Delineating the Neuropathology of Lysosomal Storage Diseases Using Patient-Derived Induced Pluripotent Stem Cells.

# publications[].label
Pattern of long-distance projections from fetal hippocampal field CA3 and CA1 cell grafts in lesioned CA3 of adult hippocampus follows intrinsic character of respective donor cells.

# publications[].label
Mo1361: HEPATOCYTE SPECIFIC DELETION OF MICRORNA-34A ALLEVIATES DUCTULAR REACTION AND LIVER FIBROSIS DURING EXPERIMENTAL CHOLESTASIS

# publications[].label
Issues to ponder when correlating hippocampal neurogenesis to a hippocampal-dependent memory function.

# publications[].label
Hippocampal neurotrophin levels after injury: Relationship to the age of the hippocampus at the time of injury.

# publications[].label
Medial Ganglionic Eminence Precursor Cell Grafting Diminishes Spontaneous Seizures and Improves Memory Function in a Rat Model of Temporal Lobe Epilepsy

# publications[].label
Antiepileptic effects of the neurosteroid allopregnanolone on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy

# publications[].label
Hippocampal neurodegeneration, spontaneous seizures, and mossy fiber sprouting in the F344 rat model of temporal lobe epilepsy.

# publications[].label
Vulnerability of hippocampal GABA-ergic interneurons to kainate-induced excitotoxic injury during old age.

# publications[].label
Reelin Signaling, Hippocampal Neurogenesis, and Efficacy of Aspirin Intake & Stem Cell Transplantation in Aging and Alzheimer's disease.

# publications[].label
Reactive astrocytes express the embryonic intermediate neurofilament nestin.

# publications[].label
Novel therapies for epilepsy in the pipeline.

# publications[].label
Special issue: Stem cells and aging - Introduction

# publications[].label
Fetal nigral grafts in the anterior eye chamber of adult rats: a long-term morphological study.

# publications[].label
Maternal, fetal and neonatal consequences associated with the use of crack cocaine during the gestational period: a systematic review and meta-analysis.

# publications[].label
Extracellular vesicles from hiPSC-NSCs can prevent peripheral inflammation-induced cognitive dysfunction with inflammasome inhibition and improved neurogenesis in the hippocampus.

# publications[].label
Proficiency of Extracellular Vesicles From hiPSC-Derived Neural Stem Cells in Modulating Proinflammatory Human Microglia: Role of Pentraxin-3 and miRNA-21-5p.

# publications[].label
Can rapamycin slow down memory decline in Alzheimer's disease with seizures?

# publications[].label
Obesity Worsens Gulf War Illness Symptom Persistence Pathology by Linking Altered Gut Microbiome Species to Long-Term Gastrointestinal, Hepatic, and Neuronal Inflammation in a Mouse Model.

# publications[].label
Administration of TSG-6 improves memory after traumatic brain injury in mice.

# publications[].label
Vulnerability of the dentate gyrus to aging and intracerebroventricular administration of kainic acid.

# publications[].label
Intranasal Administration of Exosomes from Human iPSC-Derived NSCs Enhances Neural Stem/Progenitor Cell Proliferation and Neurogenesis in the Normal Adult Hippocampus

# publications[].label
Multi-omic Analysis of the Gut Microbiome in Rats with Lithium-Pilocarpine-Induced Temporal Lobe Epilepsy.

# publications[].label
Patient-derived iPSC modeling of rare neurodevelopmental disorders: Molecular pathophysiology and prospective therapies.

# publications[].label
Disruption of the blood-brain barrier and neuronal cell death in cingulate cortex, dentate gyrus, thalamus, and hypothalamus in a rat model of Gulf-War syndrome.

# publications[].label
Neurodegeneration, spontaneous recurrent motor seizures and aberrant mossy fiber sprouting in a model of temporal lobe epilepsy using F344 rats

# publications[].label
Scalable production of standardized extracellular vesicles, extracellular vesicle preparations and uses thereof

# publications[].label
Can mild cognitive impairment and Alzheimer's disease be diagnosed by monitoring a miRNA triad in the blood?

# publications[].label
Prolonged postlesion transplantation delay adversely influences survival of both homotopic and heterotopic fetal hippocampal cell grafts in Kainate-lesioned CA3 region of adult hippocampus.

# publications[].label
Clinical prospects for neural grafting therapy for cortical lesions

# publications[].label
Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Grafting of striatal precursor cells into hippocampus shortly after status epilepticus restrains chronic temporal lobe epilepsy.

# publications[].label
Fetal brain transplantation in kainic acid lesioned caudate nucleus of adult rats.

# publications[].label
Editorial: New Directions in the Management of Status Epilepticus.

# publications[].label
Survival of fetal hippocampal CA3 cell grafts in the middle-aged and aged hippocampus: effect of host age and deafferentation.

# publications[].label
Neurite outgrowth from progeny of epidermal growth factor-responsive hippocampal stem cells is significantly less robust than from fetal hippocampal cells following grafting onto organotypic hippocampal slice cultures: effect of brain-derived neurotrophic factor.

# publications[].label
Acute Exposure to Pyridostigmine Bromide Disrupts Cholinergic Myenteric Neuroimmune Function in Mice.

# publications[].label
Neurological and Neurodegenerative Disorders: Novel Concepts and Treatment.

# publications[].label
Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat.

# publications[].label
Repair of the injured adult hippocampus through graft-mediated modulation of the plasticity of the dentate gyrus in a rat model of temporal lobe epilepsy.

# publications[].label
Extracellular Vesicles Derived From Neural Stem Cells, Astrocytes, and Microglia as Therapeutics for Easing TBI-Induced Brain Dysfunction.

# publications[].label
Efficacy of striatal precursor cell grafting into the hippocampus for suppressing the progression of status epilepticus into chronic epilepsy

# publications[].label
Fetal hippocampal CA3 cell grafts enriched with FGF-2 and BDNF exhibit robust long-term survival and integration and suppress aberrant mossy fiber sprouting in the injured middle-aged hippocampus.

# publications[].label
Postnatal age governs the extent of differentiation of hippocampal CA1 and CA3 subfield neural stem/progenitor cells into neurons and oligodendrocytes.

# publications[].label
Efficacy of Intrahippocampal Grafting of Subventricular Zone-Derived Neural Stem Cells for Easing Status Epilepticus-Induced Temporal Lobe Epilepsy and Related Comorbidities

# publications[].label
Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis, and Gene Expression.

# publications[].label
Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID-19)- Induced Pneumonia.

# publications[].label
Development of long-distance efferent projections from fetal hippocampal grafts depends upon pathway specificity and graft location in kainate-lesioned adult hippocampus.

# publications[].label
Dysbiosis in gastrointestinal pathophysiology: Role of the gut microbiome in Gulf War Illness.

# publications[].label
Promise of irisin to attenuate cognitive dysfunction in aging and Alzheimer's disease.

# publications[].label
Pretreatment of donor cells with FGF-2 enhances survival of fetal hippocampal CA3 cell transplants in the chronically lesioned young adult hippocampus.

# publications[].label
Resveratrol Treatment after Status Epilepticus Restrains Neurodegeneration and Abnormal Neurogenesis with Suppression of Oxidative Stress and Inflammation.

# publications[].label
Deafferentation enhances neurogenesis in the young and middle aged hippocampus but not in the aged hippocampus.

# publications[].label
Gulf war illness-related chemicals increase CD11b/c+ monocyte infiltration into the liver and aggravate hepatic cholestasis in a rodent model.

# publications[].label
Promise of extracellular vesicles for diagnosis and treatment of epilepsy.

# publications[].label
Differential susceptibility of interneurons expressing neuropeptide Y or parvalbumin in the aged hippocampus to acute seizure activity.

# publications[].label
Mash1-dependent Notch Signaling Pathway Regulates GABAergic Neuron-Like Differentiation from Bone Marrow-Derived Mesenchymal Stem Cells.

# publications[].label
Treating Parkinson's disease by astrocyte reprogramming: Progress and challenges.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction.

# publications[].label
SARS-CoV-2 and Hypertension: Evidence Supporting Invasion into the Brain Via Baroreflex Circuitry and the Role of Imbalanced Renin-Angiotensin-Aldosterone-System.

# publications[].label
Resveratrol prevents age-related memory and mood dysfunction with increased hippocampal neurogenesis and microvasculature, and reduced glial activation.

# publications[].label
HUMAN LIVER MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES REDUCE LIVER FIBROSIS THROUGH INHIBITION OF p53-MIR-34a AXIS IN ALD

# publications[].label
Restoration of calbindin after fetal hippocampal CA3 cell grafting into the injured hippocampus in a rat model of temporal lobe epilepsy.

# publications[].label
Exposure to gulf war illness-related chemicals increases susceptibility to cholestatic liver injury by enhancing CD11b+macrophage/monocyte infiltration into the liver

# publications[].label
Innate immune signaling and sex differences contribute to neurocognitive impairment, neuroinflammation, and mitochondrial rewiring in a mouse model of Gulf War illness

# publications[].label
Neural stem cell grafting counteracts hippocampal injury-mediated impairments in mood, memory, and neurogenesis.

# publications[].label
Curcumin treatment leads to better cognitive and mood function in a model of Gulf War Illness with enhanced neurogenesis, and alleviation of inflammation and mitochondrial dysfunction in the hippocampus.

# publications[].label
Extracellular Vesicles in the Forebrain Display Reduced miR-346 and miR-331-3p in a Rat Model of Chronic Temporal Lobe Epilepsy.

# publications[].label
Rhythms of Core Clock Genes and Spontaneous Locomotor Activity in Post-Status Epilepticus Model of Mesial Temporal Lobe Epilepsy.

# publications[].label
Development of fetal hippocampal grafts in intact and lesioned hippocampus.

# publications[].label
Clinical prospects for neural grafting therapy for hippocampal lesions and epilepsy.

# publications[].label
A&D, a bridge between aging and age-related disease

# publications[].label
Grafting of GABAergic Progenitors From Human iPSCs Into the Hippocampus After Status Epilepticus Curbs Spontaneous Seizures and Prevents Cognitive, Memory, and Mood Impairments

# publications[].label
Welcome to the new section of the Editorial Board of Aging Cell: Stem Cells in Aging

# publications[].label
microRNA-34a modulates the senescence of activated hepatic stellate cells in alcohol-associated liver injury

# publications[].label
GABA-ergic cell therapy for epilepsy: Advances, limitations and challenges.

# publications[].label
Is exposure to enriched environment beneficial for functional post-lesional recovery in temporal lobe epilepsy?

# publications[].label
Plasticity of hippocampal stem/progenitor cells to enhance neurogenesis in response to kainate-induced injury is lost by middle age.

# publications[].label
Endothelial dysfunction in pathological processes of chronic liver disease during aging.

# publications[].label
Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress.

# publications[].label
Unilateral Moderate Controlled Cortical Impact Traumatic Brain Injury Induces Enduring Deficits in Spatial, Object Location, Object Recognition and Pattern Separation Memory, and Mood Function

# publications[].label
Modeling Neuroinflammation using iMicroglia Differentiated from hiPSCs: Efficacy of NSC-derived Extracellular Vesicles for Modulating Activated Microglia

# publications[].label
Progenitor cells from the CA3 region of the embryonic day 19 rat hippocampus generate region-specific neuronal phenotypes in vitro.

# publications[].label
Brain-derived neurotrophic factor, phosphorylated cyclic AMP response element binding protein and neuropeptide Y decline as early as middle age in the dentate gyrus and CA1 and CA3 subfields of the hippocampus.

# publications[].label
Effects of Grafting of Hippocampal Stem/Progenitor Cells Shortly After Status Epilepticus on the Development of Chronic Epilepsy

# publications[].label
Non-phosphorylated neurofilament protein immunoreactivity in adult and developing rat hippocampus: specificity and application in grafting studies.

# publications[].label
Extracellular Vesicles in Health and Disease.

# publications[].label
Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy.

# publications[].label
Gulf War illness with or without post-traumatic stress disorder: differential symptoms and immune responses.

# publications[].label
Neural stem cells persist to generate new neurons in the hippocampus of adult and aged human brain - Fiction or accurate?

# publications[].label
Age Related Prevalence of Mild Cognitive Impairment in Type 2 Diabetes Mellitus Patients in the Indian Population and Association of Serum Lipids With Cognitive Dysfunction.

# publications[].label
Declined Hippocampal Neurogenesis Is Associated With Learning & Memory Impairments and Depression in a Rat Model of Gulf War Illness

# publications[].label
Effects of prenatal alcohol exposure on the postnatal morphology of the rat oculomotor nucleus.

# publications[].label
Blood brain barrier dysfunction and delayed neurological deficits in mild traumatic brain injury induced by blast shock waves.

# publications[].label
Fetal hippocampal CA3 cell grafts transplanted to lesioned CA3 region of the adult hippocampus exhibit long-term survival in a rat model of temporal lobe epilepsy.

# publications[].label
Neuroimmune mechanisms of cognitive impairment in a mouse model of Gulf War illness.

# publications[].label
Sub-acute sarin exposure leads to neuropathological and neurochemical changes in the rat brain: Dose-response relationships.

# publications[].label
Prospects of Cannabidiol for Easing Status Epilepticus-Induced Epileptogenesis and Related Comorbidities.

# publications[].label
Increased dentate neurogenesis after grafting of glial restricted progenitors or neural stem cells in the aging hippocampus.

# publications[].label
Fetal hippocampal CA3 cell grafts transplanted to lesioned CA3 region of the adult hippocampus exhibit long-term survival in a rat model of temporal lobe epilepsy

# publications[].label
miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury.

# publications[].publisher
Ovid Technologies (Wolters Kluwer Health)

# publications[].label
Alterations in neuronal development in the substantia nigra pars compacta following in utero ethanol exposure: immunohistochemical and Golgi studies.

# publications[].label
Aging impairs axonal sprouting response of dentate granule cells following target loss and partial deafferentation.

# publications[].label
Neurogenesis response of middle-aged hippocampus to acute seizure activity.

# publications[].label
Could hippocampal neurogenesis be a future drug target for treating temporal lobe epilepsy?

# publications[].label
Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain.

# publications[].label
Reelin Signaling, Hippocampal Neurogenesis, and Efficacy of Aspirin Intake & Stem Cell Transplantation in Aging and Alzheimer's disease

# publications[].label
VULNERABILITY OF HIPPOCAMPAL GABA-ERGIC INTERNEURONS TO EXCITOTOXIC INJURY DURING OLD AGE

# publications[].label
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

# publications[].label
Pathophysiological basis and promise of experimental therapies for Gulf War Illness, a chronic neuropsychiatric syndrome in veterans.

# publications[].label
Neuroinflammation in Gulf War Illness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood.

# publications[].label
Ageing changes in the transplants of fetal substantia nigra grafted to striatum of adult rat.

# publications[].label
Acute Seizures in Old Age Leads to a Greater Loss of CA1 Pyramidal Neurons, an Increased Propensity for Developing Chronic TLE and a Severe Cognitive Dysfunction.

# publications[].label
Chronic alcohol exposure reduces hippocampal neurogenesis and dendritic growth of newborn neurons.

# publications[].label
Behavior of hippocampal stem/progenitor cells following grafting into the injured aged hippocampus.

# publications[].label
Effects of prenatal ethanol exposure on the development of Bergmann glia and astrocytes in the rat cerebellum: an immunohistochemical study.

# publications[].label
A&D, a bridge between aging and age-related disease.

# publications[].label
Neural stem cell therapy for temporal lobe epilepsy

# publications[].label
Combating COVID-19 With Mesenchymal Stem/Stromal Cell Therapy: Promise and Challenges.

# publications[].label
Stem cell-based therapy for COVID-19 and ARDS: a systematic review.

# publications[].label
Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes.

# publications[].label
Hippocampal Neural Stem Cell Grafting after Status Epilepticus Alleviates Chronic Epilepsy and Abnormal Plasticity, and Maintains Better Memory and Mood Function.

# publications[].label
Acute exposure to sarin increases blood brain barrier permeability and induces neuropathological changes in the rat brain: dose-response relationships.

# publications[].label
Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in an Animal Model of Gulf War Illness.

# publications[].label
Hippocampal neurogenesis and neural stem cells in temporal lobe epilepsy.

# publications[].label
Concise review: prospects of stem cell therapy for temporal lobe epilepsy.

# publications[].label
Moderate, intermittent voluntary exercise in a model of Gulf War Illness improves cognitive and mood function with alleviation of activated microglia and astrocytes, and enhanced neurogenesis in the hippocampus.

# publications[].label
DEFINING HOW TSG-6 IMPROVES LONG TERM MEMORY AFTER TRAUMATIC BRAIN INJURY IN MICE

# publications[].label
Hippocampal neurotrophin levels in a kainate model of temporal lobe epilepsy: a lack of correlation between brain-derived neurotrophic factor content and progression of aberrant dentate mossy fiber sprouting.

# publications[].label
A Model of Chronic Temporal Lobe Epilepsy Presenting Constantly Rhythmic and Robust Spontaneous Seizures, Co-morbidities and Hippocampal Neuropathology.

# publications[].label
Parvalbumin and neuropeptide Y expressing hippocampal GABA-ergic inhibitory interneuron numbers decline in a model of Gulf War illness.

# publications[].label
Fetal hippocampal cells grafted to kainate-lesioned CA3 region of adult hippocampus suppress aberrant supragranular sprouting of host mossy fibers.

# publications[].label
Hippocampal interneuron damage, spontaneous recurrent seizures, mossy fiber sprouting, and neurosteroid efficacy in the rat pilocarpine model of temporal lobe epilepsy

# publications[].label
Progress in cell grafting therapy for temporal lobe epilepsy.

# publications[].label
Moderate Running Exercise Improves Cognitive, Memory, and Mood Function With Increased Neurogenesis in a Gulf War Illness Model

# publications[].label
Progress in neuroprotective strategies for preventing epilepsy.

# publications[].label
Maternal crack cocaine use in rats leads to depressive- and anxiety-like behavior, memory impairment, and increased seizure susceptibility in the offspring.

# publications[].label
Liver-specific deletion of microRNA-34a alleviates ductular reaction and liver fibrosis during experimental cholestasis.

# publications[].label
Status epilepticus during old age is not associated with enhanced hippocampal neurogenesis.

# publications[].label
The window and mechanisms of major age-related decline in the production of new neurons within the dentate gyrus of the hippocampus.

# publications[].label
Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease.

# publications[].label
Neural Stem Cell or Human Induced Pluripotent Stem Cell-Derived GABA-ergic Progenitor Cell Grafting in an Animal Model of Chronic Temporal Lobe Epilepsy.

# publications[].label
Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus.

# publications[].label
Concise Review: Prospects of Bone Marrow Mononuclear Cells and Mesenchymal Stem Cells for Treating Status Epilepticus and Chronic Epilepsy.

# publications[].label
In vitro survival and differentiation of neurons derived from epidermal growth factor-responsive postnatal hippocampal stem cells: inducing effects of brain-derived neurotrophic factor.

# publications[].label
Corrigendum: Blood brain barrier dysfunction and delayed neurological deficits in mild traumatic brain injury induced by blast shock waves.

# publications[].label
Prospects of levetiracetam as a neuroprotective drug against status epilepticus, traumatic brain injury, and stroke.

