# positions[].organizations[].parent[].label
College of Education and Human Development

# overview
My research interests focus on the integrative physiology of bone, with specific reference to adaptations to disuse, microgravity, and caloric deficiency.

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Physical Injury - Accidents And Adverse Effects

# keywords[]
Receptors, Vascular Endothelial Growth Factor

# keywords[]
Receptor Activator Of Nuclear Factor-kappa B

# keywords[]
Nasa Program Space Physiology And Countermeasures

# educationAndTraining[].organization.label
The Ohio State University - (Columbus, Ohio, United States)

# educationAndTraining[].organization.label
Oberlin College - (Oberlin, Ohio, United States)

# educationAndTraining[].organization.label
University of Iowa - (Iowa City, Iowa, United States)

# publications[].label
Beta-adrenergic receptor agonist administration during hindlimb unloading attenuates losses in bone geometry, structure, and mechanical properties.

# publications[].label
Is peak bone mass achieved following recovery from reduced energy availability?

# publications[].label
Simulating the Lunar Environment: Partial Weightbearing and High-LET Radiation-Induce Bone Loss and Increase Sclerostin-Positive Osteocytes.

# publications[].label
Biglycan deficiency interferes with ovariectomy-induced bone loss.

# publications[].label
Non-weightbearing exercise may increase lumbar spine bone mineral density in healthy postmenopausal women.

# publications[].label
Towards human exploration of space: the THESEUS review series on muscle and bone research priorities.

# publications[].label
Osteocytes reflect a pro-inflammatory state following spinal cord injury in a rodent model.

# publications[].label
Increased training loads do not magnify cancellous bone gains with rodent jump resistance exercise.

# publications[].label
Short-Term Reduction in Energy Availability Does Not Impair Exercise-Induced Gains in Bone Formation Rate

# publications[].label
Effects of apomorphine and pimozide on temperature regulation during exercise in the rat.

# publications[].label
The mechanical phenotype of biglycan-deficient mice is bone- and gender-specific.

# publications[].label
Summary - Bone in microgravity environments: "Houston, we have a problem"

# publications[].label
CHARACTERIZING STRAINS IN THE TIBIA OF HINDLIMB UNLOADED RATS DURING COMBINED ISOMETRIC AND ECCENTRIC STIMULATED MUSCLE CONTRACTION

# publications[].label
Cancellous Bone Volume Is Restored By Intermittent PTH After Mechanical Unloading

# publications[].label
Bone loss during partial weight bearing (1/6th gravity) is mitigated by resistance and aerobic exercise in mice

# publications[].label
Beta-1 adrenergic agonist treatment mitigates negative changes in cancellous bone microarchitecture and inhibits osteocyte apoptosis during disuse.

# publications[].label
Clinical laboratory services in preventive, rehabilitative, and research-related exercise programs

# publications[].label
The effect of simulated 1/6th and 1/3rd gravity on gastrocnemius muscle mass and fractional protein synthesis rates in mice

# publications[].label
Absence of mechanical load results in an attenuation of marrow ablation-induced increase in cancellous bone formation rate.

# publications[].label
Modifications of bone atrophy seen with hindlimb suspension by exercise and dobutamine.

# publications[].label
Positive impact of low-dose, high-energy radiation on bone in partial- and/or full-weightbearing mice.

# publications[].label
Treadmill Exercise Provides Only Short-Term Protection Against Cancellous Bone Loss with Reduced Dietary Energy Intake: Endocrine Mechanisms

# publications[].label
Can Acute Galactic Cosmic Radiation-induced Bone Loss Be Mitigated By Dietary Modulation Of Inflammatory Cytokines?

# publications[].label
Decreases in bone blood flow and bone material properties in aging Fischer-344 rats.

# publications[].label
Developing an international database on long-term health effects of spaceflight

# publications[].label
The effect of resistance exercise on in vivo-derived tomography measures and mechanical properties of rodent bone: Is more load always better?

# publications[].label
EFFECTS OF DIET ALTERATIONS, WITH OR WITHOUT FECAL MICROBIAL TRANSPLANTS, ON BONE INTEGRITY

# publications[].label
A moderately elevated soy protein diet mitigates inflammatory changes in gut and in bone turnover during chronic TNBS-induced inflammatory bowel disease.

