# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
My research focuses on the physiological and pathophysiological regulation of coronary and retinal microcirculation. In the circulatory system, the amount of blood delivered to each tissue can be regulated by the activity of arterial microvessels (<100  m in diameter). Changes in vascular tone, i.e., constriction or dilation of these microvessels, will decrease or increase blood supply to the tissue, respectively. However, the mechanisms involved in the regulation of vascular tone are not completely understood. Our current research focuses on the regulation of microvascular tone by hemodynamic (e.g., pressure and shear stress), metabolic (e.g., adenosine, osmolarity, K+, pH, pO2) and neural (adrenergic receptors) factors. To have an integrative view on the flow regulation, this basic information are reconstructed using mathematical model and computer simulation technology. This research provides a basic foundation critical to our understanding of blood flow regulation in the microvascular network under normal and disease states.

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
Calcium Release-activated Calcium Channel Protein 1 (orai1)

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Confocal Scanning Laser Ophthalmoscopy (cslo)

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
Virginia Commonwealth University Medical Center - (Richmond, Virginia, United States)

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# educationAndTraining[].organization.label
National Taiwan University - (Taipei, Taipei, Taiwan)

# publications[].label
Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo.

# publications[].label
INHIBITION OF NITRIC-OXIDE SYNTHESIS ATTENUATES CORONARY METABOLIC VASODILATION

# publications[].label
ATHEROSCLEROSIS BLUNTS AGONIST-INDUCED INCREASES IN INTRACELLULAR CALCIUM IN AORTIC ENDOTHELIAL-CELLS

# publications[].label
Progression of photoreceptor degeneration in a porcine model of retinitis pigmentosa

# publications[].label
Low-density lipoproteins impair nitric oxide-related endothelial function in coronary arterioles

# publications[].label
Modeling of endothelial nitric oxide production and diffusion

# publications[].label
Hydrogen peroxide specifically impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles: Role of arginase

# publications[].label
Activation of alpha(2)-adrenergic receptors by bromonidine evokes nitric oxide-mediated dilation of retinal microvessels

# publications[].label
C-reactive protein inhibits endothelium-dependent NO-mediated dilation in coronary arterioles by activating p38 kinase and NAD(P)H oxidase.

# publications[].label
Coronary arteriolar dilation to acidosis: role of ATP-sensitive potassium channels and pertussis toxin-sensitive G proteins.

# publications[].label
Tumor necrosis factor-induced production of superoxide inhibits endothelium-dependent NO-mediated dilation of coronary arterioles: role of ceramide signaling and xanthine oxidase

# publications[].label
ENDOTHELIAL MODULATION OF ARTERIOLAR TONE

# publications[].label
Effect of hemodilution on oxygen transport in arteriolar networks of hamster striated muscle.

# publications[].label
Dysregulation of coronary arteriolar response to the metabolic vasodilator adenosine in hypertrophic cardiomyopathy: Role of NO and O2-

# publications[].label
Divergent roles of angiotensin II AT1 and AT2 receptors in modulating coronary microvascular function.

# publications[].label
Acute and Chronic Hyperglycemia Enhance Constriction of Retinal Venules to Endothelin-1

# publications[].label
Local Regulation of Microvascular Perfusion

# publications[].label
Changes in coronary endothelial cell Ca2+ concentration during shear stress- and agonist-induced vasodilation.

# publications[].label
Adenosine A(2A) receptors mediate coronary microvascular dilation to adenosine: role of nitric oxide and ATP-sensitive potassium channels.

# publications[].label
LDLs impair vasomotor function of the coronary microcirculation: role of superoxide anions.

# publications[].label
Activation of arginase by IL-13 inhibits NO production from activated macrophages

# publications[].label
Upregulation of arginase in coronary microcirculation by ischemia/reperfusion inhibits nitric oxide-mediated vasodilation

# publications[].label
Adenosine-stimulated production of nitric oxide in porcine collateral-dependent coronary arterioles is enhanced by exercise training

# publications[].label
In vivo correlation of retinal morphological and functional changes in a porcine model of inherited retinal degeneration

# publications[].label
Estrogen enhances contractile responses of rat aorta by upregulating expression of cyclooxygenase-2 and thromboxame synthase

# publications[].label
Sodium azide dilates coronary arterioles via activation of inward rectifier K+ channels and Na+-K+-ATPase.

# publications[].label
cAMP-independent dilation of coronary arterioles to isoproterenol: Role of nitric oxide and K-ATP channels

# publications[].label
Regulation of coronary blood flow: coordination of heterogeneous control mechanisms in vascular microdomains.

# publications[].label
ENDOTOXIN IMPAIRS FLOW-INDUCED VASODILATION OF PORCINE CORONARY ARTERIOLES

# publications[].label
Stanniocalcin-2 preserves retinal function in a rat model of retinitis pigmentosa

# publications[].label
VEGF Receptor-2-Linked PI3K/Calpain/SIRT1 Activation Mediates Retinal Arteriolar Dilations to VEGF and Shear Stress.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
A prototype tissue engineered blood vessel using amniotic membrane as scaffold.

# publications[].label
Longitudinal gradients for endothelium-dependent and -independent vascular responses in the coronary microcirculation.

# publications[].label
Chapter 6 Local Regulation of Microvascular Perfusion

# publications[].label
Stromal interaction molecule 1 (STIM1) and Orai1 mediate histamine-evoked calcium entry and nuclear factor of activated T-cells (NFAT) signaling in human umbilical vein endothelial cells.

# publications[].label
Influence of hemoconcentration on arteriolar oxygen transport in hamster striated muscle.

# publications[].label
Role of arginase-I in VEGF-induced capillary-like tube formation

# publications[].label
Isoflurane-induced dilation of porcine coronary arterioles is inhibited by glyburide

# publications[].label
Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity.

# publications[].label
Endothelin-1 Signaling in Coronary Arteriolar Constriction

# publications[].label
Coronary arteriolar myogenic response is independent of endothelium.

# publications[].label
Histamine-Induced Dilation of Isolated Porcine Retinal Arterioles: Role of Endothelium-Derived Hyperpolarizing Factor.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Correlation of spectral domain optical coherence tomography with histology and electron microscopy in the porcine retina.

# publications[].label
C-reactive protein impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles via p38 kinase and NADPH oxidase activation

# publications[].label
alpha-adrenergic responses of isolated canine coronary microvessels.

# publications[].label
Endothelin-1 impairs coronary arteriolar dilation: Role of p38 kinase-mediated superoxide production from NADPH oxidase.

# publications[].label
Effect of systemic administration of simvastatin on retinal circulation.

# publications[].label
Regulation of Coronary Vasomotor Function by Oxidative Stress

# publications[].label
Retinal arteriolar responses to acute severe elevation in systemic blood pressure in cats: role of endothelium-derived factors.

# publications[].label
Isoflurane-induced dilation of porcine coronary microvessels is endothelium dependent and inhibited by glibenclamide.

# publications[].label
Hyperglycemia Augments Endothelin-1-Induced Constriction of Human Retinal Venules.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Temporal development of retinal arteriolar endothelial dysfunction in porcine type 1 diabetes.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Selective Activation of ROCK2 Isoform Contributes to Vasomotor Regulation of Retinal Arterioles

# publications[].label
IS122 POTASSIUM CHANNEL OPENERS ENHANCE ADENOSINE-INDUCED CORONARY ARTERIOLAR DILATION

# publications[].label
Acidosis enhances vasodilation of coronary arterioles to adenosine by increasing activation of K-ATP channels

# publications[].label
Regulation of coronary blood flow: coordination of heterogeneous control mechanisms in vascular microdomains

# publications[].label
Reciprocal roles of nitric oxide (NO) and hydrogen peroxide (H202) underlying vasorelaxation responses of collateral-dependent coronary arterioles in exercise-trained pigs

# publications[].label
Coronary arteriolar dilation to K+: Role of smooth muscle Kir2.1 channels and Na+/K+ ATPase

# publications[].label
Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function.

# publications[].label
Constriction of retinal arterioles to endothelin-1: requisite role of rho kinase independent of protein kinase C and L-type calcium channels.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Coronary arteriolar vasoconstriction to angiotensin II is augmented in prediabetic metabolic syndrome via activation of AT1 receptors.

# publications[].label
PKC activation impairs endothelium-dependent NO-mediated dilation of coronary arterioles via enhanced superoxide production from xanthine oxidase

# publications[].label
Endothelial cell calcium increases during flow-induced dilation in isolated arterioles

# publications[].label
Endotoxin impairs flow-induced vasodilation of porcine coronary arterioles.

# publications[].label
Myogenic and Flow-Induced Responses in Coronary Arterioles

# publications[].label
Activation of JNK and xanthine oxidase by TNF-alpha impairs nitric oxide-mediated dilation of coronary arterioles.

# publications[].label
Dietary-induced atherosclerotic lesions have increased levels of acidic FGF mRNA and altered cytoskeletal and extracellular matrix mRNA expression.

# publications[].label
Role of endothelium in vasomotor responses to endothelin system and protein kinase C activation in porcine retinal arterioles.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Erythrocyte consumption of nitric oxide: competition experiment and model analysis.

# publications[].label
C-reactive protein inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles via enhanced superoxide production.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Role of prostaglandin H2/thromboxane A2 in responses of coronary arterioles in hypertension

# publications[].label
Arterial hypertension induces retinal degeneration in mice with pressure-overload cardiac hypertrophy

# publications[].label
A pertussis toxin-sensitive G protein mediates coronary arteriolar dilation to acidosis

# publications[].label
Alterations of Ocular Hemodynamics Impair Ophthalmic Vascular and Neuroretinal Function.

# publications[].label
Alteration of ocular blood pressure and flow leads to ophthalmic vascular and neuroretinal dysfunction

# publications[].label
TNF-alpha contributes to endothelial dysfunction in ischemia/reperfusion injury.

# publications[].label
ENDOTHELIAL-CELL HETEROGENEITY AND CALCIUM AS MEASURED IN INTACT ISOLATED ARTERIOLES

# publications[].label
Adenosine potentiates flow-induced dilation of coronary arterioles by activating KATP channels in endothelium.

# publications[].label
ACIDOSIS-INDUCED CORONARY ARTERIOLAR DILATION IS MEDIATED BY THE ATP-SENSITIVE POTASSIUM CHANNELS

# publications[].label
Endothelial cell calcium increases during flow-induced dilation in isolated arterioles.

# publications[].label
Estrogen potentiates constrictor prostanoid function in female rat aorta by upregulation of cyclooxygenase-2 and thromboxane pathway expression.

# publications[].label
Elevation of superoxide in vascular smooth muscle cells restores oxyhemoglobin-inhibited NO-mediated vasodilation

# publications[].label
Requisite roles of A(2A) receptors and K-ATP channels in retinal arteriolar dilation to adenosine

# publications[].label
Regulation of nitric oxide production by arginase in vascular smooth muscle

# publications[].label
CORONARY VASOMOTOR REGULATION BY ENDOTHELIN-1 AND OXIDATIVE STRESS

# publications[].label
Angiotensin II AT1 receptor mediates potentiation of coronary arteriolar constriction to phenylephrine

# publications[].label
Transmural difference in coronary arteriolar dilation to adenosine: effect of luminal pressure and K(ATP) channels.

# publications[].label
Impaired adenosine-induced dilation in coronary arteries from transgenic mouse hearts expressing a familial hypertrophic cardiomyopathy mutation

# publications[].label
Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: counteracting role of arginase.

# publications[].label
Segmental Distribution and Control of Coronary Microvascular Resistance

# publications[].label
Selective activation of lectin-like oxidized low-density lipoprotein receptor-1 mediates C-reactive protein-evoked endothelial vasodilator dysfunction in coronary arterioles.

# publications[].label
Acute retinal ischemia inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles via enhanced superoxide production.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Longitudinal stability of retinal blood flow regulation in response to flicker stimulation and systemic hyperoxia in mice assessed with laser speckle flowgraphy.

# publications[].label
Contributions of Sodium-Hydrogen Exchanger 1 and Mitogen-Activated Protein Kinases to Enhanced Retinal Venular Constriction to Endothelin-1 in Diabetes.

# publications[].label
Retinal autoregulation: The myogenic response in retinal arterioles

# publications[].label
Functional and molecular characterization of the endothelin system in retinal arterioles.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Correlation of Fundus Autofluorescence and Histology of Laser-induced Choroidal Neovascularization in the Rat

# publications[].label
Lipopolysaccharide activates endothelial nitric oxide synthase through protein tyrosine kinase.

# publications[].label
H2O2 Mediates VEGF- and Flow-Induced Dilations of Coronary Arterioles in Early Type 1 Diabetes: Role of Vascular Arginase and PI3K-Linked eNOS Uncoupling.

# publications[].label
Diabetes induces endothelial dysfunction: role of eNOS uncoupling and arginase

# publications[].label
Stanniocalcin-1 rescues photoreceptor degeneration in a porcine model of retinitis pigmentosa

# publications[].label
Conducted remote dilations of isolated coronary arterioles require activation of barium-sensitive inward rectifier potassium channels

# publications[].label
DIFFERENTIAL ENDOTHELIUM-DEPENDENT RESPONSES TO SHEAR-STRESS AND AGONISTS IN CORONARY MICROCIRCULATION

# publications[].label
Mechanism of coronary arteriolar dilation to adenosine.

# publications[].label
TP508 (Chrysalin) reverses endothelial dysfunction and increases perfusion and myocardial function in hearts with chronic ischemia.

# publications[].label
Hydrogen peroxide induces endothelium-dependent and independent arteriolar dilation

# publications[].label
Exercise training restores coronary arteriolar dilation to NOS activation distal to coronary artery occlusion: role of hydrogen peroxide.

# publications[].label
Activation of Smooth Muscle Kir2.1 Channels and Na+/K+-ATPase Mediates Dilation of Porcine Coronary Arterioles at Physiological Levels of Potassium.

# publications[].label
Exercise training enhances basal and VEGF-stimulated nitric oxide production in porcine collateral-dependent coronary arterioles

# publications[].label
Hydrogen peroxide induces endothelium-dependent and -independent coronary arteriolar dilation: Role of cyclooxygenase and potassium channels

# publications[].label
Hypertension impairs NO-mediated dilation of coronary arterioles by upregulation of endothelial arginase

# publications[].label
Upregulation of endothelial arginase by oxidative stress impairs NO-mediated vasodilation

# publications[].label
Brimonidine evokes heterogeneous vasomotor response of retinal arterioles: diminished nitric oxide-mediated vasodilation when size goes small.

# publications[].label
C-reactive protein inhibits endothelium-dependent prostacyclin synthase-mediated dilation of coronary arterioles: Role of peroxynitrite

# publications[].label
Vascular reactivity to calcitonin gene-related peptide is enhanced in subtotal nephrectomy-salt induced hypertension.

# publications[].label
Acute retinal ischemia inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles: role of endothelin-1 and superoxide

# publications[].label
Characterization of adenosine receptor-mediated dilation of porcine coronary arterioles

# publications[].label
Acute hyperglycemia impairs NO-mediated endothelial function of coronary arterioles by reducing L-arginine availability independent of superoxide

# publications[].label
Differential effect of oxidized low-density lipoprotein on nitric oxide- and potassium channel-mediated dilation of coronary arterioles.