# publications[].label
The Interstitial System of the Brain in Health and Disease.

# publications[].label
Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Voluntary Running Exercise-Mediated Enhanced Neurogenesis Does Not Obliterate Retrograde Spatial Memory.

# publications[].label
Entorhinal axons exhibit sprouting in CA1 subfield of the adult hippocampus in a rat model of temporal lobe epilepsy.

# publications[].label
Adrenal medullary autografts in anterior eye chamber, lateral ventricle and striatum of adult rats: a long term study.

# publications[].label
Extracellular Vesicles for the Diagnosis and Treatment of Parkinson's Disease.

# publications[].label
Decreased neuronal differentiation of newly generated cells underlies reduced hippocampal neurogenesis in chronic temporal lobe epilepsy.

# publications[].label
Stress and combined exposure to low doses of pyridostigmine bromide, DEET, and permethrin produce neurochemical and neuropathological alterations in cerebral cortex, hippocampus, and cerebellum.

# publications[].label
Promise of metformin for preventing age-related cognitive dysfunction.

# publications[].label
Neural Stem Cell Therapy for Easing Status Epilepticus Induced Hippocampus Dysfunction and Chronic Temporal Lobe Epilepsy

# publications[].label
Newly born cells in the ageing dentate gyrus display normal migration, survival and neuronal fate choice but endure retarded early maturation.

# publications[].label
CHOLESTATIC LIVER INJURY IS EXACERBATED BY PRIOR EXPOSURE TO GULF WAR ILLNESS-RELATED CHEMICALS

# publications[].label
Enhanced cell survival in fetal hippocampal suspension transplants grafted to adult rat hippocampus following kainate lesions: a three-dimensional graft reconstruction study.

# publications[].label
Mild Traumatic Brain Injury Induced Through an Exposure to Blast Shock Waves Causes Lasting Hippocampus-Dependent and Hippocampus-Independent Memory Dysfunction and Depression

# publications[].label
Brain Dysfunction in a Model of Gulf War Illness Continues into Middle Age with Elevated Oxidative Stress and Waned Mitochondrial Activity

# publications[].label
Efficacy of doublecortin as a marker to analyse the absolute number and dendritic growth of newly generated neurons in the adult dentate gyrus.

# publications[].label
Promise of resveratrol for easing status epilepticus and epilepsy.

# publications[].label
HUMAN MSC-DERIVED EXTRACELLULAR VESICLE TREATMENT AFTER TBI CAN DIMINISH CHRONIC NEUROINFLAMMATION BY BLOCKING NLRP3 INFLAMMASOME-MEDIATED P38 MAPK SIGNALING CASCADE

# publications[].label
Strategies for promoting anti-seizure effects of hippocampal fetal cells grafted into the hippocampus of rats exhibiting chronic temporal lobe epilepsy.

# publications[].label
Subchronic dermal application of N,N-diethyl m-toluamide (DEET) and permethrin to adult rats, alone or in combination, causes diffuse neuronal cell death and cytoskeletal abnormalities in the cerebral cortex and the hippocampus, and Purkinje neuron loss in the cerebellum.

# publications[].label
COVID-19 in India: Are Biological and Environmental Factors Helping to Stem the Incidence and Severity?

# publications[].label
Further validation of the efficacy of mesenchymal stem cell infusions for reducing mortality in COVID-19 patients with ARDS.

# publications[].label
Aging in the rat hippocampus is associated with widespread reductions in the number of glutamate decarboxylase-67 positive interneurons but not interneuron degeneration.

# publications[].label
Neural Stem Cells in the Adult Brain: Altered Activity in Aging, Alzheimers Disease, Mood Disorders and Epilepsy

# publications[].label
Hippocampal interneurons expressing glutamic acid decarboxylase and calcium-binding proteins decrease with aging in Fischer 344 rats.

# publications[].label
Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy.

# publications[].label
Apolipoprotein  in Brain and Retinal Neurodegenerative Diseases.

# publications[].label
THE AGGRAVATING EFFECTS OF GULF WAR ILLNESS-RELATED CHEMICALS ON HEPATIC STEATOSIS AND ETHANOL-INDUCED CHRONIC LIVER INJURY IN MICE

# publications[].label
Combined neurotrophic supplementation and caspase inhibition enhances survival of fetal hippocampal CA3 cell grafts in lesioned CA3 region of the aging hippocampus.

# publications[].label
Object location and object recognition memory impairments, motivation deficits and depression in a model of Gulf War illness.

# publications[].label
Links Between Loss of Reelin(+) Interneurons, Frequency of Spontaneous Seizures, and Memory Impairments in Chronic Temporal Lobe Epilepsy

# publications[].label
Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus.

# publications[].label
HEPATOCYTE SPECIFIC DELETION OF MICRORNA-34A ALLEVIATES DUCTULAR REACTION AND LIVER FIBROSIS DURING EXPERIMENTAL CHOLESTASIS

# publications[].label
Medial ganglionic eminence-derived neural stem cell grafts ease spontaneous seizures and restore GDNF expression in a rat model of chronic temporal lobe epilepsy.

# publications[].label
Hydroelectrolytic Disorder in COVID-19 patients: Evidence Supporting the Involvement of Subfornical Organ and Paraventricular Nucleus of the Hypothalamus.

# publications[].label
Survival of grafted fetal neural cells in kainic acid lesioned CA3 region of adult hippocampus depends upon cell specificity.

# publications[].label
Quantitative graft integration of fetal hippocampal transplants labeled with 5' bromodeoxyuridine into normal adult hippocampus.

# publications[].label
Neural stem cell grafting in an animal model of chronic temporal lobe epilepsy.

# publications[].label
Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus.

# publications[].label
Monosodium luminol reinstates redox homeostasis, improves cognition, mood and neurogenesis, and alleviates neuro- and systemic inflammation in a model of Gulf War Illness.

# publications[].label
Running Exercise Does Not Promote Forgetting in Adult Rats

# publications[].label
Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties.

# publications[].label
Behavior of neural stem cells in the Alzheimer brain.

# publications[].label
Long-term changes in neuroimaging markers, cognitive function and psychiatric symptoms in an experimental model of Gulf War Illness.

# publications[].label
Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders.

# publications[].label
Hippocampal injury-induced cognitive and mood dysfunction, altered neurogenesis, and epilepsy: can early neural stem cell grafting intervention provide protection?

# publications[].label
Intracerebroventricular kainic acid administration in adult rat alters hippocampal calbindin and non-phosphorylated neurofilament expression.

# publications[].label
Implications of decreased hippocampal neurogenesis in chronic temporal lobe epilepsy.

# publications[].label
Phospholipid profiling of plasma from GW veterans and rodent models to identify potential biomarkers of Gulf War Illness.

# publications[].label
Acute exposure to sarin increases blood brain barrier permeability AND induces neuropathological changes in the rat brain: Dose response relationship

# researcherOn[].awardedBy.label
Central Texas Veterans Health Care System - (Waco, Texas, United States)

# researcherOn[].awardedBy.preferredLabel
Central Texas Veterans Health Care System

# researcherOn[].label
Mitochondrial Dysfunction and Aberrant Immune Activation in the Pathobiology of Gulf War Illness

# researcherOn[].awardedBy.label
United States Army - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
DOD-Army-Medical Research and Materiel Command

# researcherOn[].awardedBy.label
Central Texas Veterans Health Care System - (Waco, Texas, United States)

# researcherOn[].awardedBy.preferredLabel
Central Texas Veterans Health Care System

# researcherOn[].awardedBy.label
Central Texas Veterans Health Care System - (Waco, Texas, United States)

# researcherOn[].awardedBy.preferredLabel
Central Texas Veterans Health Care System

# researcherOn[].label
Vagus Nerve Stimulation as a Treatment Strategy for Gulf War Illness

# researcherOn[].awardedBy.label
United States Army - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
DOD-Army-Medical Research and Materiel Command

# researcherOn[].label
Treating Gulf War Illness via Modulation of Leukotriene Signaling

# researcherOn[].awardedBy.label
United States Army - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Monosodium Luminol for Improving Brain Function in Gulf War Illness

# researcherOn[].awardedBy.label
United States Army - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Curcumin Nanoparticle Therapy for Gulf  War Illness

# researcherOn[].awardedBy.label
United States Army - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
DOD-Army-Medical Research and Materiel Command

# researcherOn[].awardedBy.label
Central Texas Veterans Health Care System - (Waco, Texas, United States)

# researcherOn[].awardedBy.preferredLabel
Central Texas Veterans Health Care System

# researcherOn[].label
The Contributions of CD74 to Acquired Epilepsy

# researcherOn[].awardedBy.label
Citizens United for Research in Epilepsy - (Chicago, Illinois, United States)

# researcherOn[].label
Neurosteroid Therapy for Gulf War Illness

# researcherOn[].awardedBy.label
United States Army - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
U.S. Army Medical Research Acquisition Activity

# researcherOn[].label
Melatonin for Reversing Brain Dysfunction in Gulf War Illness

# researcherOn[].awardedBy.label
United States Army - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
DOD-Army-Medical Research and Materiel Command

# researcherOn[].label
Human iPSC-Derived GABA-Ergic Precursor Cell Therapy for Chronic Epilepsy

# researcherOn[].awardedBy.label
United States Army - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.label
Central Texas Veterans Health Care System - (Waco, Texas, United States)

# researcherOn[].awardedBy.preferredLabel
Central Texas Veterans Health Care System

# researcherOn[].label
Mesenchymal Stem Cell Derived A1-Exosomes for Traumatic Brain Injury

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Neurological Disorders and Stroke

# researcherOn[].label
Curcumin Nanoparticle Therapy for Gulf War Illness

# researcherOn[].awardedBy.label
Congressionally Directed Medical Research Programs - (Frederick, Maryland, United States)

# researcherOn[].awardedBy.label
Central Texas Veterans Health Care System - (Waco, Texas, United States)

# researcherOn[].awardedBy.preferredLabel
Central Texas Veterans Health Care System

# streetAddress
Texas A&M Health Science Center; Regenerative Medicine; 1114 TAMUS

# inTheNews[].label
Stem cell-derived neurons stop seizures, improve cognitive function

# inTheNews[].label
Could A Nasal Spray Of "Nanovesicles" Repair Brain Cells?

# inTheNews[].label
TEXAS A&M HEALTH FACULTY RANK AMONG TOP 2 PERCENT SCHOLARS WORLDWIDE

# inTheNews[].label
Texas A&M Professor Awarded Department Of Defense Grant For Gulf War Illness Research

# inTheNews[].label
Could stem cells be used to treat COVID-19?

# inTheNews[].label
Running could improve brain function in Gulf War illness

# inTheNews[].label
Watson, Shetty honored with College of Medicine Research Excellence Award

# inTheNews[].label
Drug shows promise for treating cognitive problems and inflammation in Gulf War illness

# inTheNews[].label
Regenerating memory with neural stem cells

# inTheNews[].label
Medical student explores progress and challenges of new therapy for Parkinson’s disease

# inTheNews[].label
Inside the stem-cell pharmaceutical factory

# inTheNews[].label
Study shows exercise won’t cause you to forget things

# inTheNews[].label
Shetty awarded Department of Defense grant for new research on Veterans with Gulf War illness

# inTheNews[].label
Could a common diabetes drug slow down aging?

# inTheNews[].label
Innovations in gut research could help veterans with Gulf War Illness

# inTheNews[].label
Preventing seizure-caused damage to the brain

# inTheNews[].label
Compound found in grapes, red wine may help prevent memory loss

# inTheNews[].label
Curcumin shows promise for treating Gulf War illness