# publications[].label
PTH replaces cancellous bone lost during 28 days of hindlimb unloading in skeletally mature rats

# publications[].label
Effects of 1,25-(OH)2D3 and EB1089 on bone cells and bones of hindlimb unloaded adult male rats.

# publications[].label
Attenuation of disuse bone loss by estrogen and raloxifene in mature male rats.

# publications[].label
Differential responses of mechanosensitive osteocyte proteins in fore- and hindlimbs of hindlimb-unloaded rats.

# publications[].label
Biglycan deficiency interferes with ovariectomy-induced bone loss.

# publications[].label
Changes in musculoskeletal structure and function with prolonged bed rest.

# publications[].label
Beyond Sclerostin: Influence of Disuse and Recovery from Disuse on Mechanosensitive Osteocyte Proteins

# publications[].label
DSS-induced colitis produces inflammation-induced bone loss while irisin treatment mitigates the inflammatory state in both gut and bone.

# publications[].label
Site- and compartment-specific changes in bone with hindlimb unloading in mature adult rats.

# publications[].label
Beta-blockade mitigates bone loss with hindlimb unloading

# publications[].label
Previous exposure to simulated microgravity does not exacerbate bone loss during subsequent exposure in the proximal tibia of adult rats.

# publications[].label
MATURE RAT SKELETAL CHANGES IN RESPONSE TO SIMULATED MIRCROGRAVITY: A GENDER COMPARISON

# publications[].label
ANALYSIS OF IN VIVO STRAINS IN THE TIBIAL METAPHYSIS OF ADULT RATS DURING VOLUNTARY EXERCISING PROTOCOLS

# publications[].label
Differential skeletal responses of hindlimb unloaded rats on a vitamin D-deficient diet to 1,25-dihydroxyvitamin D3 and its analog, seocalcitol (EB1089).

# publications[].label
Changes in vasoactive factors associated with altered vessel morphology in the tibial metaphysis during ovariectomy-induced bone loss in rats.

# publications[].label
Effects of physical deconditioning after intense endurance training on left ventricular dimensions and stroke volume.

# publications[].label
Microgravity Stress: Bone and Connective Tissue.

# publications[].label
Effects of alfalfa based molt diets on cortical, cancellous and medullary bone qualities using pQCT

# publications[].label
Raloxifene attenuates bone loss in mechanically unloaded, ovariectomized female rats.

# publications[].label
Food restriction and simulated microgravity: effects on bone and serum leptin.

# publications[].label
Bone mass and endocrine adaptations to training in spinal cord injured individuals.

# publications[].label
Exogenous Irisin Treatment Ameliorates Inflammatory Changes in Osteocyte Proteins and Altered Bone Turnover in Chronic DSS-induced Inflammatory Bowel Disease

# publications[].label
Weightbearing In Simulated 1/6th and 1/3rd Gravity Does Not Prevent Cancellous Bone Loss

# publications[].label
Increased resistance during jump exercise does not enhance cortical bone formation.

# publications[].label
Cellular and molecular mechanisms for the bone response to mechanical loading

# publications[].label
Exposure to Low-Dose X-Ray Radiation Alters Bone Progenitor Cells and Bone Microarchitecture.

# publications[].label
Disuse bone loss in hindquarter suspended rats: partial weightbearing, exercise and ibandronate treatment as countermeasures.

# publications[].label
Exercise Can Reverse the Phenotype of Biglycan Deficient Mice

# publications[].label
Fat and Lean Mass Predict Bone Mass During Energy Restriction in Sedentary and Exercising Rodents.

# publications[].label
Cancellous bone formation response to simulated resistance training during disuse is blunted by concurrent alendronate treatment.

# publications[].label
LARC Implant Use Does Not Exacerbate Bone Loss Associated With Hindlimb Unloading

# publications[].label
Hindlimb unloading causes regional loading-dependent changes in osteocyte inflammatory cytokines that are modulated by exogenous irisin treatment.

# publications[].label
Impact Of Long-acting Reversible Contraceptives On Bone Density During Simulated Microgravity

# publications[].label
Restriction of dietary energy intake has a greater impact on bone integrity than does restriction of calcium in exercising female rats.

# publications[].label
Attentuation of disuse-induced bone loss by estrogen and vitamin D receptor ligands in unloaded and ambulatory female rats.

# publications[].label
Thresholds for bone loss with energy restriction change with exercise status

# publications[].label
Changes in gene expression by estrogen receptor Ligands in the femora of Hindlimb unloaded male rats.

# publications[].label
Moderate intensity resistive exercise improves metaphyseal cancellous bone recovery following an initial disuse period, but does not mitigate decrements during a subsequent disuse period in adult rats (vol 66, pg 296, 2014)

# publications[].label
Hindlimb unloading increases iNOS protein expression and NF-kappaB DNA binding activity in rat skeletal muscle

# publications[].label
Does altered blood flow to bone in microgravity impact on mechanotransduction?

# publications[].label
Elevated osteocyte TNF-, IL-6, and sclerostin in a rodent model of spinal cord injury correlates with altered bone turnover.

# publications[].label
Effects of Simulated Resistive Exercise on Cortical Bone in the Tibia Mid-Diapyhsis of Hindlimb Unloaded Rats

# publications[].label
Combined Effects of Lunar Gravity and Heavy Ion Exposure on Skeletal Muscle Anabolic Signaling

# publications[].label
Cancellous bone loss in adult rats following reduction in chow calcium and Vitamin D contents to NRC-recommended levels.

# publications[].label
Hindlimb unloading has a greater effect on cortical compared with cancellous bone in mature female rats.

# publications[].label
Blood lactate threshold in some well-trained ischemic heart disease patients.

# publications[].label
Short-term hindlimb unloading diminishes bone mineral density, area and blood flow in rats.

# publications[].label
Mechanical loading increases detection of estrogen receptor-alpha in osteocytes and osteoblasts despite chronic energy restriction.

# publications[].label
Contributions of physical activity to bone health over the lifespan

# publications[].label
Intermittent PTH Restores Cancellous BMD And Mechanical Properties During Recovery From Hindlimb Unloading

# publications[].label
Space Environmental Factor Impacts upon Murine Colon Microbiota and Mucosal Homeostasis.

# publications[].label
Molt performance and bone density of cortical, medullary, and cancellous bone in laying hens during feed restriction or alfalfa-based feed molt.

# publications[].label
Inflammatory Bowel Disease in a Rodent Model Alters Osteocyte Protein Levels Controlling Bone Turnover.

# publications[].label
Cellular and molecular responses to altered loading of bone

# publications[].label
Biomechanical aspects of the muscle-bone interaction.

# publications[].label
Biglycan-deficient mice have delayed osteogenesis after marrow ablation.

# publications[].label
-1 adrenergic agonist mitigates unloading-induced bone loss by maintaining formation.

# publications[].label
Rescuing the phenotype of biglycan-deficient mice via exercise.

# publications[].label
Effects of vigorous exercise training and beta-agonist administration on bone response to hindlimb suspension.

# publications[].label
Bone and muscle recovery after 28 days of hindlimb unloading in mature male rats.

# publications[].label
Combined effects of heavy ion exposure and simulated Lunar gravity on skeletal muscle.

# publications[].label
Does Osteocyte Sclerostin Response to Unloading and Exercise Vary across Bone Compartments?

# publications[].label
Estradiol effect on anterior crural muscles-tibial bone relationship and susceptibility to injury.

# publications[].label
Effects of exercise and lack of exercise on glucose tolerance and insulin sensitivity.

# publications[].label
Greater deficit of bone formation in the mature adult rat with 28-d hindlimb unloading

# publications[].label
Intermittent PTH during recovery replaces cancellous bone lost during hindlimb unloading by increasing bone formation rate

# publications[].label
Restricting dietary protein may improve skeletal integrity in exercising female rats

# publications[].label
Beta-blockade mitigates bone loss with hindlimb unloading

# publications[].label
Simulated resistance training during hindlimb unloading abolishes disuse bone loss and maintains muscle strength.

# publications[].label
Effects of detraining on responses to submaximal exercise.

# publications[].label
Time course of bone and muscle alterations after hindlimb suspension and 24-hour reambulation in mice.

# publications[].label
Skeletal muscle IGF-I overexpression alters bone development and prevents short-term hindlimb unloading bone loss in adult mouse tibia.

# publications[].label
Increase of both angiogenesis and bone mass in response to exercise depends on VEGF.

# publications[].label
Discordant recovery of bone mass and mechanical properties during prolonged recovery from disuse.

# publications[].label
Omega-3 fatty acid modulation of serum and osteocyte tumor necrosis factor- in adult mice exposed to ionizing radiation.

# publications[].label
Catecholamine response to exercise and training in individuals with spinal cord injury.

# publications[].label
American College of Sports Medicine Position Stand: physical activity and bone health.

# publications[].label
1,25(OH)(2)D-3 and EB1089 produce higher femoral cancellous bone density after 28-d hindlimb unloading while only 1,25(OH)(2)D-3 enhances material properties.

# publications[].label
Functional recovery of the plantarflexor muscle group after hindlimb unloading in the rat.

# publications[].label
Exercise during energy restriction mitigates bone loss but not alterations in estrogen status or metabolic hormones.

# publications[].label
Fat and Lean Mass Predict Total Body Bone Mineral Content during Energy Restriction with Exercise

# publications[].label
Characterizing strain in the tibia of rats exposed to hindlimb unloading with an exercise countermeasure

# publications[].label
Left ventricular response to graded isometric exercise in patients with coronary heart disease.

# publications[].label
Blocking -adrenergic signaling attenuates reductions in circulating leptin, cancellous bone mass, and marrow adiposity seen with dietary energy restriction.

# publications[].label
Simulated resistance training, but not alendronate, increases cortical bone formation and suppresses sclerostin during disuse.

# publications[].label
Effects of age, vitamin D3, and fructooligosaccharides on bone growth and skeletal integrity of broiler chicks.

# publications[].label
Moderate intensity resistive exercise improves metaphyseal cancellous bone recovery following an initial disuse period, but does not mitigate decrements during a subsequent disuse period in adult rats.

# publications[].label
Low dose X-ray but not silicon radiation exposure can exacerbate cancellous bone loss during partial weightbearing

# publications[].label
Effect of prolonged intense endurance training on systolic time intervals in patients with coronary artery disease.

# publications[].label
Short-term hind-limb unloading alters TGF-beta and cytokine gene expression in femur and humeri of rats

# publications[].label
EARLY ENZYME CHANGES IN MURINE TIBIAE AFTER HIGH-FORCE MUSCLE CONTRACTIONS

# publications[].label
Effects of Sex and Gender on Adaptation to Space: Musculoskeletal Health

# publications[].label
Cellular and molecular mechanisms for the bone response to mechanical loading.

# publications[].label
Oral Estradiol Impact on Mitigating Unloading-Induced Bone Loss in Ovary-Intact Rats.

# publications[].label
Partial or Complete Unloading of Skeletal Muscle Leads to Specific Alterations of Anabolic Signal Transduction

# publications[].label
Electrically stimulated eccentric muscle contraction benefits bone in the tibia of hindlimb unloaded rats at both the mid-diaphysis and proximal methaphysis

# publications[].label
Partial weight bearing does not prevent musculoskeletal losses associated with disuse.

# publications[].label
Alendronate Inhibits Bone Formation Response To Simulated Resistance Training During Disuse

# publications[].label
Local Adaptations of Osteocyte Proteins to Increased and Decreased Mechanical Forces Correlate with Osteoblast Levels

# publications[].label
Alterations in skeletal perfusion with simulated microgravity: a possible mechanism for bone remodeling.

# publications[].label
Effects of eccentric exercise training on cortical bone and muscle strength in the estrogen-deficient mouse.

# publications[].label
Comparison of serum leptin concentration under simulated microgravity condition or food restriction or combination of two.

# publications[].label
Effects of ethanol on gene expression in rat bone: transient dose-dependent changes in mRNA levels for matrix proteins, skeletal growth factors, and cytokines are followed by reductions in bone formation.

# publications[].label
Simulated resistive exercise benefits bone in hindlimb unloaded rats.

# publications[].label
Energy Restriction Effects on Cancellous Bone Microarchitecture: Impact of Endurance Exercise

# publications[].label
Concepts and methods for understanding bone metabolism in laying hens

# publications[].label
Clinical laboratory services in preventive, rehabilitative, and research-related exercise programs

# publications[].label
An overview of the issues: physiological effects of bed rest and restricted physical activity.

# publications[].label
High dietary iron and 137Cs radiation exposure induce oxidative stress and reduce bone mass

# publications[].label
BONE RESPONSE TO EXERCISE DURING RECOVERY BETWEEN UNLOADING BOUTS IN ADULT MALE RATS

# publications[].label
Differential bone and muscle recovery following hindlimb unloading in skeletally mature male rats.

# publications[].label
Effects of downhill running on the responses to an oral glucose challenge.

# publications[].label
Beta-Adrenergic Receptor Agonist Administration During Hindlimb Unloading Effectively Mitigates Reductions in Cancellous Bone Formation

# publications[].label
Beta-adrenergic blockade and leptin replacement effectively mitigate disuse bone loss.

# publications[].label
Inflammation-induced lymphatic architecture and bone turnover changes are ameliorated by irisin treatment in chronic inflammatory bowel disease.

# publications[].label
A rodent model of human dose-equivalent progestin-only implantable contraception.

# publications[].label
Alterations in the mechanical properties of bone due to Type II diabetes.

# publications[].label
Exercise-induced changes in the cortical bone of growing mice are bone- and gender-specific.

# publications[].label
Mechanical loading attenuates bone loss due to immobilization and calcium deficiency.

# publications[].label
Novel Findings in Bone Biology: Impact on Bone Health for Women

# publications[].label
Biglycan deficient mice have delayed bone formation after bone marrow ablation.

# publications[].label
Altered bone mass, geometry and mechanical properties during the development and progression of type 2 diabetes in the Zucker diabetic fatty rat.

# researcherOn[].label
Retired Astronauts Medical Data Repository (RADAR): a Feasibility Project

# researcherOn[].awardedBy.label
National Aeronautics and Space Administration - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Mitigating Radiation Induced Bone Loss via Dietary Modulation of Inflammatory Cytokines

# researcherOn[].awardedBy.label
Johnson Space Center - (Houston, Texas, United States)

# researcherOn[].label
Inflamm-aging and bone loss in a rodent model of spinal cord injury

# researcherOn[].awardedBy.label
Craig H Neilsen Foundation - (Los Angeles, California, United States)

# researcherOn[].label
Sclerostin's role in regulating bone formation during long-term simulated microgravity and subsequent recovery-

# researcherOn[].awardedBy.label
Johnson Space Center - (Houston, Texas, United States)

# researcherOn[].label
Iron Overload and Oxidative Damage: Regulators of Bone Homeostasis in the Space Environment

# researcherOn[].awardedBy.label
Ames Research Center - (Mountain View, California, United States)

# researcherOn[].label
Pre-Treatment Approaches for Improving the Response of Bone to Disuse and Recovery -

# researcherOn[].awardedBy.label
National Aeronautics and Space Administration - (Washington D.C., District of Columbia, United States)

# streetAddress
Texas A&M University; Health And Kinesiology; 1113 TAMU

# organizations[]
College of Education and Human Development

# schools[]
College of Education and Human Development

# etdChairOf[].label
Swift, Sibyl Nichole (2011-10). Energy Restriction Effects on Estrogen Status and the Skeletal Response to Loading. Doctoral Dissertation.

# etdChairOf[].label
Baek, Kyunghwa (2009-05). Bone loss during energy restriction: mechanistic role of leptin. Doctoral Dissertation.

# etdChairOf[].label
Jeffery, Jay Melvin (2009-05). Quantifying the strain response in the rat tibia during simulated resistance training used as a disuse countermeasure. Master's Thesis.

# etdChairOf[].label
Marich, Alexandra Marie (2018-05). CONTINUOUS, LOW DOSE IRRADIATION RESULTS IN NO DETRIMENT TO BONE AFTER 4, 12, AND 28 DAYS. Master's Thesis.