# overview
My research is focused on the studying the cellular and molecular mechanisms regulating the development of cardiometabolic disorders and identifying novel pharmacologic strategies to combat cardiovascular diseases such as atherosclerosis, endothelial and vascular dysfunction in diabetic, obese and aging patients. Currently we are exploring the role of gut microbe-derived metabolites in endothelial and vascular cell signaling.

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5 Development Of Treatments And Therapeutic Interventions

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NLR Family, Pyrin Domain-Containing 3 Protein

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Tumor Necrosis Factor (tnf)‐alpha Converting Enzyme

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Leukemia, Myelogenous, Chronic, Bcr-abl Positive

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Cyclic Nucleotide Phosphodiesterases, Type 5

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5 Development Of Treatments And Therapeutic Interventions

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NLR Family, Pyrin Domain-Containing 3 Protein

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NLR Family, Pyrin Domain-Containing 3 Protein

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5 Development Of Treatments And Therapeutic Interventions

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5 Development Of Treatments And Therapeutic Interventions

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3214 Pharmacology And Pharmaceutical Sciences

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1.1 Normal Biological Development And Functioning

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NLR Family, Pyrin Domain-Containing 3 Protein

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3404 Medicinal And Biomolecular Chemistry

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NLR Family, Pyrin Domain-Containing 3 Protein

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NLR Family, Pyrin Domain-Containing 3 Protein

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NLR Family, Pyrin Domain-Containing 3 Protein

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Cyclic GMP-Dependent Protein Kinase Type I

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3214 Pharmacology And Pharmaceutical Sciences

# educationAndTraining[].organization.label
Andhra University - (Visakhapatnam, Andhra Pradesh, India)

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Andhra University - (Visakhapatnam, Andhra Pradesh, India)

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University of Tubingen - (Tübingen, Germany)

# awardsAndHonors[].label
American Radiolabeled Chemicals Junior Scientist Award in Pharmacology

# publications[].label
Chronic inhibition of phosphodiesterase 5 with tadalafil affords cardioprotection in a mouse model of metabolic syndrome: role of nitric oxide.

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Targeting glutathione by dimethylfumarate protects against experimental malaria by enhancing erythrocyte cell membrane scrambling.

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PDE-5 Inhibitors in Protection of Diabetic Heart

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Characterization and Activation of NLRP3 Inflammasomes in the Renal Medulla in Mice.

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Regulation of erythrocyte survival by AMP-activated protein kinase.

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Enhanced susceptibility to suicidal death of erythrocytes from transgenic mice overexpressing erythropoietin.

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Role of High Mobility Group Box 1 in TrimethylamineNOxideInduced Podocyte Injury and Glomerular Sclerosis

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PERK specific inhibitor AMG-44 protects against Trimethylamine N-oxide (TMAO)-induced Endoplasmic Reticular Stress and Endothelial Dysfunction

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Endothelial NLRP3 Inflammasome Activation and Neointima Formation in Mice by Gut Microbial Metabolite TrimethylamineNOxide

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Choline Treatment Activates NLRP3 Inflammasome Formation and Leads to Endothelial Dysfunction in Mice

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TACE inhibition: a promising therapeutic intervention against AATF-mediated steatohepatitis to hepatocarcinogenesis.

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Non-selective cation channel-mediated Ca2+-entry and activation of Ca2+/calmodulin-dependent kinase II contribute to G2/M cell cycle arrest and survival of irradiated leukemia cells.

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TRPC6 contributes to the Ca(2+) leak of human erythrocytes.

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Functional significance of the intermediate conductance Ca2+-activated K+ channel for the short-term survival of injured erythrocytes.

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American Society for Pharmacology & Experimental Therapeutics (ASPET)

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Contribution of Membrane Raft Redox Signaling to VisfatinInduced Inflammasome Activation and Podocyte Injury

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Phosphodiesterase-5 inhibitor tadalafil attenuates oxidative stress and protects against myocardial ischemia/reperfusion injury in type 2 diabetic mice.

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Phosphodiesterse-5 inhibition with Tadalafil attenuates detrimental proteomic changes in type 2 diabetic myocardium

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TrimethylamineNOxide, an Intestinal Microbial Metabolite Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction

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Iron deficiency influences the course of malaria in Plasmodium berghei infected mice.

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Attenuation of Doxorubicin-induced Cardiotoxicity by Tadalafil: A Long Acting Phosphodiesterase-5 Inhibitor.

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Contribution of membrane raft redox signalling to visfatin-induced inflammasome activation and podocyte injury.

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Lead decreases parasitemia and enhances survival of Plasmodium berghei-infected mice.

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Instigation of NLRP3 inflammasome activation and glomerular injury in mice on the high fat diet: role of acid sphingomyelinase gene.

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Enhanced insulin sensitivity of gene-targeted mice lacking functional KCNQ1.

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High Mobility Group Box 1 Mediates TMAO-Induced Endothelial Dysfunction.

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Identification of proteomic alterations in TMAOInduced Cardiac Injury

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Nitric Oxide-cGMP-PKG Signaling in the Cardioprotective Effects of Phosphodiesterase 5 Inhibitors

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Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide.

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Contribution of High Mobility Group Box 1 to NicotineInduced Podocyte Injury

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Suicide for survival--death of infected erythrocytes as a host mechanism to survive malaria.

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Reduced Ca2+ entry and suicidal death of erythrocytes in PDK1 hypomorphic mice.

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Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency.

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Interactions Between Gut Microbiota and Lipophilic Vitamins in Health and Disease

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Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein expression.

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Phosphodiesterase-5 inhibition and Cardioprotection in Type 2 Diabetes

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Contribution of High Mobility Group Box 1 to ObesityInduced Podocyte Dysfunction and Glomerular Injury

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Influence of paclitaxel on parasitemia and survival of Plasmodium berghei infected mice.

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Abstract P017: Contribution of High Mobility Group Box 1 to Hyperhomocysteinemia-induced Podocyte Injury and Glomerular Sclerosis

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Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia.

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Abstract 17038: Long-Acting Phosphodiesterase-5 Inhibitor Tadalafil Attenuates Oxidative Stress and Protects Against Myocardial Ischemia/Reperfusion Injury in Type 2 Diabetic Mice

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Sphingolipids in obesity and related complications.

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Rebuttal to letter to the editor on effect of cyclosporine on parasitemia and survival of Plasmodium berghei-infected mice

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Oxidation induces ClC-3-dependent anion channels in human leukaemia cells.

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Influence of amitriptyline on eryptosis, parasitemia and survival of Plasmodium berghei-infected mice.

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Inhibition of acid sphingomyelinasemediated autophagic flux contributes to amitriptylineinduced perturbation of tube formation in murine endothelial cells

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Nicotine instigates podocyte injury via NLRP3 inflammasomes activation.

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Obesity: an overview on its current perspectives and treatment options.

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NLRP3 Inflammasome as a Novel Target to Abrogate NicotineInduced Podocyte Injury

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Influence of chlorpromazine on eryptosis, parasitemia and survival of Plasmodium berghe infected mice.

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TMAO Activates Carotid Endothelial Inflammasomes Leading to Enhanced Neointimal Formation in Nlrp3 Mice

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Effect of cyclosporine on parasitemia and survival of Plasmodium berghei infected mice.

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Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1 signaling.

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SKQ1 Improves Trimethylamine-N-Oxide-Induced Endothelial Dysfunction by Attenuating Oxidative Stress and Restoring Junctional Proteins

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Influence of NO synthase inhibitor L-NAME on parasitemia and survival of Plasmodium berghei infected mice.

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Gut Microbial Metabolite TrimethylamineNOxide Instigates NLRP3 Inflammasomes Activation and Podocyte Injury

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Thioredoxin Interacting Protein Deficiency Protects Against ObesityInduced Podocyte Injury and Glomerular Sclerosis

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Azathioprine favourably influences the course of malaria.

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Emerging new uses of phosphodiesterase-5 inhibitors in cardiovascular diseases.

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Simvastatin improves lysosome function via enhancing lysosome biogenesis in endothelial cells.

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Accelerated suicidal erythrocyte death in Klotho-deficient mice.

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GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak.

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American Society for Clinical Investigation

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A high specificity and affinity interaction with serum albumin stimulates an anion conductance in malaria-infected erythrocytes.

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Podocyte NLRP3 Inflammasome Activation and Formation by Adipokine Visfatin.

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Role of NLRP3 Inflammasomes in Obesity-Induced Cardiovascular Diseases

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SIRT1 Activator II Protects against Myocardial Injury in High Fat DietInduced Diabetic Mice

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Treating diabetes with combination of phosphodiesterase 5 inhibitors and hydroxychloroquine-apossible prevention strategy for COVID-19?

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A simple and sensitive HPLC fluorescence method for determination of tadalafil in mouse plasma.

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Inhibition of suicidal erythrocyte death by nitric oxide.

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Phosphodiesterase5 Inhibition with Tadalafil Attenuates Left Ventricular Dysfunction and Cardiomyocyte Apoptosis in Doxorubicininduced Cardiotoxicity in Mice

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Inhibition of eryptosis and intraerythrocytic growth of Plasmodium falciparum by flufenamic acid.

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Anemia and splenomegaly in cGKI-deficient mice.

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Proceedings of the National Academy of Sciences

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NicotineInduced Glomerular Injury is Ameliorated in NLRP3 Gene Knockout Mice

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Chronic treatment with long acting phosphodiesterase-5 inhibitor tadalafil alters proteomic changes associated with cytoskeletal rearrangement and redox regulation in Type 2 diabetic hearts.

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Acid Sphingomyelinase Inhibitor Protects Against the Nicotine-Induced Podocyte Injury

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American Society for Pharmacology & Experimental Therapeutics (ASPET)

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Gut Microbial Metabolite TMAO Induces Endothelial Dysfunction by Activating the HMGB1/TLR4 Signalling Pathway

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Adiponectin Protects Mouse Podocytes from Acid Ceramidase InhibitionInduced Injury

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Enhanced suicidal death of erythrocytes from gene-targeted mice lacking the Cl-/HCO(3)(-) exchanger AE1.

# researcherOn[].label
Role of Trimethylamine-N-Oxide in endothelial dysfunction (Koka, Sai)

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National Heart Lung and Blood Institute - (Bethesda, Maryland, United States)

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Gut microbial metabolite- Trimethylamine-N-Oxide and endothelial inflammasome signalling in cardiovascular injury (Koka, Sai)

# researcherOn[].awardedBy.label
National Heart Lung and Blood Institute - (Bethesda, Maryland, United States)