# publications[].label
Myogenic and flow-dependent control mechanisms in the coronary microcirculation.

# publications[].label
Intravascular flow decreases erythrocyte consumption of nitric oxide.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
THE ROLE OF NITRIC-OXIDE IN CORONARY MICROVASCULAR DILATATION BY ADENOSINE

# publications[].label
Contribution of regional circulations to the pulmonary edema and hemorrhage induced by epinephrine.

# publications[].label
Gating and Assembling Mechanisms of CRAC Channels

# publications[].label
C-reactive protein impairs coronary arteriolar dilation to prostacyclin synthase activation: role of peroxynitrite.

# publications[].label
Erythrocytes possess an intrinsic barrier to nitric oxide consumption.

# publications[].label
In vivo and in vitro vasoactive reactions of coronary arteriolar microvessels to nitroglycerin

# publications[].label
cAMP-independent dilation of coronary arterioles to adenosine : role of nitric oxide, G proteins, and K(ATP) channels.

# publications[].label
PARADOXICAL INVIVO AND INVITRO RESPONSES OF CORONARY ARTERIOLES TO ALPHA-ADRENERGIC ACTIVATION

# publications[].label
NITROVASODILATOR-MEDIATED FLOW-INDUCED DILATION IN ISOLATED PORCINE CORONARY VENULES

# publications[].label
The involvement of tyrosine kinases, cyclic AMP/protein kinase A, and p38 mitogen-activated protein kinase in IL-13-mediated arginase I induction in macrophages: its implications in IL-13-inhibited nitric oxide production.

# publications[].publisher
The American Association of Immunologists

# publications[].label
Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.

# publications[].label
Oxidized LDL specifically impairs nitric oxide-mediated dilation of coronary arterioles

# publications[].label
Cardiac Pressure Overload Elicits Coronary Circulatory Dysfunction in Mice

# publications[].label
Intravitreal stanniocalcin-2 reduces photoreceptor degeneration and improves oscillatory potentials with elevated ocular blood flow in retinitis pigmentosa

# publications[].label
Myogenic activity in isolated subepicardial and subendocardial coronary arterioles.

# publications[].label
Divergent roles of nitric oxide and rho kinase in vasomotor regulation of human retinal arterioles.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Effective diffusion distance of nitric oxide in the microcirculation.

# publications[].label
Interaction between adenosine and flow-induced dilation in coronary microvascular network

# publications[].label
Simvastatin elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and mevalonate-rho kinase pathways.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Arginase modulates nitric oxide production in activated macrophages.

# publications[].label
CRP activates LOX-1 and inhibits prostacyclin-mediated dilation of coronary arterioles

# publications[].label
Stimulation of alpha(2)- and beta(2)-adrenergic receptors by norepinephrine elicits endothelium-dependent nitric oxide-mediated dilation of coronary arterioles.

# publications[].label
Heterogeneous coronary arteriolar dilation to beta(2)-adrenergic receptor activation: Role of nitric oxide and K-ATP channels

# publications[].label
Monitoring Retinal Degeneration in a Porcine Model of Retinitis Pigmentosa with Spectral Domain Optical Coherence Tomography and Electroretinography

# publications[].label
Impaired nitric oxide-mediated coronary arteriolar dilation in hypertrophic cardiomyopathy: role of angiotensin-II and oxidative stress

# publications[].label
Functional and molecular studies of adenosine receptors and K-ATP channels in the coronary microcirculation

# publications[].label
Integrin-binding peptides containing RGD produce coronary arteriolar dilation via cyclooxygenase activation.

# publications[].label
Role of Myocardial EndothelinConverting Enzyme in Promoting Coronary Arteriolar Constriction during Diabetes

# publications[].label
Effects of regional sympathectomy on the cardiovascular responses and pulmonary changes induced by cerebral compression

# publications[].label
-Adrenergic responses of isolated canine coronary microvessels

# publications[].label
Distribution and control of coronary microvascular resistance.

# publications[].label
Regulation of nitric oxide consumption by hypoxic red blood cells.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Heterogeneous beta2-adrenoceptor expression and dilation in coronary arterioles across the left ventricular wall.

# publications[].label
RESPONSE GRADIENT FOR FLOW-INDUCED DILATION IN THE PORCINE CORONARY MICROVASCULAR NETWORK

# publications[].label
Activation of angiotensin II AT1 receptor inhibits endothelium-dependent nitric oxide-mediated dilation of coronary arterioles: Role of superoxide anion

# publications[].label
C-reactive protein dilates coronary arterioles via barium-sensitive inward rectifier potassium channels

# publications[].label
Retinal arteriolar endothelial dysfunction in early stage of diabetes in porcine model

# publications[].label
Arterial hypertension induces ocular vascular dysfunction in mice with pressure-overload cardiac hypertrophy

# publications[].label
Cardiac hypertrophy leads to coronary microvascular dysfunction and enhanced endothelin1/Rhokinase signaling in mice with transverse aortic coarctation (676.1)

# publications[].label
oxLDL specifically impairs endothelium-dependent, NO-mediated dilation of coronary arterioles.

# publications[].label
Interaction of pressure- and flow-induced responses in porcine coronary resistance vessels.

# publications[].label
Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice.

# publications[].label
Resveratrol, a component of red wine, elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Coronary vasodilation and K-ATP channels: Independence from nitric oxide

# publications[].label
Cellular signalling pathways mediating dilation of porcine pial arterioles to adenosine AA receptor activation.

# publications[].label
Activation of Smooth Muscle Kir2.1 Channels and Na+/K+ ATPase Mediates Dilation of Porcine Coronary Arterioles to Potassium

# publications[].label
C-reactive protein inhibits endothelium-dependent nitric oxidemediated dilation in coronary arterioles: roles of superoxide and vascular NADPH oxidase

# publications[].label
ADENOSINE POTENTIATES FLOW-INDUCED DILATION IN CORONARY MICROCIRCULATION

# publications[].label
Activation of Coronary Arteriolar PKC2 Impairs Endothelial NO-Mediated Vasodilation: Role of JNK/Rho Kinase Signaling and Xanthine Oxidase Activation.

# publications[].label
Ischemia/reperfusion inhibits nitric oxide-mediated dilation in coronary arterioles by upregulation of arginase

# publications[].label
cAMP-independent dilation of coronary arterioles to adenosine: Role of nitric oxide, G-proteins, and K-ATP channels.

# publications[].label
Regulation of Coronary Vasomotor Function by Reactive Oxygen Species.

# publications[].label
Data on SD-OCT image acquisition, ultrastructural features, and horizontal tissue shrinkage in the porcine retina.

# publications[].label
Hyperglycemia Enhances Constriction of Retinal Venules to Endothelin1 via Activation of the ReverseMode SodiumCalcium Exchanger

# publications[].label
Venous-to-arterial compliance ratios in the canine systemic and pulmonary circulation

# publications[].label
Role of arginase-I in capillary tube formation and ischemia-induced angiogenesis

# publications[].label
Downregulation of endothelial constitutive nitric oxide synthase expression by lipopolysaccharide.

# publications[].label
In vivo and in vitro vasoactive reactions of coronary arteriolar microvessels to nitroglycerin.

# publications[].label
Demonstration of eNOS uncoupling, altered proteinprotein association and impaired vascular reactivity:CRPmediated effects in vascular endothelium

# publications[].label
Mechanism of shear stress-induced coronary microvascular dilation

# publications[].label
Regulation of vasomotor function by integrins

# publications[].label
Oxidized low-density lipoprotein impairs nitric oxide-mediated dilation of coronary arterioles

# publications[].label
Estimation of nitric oxide production and reaction rates in tissue by use of a mathematical model.

# publications[].label
Basic fibroblast growth factor and heparin cause endothelium-dependent dilation in coronary arterioles.

# publications[].label
K-ATP channel-mediated coronary arteriolar dilation to adenosine is independent of cAMP

# publications[].label
Safety and toxicity of nanomaterials for ocular drug delivery applications.

# publications[].label
High glucose impairs EDHF-mediated dilation of coronary arterioles via reduced cytochrome P450 activity.

# publications[].label
Constriction of Retinal Venules to Endothelin-1: Obligatory Roles of ETA Receptors, Extracellular Calcium Entry, and Rho Kinase.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Interaction between adenosine and flow-induced dilation in coronary microvascular network.

# publications[].label
Hydrogen peroxide induces endothelium-dependent and -independent coronary arteriolar dilation: role of cyclooxygenase and potassium channels.

# publications[].label
Monitoring Retinal Degeneration in a Porcine Model of Retinitis Pigmentosa with Spectral Domain Optical Oherence Tomography and Electroretinography

# publications[].label
ENDOTHELIN-1 AND CORONARY VASOMOTOR DYSFUNCTION: ROLE OF P38 KINASE AND NADPH OXIDASE

# publications[].label
Endothelin-1 Inhibits Endothelium-Dependent NO-Mediated Dilation of Coronary Arterioles via p38 Kinase Linked Superoxide Production From NAD(P)H Oxidase

# publications[].label
Modulation of nitric oxide bioavailability by erythrocytes

# publications[].label
Modulation of nitric oxide bioavailability by erythrocytes.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Role of Arginase in Selective Impairment of Endothelium-Dependent Nitric Oxide Synthase-Mediated Dilation of Retinal Arterioles during Early Diabetes.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Hyperglycemia Enhances Constriction of Retinal Venules via Activation of the Reverse-Mode Sodium-Calcium Exchanger.

# publications[].label
Intravitreal Administration of Stanniocalcin-1 Rescues Photoreceptor Degeneration with Reduced Oxidative Stress and Inflammation in a Porcine Model of Retinitis Pigmentosa.

# publications[].label
CORONARY VASOMOTOR REGULATION BY CRP AND LOX-1 RECEPTORS

# publications[].label
Elevated intraocular pressure inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles: Role of superoxide

# publications[].label
Requisite roles of A2A receptors, nitric oxide, and KATP channels in retinal arteriolar dilation in response to adenosine.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Pathophysiological consequences of atherosclerosis extend into the coronary microcirculation. Restoration of endothelium-dependent responses by L-arginine.

# publications[].label
Erythrocyte Consumption of Nitric Oxide: Competition Experiment and Model Analysis Volume 5, Number 1 (2001), pages 1831

# publications[].label
Dilation of retinal arterioles in response to lactate: role of nitric oxide, guanylyl cyclase, and ATP-sensitive potassium channels.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
A mathematical model for the distribution of hemodynamic parameters in the human retinal microvascular network

# publications[].label
Requisite roles of LOX-1, JNK, and arginase in diabetes-induced endothelial vasodilator dysfunction of porcine coronary arterioles.

# publications[].label
Rho kinase-mediated coronary arteriolar constriction to endothelin-1: Mechanistic implications for cardiac syndrome X

# publications[].label
Centrogenic pulmonary hemorrhagic edema induced by cerebral compression in rats. Mechanism of volume and pressure loading in the pulmonary circulation.

# publications[].label
Acidosis-induced coronary arteriolar dilation is mediated by ATP-sensitive potassium channels in vascular smooth muscle.

# publications[].label
Vasomotor regulation of coronary microcirculation by oxidative stress: role of arginase.

# publications[].label
Mechanisms of adrenaline-induced antinociception in mice.

# publications[].label
Coronary Microvascular Responses to Flow

# publications[].label
Functional and molecular characterization of receptor subtypes mediating coronary microvascular dilation to adenosine.

# publications[].label
Endothelial ATP-sensitive potassium channels mediate coronary microvascular dilation to hyperosmolarity.

# publications[].label
C-reactive protein impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles by activating the LOX-1 receptor and NADPH oxidase

# publications[].label
Acute and Chronic Hyperglycemia Elicit JIP1/JNK-Mediated Endothelial Vasodilator Dysfunction of Retinal Arterioles.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Requisite Roles of Endothelial Nitric Oxide Synthase and Smooth Muscle Phosphoinositide 3-Kinase/Rho Kinase In Vasomotor Regulation of Human Retinal Arterioles

# publications[].label
Mechanisms of shear stress-induced release of nitric oxide from coronary endothelium

# publications[].label
Exercise restores coronary arteriolar dilation to NOS activation: Role of hydrogen peroxide

# publications[].label
Endothelial regulation of coronary microvascular tone under physiological and pathophysiological conditions.

# publications[].label
Stanniocalcin-1 enhances ellipsoid zone intensity and cone function in the P23H rhodopsin transgenic pig

# publications[].label
Sildenafil (Viagra) evokes retinal arteriolar dilation: dual pathways via NOS activation and phosphodiesterase inhibition.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Oxidized low-density lipoprotein inhibits nitric oxide-mediated coronary arteriolar dilation by up-regulating endothelial arginase I.

# publications[].label
Role of nitric oxide in the coronary microvascular responses to adenosine and increased metabolic demand.

# publications[].label
Estrogen enhances constrictor prostanoids and blood pressure in aortic coarctation-induced hypertension in female rats

# publications[].label
In vivo and in vitro vasoactive reactions of coronary arteriolar microvessels to nitroglycerin

# publications[].label
Functional and molecular evidence of adenosine A(2A) receptor in coronary arteriolar dilation to adenosine

# publications[].label
A human study model for nitric oxide research in sinonasal disease.

# publications[].label
Intravitreal Stanniocalcin-1 enhances new blood vessel growth in a rat model of laser-induced choroidal neovascularization

# publications[].label
Regulation of nitric oxide-mediated dilation by arginase in coronary arterioles.

# publications[].label
Cardiovascular metabolic engineering for modulating nitric oxide production during sepsis

# publications[].label
Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles.

# publications[].label
Upregulation of arginase by H2O2 impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles.

# publications[].label
INFLUENCE OF HEMOCONCENTRATION ON ARTERIOLAR OXYGEN-TRANSPORT IN HAMSTER STRIATED-MUSCLE

# publications[].label
Intraluminal pressure influences K-ATP channel-mediated coronary arteriolar dilation

# publications[].label
Activation of barium-sensitive inward rectifier potassium channels mediates remote dilation of coronary arterioles.

# publications[].label
CORONARY ARTERIOLAR ESCAPE FROM DILATION BY NITROGLYCERIN

# publications[].label
Differential progressive remodeling of coronary and cerebral arteries and arterioles in an aortic coarctation model of hypertension.

# publications[].label
Coronary venular responses to flow and pressure.

# publications[].label
Intravitreal Stanniocalcin-1 Enhances New Blood Vessel Growth in a Rat Model of Laser-Induced Choroidal Neovascularization.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Newly Identified Peptide, Peptide Lv, Promotes Pathological Angiogenesis.

# publications[].label
Mechanisms of shear stress-induced production of nitric oxide from coronary endothelium

# publications[].label
Local Regulation of Microvascular Perfusion

# researcherOn[].label
Intravitreal ECE-1 siRNA Treatment for Retinal Dysfunction during Early Diabetes

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Vasomotor Dysfunction of Retinal Arterioles in Diabetes

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Roles of LOX-1 and Stress-Activated Kinases in Retinal Dysfunction during Early Diabetes

# researcherOn[].awardedBy.label
United States Department of Health and Human Services - (Washington D.C., District of Columbia, United States)

# streetAddress
Texas A&M Health Science Center; Medical Physiology; 8447 Riverside Parkway

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine