# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# keywords[]
NLR Family, Pyrin Domain-Containing 3 Protein

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Receptors, Tumor Necrosis Factor, Type I

# keywords[]
Bh3 Interacting Domain Death Agonist Protein

# keywords[]
Receptors, Tumor Necrosis Factor, Type Ii

# publications[].label
Comparative evaluation of apoptosis induced by Shiga toxin 1 and/or lipopolysaccharides in human monocytic and macrophage-like cells.

# publications[].label
URINARY CYTOKINES IN A PRIMATE MODEL OF SHIGA-LIKE TOXIN-INDUCED HEMOLYTIC-UREMIC SYNDROME

# publications[].label
Shiga Toxin Type 1 Activates Tumor Necrosis Factor- Gene Transcription and Nuclear Translocation of the Transcriptional Activators Nuclear Factor-B and Activator Protein-1

# publications[].label
Shiga toxin 1‐induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage‐like THP‐1 cell line

# publications[].label
Shiga toxins induce autophagy leading to differential signalling pathways in toxin-sensitive and toxin-resistant human cells.

# publications[].label
The interaction of Escherichia coli with normal human serum: factors affecting the capacity of serum to mediate lipopolysaccharide release.

# publications[].label
Interaction of Shiga toxins with human brain microvascular endothelial cells: cytokines as sensitizing agents.

# publications[].label
Announcing the 2017 Toxins Travel Awards for Post-Doctoral Fellows and Ph.D. Students.

# publications[].label
Endotoxin interactions with serum proteins relationship to biological activity.

# publications[].label
Distinct renal pathology and a chemotactic phenotype after enterohemorrhagic Escherichia coli shiga toxins in non-human primate models of hemolytic uremic syndrome.

# publications[].label
Adherence and colonization mechanisms of enteropathogenic and enterohemorrhagic Escherichia coli.

# publications[].label
Shiga Toxin and Shiga-Like Ribosome-Inactivating Proteins

# publications[].label
Inhibition of O-GlcNAcylation protects from Shiga toxin-mediated cell injury and lethality in host.

# publications[].label
Shiga Toxins Activate the NLRP3 Inflammasome Pathway To Promote Both Production of the Proinflammatory Cytokine Interleukin-1 and Apoptotic Cell Death.

# publications[].label
Characterization of the baboon responses to Shiga-like toxin: descriptive study of a new primate model of toxic responses to Stx-1.

# publications[].label
Shiga toxins: intracellular trafficking to the ER leading to activation of host cell stress responses.

# publications[].label
Shiga toxins--not just cytotoxins anymore.

# publications[].label
The induction of apoptosis by Shiga toxins and ricin.

# publications[].label
Role of tumor necrosis factor alpha in disease using a mouse model of Shiga toxin-mediated renal damage.

# publications[].label
THE ENDOTHELIN-NITRIC OXIDE AXIS IN A PRIMATE MODEL OF SHIGA-LIKE TOXIN-INDUCED HEMOLYTIC-UREMIC SYNDROME

# publications[].label
The physical-chemical characterization and biologic activity of serum released lipopolysaccharides.

# publications[].publisher
The American Association of Immunologists

# publications[].label
Stx1 induced cytokine expression is mediated by MAP kinase pathways and through translation initiation factor eIF-4E in the macrophage-like cell line THP-1

# publications[].label
Reduced nitric oxide bioavailability in a baboon model of Shiga toxin mediated hemolytic uremic syndrome (HUS).

# publications[].label
Announcing the 2016 Toxins Travel Awards for Post-Doctoral Fellows and Ph.D. Students.

# publications[].label
Response to Shiga toxin 1 and 2 in a baboon model of hemolytic uremic syndrome.

# publications[].label
Global transcriptional response of macrophage-like THP-1 cells to Shiga toxin type 1.

# publications[].label
Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells.

# publications[].label
Differential response of the human renal proximal tubular epithelial cell line HK-2 to Shiga toxin types 1 and 2.

# publications[].label
Characterization of the baboon responses to Shiga-like toxin (descriptive study of new toxic and hemolytic uremic responses to SLT-1).

# publications[].label
Shiga toxin 1-induced proinflammatory cytokine production is regulated by the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway.

# publications[].label
Renal prostacyclin biosynthesis in a baboon model of Shiga toxin mediated hemolytic uremic syndrome.

# publications[].label
Shiga toxin type 1 activates tumor necrosis factor-alpha gene transcription and nuclear translocation of the transcriptional activators nuclear factor-kappaB and activator protein-1.

# publications[].label
Bcl-2 regulates the onset of shiga toxin 1-induced apoptosis in THP-1 cells.

# publications[].label
Shiga toxin 1-induced activation of c-Jun NH(2)-terminal kinase and p38 in the human monocytic cell line THP-1: possible involvement in the production of TNF-alpha.

# publications[].label
URINARY PROSTAGLANDINS IN A PRIMATE MODEL OF SHIGA-LIKE TOXIN (SLT) INDUCED HEMOLYTIC-UREMIC SYNDROME

# publications[].label
Signaling through C/EBP homologous protein and death receptor 5 and calpain activation differentially regulate THP-1 cell maturation-dependent apoptosis induced by Shiga toxin type 1.

# publications[].label
QUANTITATION AND LOCALIZATION OF SHIGA TOXIN SHIGA-LIKE TOXIN-BINDING GLYCOLIPID RECEPTORS IN HUMAN AND BABOON TISSUES

# publications[].label
Mutation of flgM attenuates virulence of Salmonella typhimurium, and mutation of fliA represses the attenuated phenotype.

# publications[].label
Coxiella burnetii induces apoptosis during early stage infection via a caspase-independent pathway in human monocytic THP-1 cells.

# publications[].label
Regulation of cytokine and chemokine expression by the ribotoxic stress response elicited by Shiga toxin type 1 in human macrophage-like THP-1 cells.

# publications[].label
Exosomes released from Shiga toxin 2a-treated human macrophages modulate inflammatory responses and induce cell death in toxin receptor expressing human cells.

# publications[].label
Comparison of Shiga toxin-1 (Stx-1)-induced apoptosis mechanisms between monocytic and macrophage-like THP-1 cells

# publications[].label
Roles of Shiga Toxins in Immunopathology.

# publications[].label
Evaluation of the role of Shiga and Shiga-like toxins in mediating direct damage to human vascular endothelial cells.

# publications[].label
Prophylactic heparinization is ineffective in a primate model of hemolytic uremic syndrome.

# publications[].label
Characterization and Localization of Lipopolysaccharides Following the Ingestion of E. Coli by Murine Macrophages in Vitro

# publications[].label
Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses, Role in Pathogenesis and Therapeutic Applications.

# publications[].label
Differentiation-associated toxin receptor modulation, cytokine production, and sensitivity to Shiga-like toxins in human monocytes and monocytic cell lines.

# publications[].label
Procalcitonin in children with Escherichia coli O157:H7 associated hemolytic uremic syndrome.

# publications[].label
A baboon model of shiga-like toxin (SLT) mediated hemolytic uremic syndrome (HUS).

# publications[].label
Comparison of the relative toxicities of Shiga-like toxins type I and type II for mice.

# publications[].label
Response to single and divided doses of Shiga toxin-1 in a primate model of hemolytic uremic syndrome.

# publications[].label
Virulence of enterohemorrhagic Escherichia coli: role of molecular crosstalk.

# publications[].label
The interaction of Escherichia coli with normal human serum: the kinetics of serum-mediated lipopolysaccharide release and its dissociation from bacterial killing.

# publications[].publisher
The American Association of Immunologists

# publications[].label
Simultaneous induction of apoptotic and survival signaling pathways in macrophage-like THP-1 cells by Shiga toxin 1.

# publications[].label
Regulation of proinflammatory cytokine expression by Shiga toxin 1 and/or lipopolysaccharides in the human monocytic cell line THP-1.

# publications[].label
The pathogenic mechanisms of Shiga toxin and the Shiga-like toxins.

# publications[].label
Toxins: State of the Journal Report, 2017.

# publications[].label
Chemokine expression in the monocytic cell line THP-1 in response to purified shiga toxin 1 and/or lipopolysaccharides.

# publications[].label
Shiga toxin-induced tumor necrosis factor alpha expression: requirement for toxin enzymatic activity and monocyte protein kinase C and protein tyrosine kinases.

# publications[].label
Shiga toxins expressed by human pathogenic bacteria induce immune responses in host cells.

# publications[].label
Distinct physiologic and inflammatory responses elicited in baboons after challenge with Shiga toxin type 1 or 2 from enterohemorrhagic Escherichia coli.

# publications[].label
von Willebrand Factor expression in a Shiga toxin-mediated primate model of hemolytic uremic syndrome.

# publications[].label
Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis.

# publications[].label
Shiga Toxin 1 Induces Apoptosis in the Human Myelogenous Leukemia Cell Line THP-1 by a Caspase-8-Dependent, Tumor Necrosis Factor Receptor-Independent Mechanism

# publications[].label
Response to Shiga toxin-1, with and without lipopolysaccharide, in a primate model of hemolytic uremic syndrome.

# publications[].label
Editorial: Recent Advances in Understanding the Pathogenesis of Shiga Toxin-Producing Shigella and Escherichia coli.

# publications[].label
Lipopolysaccharide upregulates renal shiga toxin receptors in a primate model of hemolytic uremic syndrome.

# publications[].label
Activation of cell stress response pathways by Shiga toxins.

# publications[].label
Shiga Toxins Induce Apoptosis and ER Stress in Human Retinal Pigment Epithelial Cells.

# publications[].label
Purified Shiga-like toxins induce expression of proinflammatory cytokines from murine peritoneal macrophages.

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine