# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
The overall goal of my laboratory is to understand mechanisms regulating inflammation and thereby develop strategies for modulating immune responses. One project focuses on the role of the cytokine thymic stromal lymphopoietin (TSLP) as the master switch in the pathobiology of allergic inflammation and asthma. The role of allergens and respiratory viruses on the induction of TSLP transcription by mast cells and epithelial cells is being studied in vitro and in human subjects.

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
6 Evaluation Of Treatments And Therapeutic Interventions

# keywords[]
Nuclear Receptor Subfamily 4, Group A, Member 1

# keywords[]
Attention Deficit Disorder With Hyperactivity

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
Nuclear Receptor Subfamily 1, Group F, Member 3

# educationAndTraining[].organization.label
Wake Forest University - (Winston-Salem, North Carolina, United States)

# educationAndTraining[].organization.label
Baylor College of Medicine - (Houston, Texas, United States)

# educationAndTraining[].organization.label
Wofford College - (Spartanburg, South Carolina, United States)

# educationAndTraining[].organization.label
Baylor College of Medicine - (Houston, Texas, United States)

# awardsAndHonors[].label
Medical Alumni Association Distinguished Achievement Award

# awardsAndHonors[].label
Residency Review Committee for Allergy and Immunology

# publications[].label
ALLERGEN-SPECIFIC T-LYMPHOCYTES (A/S T-LC) ACCUMULATE IN THE AIRWAYS OF ATOPIC ASTHMATICS AND NONATOPIC NORMALS BUT DIFFER IN THEIR CAPACITIES FOR IL-5 SYNTHESIS

# publications[].label
NZB cytotoxic lymphocyte responses. Kinetic analyses.

# publications[].label
JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization.

# publications[].label
MATERNALLY TRANSMITTED ANTIGEN - ANALYSIS BY CLONED CYTO-TOXIC LYMPHOCYTES-T

# publications[].label
HUMAN B-CELLS EXPRESS IL-5 RECEPTOR MESSENGER-RNA AND RESPOND TO IL-5 WITH ENHANCED IGM PRODUCTION UNDER SELECTIVE MITOGENIC STIMULATION

# publications[].label
Behet's-like syndrome associated with idiopathic CD4+ T-lymphocytopenia, opportunistic infections, and a large population of TCR alpha beta+ CD4- CD8- T cells.

# publications[].label
ANALYSES OF STIMULATOR REQUIREMENTS FOR PRIMARY ANTI-QA-1 CTL RESPONSES

# publications[].label
Aerosolized Toll-like Receptor Agonists Suppress Allergic Inflammation

# publications[].publisher
The American Association of Immunologists

# publications[].label
EFFECTS OF IMMUNOSUPPRESSIVE DRUGS ON IL-5 SECRETION BY T-LYMPHOCYTES (T-LC) IN-VITRO

# publications[].label
T-regulatory cells in common variable immunodeficiency

# publications[].label
Engineering novel therapeutic antagonists of interleukin-5 bioactivity and signaling

# publications[].label
709 Creation of a functional IL-5 monomer targets a single helical bundle for the development of therapeutic analogues

# publications[].label
Understanding the pathogenesis of allergic asthma using mouse models.

# publications[].label
CXCL13 neutralization reduces the severity of collagen-induced arthritis.

# publications[].label
The cellular and genetic basis of murine lupus.

# publications[].label
Cyclosporine therapy of central nervous system sarcoidosis.

# publications[].label
Human B cells express IL-5 receptor messenger ribonucleic acid and respond to IL-5 with enhanced IgM production after mitogenic stimulation with Moraxella catarrhalis.

# publications[].publisher
The American Association of Immunologists

# publications[].label
Natural killer cell suppression of IgM production.

# publications[].label
Disparities in the use of biologic therapies for the treatment of rheumatoid arthritis.

# publications[].label
EFFECTS OF STAPHYLOCOCCUS ENTEROTOXIN-A ON HUMAN B-CELL PROLIFERATION AND DIFFERENTIATION

# publications[].label
Decoding the Enigma of Urticaria and Angioedema.

# publications[].label
Interleukin-5, a therapeutic target in allergic inflammation.

# publications[].label
Epithelial Immunomodulation by Aerosolized Toll-like Receptor Agonists Attenuates Allergic Responsiveness in Mice

# publications[].label
Late response to allergen is associated with increased concentrations of tumor necrosis factor- and IL-5 in induced sputum

# publications[].label
Gene therapy in Wiskott-Aldrich syndrome: The next step?

# publications[].label
Late response to allergen is associated with increased concentrations of tumor necrosis factor-alpha and IL-5 in induced sputum.

# publications[].label
Allergen-induced proliferation and interleukin-5 production by bronchoalveolar lavage and blood T cells after segmental allergen challenge.

# publications[].label
Workshop C: The growing importance of clinical immunology: Impact on the allergy training program and the practice of allergy

# publications[].label
Cytokine regulation of IL-5 receptor alpha chain (IL-5R alpha) isoform expression.

# publications[].label
Therapeutic efficacy of an anti-IL-5 monoclonal antibody delivered into the respiratory tract in a murine model of asthma.

# publications[].label
MORAXELLA-CATARRHALIS (MCAT) AND STAPHYLOCOCCUS-AUREUS (SAC) ARE PROTOTYPES OF DISTINCT INDUCERS OF HUMAN B-CELL DIFFERENTIATION

# publications[].label
Suppression of Ia-unrestricted primary anti-Qa-1 cytotoxic T lymphocyte responses by class II major histocompatibility complex-restricted cellular interactions.

# publications[].publisher
The American Association of Immunologists

# publications[].label
Differences in maternal lineages of New Zealand Black mice defined by restriction endonuclease analysis of mitochondrial DNA and by expression of maternally transmitted antigen.

# publications[].label
Guiding Preclinical Medical Students in Finding, Synthesizing, and Communicating Translational Basic Research Literature: Roles for Basic Science Research Mentors.

# publications[].label
Animal models of human systemic lupus erythematosus.

# publications[].label
Unneutral neutrophils in patients with late-phase allergic reactions.

# publications[].label
Trends in biologics utilization in a large cohort of patients with rheumatoid arthritis.

# publications[].label
Defective B-cell response to Toll-like receptor-9 ligands in common variable immunodeficiency.

# publications[].label
Subcutaneous nodular amyloidosis: a case report and review of the literature.

# publications[].label
HIV-1 nef suppression of B-cell immunoglobulin heavy chain class-switch recombination

# publications[].label
1990 Training program directors' retreat core curriculum workshop report

# publications[].label
Emerging role of human basophil biology in health and disease.

# publications[].label
Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccines.

# publications[].label
American Academy of Allergy and Immunology Training Program Directors' Retreat, Jan. 10-12, 1992. Core curriculum outline.

# publications[].label
DIAGNOSTIC LABORATORY IMMUNOLOGY - PREFACE

# publications[].label
Mitochondrial modulation of maternally transmitted antigen: analysis of cell hybrids.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Immunoglobulin deficiency syndromes and therapy.

# publications[].label
The Merck Manual of Diagnosis and Therapy

# publications[].label
Cytokine regulation of IL-5 receptor alpha chain (IL-5Ra) and beta chain (bc) isoform expression

# publications[].label
Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1.

# publications[].label
Parafalcine and bilateral convexity neurosarcoidosis mimicking meningioma: case report and review of the literature.

# publications[].label
Delineation of IL-5 domains predicted to engage the IL-5 receptor complex.

# publications[].publisher
The American Association of Immunologists

# publications[].label
Amyloidosis in systemic lupus erythematosus.

# publications[].label
Idiopathic granulomatous myositis successfully treated with IVIG

# publications[].label
Takayasu arteritis in a patient with absolute IgA deficiency and atopic dermatitis.

# publications[].label
IL-13 production by allergen-stimulated T cells is increased in allergic disease and associated with IL-5 but not IFN-gamma expression.

# publications[].label
IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells.

# publications[].label
Cellular requirements for the generation of primary cell-mediated lympholysis responses to Qa-1 antigens.

# publications[].publisher
The American Association of Immunologists

# publications[].label
Proliferation and release of IL-5 and IFN-gamma by peripheral blood mononuclear cells from cat-allergic asthmatics and rhinitics, non-cat-allergic asthmatics, and normal controls to peptides derived from Fel d 1 chain 1.

# publications[].label
SUPPRESSION OF PRIMARY ANTI-QA-1 CYTOTOXIC LYMPHOCYTE-T (CTL) RESPONSES BY CLASS II-RESTRICTED CELLULAR INTERACTIONS

# publications[].label
HIERARCHY OF TARGET ANTIGENS FOR H-2-UNRESTRICTED CYTOLYSIS BY NZB AND F1 CYTO-TOXIC LYMPHOCYTES-T

# publications[].label
Primary cell-mediated lympholysis response to a maternally transmitted antigen.

# publications[].label
Proteasome regulation of beta c signalling: A novel mechanism for cytokine receptor heterotypic desensitization

# publications[].label
GM-CSF, IL-5 and RANTES immunoreactivity and mRNA expression in chronic hyperplastic sinusitis with nasal polyposis (NP).

# publications[].label
Aerosolized Toll-Like Receptor Agonists Suppress Allergic Inflammation

# publications[].label
Therapy of chronic idiopathic urticaria with nifedipine: demonstration of beneficial effect in a double-blinded, placebo-controlled, crossover trial.

# publications[].label
708 IL-5 secretion by allergen-specific CD4+ cells in short-term culture: dissociation from allergen-induced proliferation and dependence on B7-2 co-stimulation

# publications[].label
Enhanced detection of human IL-5 in biological fluids utilizing murine monoclonal antibodies which delineate distinct neutralizing epitopes.

# publications[].label
Aerosolized Toll-like Receptor Agonists Suppress Allergic Inflammation

# publications[].label
Increased non-canonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes

# publications[].label
Thymus transplantation advances in DiGeorge syndrome

# publications[].label
Alternative strategies for antagonism of IL-5

# publications[].label
Controlled pilot trial of monthly intravenous cyclophosphamide in multiple sclerosis.

# publications[].label
Secretion by allergen-stimulated CD4+ T cells in primary culture: Relationship to expression of allergic disease

# publications[].label
IL-5 production by allergen-stimulated T cells following grass pollen immunotherapy for seasonal allergic rhinitis.

# publications[].label
Partial genomic deletion of ICOS as a cause of hereditary common variable immune deficiency

# publications[].label
Therapeutic strategies for harnessing human eosinophils in allergic inflammation, hypereosinophilic disorders, and cancer.

# publications[].label
Previously undiagnosed hyper-IgE syndrome in an adult with multiple systemic fungal infections.

# publications[].label
Mitochondria control expression of a murine cell surface antigen.

# publications[].label
Core content outline for clinical and laboratory immunology. AAAI Training Program Directors' Committee.

# publications[].label
Defects in interleukin-17 immunity in the pathogenesis of chronic mucocutaneous candidiasis.

# publications[].label
Reduction of the incidence and severity of collagen-induced arthritis by constitutive Nur77 expression in the T cell lineage.

# publications[].label
DETECTION OF CLONAL TCR GENE REARRANGEMENTS IN ACTIVATED CD8+ T-CELLS FROM PERIPHERAL-BLOOD OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY (CVID)

# publications[].label
Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF.

# publications[].label
250 Grass pollen induced IL-5 production by peripheral blood mononuclear cells (PBMC) is increased in allergic rhinitis and inhibited by immunotherapy (IT)

# publications[].label
Chronic Effects of an Elevation Training Mask on Aerobic Capacity, Anaerobic Endurance, and Pulmonary Function

# publications[].label
PREVENTION OF MAST-CELL DE-GRANULATION IN PATIENTS WITH PHYSICAL URTICARIAS

# publications[].label
Evidence-based evaluation for allergies to avoid inappropriate testing, diagnosis, and treatment.

# publications[].label
Disparities in the use of biologic therapies for the treatment of RA

# publications[].label
Secretion of the eosinophil-active cytokines interleukin-5, granulocyte/macrophage colony-stimulating factor and interleukin-3 by bronchoalveolar lavage CD4+ and CD8+ T cell lines in atopic asthmatics, and atopic and non-atopic controls.

# publications[].label
Prevention of mast-cell degranulation by ketotifen in patients with physical urticarias.

# publications[].label
Abnormal response to IL-5 in B-cell chronic lymphocytic leukemia.

# publications[].label
DETECTION OF HUMAN IL-5 IN BIOLOGICAL-FLUIDS AND CHARACTERIZATION OF DISTINCT IL-5 EPITOPES USING MURINE MONOCLONAL-ANTIBODIES

# publications[].label
Chronic Effects of an Elevation Training Mask on Aerobic Capacity, Anaerobic Endurance, and Pulmonary Function

# publications[].label
IMMUNE THROMBOCYTOPENIA IN HOMOSEXUAL MEN

# publications[].label
Innovations in MD-only physician-scientist training: experiences from the Burroughs Wellcome Fund physician-scientist institutional award initiative.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Clinical immunophenotypic heterogeneity of subclinical T cell leukemia

# publications[].label
ANALYSIS OF AUTOSOMAL DOMINANTLY INHERITED SELECTIVE IGG3 DEFICIENCY

# publications[].label
Creation of a biologically active interleukin-5 monomer.

# publications[].label
Production of IL-5 and granulocyte-macrophage colony-stimulating factor by naive human mast cells activated by high-affinity IgE receptor ligation.

# publications[].label
331 Naive human mast cells (MC) transcribe IL-3, IL-5 and GM-CSF mRNA and secrete IL-5 and GM-CSF protein following FcRI ligation

# publications[].label
Epithelial immunomodulation by aerosolized Toll-like receptor agonists prevents allergic inflammation in airway mucosa in mice.

# publications[].label
Effect of plasmapheresis on T anc B lymphocyte functions in patients with systemic lupus erythematosus: a double blind study.

# publications[].label
Proteasomal regulation of betac signaling reveals a novel mechanism for cytokine receptor heterotypic desensitization.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Translating the biology of  common receptor-engaging cytokines into clinical medicine.

# publications[].label
Requlation of cytotoxic lymphocyte responses in New Zealand mice by alloantigen-activated spleen cells.

# publications[].publisher
The American Association of Immunologists

# publications[].label
IMMUNOPATHOLOGIC DESCRIPTION OF ACUTE ARTHRITIS IN CYSTIC-FIBROSIS

# publications[].label
Effects of the thymic microenvironment on autoantibody production in (NZB X NZW)F1 mice.

# publications[].label
Trends in biologics utilization in a large cohort of RA patients

# publications[].label
Proinflammatory Stimuli Induce The Generation Of IL-17-producing T(H)2 Memory Cells That Is Associated With Exacerbated Allergic Diseases

# publications[].label
Interleukins-4, -5, and -13: emerging therapeutic targets in allergic disease.

# publications[].label
IL-5 secretion by allergen-stimulated CD4+ T cells in primary culture: relationship to expression of allergic disease.

# publications[].label
Versatile E. coli thioredoxin specific monoclonal antibodies afford convenient analysis and purification of prokaryote expressed soluble fusion protein.

# publications[].label
Thymic stromal lymphopoietin:a potential therapeutic target for allergy and asthma.

# publications[].label
The role of B lymphocytes in the development of collagen induced arthritis: Antibody-producers or antigen-presenters?

# publications[].label
Attenuation of the allergen induced late asthmatic reaction (LAR) by cyclosporin a (CsA) is associated with inhibition of bronchial-associated eosinophils, IL-5, eotaxin and GM-CSF.

# publications[].label
ANALYSIS OF IMMUNOGLOBULIN PRODUCTION IN SELECTIVE IGM DEFICIENCY

# publications[].label
Randomised trial of plasma exchange in mild systemic lupus erythematosus.

# publications[].label
Regulation of primary cytotoxic T lymphocyte responses generated during mixed leukocyte culture with H-2d identical Qa-1-disparate cells.

# publications[].publisher
The American Association of Immunologists

# publications[].label
840 Idiopathic CD4+ T-lymphocytopenia (ICL) with systemic nocardiosis and a large population of CD3+ CD4CD8 T cell receptor (TCR) /+ lymphocytes

# publications[].label
Wegener's granulomatosis presenting with unilateral parotid enlargement.

# publications[].label
Preferential lysis of undifferentiated thymocytes by natural thymocytotoxic antibodies from New Zealand black mice.

# publications[].publisher
The American Association of Immunologists

# publications[].label
Successful immunosuppressive therapy in a patient with autoantibodies to insulin receptors and immune complex glomerulonephritis.

# publications[].label
Aerosolized Toll-Like Receptor Agonists Suppress House Dust Mite Allergic Asthma

# publications[].label
POEMS syndrome: studies in a patient with an IgG-kappa M protein but no polyneuropathy.

# publications[].label
Immune dysregulation in the pathogenesis of pulmonary alveolar proteinosis.

# publications[].label
ADVANTAGES OF THE CRITHIDIA ASSAY IN SLE - REPLY

# publications[].label
Mechanism of Staphylococcus aureus exotoxin A inhibition of Ig production by human B cells.

# publications[].publisher
The American Association of Immunologists

# publications[].label
Engineering of a functional interleukin-5 monomer: a paradigm for redesigning helical bundle cytokines with therapeutic potential in allergy and asthma.

# publications[].label
Increased noncanonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes.

# publications[].label
Disparities in the use of biologic therapies for the treatment of rheumatoid arthritis.

# publications[].label
Correlation of serum IgG, IgM, and anti-native-DNA antibodies with renal and clinical indexes of activity in systemic lupus erythematosus.

# publications[].label
A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma.

# publications[].label
T cell abnormalities in NZB mice occur independently of autoantibody production.

# publications[].label
Permissive splicing is a novel model for providing the structural basis for expression of untolerized autoantigen epitopes

# publications[].label
Therapeutic targets in airway inflammation

# researcherOn[].awardedBy.label
Burroughs Wellcome Fund - (Durham, North Carolina, United States)

# researcherOn[].label
Clinical Research - Mechanisms of Human Basophil-Mediated Allergic Inflammation

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# streetAddress
Texas A&M Health Science Center; Ctr For Clinical/Translational Med; 1201 TAMUS

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine