# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
Cardiovascular disease remains as the number one cause of mortality. About 50% of heart failure patients will perish in five years. At age 40, lifetime risk of developing heart failure is one in five. Diastolic dysfunction heart failure prevalence has increased to 50% of all heart failure. In this context, My research is dedicated to elucidating underlying mechanisms and translating discoveries to new treatments.

# hrJobTitle
Associate Professor and Director of the Division of Cardiac Health and Disease

# keywords[]
National Heart, Lung, And Blood Institute (U.S.)

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
National Heart, Lung, And Blood Institute (U.S.)

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
Cmybp-c, Cardiac Myosin Binding Protein-c

# keywords[]
3sd, Mutated 3 Serines To 3 aspartic Acids To Mimic Phosphorylated Cmybp-c (s273d, S282d, And S302d)

# keywords[]
3sa, Mutated 3 Serines To 3 alanines To Mimic Hypophosphorylated Cardiac Myosin Binding Protein-c (s273a, S282a, And S302a)

# keywords[]
Hfpef, Heart Failure With Preserved Ejection Fraction

# keywords[]
3201 Cardiovascular Medicine And Haematology

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# educationAndTraining[].organization.label
Air Force Institute of Technology - (Dayton, Ohio, United States)

# educationAndTraining[].organization.label
University of Wisconsin Hospital and Clinics - (Madison, Wisconsin, United States)

# educationAndTraining[].organization.label
Duke Medical Center - (Durham, North Carolina, United States)

# educationAndTraining[].organization.label
Texas A&M Health Science Center - (College Station, Texas, United States)

# publications[].label
Cardiac Myosin Binding Protein C Regulates Cross-bridge Kinetics to Affect Diastolic Function

# publications[].label
HIGH IMPACT, HIGH RISK: PERCUTANEOUS CORONARY INTERVENTION IN POST-CARDIAC ARREST PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION IS ASSOCIATED WITH INCREASED SURVIVAL ALONG WITH INCREASED PUBLIC REPORTING MORTALITY

# publications[].label
Abstract 15569: Pressure Stress Triggers Src/Focal Adhesion Kinase Complex to Phosphorylate Tyrosine Residue of Cardiac Myosin Binding Protein-C

# publications[].label
Abstract 16633: Cardiac Myosin Binding Protein-C Prevents Immune Response-Triggered Cardiac Myocyte Death During Inflammation

# publications[].label
Src/FAK complex phosphorylates cardiac myosin binding protein c (cMyBP-C) in vitro and in vivo

# publications[].label
Estrogen Protects Cardiac Function and Energy Metabolism in Dilated Cardiomyopathy Induced by Loss of Cardiac IRS1 and IRS2.

# publications[].label
Absence of protein kinase a phosphorylation of cardiac myosin binding protein causes myocardial dysfunction and hypertrophy

# publications[].label
Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Challenges facing early career academic cardiologists.

# publications[].label
Preparation of Neonatal Rat Papillary Muscles for Contractile Studies.

# publications[].label
Phosphorylation of myosin binding protein C affects skinned myocyte fiber mechanics

# publications[].label
Cardiac Myosin Binding Protein C Couples Cross-Bridge Cycling to Calcium Transients to Provide Normal Cardiac Function

# publications[].label
Serum Cardiac Myosin Binding Protein-C Correlates With Severity of Overall Cardiovascular Stress

# publications[].label
Phosphorylation of cardiac Myosin-binding protein-C is a critical mediator of diastolic function.

# publications[].label
Abstract 19920: Cardiac Myosin Binding Protein-C Modulates the Cellular Immune Response to Protect the Heart

# publications[].label
Deletion of Cdc42 in embryonic cardiomyocytes results in right ventricle hypoplasia.

# publications[].label
Abstract 17263: Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Pressure-Overload Heart Failure Despite Alterations in Calcium Handling

# publications[].label
Abstract P213: Epidermal Growth Factor Receptor and c-Src Are Involved in Stretch-Induced Activation of JNK1/2 and P38 in Cardiac Myocytes and Cardiac Fibroblasts

# publications[].label
Perturbation of Tropomyosin Amino Acid Residues Binding to Actin at the "Off" State of Tropomyosin Increase Cardiac Muscle Dynamics

# publications[].label
National Institutes of Health Career Development Awards for Cardiovascular Physician-Scientists: Recent Trends and Strategies for Success.

# publications[].label
Reduced Responsiveness to beta-Adrenergic Agonists in Murine cMyBP-C Cardiomyopathy

# publications[].label
Cardiac Myosin Binding Protein-C Phosphorylation Is Critical for Normal Diastolic Function

# publications[].label
CARDIAC MYOSIN BINDING PROTEIN-C DE-PHOSPHORYLATION MEDIATED SLOWING OF CROSS-DETACHMENT WORSENS HEART FAILURE

# publications[].label
Abstract 231: Cardiac Myosin Binding Protein C Couples Cross-Bridge Cycling to Calcium Transients to Provide Normal Cardiac Function

# publications[].label
Abstract 16507: Frequency Dependent Phosphorylation of Cardiac Myosin Binding Protein-C Mediates Acceleration of Myocardial Relaxation to Support Normal Diastolic Function

# publications[].label
Abstract 15477: Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Aging Induced Heart Dysfunction

# publications[].label
Cardiac Myosin Binding Protein-C Phosphorylation Preserves Diastolic Function in Aging Hearts

# publications[].label
LACK OF CARDIAC MYOSIN BINDING PROTEIN-C PHOSPHORYLATION IS A MODEL OF HEART FAILURE WITH PRESERVED EJECTION FRACTION

# publications[].label
Abstract 5404: Perturbation of Tropomyosin Amino Acid Residues Binding to Actin at the Off State of Tropomyosin Increase Cardiac Muscle Dynamics

# publications[].label
Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C During Increased Pacing Frequency or 1-Adrenergic Stimulation.

# publications[].label
Myosin-binding protein C (MyBP-C) stabilizes, but is not the sole determinant of, SRX myosin in cardiac muscle

# publications[].label
Acceleration of crossbridge kinetics by protein kinase A phosphorylation of cardiac myosin binding protein C modulates cardiac function.

# publications[].label
Temporary left ventricular assist device through an axillary access is a promising approach to improve outcomes in refractory cardiogenic shock patients.

# publications[].label
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

# publications[].label
Electrical Pacing Improves Contractile Function of Engineered Cardiac Tissue

# publications[].label
Charged residue alterations in the inner-core domain and carboxy-terminus of alpha-tropomyosin differentially affect mouse cardiac muscle contractility

# publications[].label
Phosphorylation of Myosin Binding Protein C Contributes to the Force-Frequency Response and Beta-Adrenergic Enhancement of Cardiac Contraction

# publications[].label
Abstract 3850: Cardiac Myosin Binding Protein C Regulates Cross-bridge Kinetics to Affect Diastolic Function

# publications[].label
Cardiac Myosin Binding Protein-C Phosphorylation: a Potential Mechanism for the Treatment of Heart Failure with Preserved Ejection Fraction

# publications[].label
Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Pressure-Overload Heart Failure Despite Alterations in Calcium Handling

# publications[].label
Pressure Stress Triggers Src/Focal Adhesion Kinase Complex to Phosphorylate Tyrosine Residue of Cardiac Myosin Binding Protein-C

# publications[].label
ABSENCE OF CARDIAC MYOSIN BINDING PROTEIN-C INCREASES INFLAMMATORY DAMAGE TO THE HEART

# publications[].label
ACUTE DECOMPENSATED HEART FAILURE: THE JOURNEY FROM PATIENTS' PERSPECTIVE

# publications[].label
Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Pressure-Overload Induced Heart Failure

# publications[].label
Multisensor Fusion Of Ladar And Passive Infrared Imagery For Target Segmentation

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Cardiac Myosin Binding Protein-C Phosphorylation is Essential for Normal Diastolic Function

# publications[].label
Abstract P219: Role of Angiotensin Type I Receptor and  1 Integrin in Stretch-Induced Activation of Akt and JNK in Cardiac Myocytes

# publications[].label
Phosphorylation status of cardiac myosin binding protein C impacts acto-myosin ATPase activity

# publications[].label
CARDIAC MYOSIN BINDING PROTEIN-C PHOSPHORYLATION ENHANCES DIASTOLIC FUNCTION DESPITE AGING

# publications[].label
Cardiac myosin-binding protein-C is a critical mediator of diastolic function.

# publications[].label
Abstract 20432: Phosphorylated Cardiac Myosin Binding Protein-C Alters Signaling Response to Improve Survival in Heart Failure With Reduced Ejection Fraction

# publications[].label
Cardiac Myosin Binding Protein-C Phosphorylation Modulates Relaxation in Myocardium

# publications[].label
Preparation and Identification of Cardiac Myofibrils from Whole Heart Samples.

# publications[].label
Left Ventricular Free Wall Adaptations in Heart Failure With Preserved Ejection Fraction: Insights From a Murine Model

# publications[].label
Frequency Dependent Phosphorylation of Cardiac Myosin Binding Protein-C Mediates Acceleration of Myocardial Relaxation to Support Normal Diastolic Function

# publications[].label
Cardiac Myosin Binding Protein-C Phosphorylation in Ser-273 and Ser-282 is Critical to Maintain Cardiac Function During Aging

# publications[].label
Loss of Cardiac Myosin Binding Protein-C Leads to Ineffective Contraction and Relaxation Kinetics Which are Reinstated by Reintroducing the Phosphorylated Protein

# publications[].label
Methyltransferase-14 Regulation of Adenosine Methylation on mRNA Contributes to Normal and Adaptive Heart Structure and Function

# publications[].label
Charged residue alterations in the inner-core domain and carboxy-terminus of alpha-tropomyosin differentially affect mouse cardiac muscle contractility.

# publications[].label
Launching the new American College of Cardiology Research Network: advancing high-value collaborative research via "innovative networking".

# publications[].label
(151) Impella 5.0 through an Axillary Access Is a Promising Approach to Improve Outcomes in Decompensated Heart Failure Patients to Receive Long-term Mechanical Circulatory Assistance

# publications[].label
Measurements of the cross-bridge attachment/detachment process within intact sarcomeres by surface plasmon resonance.

# publications[].label
Abstract P251: Mechanical Stretch Induces Phosphorylation of Cardiac Myosin Binding Protein-C

# publications[].label
Role of myosin binding protein C phosphorylation in force frequency relationship of the heart

# publications[].label
Role of tropomyosin and myosin binding protein C in force frequency relationship of cardiac muscle

# publications[].label
Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium.

# publications[].label
Abstract 18321: Serum Cardiac Myosin Binding Protein-C Correlates With Severity of Overall Cardiovascular Stress

# publications[].label
MOUSE ENGINEERED CARDIAC TISSUE: A NOVEL PLATFORM FOR STUDYING THE PHYSIOLOGICAL EFFECTS OF HCM-CAUSING MUTATIONS ON CARDIAC FUNCTION

# publications[].label
Myosin Binding Protein C is Essential for Beta-adrenergic Mediated Acceleration of Cardiac Relaxation

# publications[].label
Type I interferon potentiates metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice

# publications[].label
The Coupling of Tumor Endothelial Marker-8 and Capillary Morphogenesis Gene-2 Receptors to Contractile-Related Signaling Pathway in Cardiac Myocytes

# publications[].label
Abstract 125: Cardiac Myosin Binding Protein-C Phosphorylation Is Critical for Normal Diastolic Function

# publications[].label
Constitutive Phosphorylation of Cardiac Myosin Binding Protein-C Increases the Probability of Myosin Cross-bridge Interaction with Actin

# publications[].label
Abstract 536: Absence of Protein Kinase A Phosphorylation of Cardiac Myosin Binding Protein Causes Myocardial Dysfunction and Hypertrophy

# publications[].label
Multisensor Data Fusion Of Laser Radar And Forward Looking Infrared (FLIR) For Target Segmentation And Enhancement

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Abstract 17970: Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Pressure-Overload Induced Heart Failure

# publications[].label
Abstract 621: Cardiac Myosin Binding Protein-C Phosphorylation in Ser-273 and Ser-282 is Critical to Maintain Cardiac Function During Aging

# publications[].label
Pump Dysfunction and Depressed Contractile Reserve in a Murine Model of Hypertrophic Cardiomyopathy

# publications[].label
Usefulness of Released Cardiac Myosin Binding Protein-C as a Predictor of Cardiovascular Events.

# publications[].label
Using surface plasmon resonance to monitor acto-myosin attachment/detachment within intact sarcomeres

# publications[].label
CARDIAC MYOSIN BINDING PROTEIN-C MEDIATES CALCIUM TO FORCE COUPLING FOR EFFECTIVE CONTRACTION AND RELAXATION

# publications[].label
Coronary Arteriolar Vasomotor Dysfunction Precedes Cardiac Diastolic Dysfunction in Diabetic Cardiomyopathy

# publications[].label
Abstract 1578: Myosin Binding Protein C is Essential for Beta-adrenergic Mediated Acceleration of Cardiac Relaxation

# publications[].label
Cardiac Myosin Binding Protein C Contributes to the Protection of the Heart During Immune Response to Infection

# publications[].label
STATUS OF EARLY CAREER ACADEMIC CARDIOLOGY: A GLOBAL PERSPECTIVE

# publications[].label
Cardiac Myosin Binding Protein-C Modulates the Cellular Immune Response to Protect the Heart

# publications[].label
Abstract 19019: Loss of Cardiac Myosin Binding Protein-C Leads to Ineffective Contraction and Relaxation Kinetics Which are Reinstated by Reintroducing the Phosphorylated Protein

# publications[].label
Abstract P220: Anthrax Receptor Regulation of FAK and JNK Activation in Cardiac Myocytes

# publications[].label
Status of Early-Career Academic Cardiology: A Global Perspective.

# publications[].label
Abstract 283: The Coupling of Tumor Endothelial Marker-8 and Capillary Morphogenesis Gene-2 Receptors to Contractile-Related Signaling Pathway in Cardiac Myocytes

# publications[].label
Automated analysis of contractile force and Ca2+ transients in engineered heart tissue.

# publications[].label
Abstract 14317: Left Ventricular Free Wall Adaptations in Heart Failure With Preserved Ejection Fraction: Insights From a Murine Model

# publications[].label
Abstract 19346: Cardiac Myosin Binding Protein-C Phosphorylation Preserves Diastolic Function in Aging Hearts

# publications[].label
Abstract 17755: Cardiac Myosin Binding Protein C Contributes to the Protection of the Heart During Immune Response to Infection

# publications[].label
Roles of phosphorylation of myosin binding protein-C and troponin I in mouse cardiac muscle twitch dynamics.

# publications[].label
Isolation of Adult Mouse Cardiomyocytes Using Langendorff Perfusion Apparatus.

# publications[].label
Mechanosensing and Regulation of Cardiac Function.

# publications[].label
Abstract 15341: Coronary Arteriolar Vasomotor Dysfunction Precedes Cardiac Diastolic Dysfunction in Diabetic Cardiomyopathy

# publications[].label
Phosphorylated Cardiac Myosin Binding Protein-C Alters Signaling Response to Improve Survival in Heart Failure With Reduced Ejection Fraction

# publications[].label
Abstract 13462: Cardiac Myosin Binding Protein-C Phosphorylation is Essential for Normal Diastolic Function

# publications[].label
Myosin-Binding Protein C Stabilizes, But Is Not the Sole Determinant of SRX Myosin in Cardiac Muscle

# publications[].label
Abstract 1580: Phosphorylation of Myosin Binding Protein C Contributes to the Force-Frequency Response and Beta-Adrenergic Enhancement of Cardiac Contraction

# publications[].label
Cardiac Myosin Binding Protein-C Prevents Immune Response-Triggered Cardiac Myocyte Death During Inflammation

# publications[].label
CARDIAC MYOSIN-BINDING PROTEIN C PHOSPHORYLATION ENHANCES CARDIAC RELAXATION

# publications[].label
Myosin-binding protein C stabilizes, but is not the sole determinant of SRX myosin in cardiac muscle.

# publications[].label
Neonatal mouse-derived engineered cardiac tissue: a novel model system for studying genetic heart disease.

# publications[].label
Reply: is it time to launch JACC: early career?

# publications[].label
ELECTRICAL PACING OF RAT ENGINEERED CARDIAC TISSUE (ECT) IMPROVES CARDIAC FUNCTION BY INCREASING CARDIOMYOCYTE DIFFERENTIATION AND SURVIVAL

# publications[].label
Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Age-RelatedCardiac Dysfunction: Hope for Better Aging?

# publications[].label
Sexual Dimorphism in Control of Heart Failure in Insulin Resistance

# publications[].label
PHOSPHORYLATED CARDIAC MYOSIN BINDING PROTEIN-C ENHANCES LUSITROPY

# researcherOn[].label
Contributions of Cardiac Myosin Binding Protein-C to Healthy and Failing Hearts

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Cardiac Myosin Binding Protein-C Modulates Immune Response to Protect The Heart

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Cardiac Myosin Binding Protein-C in Development and Reversal of Heart Failure

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Heart, Lung, and Blood Institute

# streetAddress
Texas A&M Health Science Center; Medical Physiology; 1114 TAMUS

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine

# inTheNews[].label
Presidential Clinical Research Partnership Grants Fund Six Research Projects