# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
My research focuses on the physiological and pathophysiological regulation of coronary and retinal microcirculation. In the circulatory system, the amount of blood delivered to each tissue can be regulated by the activity of arterial microvessels (<100  m in diameter). Changes in vascular tone, i.e., constriction or dilation of these microvessels, will decrease or increase blood supply to the tissue, respectively. However, the mechanisms involved in the regulation of vascular tone are not completely understood. Our current research focuses on the regulation of microvascular tone by hemodynamic (e.g., pressure and shear stress), metabolic (e.g., adenosine, osmolarity, K+, pH, pO2) and neural (adrenergic receptors) factors. To have an integrative view on the flow regulation, this basic information are reconstructed using mathematical model and computer simulation technology. This research provides a basic foundation critical to our understanding of blood flow regulation in the microvascular network under normal and disease states.

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Confocal Scanning Laser Ophthalmoscopy (cslo)

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Calcium Release-activated Calcium Channel Protein 1 (ORAI1)

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# educationAndTraining[].organization.label
National Taiwan University - (Taipei, Taipei, Taiwan)

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# educationAndTraining[].organization.label
Virginia Commonwealth University Medical Center - (Richmond, Virginia, United States)

# publications[].label
Arginase modulates nitric oxide production in activated macrophages.

# publications[].label
Role of endothelium in vasomotor responses to endothelin system and protein kinase C activation in porcine retinal arterioles.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
alpha-adrenergic responses of isolated canine coronary microvessels.

# publications[].label
Activation of JNK and xanthine oxidase by TNF-alpha impairs nitric oxide-mediated dilation of coronary arterioles.

# publications[].label
Simvastatin elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and mevalonate-rho kinase pathways.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
INHIBITION OF NITRIC-OXIDE SYNTHESIS ATTENUATES CORONARY METABOLIC VASODILATION

# publications[].label
Upregulation of endothelial arginase by oxidative stress impairs NO-mediated vasodilation

# publications[].label
The involvement of tyrosine kinases, cyclic AMP/protein kinase A, and p38 mitogen-activated protein kinase in IL-13-mediated arginase I induction in macrophages: its implications in IL-13-inhibited nitric oxide production.

# publications[].publisher
The American Association of Immunologists

# publications[].label
Coronary Microvascular Responses to Flow

# publications[].label
Tumor necrosis factor-induced production of superoxide inhibits endothelium-dependent NO-mediated dilation of coronary arterioles: role of ceramide signaling and xanthine oxidase

# publications[].label
Centrogenic pulmonary hemorrhagic edema induced by cerebral compression in rats. Mechanism of volume and pressure loading in the pulmonary circulation.

# publications[].label
H2O2 Mediates VEGF- and Flow-Induced Dilations of Coronary Arterioles in Early Type 1 Diabetes: Role of Vascular Arginase and PI3K-Linked eNOS Uncoupling.

# publications[].label
Regulation of nitric oxide production by arginase in vascular smooth muscle

# publications[].label
Angiotensin II AT1 receptor mediates potentiation of coronary arteriolar constriction to phenylephrine

# publications[].label
CORONARY VASOMOTOR REGULATION BY ENDOTHELIN-1 AND OXIDATIVE STRESS

# publications[].label
Lipopolysaccharide activates endothelial nitric oxide synthase through protein tyrosine kinase.

# publications[].label
Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles.

# publications[].label
cAMP-independent dilation of coronary arterioles to isoproterenol: Role of nitric oxide and K-ATP channels

# publications[].label
Requisite Roles of Endothelial Nitric Oxide Synthase and Smooth Muscle Phosphoinositide 3-Kinase/Rho Kinase In Vasomotor Regulation of Human Retinal Arterioles

# publications[].label
C-reactive protein inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles via enhanced superoxide production.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
ATHEROSCLEROSIS BLUNTS AGONIST-INDUCED INCREASES IN INTRACELLULAR CALCIUM IN AORTIC ENDOTHELIAL-CELLS

# publications[].label
Retinal arteriolar endothelial dysfunction in early stage of diabetes in porcine model

# publications[].label
Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.

# publications[].label
Dysregulation of coronary arteriolar response to the metabolic vasodilator adenosine in hypertrophic cardiomyopathy: Role of NO and O2-

# publications[].label
Intravitreal Stanniocalcin-1 enhances new blood vessel growth in a rat model of laser-induced choroidal neovascularization

# publications[].label
Cardiovascular metabolic engineering for modulating nitric oxide production during sepsis

# publications[].label
Effective diffusion distance of nitric oxide in the microcirculation.

# publications[].label
Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice.

# publications[].label
Acute and Chronic Hyperglycemia Elicit JIP1/JNK-Mediated Endothelial Vasodilator Dysfunction of Retinal Arterioles.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Sodium azide dilates coronary arterioles via activation of inward rectifier K+ channels and Na+-K+-ATPase.

# publications[].label
cAMP-independent dilation of coronary arterioles to adenosine: Role of nitric oxide, G-proteins, and K-ATP channels.

# publications[].label
Oxidized low-density lipoprotein impairs nitric oxide-mediated dilation of coronary arterioles

# publications[].label
Histamine-Induced Dilation of Isolated Porcine Retinal Arterioles: Role of Endothelium-Derived Hyperpolarizing Factor.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Effect of hemodilution on oxygen transport in arteriolar networks of hamster striated muscle.

# publications[].label
Coronary arteriolar vasoconstriction to angiotensin II is augmented in prediabetic metabolic syndrome via activation of AT1 receptors.

# publications[].label
Resveratrol, a component of red wine, elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Cardiac hypertrophy leads to coronary microvascular dysfunction and enhanced endothelin1/Rhokinase signaling in mice with transverse aortic coarctation (676.1)

# publications[].label
High glucose impairs EDHF-mediated dilation of coronary arterioles via reduced cytochrome P450 activity.

# publications[].label
Demonstration of eNOS uncoupling, altered proteinprotein association and impaired vascular reactivity:CRPmediated effects in vascular endothelium

# publications[].label
CRP activates LOX-1 and inhibits prostacyclin-mediated dilation of coronary arterioles

# publications[].label
Activation of Coronary Arteriolar PKC2 Impairs Endothelial NO-Mediated Vasodilation: Role of JNK/Rho Kinase Signaling and Xanthine Oxidase Activation.

# publications[].label
Safety and toxicity of nanomaterials for ocular drug delivery applications.

# publications[].label
Vasomotor regulation of coronary microcirculation by oxidative stress: role of arginase.

# publications[].label
Distribution and control of coronary microvascular resistance.

# publications[].label
Alterations of Ocular Hemodynamics Impair Ophthalmic Vascular and Neuroretinal Function.

# publications[].label
Effect of systemic administration of simvastatin on retinal circulation.

# publications[].label
Coronary vasodilation and K-ATP channels: Independence from nitric oxide

# publications[].label
ENDOTHELIAL MODULATION OF ARTERIOLAR TONE

# publications[].label
Erythrocyte consumption of nitric oxide: competition experiment and model analysis.

# publications[].label
C-reactive protein impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles by activating the LOX-1 receptor and NADPH oxidase

# publications[].label
Arterial hypertension induces ocular vascular dysfunction in mice with pressure-overload cardiac hypertrophy

# publications[].label
Regulation of nitric oxide-mediated dilation by arginase in coronary arterioles.

# publications[].label
Local Regulation of Microvascular Perfusion

# publications[].label
Coronary venular responses to flow and pressure.

# publications[].label
Correlation of Fundus Autofluorescence and Histology of Laser-induced Choroidal Neovascularization in the Rat

# publications[].label
Characterization of adenosine receptor-mediated dilation of porcine coronary arterioles

# publications[].label
Influence of hemoconcentration on arteriolar oxygen transport in hamster striated muscle.

# publications[].label
Ischemia/reperfusion inhibits nitric oxide-mediated dilation in coronary arterioles by upregulation of arginase

# publications[].label
Acidosis enhances vasodilation of coronary arterioles to adenosine by increasing activation of K-ATP channels

# publications[].label
Regulation of coronary blood flow: coordination of heterogeneous control mechanisms in vascular microdomains.

# publications[].label
NITROVASODILATOR-MEDIATED FLOW-INDUCED DILATION IN ISOLATED PORCINE CORONARY VENULES

# publications[].label
Regulation of nitric oxide consumption by hypoxic red blood cells.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Alteration of ocular blood pressure and flow leads to ophthalmic vascular and neuroretinal dysfunction

# publications[].label
Activation of Smooth Muscle Kir2.1 Channels and Na+/K+-ATPase Mediates Dilation of Porcine Coronary Arterioles at Physiological Levels of Potassium.

# publications[].label
Heterogeneous beta2-adrenoceptor expression and dilation in coronary arterioles across the left ventricular wall.

# publications[].label
Activation of angiotensin II AT1 receptor inhibits endothelium-dependent nitric oxide-mediated dilation of coronary arterioles: Role of superoxide anion

# publications[].label
PARADOXICAL INVIVO AND INVITRO RESPONSES OF CORONARY ARTERIOLES TO ALPHA-ADRENERGIC ACTIVATION

# publications[].label
Regulation of coronary blood flow: coordination of heterogeneous control mechanisms in vascular microdomains

# publications[].label
Gating and Assembling Mechanisms of CRAC Channels

# publications[].label
Estimation of nitric oxide production and reaction rates in tissue by use of a mathematical model.

# publications[].label
Role of nitric oxide in the coronary microvascular responses to adenosine and increased metabolic demand.

# publications[].label
Intravascular flow decreases erythrocyte consumption of nitric oxide.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Modulation of nitric oxide bioavailability by erythrocytes

# publications[].label
Myogenic and flow-dependent control mechanisms in the coronary microcirculation.

# publications[].label
Cellular signalling pathways mediating dilation of porcine pial arterioles to adenosine AA receptor activation.

# publications[].label
Stromal interaction molecule 1 (STIM1) and Orai1 mediate histamine-evoked calcium entry and nuclear factor of activated T-cells (NFAT) signaling in human umbilical vein endothelial cells.

# publications[].label
Role of Myocardial EndothelinConverting Enzyme in Promoting Coronary Arteriolar Constriction during Diabetes

# publications[].label
ENDOTOXIN IMPAIRS FLOW-INDUCED VASODILATION OF PORCINE CORONARY ARTERIOLES

# publications[].label
In vivo and in vitro vasoactive reactions of coronary arteriolar microvessels to nitroglycerin

# publications[].label
Dilation of retinal arterioles in response to lactate: role of nitric oxide, guanylyl cyclase, and ATP-sensitive potassium channels.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Coronary arteriolar dilation to acidosis: role of ATP-sensitive potassium channels and pertussis toxin-sensitive G proteins.

# publications[].label
DIFFERENTIAL ENDOTHELIUM-DEPENDENT RESPONSES TO SHEAR-STRESS AND AGONISTS IN CORONARY MICROCIRCULATION

# publications[].label
Impaired adenosine-induced dilation in coronary arteries from transgenic mouse hearts expressing a familial hypertrophic cardiomyopathy mutation

# publications[].label
C-reactive protein impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles via p38 kinase and NADPH oxidase activation

# publications[].label
Sildenafil (Viagra) evokes retinal arteriolar dilation: dual pathways via NOS activation and phosphodiesterase inhibition.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Adenosine A(2A) receptors mediate coronary microvascular dilation to adenosine: role of nitric oxide and ATP-sensitive potassium channels.

# publications[].label
Differential effect of oxidized low-density lipoprotein on nitric oxide- and potassium channel-mediated dilation of coronary arterioles.

# publications[].label
Role of arginase-I in capillary tube formation and ischemia-induced angiogenesis

# publications[].label
oxLDL specifically impairs endothelium-dependent, NO-mediated dilation of coronary arterioles.

# publications[].label
ADENOSINE POTENTIATES FLOW-INDUCED DILATION IN CORONARY MICROCIRCULATION

# publications[].label
A mathematical model for the distribution of hemodynamic parameters in the human retinal microvascular network

# publications[].label
Differential progressive remodeling of coronary and cerebral arteries and arterioles in an aortic coarctation model of hypertension.

# publications[].label
Data on SD-OCT image acquisition, ultrastructural features, and horizontal tissue shrinkage in the porcine retina.

# publications[].label
Local Regulation of Microvascular Perfusion

# publications[].label
Mechanisms of shear stress-induced production of nitric oxide from coronary endothelium

# publications[].label
Functional and molecular characterization of receptor subtypes mediating coronary microvascular dilation to adenosine.

# publications[].label
Requisite roles of LOX-1, JNK, and arginase in diabetes-induced endothelial vasodilator dysfunction of porcine coronary arterioles.

# publications[].label
Arterial hypertension induces retinal degeneration in mice with pressure-overload cardiac hypertrophy

# publications[].label
A pertussis toxin-sensitive G protein mediates coronary arteriolar dilation to acidosis

# publications[].label
Hydrogen peroxide induces endothelium-dependent and independent arteriolar dilation

# publications[].label
Interaction between adenosine and flow-induced dilation in coronary microvascular network

# publications[].label
TP508 (Chrysalin) reverses endothelial dysfunction and increases perfusion and myocardial function in hearts with chronic ischemia.

# publications[].label
Stimulation of alpha(2)- and beta(2)-adrenergic receptors by norepinephrine elicits endothelium-dependent nitric oxide-mediated dilation of coronary arterioles.

# publications[].label
In vivo and in vitro vasoactive reactions of coronary arteriolar microvessels to nitroglycerin

# publications[].label
Chapter 6 Local Regulation of Microvascular Perfusion

# publications[].label
Acute and Chronic Hyperglycemia Enhance Constriction of Retinal Venules to Endothelin-1

# publications[].label
ACIDOSIS-INDUCED CORONARY ARTERIOLAR DILATION IS MEDIATED BY THE ATP-SENSITIVE POTASSIUM CHANNELS

# publications[].label
Mechanism of coronary arteriolar dilation to adenosine.

# publications[].label
Upregulation of arginase by H2O2 impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles.

# publications[].label
TNF-alpha contributes to endothelial dysfunction in ischemia/reperfusion injury.

# publications[].label
Diabetes induces endothelial dysfunction: role of eNOS uncoupling and arginase

# publications[].label
Hyperglycemia Enhances Constriction of Retinal Venules via Activation of the Reverse-Mode Sodium-Calcium Exchanger.

# publications[].label
Oxidized low-density lipoprotein inhibits nitric oxide-mediated coronary arteriolar dilation by up-regulating endothelial arginase I.

# publications[].label
Hyperglycemia Enhances Constriction of Retinal Venules to Endothelin1 via Activation of the ReverseMode SodiumCalcium Exchanger

# publications[].label
ENDOTHELIAL-CELL HETEROGENEITY AND CALCIUM AS MEASURED IN INTACT ISOLATED ARTERIOLES

# publications[].label
Intravitreal Administration of Stanniocalcin-1 Rescues Photoreceptor Degeneration with Reduced Oxidative Stress and Inflammation in a Porcine Model of Retinitis Pigmentosa.

# publications[].label
Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: counteracting role of arginase.

# publications[].label
Rho kinase-mediated coronary arteriolar constriction to endothelin-1: Mechanistic implications for cardiac syndrome X

# publications[].label
IS122 POTASSIUM CHANNEL OPENERS ENHANCE ADENOSINE-INDUCED CORONARY ARTERIOLAR DILATION

# publications[].label
Intravitreal Stanniocalcin-1 Enhances New Blood Vessel Growth in a Rat Model of Laser-Induced Choroidal Neovascularization.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
C-reactive protein inhibits endothelium-dependent nitric oxidemediated dilation in coronary arterioles: roles of superoxide and vascular NADPH oxidase

# publications[].label
Modulation of nitric oxide bioavailability by erythrocytes.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Acute hyperglycemia impairs NO-mediated endothelial function of coronary arterioles by reducing L-arginine availability independent of superoxide

# publications[].label
Newly Identified Peptide, Peptide Lv, Promotes Pathological Angiogenesis.

# publications[].label
Intraluminal pressure influences K-ATP channel-mediated coronary arteriolar dilation

# publications[].label
Low-density lipoproteins impair nitric oxide-related endothelial function in coronary arterioles

# publications[].label
Coronary arteriolar myogenic response is independent of endothelium.

# publications[].label
Stanniocalcin-2 preserves retinal function in a rat model of retinitis pigmentosa

# publications[].label
Activation of alpha(2)-adrenergic receptors by bromonidine evokes nitric oxide-mediated dilation of retinal microvessels

# publications[].label
Hydrogen peroxide specifically impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles: Role of arginase

# publications[].label
Longitudinal stability of retinal blood flow regulation in response to flicker stimulation and systemic hyperoxia in mice assessed with laser speckle flowgraphy.

# publications[].label
Stanniocalcin-1 enhances ellipsoid zone intensity and cone function in the P23H rhodopsin transgenic pig

# publications[].label
Myogenic activity in isolated subepicardial and subendocardial coronary arterioles.

# publications[].label
Role of Arginase in Selective Impairment of Endothelium-Dependent Nitric Oxide Synthase-Mediated Dilation of Retinal Arterioles during Early Diabetes.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Divergent roles of nitric oxide and rho kinase in vasomotor regulation of human retinal arterioles.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Selective activation of lectin-like oxidized low-density lipoprotein receptor-1 mediates C-reactive protein-evoked endothelial vasodilator dysfunction in coronary arterioles.

# publications[].label
Elevation of superoxide in vascular smooth muscle cells restores oxyhemoglobin-inhibited NO-mediated vasodilation

# publications[].label
Activation of barium-sensitive inward rectifier potassium channels mediates remote dilation of coronary arterioles.

# publications[].label
Requisite roles of A(2A) receptors and K-ATP channels in retinal arteriolar dilation to adenosine

# publications[].label
Mechanisms of shear stress-induced release of nitric oxide from coronary endothelium

# publications[].label
INFLUENCE OF HEMOCONCENTRATION ON ARTERIOLAR OXYGEN-TRANSPORT IN HAMSTER STRIATED-MUSCLE

# publications[].label
Contributions of Sodium-Hydrogen Exchanger 1 and Mitogen-Activated Protein Kinases to Enhanced Retinal Venular Constriction to Endothelin-1 in Diabetes.

# publications[].label
Integrin-binding peptides containing RGD produce coronary arteriolar dilation via cyclooxygenase activation.

# publications[].label
Constriction of Retinal Venules to Endothelin-1: Obligatory Roles of ETA Receptors, Extracellular Calcium Entry, and Rho Kinase.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Hypertension impairs NO-mediated dilation of coronary arterioles by upregulation of endothelial arginase

# publications[].label
Hyperglycemia Augments Endothelin-1-Induced Constriction of Human Retinal Venules.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Acute retinal ischemia inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles via enhanced superoxide production.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
C-reactive protein dilates coronary arterioles via barium-sensitive inward rectifier potassium channels

# publications[].label
Hydrogen peroxide induces endothelium-dependent and -independent coronary arteriolar dilation: Role of cyclooxygenase and potassium channels

# publications[].label
Reciprocal roles of nitric oxide (NO) and hydrogen peroxide (H202) underlying vasorelaxation responses of collateral-dependent coronary arterioles in exercise-trained pigs

# publications[].label
Brimonidine evokes heterogeneous vasomotor response of retinal arterioles: diminished nitric oxide-mediated vasodilation when size goes small.

# publications[].label
Erythrocyte Consumption of Nitric Oxide: Competition Experiment and Model Analysis Volume 5, Number 1 (2001), pages 1831

# publications[].label
Myogenic and Flow-Induced Responses in Coronary Arterioles

# publications[].label
Transmural difference in coronary arteriolar dilation to adenosine: effect of luminal pressure and K(ATP) channels.

# publications[].label
LDLs impair vasomotor function of the coronary microcirculation: role of superoxide anions.

# publications[].label
CORONARY ARTERIOLAR ESCAPE FROM DILATION BY NITROGLYCERIN

# publications[].label
Coronary arteriolar dilation to K+: Role of smooth muscle Kir2.1 channels and Na+/K+ ATPase

# publications[].label
Endothelial ATP-sensitive potassium channels mediate coronary microvascular dilation to hyperosmolarity.

# publications[].label
Endothelial cell calcium increases during flow-induced dilation in isolated arterioles.

# publications[].label
C-reactive protein impairs coronary arteriolar dilation to prostacyclin synthase activation: role of peroxynitrite.

# publications[].label
Interaction between adenosine and flow-induced dilation in coronary microvascular network.

# publications[].label
Exercise training restores coronary arteriolar dilation to NOS activation distal to coronary artery occlusion: role of hydrogen peroxide.

# publications[].label
Regulation of Coronary Vasomotor Function by Oxidative Stress

# publications[].label
Role of prostaglandin H2/thromboxane A2 in responses of coronary arterioles in hypertension

# publications[].label
cAMP-independent dilation of coronary arterioles to adenosine : role of nitric oxide, G proteins, and K(ATP) channels.

# publications[].label
K-ATP channel-mediated coronary arteriolar dilation to adenosine is independent of cAMP

# publications[].label
Adenosine-stimulated production of nitric oxide in porcine collateral-dependent coronary arterioles is enhanced by exercise training

# publications[].label
Temporal development of retinal arteriolar endothelial dysfunction in porcine type 1 diabetes.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
In vivo correlation of retinal morphological and functional changes in a porcine model of inherited retinal degeneration

# publications[].label
CORONARY VASOMOTOR REGULATION BY CRP AND LOX-1 RECEPTORS

# publications[].label
RESPONSE GRADIENT FOR FLOW-INDUCED DILATION IN THE PORCINE CORONARY MICROVASCULAR NETWORK

# publications[].label
Conducted remote dilations of isolated coronary arterioles require activation of barium-sensitive inward rectifier potassium channels

# publications[].label
Stanniocalcin-1 rescues photoreceptor degeneration in a porcine model of retinitis pigmentosa

# publications[].label
THE ROLE OF NITRIC-OXIDE IN CORONARY MICROVASCULAR DILATATION BY ADENOSINE

# publications[].label
Estrogen enhances constrictor prostanoids and blood pressure in aortic coarctation-induced hypertension in female rats

# publications[].label
Contribution of regional circulations to the pulmonary edema and hemorrhage induced by epinephrine.

# publications[].label
PKC activation impairs endothelium-dependent NO-mediated dilation of coronary arterioles via enhanced superoxide production from xanthine oxidase

# publications[].label
VEGF Receptor-2-Linked PI3K/Calpain/SIRT1 Activation Mediates Retinal Arteriolar Dilations to VEGF and Shear Stress.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Exercise training enhances basal and VEGF-stimulated nitric oxide production in porcine collateral-dependent coronary arterioles

# publications[].label
Dietary-induced atherosclerotic lesions have increased levels of acidic FGF mRNA and altered cytoskeletal and extracellular matrix mRNA expression.

# publications[].label
-Adrenergic responses of isolated canine coronary microvessels

# publications[].label
In vivo and in vitro vasoactive reactions of coronary arteriolar microvessels to nitroglycerin.

# publications[].label
Mechanism of shear stress-induced coronary microvascular dilation

# publications[].label
Downregulation of endothelial constitutive nitric oxide synthase expression by lipopolysaccharide.

# publications[].label
Oxidized LDL specifically impairs nitric oxide-mediated dilation of coronary arterioles

# publications[].label
Cardiac Pressure Overload Elicits Coronary Circulatory Dysfunction in Mice

# publications[].label
Elevated intraocular pressure inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles: Role of superoxide

# publications[].label
ENDOTHELIN-1 AND CORONARY VASOMOTOR DYSFUNCTION: ROLE OF P38 KINASE AND NADPH OXIDASE

# publications[].label
Vascular reactivity to calcitonin gene-related peptide is enhanced in subtotal nephrectomy-salt induced hypertension.

# publications[].label
Endotoxin impairs flow-induced vasodilation of porcine coronary arterioles.

# publications[].label
Segmental Distribution and Control of Coronary Microvascular Resistance

# publications[].label
Changes in coronary endothelial cell Ca2+ concentration during shear stress- and agonist-induced vasodilation.

# publications[].label
Divergent roles of angiotensin II AT1 and AT2 receptors in modulating coronary microvascular function.

# publications[].label
Endothelin-1 Inhibits Endothelium-Dependent NO-Mediated Dilation of Coronary Arterioles via p38 Kinase Linked Superoxide Production From NAD(P)H Oxidase

# publications[].label
Interaction of pressure- and flow-induced responses in porcine coronary resistance vessels.

# publications[].label
A human study model for nitric oxide research in sinonasal disease.

# publications[].label
Intravitreal stanniocalcin-2 reduces photoreceptor degeneration and improves oscillatory potentials with elevated ocular blood flow in retinitis pigmentosa

# publications[].label
Endothelial cell calcium increases during flow-induced dilation in isolated arterioles

# publications[].label
Basic fibroblast growth factor and heparin cause endothelium-dependent dilation in coronary arterioles.

# publications[].label
Heterogeneous coronary arteriolar dilation to beta(2)-adrenergic receptor activation: Role of nitric oxide and K-ATP channels

# publications[].label
Endothelin-1 Signaling in Coronary Arteriolar Constriction

# publications[].label
Modeling of endothelial nitric oxide production and diffusion

# publications[].label
C-reactive protein inhibits endothelium-dependent NO-mediated dilation in coronary arterioles by activating p38 kinase and NAD(P)H oxidase.

# publications[].label
Correlation of spectral domain optical coherence tomography with histology and electron microscopy in the porcine retina.

# publications[].label
Endothelin-1 impairs coronary arteriolar dilation: Role of p38 kinase-mediated superoxide production from NADPH oxidase.

# publications[].label
Requisite roles of A2A receptors, nitric oxide, and KATP channels in retinal arteriolar dilation in response to adenosine.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Regulation of Coronary Vasomotor Function by Reactive Oxygen Species.

# publications[].label
Venous-to-arterial compliance ratios in the canine systemic and pulmonary circulation

# publications[].label
Erythrocytes possess an intrinsic barrier to nitric oxide consumption.

# publications[].label
Acute retinal ischemia inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles: role of endothelin-1 and superoxide

# publications[].label
Regulation of vasomotor function by integrins

# publications[].label
Endothelial regulation of coronary microvascular tone under physiological and pathophysiological conditions.

# publications[].label
Estrogen enhances contractile responses of rat aorta by upregulating expression of cyclooxygenase-2 and thromboxame synthase

# publications[].label
Hydrogen peroxide induces endothelium-dependent and -independent coronary arteriolar dilation: role of cyclooxygenase and potassium channels.

# publications[].label
Functional and molecular characterization of the endothelin system in retinal arterioles.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Isoflurane-induced dilation of porcine coronary arterioles is inhibited by glyburide

# publications[].label
Effects of regional sympathectomy on the cardiovascular responses and pulmonary changes induced by cerebral compression

# publications[].label
Constriction of retinal arterioles to endothelin-1: requisite role of rho kinase independent of protein kinase C and L-type calcium channels.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Progression of photoreceptor degeneration in a porcine model of retinitis pigmentosa

# publications[].label
Adenosine potentiates flow-induced dilation of coronary arterioles by activating KATP channels in endothelium.

# publications[].label
Upregulation of arginase in coronary microcirculation by ischemia/reperfusion inhibits nitric oxide-mediated vasodilation

# publications[].label
Activation of arginase by IL-13 inhibits NO production from activated macrophages

# publications[].label
Longitudinal gradients for endothelium-dependent and -independent vascular responses in the coronary microcirculation.

# publications[].label
Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity.

# publications[].label
Impaired nitric oxide-mediated coronary arteriolar dilation in hypertrophic cardiomyopathy: role of angiotensin-II and oxidative stress

# publications[].label
Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function.

# publications[].label
Functional and molecular evidence of adenosine A(2A) receptor in coronary arteriolar dilation to adenosine

# publications[].label
Retinal autoregulation: The myogenic response in retinal arterioles

# publications[].label
A prototype tissue engineered blood vessel using amniotic membrane as scaffold.

# publications[].label
Isoflurane-induced dilation of porcine coronary microvessels is endothelium dependent and inhibited by glibenclamide.

# publications[].label
Role of arginase-I in VEGF-induced capillary-like tube formation

# publications[].label
Exercise restores coronary arteriolar dilation to NOS activation: Role of hydrogen peroxide

# publications[].label
Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo.

# publications[].label
Activation of Smooth Muscle Kir2.1 Channels and Na+/K+ ATPase Mediates Dilation of Porcine Coronary Arterioles to Potassium

# publications[].label
Functional and molecular studies of adenosine receptors and K-ATP channels in the coronary microcirculation

# publications[].label
Estrogen potentiates constrictor prostanoid function in female rat aorta by upregulation of cyclooxygenase-2 and thromboxane pathway expression.

# publications[].label
Pathophysiological consequences of atherosclerosis extend into the coronary microcirculation. Restoration of endothelium-dependent responses by L-arginine.

# publications[].label
Mechanisms of adrenaline-induced antinociception in mice.

# publications[].label
C-reactive protein inhibits endothelium-dependent prostacyclin synthase-mediated dilation of coronary arterioles: Role of peroxynitrite

# publications[].label
Selective Activation of ROCK2 Isoform Contributes to Vasomotor Regulation of Retinal Arterioles

# publications[].label
Acidosis-induced coronary arteriolar dilation is mediated by ATP-sensitive potassium channels in vascular smooth muscle.

# publications[].label
Retinal arteriolar responses to acute severe elevation in systemic blood pressure in cats: role of endothelium-derived factors.

# researcherOn[].label
Vasomotor Dysfunction of Retinal Arterioles in Diabetes

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Intravitreal ECE-1 siRNA Treatment for Retinal Dysfunction during Early Diabetes

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Roles of LOX-1 and Stress-Activated Kinases in Retinal Dysfunction during Early Diabetes

# researcherOn[].awardedBy.label
United States Department of Health and Human Services - (Washington D.C., District of Columbia, United States)

# streetAddress
Texas A&M Health Science Center; Medical Physiology; 8447 Riverside Parkway

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine