# positions[].organizations[].parent[].label
College of Veterinary Medicine and Biomedical Sciences

# positions[].organizations[].parent[].label
School of Veterinary Medicine and Biomedical Sciences

# overview
Mechanisms of disease pathogenesis of neurotropic viruses. Immunological therapies for multiple sclerosis and epilepsy. Neuroimmunological changes in the injured CNS

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Physical Injury - Accidents And Adverse Effects

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Theiler's Murine Encephalomyelitis Virus, (tmev)

# educationAndTraining[].organization.label
University College London - (London, United Kingdom)

# educationAndTraining[].organization.label
University College London - (London, United Kingdom)

# publications[].label
Social conflict exacerbates an animal model of multiple sclerosis.

# publications[].label
Ovine IFN-tau modulates the expression of MHC antigens on murine cerebrovascular endothelial cells and inhibits replication of Theiler's virus.

# publications[].label
The detection of heat-aggregated IgG (as a model for immune complexes) by reverse passive haemagglutination using a human monoclonal rheumatoid factor coupled to erythrocytes.

# publications[].label
A Three-Dimensional Arrayed Microfluidic Blood-Brain Barrier Model With Integrated Electrical Sensor Array.

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
Restraint stress facilitates systemic dissemination of Theiler's virus and alters its pathogenecity.

# publications[].label
The effects of restraint stress on the neuropathogenesis of Theiler's virus induced demyelination: A murine model for multiple sclerosis

# publications[].label
Identification of the target cells and sequence of infection during experimental infection of ovine fetuses with Cache Valley virus.

# publications[].label
Host genetic background influences diverse neurological responses to viral infection in mice.

# publications[].label
Uveitis, vitreous humour, and klebsiella. II. Cross-reactivity studies with radioimmunoassay.

# publications[].label
Interferon-tau upregulates the expression of MHC class I on cerebrovascular endothelial cells derived from SJL mice

# publications[].label
Galectin-9 is up-regulated in astrocytes by TNF and promotes encephalitogenic T-cell apoptosis

# publications[].label
Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division.

# publications[].label
Serum Cytokines Predict Neurological Damage in Genetically Diverse Mouse Models.

# publications[].label
The role of CD8+T cells in the acute and chronic phases of Theiler's murine encephalomyelitis virus-induced disease in mice.

# publications[].label
MOLECULAR MIMICRY AS A PATHOGENIC MECHANISM IN RHEUMATIC-FEVER

# publications[].label
Investigation of the role of delayed-type-hypersensitivity responses to myelin in the pathogenesis of Theiler's virus-induced demyelinating disease.

# publications[].label
Social Stress Alters the Severity of a Virally Initiated Model of Multiple Sclerosis

# publications[].label
Neonatal experience interacts with adult social stress to alter acute and chronic Theiler's virus infection.

# publications[].label
Expression of matrix-metalloproteinases and their inhibitors in Theiler's murine encephalomyelitis-variation with virus strain

# publications[].label
Cytokine-induced, nitric oxide-dependent, intracellular antirickettsial activity of mouse endothelial cells.

# publications[].label
Hormone and immune system interactions in demyelinating disease.

# publications[].label
Circulating neutrophil activation in dogs with naturally occurring spinal cord injury secondary to intervertebral disk herniation.

# publications[].publisher
American Veterinary Medical Association (AVMA)

# publications[].label
CROSS-REACTIVITY BETWEEN VITREOUS-HUMOR, KLEBSIELLA ENTEROBACTER MICROORGANISMS AND HUMAN LYMPHOCYTES - POSSIBLE MECHANISM FOR UVEITIS AND ANKYLOSING-SPONDYLITIS

# publications[].label
Peripheral blood neutrophil activity profiles in dogs with spinal cord injuries: a longitudinal analysis

# publications[].publisher
Federation of American Society of Experimental Biology

# publications[].label
Impact of stressors on disease resistance of different genotypes

# publications[].label
Social stress alters the severity of an animal model of multiple sclerosis

# publications[].label
Ankylosing spondylitis, HLA-B27 and Klebsiella. I. Cross-reactivity studies with rabbit antisera.

# publications[].label
Arachidonic acid pathway alterations in cerebrospinal fluid of dogs with naturally occurring spinal cord injury.

# publications[].label
The blood-brain barrier in virus-induced demyelination.

# publications[].label
Early rheumatoid-like synovial lesions in rabbits drinking cow's milk. II. Antibody responses to bovine serum proteins.

# publications[].label
The effects of restraint stress on the neuropathogenesis of Theiler's virus infection: I. Acute disease.

# publications[].label
Glucocorticoid exposure alters the pathogenesis of Theiler's murine encephalomyelitis virus during acute infection.

# publications[].label
Social disruption induced priming of CNS inflammatory response to Theiler's virus is dependent upon stress induced IL-6 release.

# publications[].label
Castration of male C57L/J mice increases susceptibility and estrogen treatment restores resistance to Theiler's virus-induced demyelinating disease.

# publications[].label
Neuroimmune interactions in a model of multiple sclerosis.

# publications[].label
Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice.

# publications[].label
The effect of stress on the neuropathogenesis of Theiler's virus-induced demyelination (TVID) as a model for multiple sclerosis

# publications[].label
ANKYLOSING-SPONDYLITIS, HLA-B27, AND KLEBSIELLA - CROSS-REACTIVITY STUDIES WITH RABBIT ANTI-LYMPHOCYTE SERA AND HUMAN-TISSUE TYPING SERA

# publications[].label
Immunomodulation of Theiler's virus-induced demyelination [TVID] using encapsulated ovine interferon-tau [IFNT]: The novel administration of a novel type IIFN in an animal model of multiple sclerosis [MS]

# publications[].label
Foreword for Neuroimmunomodulation in health and disease.

# publications[].label
Synovitis associated with serum IgM rheumatoid factor arising spontaneously in 'Old English' rabbits.

# publications[].label
Characterization of Plaque-Sized Variants of Daniel's (DA)Strain in Theiler's Virus-Induced Epilepsy.

# publications[].label
Cerebrospinal fluid inflammatory cytokines and chemokines in naturally occurring canine spinal cord injury.

# publications[].label
Neonatal maternal separation alters immune, endocrine, and behavioral responses to acute Theiler's virus infection in adult mice.

# publications[].label
Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.

# publications[].label
Social stress alters the severity and onset of the chronic phase of Theiler's virus infection.

# publications[].label
#62 Possible role for IL-6 in social stress exacerbations of acute Theilers virus infection

# publications[].label
Social stress exacerbates the acute and chronic phase of Theiler's virus infection

# publications[].label
Effects of restraint stress on adaptive immune responses to acute Theiler's virus infection in SJL mice

# publications[].label
Acute Phase Proteins in Cerebrospinal Fluid from Dogs with Naturally-Occurring Spinal Cord Injury.

# publications[].label
The effects of restraint stress on the neuropathogenesis of Theiler's virus infection II: NK cell function and cytokine levels in acute disease.

# publications[].label
Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity.

# publications[].label
Comparison of the arthritogenic properties of dietary cow's milk, egg albumin and soya milk in experimental animals.

# publications[].label
Social stress alters the severity of acute Theiler's virus infection.

# publications[].label
Cloned mouse cerebrovascular endothelial cells that maintain their differentiation markers for factor VIII, low density lipoprotein, and angiotensin-converting enzyme.

# publications[].label
CHAPTER 52 Social Stress Alters the Severity of a Virally Initiated Model of Multiple Sclerosis

# publications[].label
Inflammatory Disorders of the Nervous System Pathogenesis, Immunology, and Clinical Management. 2005. In: Alireza Minagar, Steven Alexander, J. (Eds.), Humana Press, Totowa, New Jersey. Louisiana State University, Health Science Center, Shreveport, LA

# publications[].label
42. Prior exposure to social stress sensitizes virus-induced cytokine expression during acute Theilers virus infection

# publications[].label
Viral Clearance and Neuroinflammation in Acute TMEV Infection Vary by Host Genetic Background.

# publications[].label
Impact of stress on an animal model of multiple sclerosis

# publications[].label
Differential abilities of central nervous system resident endothelial cells and astrocytes to serve as inducible antigen-presenting cells.

# publications[].label
Neuroimmunomodulation in health and disease.

# publications[].label
Study of the mechanisms by which CD4+ T cells contribute to protection in Theiler's murine encephalomyelitis.

# publications[].label
Restraint stress decreases virus-induced pro-inflammatory cytokine mRNA expression during acute Theiler's virus infection.

# publications[].label
Consequences of perinatal bisphenol A exposure in a mouse model of multiple sclerosis.

# publications[].label
Resilience in Long-Term Viral Infection: Genetic Determinants and Interactions.

# publications[].label
Sex-dependent effects of chronic restraint stress during early Theiler's virus infection on the subsequent demyelinating disease in CBA mice.

# publications[].label
Sex Differences in Neurological Diseases

# publications[].label
Uveitis, vitreous humor, and klebsiella. I. Binding studies with rabbit antisera.

# publications[].label
A multi-channel in vitro blood-brain barrier model

# publications[].label
Enhancement of immune function in rodents using a complex plant carbohydrate which stimulates macrophage secretion of immunointeractive cytokines

# publications[].label
The effects of restraint stress (RS) on immune responses to Theiler's murine encephalomyelitis virus (TMEV) in SJL mice

# publications[].label
Histamine-induced microvascular leakage in pial venules: differences between the SJL/J and BALB/c inbred strains of mice.

# publications[].label
Monoclonal antibodies for the depletion of specific subpopulations of lymphocytes.

# publications[].label
The effect of L3T4 T cell depletion on the pathogenesis of Theiler's murine encephalomyelitis virus infection in CBA mice.

# publications[].label
Ankylosing spondylitis, HLA-B27 and Klebsiella. II. Cross-reactivity studies with human tissue typing sera.

# publications[].label
Theiler's virus: an experimental model of virus-induced demyelination.

# publications[].label
Restraint stress modulates virus specific adaptive immunity during acute Theiler's virus infection.

# publications[].label
Experimental induction of rheumatoid factor and joint lesions in rabbits after intravenous injections of killed bacteria.

# publications[].label
Effects of stress on the immune response to Theiler's virus--implications for virus-induced autoimmunity.

# publications[].label
A comparison of the neurotropism of Theiler's virus and poliovirus in CBA mice.

# publications[].label
Social stress and inflammation in the exacerbation of multiple sclerosis: An animal model with implications for humans.

# publications[].label
Maternal separation alters Theiler's virus infection in adulthood

# publications[].label
78. Impact of chronic restraint stress during early Theilers virus infection on CNS disease severity in SJL mice

# publications[].label
UVEITUS AND CROSS-REACTIVITY STUDIES BETWEEN VITREOUS-HUMOR AND KLEBSIELLA, USING RADIOIMMUNOASSAY

# publications[].label
Alterations in chemokine expression following Theiler's virus infection and restraint stress.

# publications[].label
Theiler's Virus (TMEV) upregulates the expression of MHC class I on cerebrovascular endothelial cells

# publications[].label
Baseline Gait and Motor Function Predict Long-Term Severity of Neurological Outcomes of Viral Infection.

# publications[].label
Galectin-9 is upregulated in astrocytes by proinflammatory cytokines and suppresses encephalitogenic T-cells in the CNS

# publications[].label
Ovine fetal immune response to Cache Valley virus infection.

# publications[].label
Chronic social stress impairs virus specific adaptive immunity during acute Theiler's virus infection.

# publications[].label
Interleukin-6 as a mechanism for the adverse effects of social stress on acute Theiler's virus infection.

# publications[].label
Restraint stress fails to render C57BL/6 mice susceptible to Theiler's virus-induced demyelination.

# publications[].label
Observations on demyelinating lesions induced by Theiler's virus in CBA mice.

# publications[].label
Early rheumatoid-like synovial lesions in rabbits drinking cow's milk. I. Joint pathology.

# publications[].label
Genetic and immunological contributors to virus-induced paralysis.

# publications[].label
Characteristics of cloned cerebrovascular endothelial cells following infection with Theiler's virus. I. Acute infection.

# publications[].label
Neural and neuroendocrine mechanisms in host defense and autoimmunity

# publications[].label
Therapeutic effects of estrogens on inflammatory demyelination in a mouse model of multiple sclerosis.

# publications[].label
Correlation between susceptibility to demyelination and interferon-gamma induction of major histocompatibility complex class II antigens on murine cerebrovascular endothelial cells.

# publications[].label
Chapter 12 Sex Differences in Neurological Diseases

# publications[].label
Antecedent presentation of neurological phenotypes in the Collaborative Cross reveals four classes with complex sex-dependencies.

# publications[].label
Host genetic diversity drives variable central nervous system lesion distribution in chronic phase of Theiler's Murine Encephalomyelitis Virus (TMEV) infection.

# publications[].label
Production and preliminary characterization of monoclonal antibodies to human liver-specific lipoprotein (LSP).

# publications[].label
Characteristics of cloned cerebrovascular endothelial cells following infection with Theiler's virus. II. Persistent infection.

# publications[].label
An animal model of hypnotic pain attenuation.

# publications[].label
Measurement of serum antibodies to C1q and conglutinin in rabbits following feeding with cows' milk and in normal human serum.

# publications[].label
Social disruption alters pain and cognition in an animal model of multiple sclerosis.

# researcherOn[].label
Host Genetic Determinants of Diversity in Viral-Induced Neuropathology

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Neurological Disorders and Stroke

# streetAddress
Raymond Stotzer Parkway; Veterinary Integrative Biosciences; 4458 TAMU

# organizations[]
College of Veterinary Medicine and Biomedical Sciences

# organizations[]
School of Veterinary Medicine and Biomedical Sciences

# schools[]
College of Veterinary Medicine and Biomedical Sciences

# schools[]
School of Veterinary Medicine and Biomedical Sciences

# etdChairOf[].label
Russell, Rae Leigh (2019-04). Characterizing Neutrophil Response Following Naturally-Occurring Spinal Cord Injury. Doctoral Dissertation.

# etdChairOf[].label
Hodo, Carolyn Louise (2017-08). The Ecology of Trypanosoma cruzi and Its Mammalian Hosts in Texas, USA. Doctoral Dissertation.

# etdChairOf[].label
Bhattarai, Bikash (2013-08). Economic Consequences Associated with Johne’s Disease in Cow-Calf Operations. Doctoral Dissertation.

# etdChairOf[].label
Rodrigues, Aline (2012-02). The Pathogenesis of Cache Valley Virus in the Ovine Fetus. Doctoral Dissertation.

# etdChairOf[].label
Gomez, Francisco Pascual (2012-08). Estrogen Therapy in a Viral Murine Model of Multiple Sclerosis. Master's Thesis.

# etdChairOf[].label
Bijalwan, Megha (2017-12). Pathogenesis of Theiler’s Murine Encephalomyelitis Virus (TMEV) in an Experimental Model of Epilepsy. Doctoral Dissertation.

# etdChairOf[].label
Villarreal, Dorissa (2005-08). Neurotropism of Theiler's murine  encephalomyelitis virus. Master's Thesis.

# etdChairOf[].label
Mi, Wentao (2005-08). The effect of stress on the neuropathogenesis of Theiler's virus-induced demyelination as an animal model of multiple sclerosis. Doctoral Dissertation.

# etdChairOf[].label
Steelman, Andrew Jonathan (2008-05). The Effects of Chronic Restraint Stress on Innate and Adaptive Immune Responses to Acute Theiler?s Murine Encephalomyelitis Virus Infection ? An Animal Model of Human Multiple Sclerosis. Doctoral Dissertation.