# overview
We use novel strategies Exploring Key Orientations (EKO) that feature datamining to compare simulated preferred conformers of chemotypes we design with key features at protein-protein interfaces. Many chemotype candidates can be screened against one PPI, or one chemotype can be screened against all the PPI interfaces in the PDB. Virtual hit chemotypes are prepared in my lab, then tested against protein-protein interactions of biomedicinal interest using an array of biophysical and cellular assays.

We also design small molecules to target cell surface receptors that are selectively overexpressed in cancer cells. Much or our work has been focused on the TrkC receptor that is particularly important to metastatic breast cancer and melanoma. Going forwards we are interested in expanding the targets to include cell surface receptors that are overexpressed when cancer cells undergo aberrant epithelial to mesenchymal transitions (EMT) to produce circulating tumor cells and cancer stem cells. Much of this work involves design and synthesis of the small molecules for this targeting.

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
0306 Physical Chemistry (incl. Structural)

# keywords[]
4009 Electronics, Sensors And Digital Hardware

# keywords[]
5102 Atomic, Molecular And Optical Physics

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
Kinetic Amplification Of Diastereomeric Excess

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
3407 Theoretical And Computational Chemistry

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
0306 Physical Chemistry (incl. Structural)

# keywords[]
3403 Macromolecular And Materials Chemistry

# keywords[]
0303 Macromolecular And Materials Chemistry

# keywords[]
Platelet Endothelial Cell Adhesion Molecule-1

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# educationAndTraining[].organization.label
University of Cambridge - (Cambridge, United Kingdom)

# awardsAndHonors[].label
Association of Former Students University-Level Distinguished Achievement Award, The

# publications[].label
Anthranilic acid-containing cyclic tetrapeptides: at the crossroads of conformational rigidity and synthetic accessibility.

# publications[].label
Protein labelling and albumin binding characteristics of the near-IR Cy7 fluorophore, QuatCy.

# publications[].label
CORRELATIONS OF ANTI-OPIATE PEPTIDOMIMETIC SOLUTION STRUCTURES WITH THEIR PHARMACOLOGICAL ACTIVITIES

# publications[].label
ORGN 477-Water-soluble benzophenoxazine dyes and its application in syntheses of through bond energy transfer cassettes

# publications[].label
Anthracene-BODIPY cassettes: syntheses and energy transfer.

# publications[].label
A rigid linker-scaffold for solid-phase synthesis of dimeric pharmacophores.

# publications[].label
Recent progress in solid phase synthesis using SNAr reactions.

# publications[].label
Syntheses, photophysical properties, and application of through-bond energy-transfer cassettes for biotechnology.

# publications[].label
alpha-Oligopyrrolidones: The "missing piece" in peptide mimicry

# publications[].label
ASYMMETRIC SYNTHESES OF PROTECTED DERIVATIVES OF ORNITHINE- -METHANOLOGS AND ARGININE-2,3-METHANOLOGS

# publications[].label
PREPARATION OF A DEOXYNOJIRIMYCIN ANALOG CONTAINING AN IMIDAZOLE RING

# publications[].publisher
The Japan Institute of Heterocyclic Chemistry

# publications[].label
Solid phase syntheses of monovalent and bivalent peptidomimetics of the neurotrophins

# publications[].label
KINETIC RESOLUTIONS OF CHIRAL UNSATURATED ALCOHOLS THAT CANNOT BE RESOLVED EFFICIENTLY VIA ENANTIOSELECTIVE EPOXIDATION

# publications[].label
Methodology for syntheses of ureas libraries

# publications[].label
Syntheses and incorporation of PNA-analog triphosphates by DNA polymerases: A possible new set of chain terminators

# publications[].label
A NEW APPROACH TO SWAINSONINE AND CASTANOSPERMINE ANALOGS

# publications[].label
Design criteria for minimalist mimics of protein-protein interface segments.

# publications[].label
Design and optimization of new phosphine oxazoline ligands via high-throughput catalyst screening

# publications[].label
STEREOSELECTIVE SYNTHESES OF GAMMA-HYDROXY-ALPHA,BETA-UNSATURATED ESTERS - AN ASYMMETRIC VERSION OF THE SPAC REACTION

# publications[].label
Correlations of structure and rates of energy transfer for through-bond energy-transfer cassettes.

# publications[].label
A SELECTION OF RECENT TOPICS FROM CHEMICAL LITERATURE

# publications[].label
Nicotine abstinence syndrome precipitated by an analog of neuropeptide FF.

# publications[].label
A blue-to-red energy-transfer thymidine analogue that functions in DNA.

# publications[].label
New and efficient synthesis of an amino acid for preparing phosphine-functionalized peptidomimetics

# publications[].label
TrkC-Targeted Kinase Inhibitors And PROTACs.

# publications[].label
Asymmetric hydrogenation routes to deoxypolyketide chirons.

# publications[].label
Enhanced antiopiate activity in peptidomimetics of FMRFamide containing Z-2,3-methanomethionine.

# publications[].label
Chiral 1,3-cyclobutane amino acids: Syntheses and extended conformations

# publications[].label
Energy transfer cassettes in silica nanoparticles target intracellular organelles.

# publications[].label
A labeled guanidine ligand for studying sweet taste.

# publications[].label
Conjugation of Dasatinib with MHI-148 Has a Significant Advantageous Effect in Viability Assays for Glioblastoma Cells.

# publications[].label
Chiral imidazolylidine ligands for asymmetric catalysis

# publications[].label
ON TITANIUM-PROMOTED HYDROBORATIONS OF ALKENES BY BOROHYDRIDE AND BY CATECHOLBORANE

# publications[].label
Selective, Intrinsically Fluorescent Trk Modulating Probes.

# publications[].label
ORGN 288-Photoinduced forward and backward electron transfer in donor-acceptor dyads

# publications[].label
Cyanine-Gemcitabine Conjugates as Targeted Theranostic Agents for Glioblastoma Tumor Cells.

# publications[].label
Syntheses of nucleosides designed for combinatorial DNA sequencing

# publications[].label
ORGN 445-Cellular import of proteins bearing pH probes

# publications[].label
ON CATALYZED AND UNCATALYZED HYDROBORATIONS OF CHIRAL ALLYLIC ALCOHOLS AND AMINES

# publications[].label
Synthesis of a photocleavable peptide analog

# publications[].label
A modular approach to trans-chelating, N-heterocyclic carbene ligand complexes

# publications[].label
ASYMMETRIC SYNTHESES OF THE STEREOISOMERS OF PROTECTED 2,3-METHANOGLUTAMINE

# publications[].label
Oxidative induction of beta-turn conformations in cyclic peptidomimetics: conformational analyses as indicators of configuration.

# publications[].label
Synthesis of vicinal dimethyl chirons by asymmetric hydrogenation of trisubstituted alkenes.

# publications[].label
REACTION OF THE UNSATURATED MIXED METAL CLUSTER [OS3(MU-H)(CO)10-(MU-AUPR3)] (R=PH, ET) WITH CARBON-MONOXIDE AND THE CHEMISTRY OF THE PRODUCTS - THE X-RAY CRYSTAL-STRUCTURE OF [OS3(CO)10(MU-AUPET3)2]

# publications[].label
A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist.

# publications[].label
Non-covalent delivery of proteins into mammalian cells.

# publications[].label
SUBSTRATE-CONTROLLED DIASTEREOSELECTIVITIES IN CATALYZED AND UNCATALYZED HYDROBORATIONS OF ACYCLIC ALLYLIC ALCOHOL DERIVATIVES - SECONDARY ORBITAL EFFECTS INVOLVING D-PI-P-PI INTERACTIONS

# publications[].label
Solid phase syntheses of Turn structures.

# publications[].label
ORGN 561-A dixanthene-BODIPY cassette as a water-soluble ratiometric fluorescent pH probe

# publications[].label
Near-infrared zwitterionic dye to target TrkC expressing cancer cells

# publications[].label
A diversity oriented synthesis of 3'-O-modified nucleoside triphosphates for DNA 'sequencing by synthesis'.

# publications[].label
Piptide Chemotypes for Perturbation of the Interaction of Urokinase with Its Receptor.

# publications[].label
Solid-phase SNAr macrocyclizations to give turn- extended-turn peptidomimetics

# publications[].label
Asymmetric synthesis of 3-phenyl-2,3-methanophenylalanine developed by panning catalysts in a library format

# publications[].label
On the stability of furanopyrimidin-2-one bases in oligonucleotides.

# publications[].label
Small Molecule Ligands For Active Targeting Of TrkC-expressing Tumor Cells.

# publications[].label
In vivo studies of nanostructure-based photosensitizers for photodynamic cancer therapy.

# publications[].label
An allylic/acyclic adenosine nucleoside triphosphate for termination of DNA synthesis by DNA template-dependent polymerases.

# publications[].label
Manganese-catalyzed epoxidations of alkenes in bicarbonate solutions.

# publications[].label
Preparation of Nano-ZrO2 powder via a microwave-assisted hydrothermal method

# publications[].label
Fluorescent kinase inhibitors as probes in cancer.

# publications[].label
Bicyclic Schellman Loop Mimics (BSMs): Rigid Synthetic C-Caps for Enforcing Peptide Helicity.

# publications[].label
Piptides: New, Easily Accessible Chemotypes For Interactions With Biomolecules.

# publications[].label
SYNTHESIS AND BIOLOGICAL-ACTIVITY OF F1327, A HIGHLY EFFICACIOUS NONESTER PYRETHROID INSECTICIDE AND ACARICIDE

# publications[].label
Test of the potential of a dATP surrogate for sequencing via MALDI-MS.

# publications[].label
Conformations of peptidomimetics formed by SNAr macrocyclizations: 13-to 16-membered ring systems

# publications[].label
Oxidative induction of B-TURN conformations in cyclic peptidomimetics.

# publications[].label
Syntheses of regioisomerically pure 5- or 6-halogenated fluoresceins.

# publications[].label
Highly efficient and photostable photonic materials from diiodinated BODIPY laser dyes

# publications[].label
Designing small molecules that mimic protein-protein-interface regions: Should we be searching for a big fish or Moby Dick?

# publications[].label
ENANTIOSELECTIVE ESTERIFICATIONS OF UNSATURATED ALCOHOLS MEDIATED BY A LIPASE PREPARED FROM PSEUDOMONAS SP

# publications[].label
A SIDE-CHAIN CONSTRAINED, CYCLIC, RGD DIMERS - ANALOGS OF CYCLO-[RGDRGD]

# publications[].label
A small library of peptidomimetics to systematically vary and test the effects of X(1) constraints

# publications[].label
Iridium-mediated asymmetric hydrogenation of 2,3-diphenylbutadiene: a revealing kinetic study.

# publications[].label
Synthesis and spectroscopic properties of 2-ketopyrrole-BF2 complexes: a new class of fluorescent dye

# publications[].label
Dimeric beta-turn peptidomimetics as ligands for the neurotrophin receptor TrkC.

# publications[].label
A peptidomimetic of NT-3 acts as a TrkC antagonist.

# publications[].label
Lipid diffusion from single molecules of a labeled protein undergoing dynamic association with giant unilamellar vesicles and supported bilayers.

# publications[].label
Metathesis for catalyst design: metacatalysis

# publications[].label
Correction to A Near-IR Fluorescent Dasatinib Derivative That Localizes in Cancer Cells.

# publications[].label
Fluors for tumour-initiating cells in lung cancer

# publications[].label
Bivalent peptidomimetic ligands of TrkC are biased agonists and selectively induce neuritogenesis or potentiate neurotrophin-3 trophic signals.

# publications[].label
A fluorescent electrophile for CLIPS: self indicating TrkB binders.

# publications[].label
Through-space C-13-F-19 coupling can reveal conformations of modified BODIPY dyes

# publications[].label
Water-soluble through-bond energy transfer cassettes for intracellular imaging.

# publications[].label
Syntheses and spectroscopic properties of energy transfer systems based on squaraines

# publications[].label
Enantioselective hydrogenation of aryl-substituted alkenes and dienes.

# publications[].label
Enhanced antiopiate activity and enzyme resistance in a peptidomimetic of FMRFamide containing E-2,3-methanomethionine and E-2,3-methanophenylalanine.

# publications[].label
Syntheses and properties of water-soluble Nile Red derivatives.

# publications[].label
ON HYDROBORATIONS OF ALKENES CATALYZED BY TITANIUM COMPLEXES

# publications[].label
Iridium-catalyzed asymmetric hydrogenation of vinyl ethers

# publications[].label
Small molecule and protein-based neurotrophic ligands: agonists and antagonists as therapeutic agents

# publications[].label
Near-infrared aza-BODIPY fluorescent probe for selective Cu2+ detection and its potential in living cell imaging.

# publications[].label
ON DEUTERIUM-LABELING STUDIES FOR PROBING RHODIUM-CATALYZED HYDROBORATION REACTIONS

# publications[].label
Fluorescent tags designed for through-bond energy transfer.

# publications[].label
COMPARISON OF THE EFFECTS OF (2S,3S)-2,3-METHANOMETHIONINE, (2R,3R)-2,3-METHANOMETHIONINE, AND (2R,3R)-2,3-METHANOPHENYLALANINE ON THE CONFORMATIONS OF SMALL PEPTIDES

# publications[].label
ORGN 395-Photoinduced electron transfer in through-bond energy transfer cassettes

# publications[].label
STEREOCHEMICAL ASSIGNMENTS VIA CYCLIC-DERIVATIVES - A CAUTIONARY NOTE

# publications[].label
Side-chain variations on a fixed cyclic peptide scaffold

# publications[].label
Fluorescent photolabile protecting groups for DNA sequencing

# publications[].label
Synthesis and spectroscopic properties of rosamines with cyclic amine substituents.

# publications[].label
Optimized Heptamethine Cyanines for Photodynamic Therapy.

# publications[].label
How helical are minimalist helical mimics?

# publications[].label
SYNTHETIC APPROACHES TO STEREOISOMERS AND ANALOGS OF CASTANOSPERMINE

# publications[].label
DiSSiMiL: Diverse Small Size Mini-Libraries applied to simple and rapid epitope mapping of a monoclonal antibody.

# publications[].publisher
International Union of Crystallography (IUCr)

# publications[].label
ON HYDROBORATIONS OF ALKENES CATALYZED BY TITANIUM COMPLEXES

# publications[].label
Optically active iridium imidazol-2-ylidene-oxazoline complexes: preparation and use in asymmetric hydrogenation of arylalkenes.

# publications[].label
Photophysics and stability of cyano-substituted boradiazaindacene dyes.

# publications[].label
2R,3R-METHANOMETHIONINE CAN INDUCE AN INVERSE GAMMA-TURN AND REINFORCE A NATURAL TENDENCY TO FORM AN ASX TURN

# publications[].label
A new synthesis of symmetric boraindacene (BODIPY) dyes.

# publications[].label
Through bond energy transfer in fluorescent dyes for labelling biological molecules

# publications[].label
Small library synthesis and conformational analysis of cyclic peptidomimetics of beta turns of NGF.

# publications[].label
PROTAC Compatibilities, Degrading Cell-Surface Receptors, and the Sticky Problem of Finding a Molecular Glue.

# publications[].label
In glaucoma the upregulated truncated TrkC.T1 receptor isoform in glia causes increased TNF-alpha production, leading to retinal ganglion cell death.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Synthesis of fluorescent, photolabile 3'-O-protected nucleoside triphosphates for the base addition sequencing scheme.

# publications[].label
Divergent ligand syntheses and high-throughput screening of transition-metal catalysts.

# publications[].label
Stereochemical implications on diversity in beta-turn peptidomimetic libraries

# publications[].label
Spectral dispersion and water solubilization of BODIPY dyes via palladium-catalyzed C-H functionalization.

# publications[].label
TITANIUM-MEDIATED ADDITIONS OF BOROHYDRIDE TO ALKENES

# publications[].label
Rigid, conjugated, fluoresceinated thymidine triphosphates: syntheses and polymerase mediated incorporation into DNA analogues.

# publications[].label
Ring closure to beta-turn mimics via copper-catalyzed azide/alkyne cycloadditions.

# publications[].label
Double-targeting using a TrkC ligand conjugated to dipyrrometheneboron difluoride (BODIPY) based photodynamic therapy (PDT) agent.

# publications[].label
THE SYNTHESIS OF CONDENSED QUINOLIZINIUM SYSTEMS

# publications[].label
The concept of background equivalent concentration in spectrochemistry

# publications[].label
Synthesis of Regioisomerically Pure 5-Functionalized 2 ',7 '-Dichlorofluoresceins

# publications[].label
QuatCy-I2 and MHI-I2 in Photodynamic Therapy.

# publications[].label
Libraries of opiate and anti-opiate peptidomimetics containing 2,3-methanoleucine.

# publications[].label
Syntheses and conformational properties of 3,4 methanophenylalanine.

# publications[].label
FURTHER EVIDENCE FOR THE ROLE OF D-PI-P-PI BONDING IN RHODIUM-MEDIATED HYDROBORATIONS

# publications[].label
Hydrogenation of 2,3-diphenylbutadiene: A revealing kinetic study

# publications[].label
Pyrrole-based scaffolds for turn mimics.

# publications[].label
A Linker Scaffold to Present Dimers of Pharmacophores Prepared by Solid-Phase Syntheses.

# publications[].label
Facile macrocyclizations to beta-turn mimics with diverse structural, physical, and conformational properties.

# publications[].label
2,3-methanoamino acid analogs of Arg stabilize secondary structures of a 13 amino acid peptide in aqueous solution

# publications[].label
SYNTHESIS OF A PEPTIDOMIMETIC LIBRARY CONTAINING 4 2,3-METHANOLEUCINE STEREOISOMERS TO TEST SIDE-CHAIN CONSTRAINTS

# publications[].label
A combinatorial method for solution-phase synthesis of labeled bivalent beta-turn mimics.

# publications[].label
Monovalent and divalent beta-turn mimics.

# publications[].label
Striking Similarities between CDRs in Some mAbs That Neutralize COVID-19.

# publications[].label
Microwave-assisted synthesis and elaboration of fluorescein and rhodamine derivatives

# publications[].label
Catalytic homogeneous asymmetric hydrogenations of largely unfunctionalized alkenes.

# publications[].label
Small molecule peptidomimetic to perturb protein-protein interactions targeting NEDD8-NAE

# publications[].label
Bioinformatics leading to conveniently accessible, helix enforcing, bicyclic ASX motif mimics (BAMMs).

# publications[].label
A combinatorial approach for targeted delivery using small molecules and reversible masking to bypass nonspecific uptake in vivo.

# publications[].label
In Experimental Glaucoma Using Agonists or Antagonists of TrkA, TrkB, or TrkC Reveal Neuro-Glial Mechanisms of Action and Novel Approaches to Neuroprotection

# publications[].label
Iridium catalyzed enantioselective hydrogenation of alpha-alkoxy and beta-alkoxy vinyl ethers

# publications[].label
Synthesis of nonnatural amino acids from alpha-pinene

# publications[].label
Levels of PD-L1 expression elevated by CDK4/6 inhibitors

# publications[].label
A REAGENT FOR DETERMINING OPTICAL PURITIES OF DIOLS BY FORMATION OF DIASTEREOMERIC ARYLBORONATE ESTERS

# publications[].label
A designed peptidomimetic agonistic ligand of TrkA nerve growth factor receptors.

# publications[].label
How relevant is secondary structure mimicry in design of small molecules to disrupt protein-protein interfaces?

# publications[].label
Solid phase synthesis of peptide analogs via snap cyclization.

# publications[].label
Fluorescent through-bond energy transfer cassettes based on xanthine and pyronin derivatives

# publications[].label
Design and syntheses of b-turn peptidomimetics of neurotrophins

# publications[].label
SYNTHESES AND PROPERTIES OF PHOTOLABILE, 3'-PROTECTED NUCLEOSIDES FOR DNA-SEQUENCING WITHOUT GEL-ELECTROPHORESIS

# publications[].label
New catalysts and conditions for a C-H insertion reaction identified by high throughput catalyst screening

# publications[].label
Testing the limits of the one compound per well concept in library screening

# publications[].label
Heterovalent selectivity and the combinatorial advantage.

# publications[].label
Synthesis and properties of long-wavelength BF2-dipyrromethene fluorescent dyes.

# publications[].label
Syntheses and activities of new C10 beta-turn peptidomimetics.

# publications[].label
Small molecules targeting the NEDD8NAE protein-protein interaction.

# publications[].label
Resin type can have important effects on solid phase asymmetric alkylation reactions

# publications[].label
Base dependence in copper-catalyzed Huisgen reactions: efficient formation of bistriazoles.

# publications[].label
BODIPY (R) Dyes and Their Derivatives: Syntheses and Spectroscopic Properties

# publications[].label
A cheap, catalytic, scalable, and environmentally benign method for alkene epoxidations.

# publications[].label
SYNTHESIS OF AN OXYAMIDE LINKED NUCLEOTIDE DIMER AND INCORPORATION INTO ANTISENSE OLIGONUCLEOTIDE SEQUENCES

# publications[].label
The conformational bias of F((2R,3S)-cyclo-M)RFa induced by the cis-2,3-methanomethionine residue

# publications[].label
ORGN 393-Synthesis of highly fluorescent GFP-chromophore analogs

# publications[].label
Omegatides: constrained analogs of peptide primary sequence.

# publications[].label
MALDI and FAB mass spectrometry of nucleoside triphosphates: A comparative study

# publications[].label
Homo-Roche ester derivatives by asymmetric hydrogenation and organocatalysis.

# publications[].label
STEREOCONTROL IN CATALYZED AND UNCATALYZED HYDROBORATIONS

# publications[].label
Fluorescent cassettes for monitoring three-component interactions in vitro and in living cells.

# publications[].label
Discovery and optimization of catalysts through parallel screening methods.

# publications[].label
Near-infrared aza-BODIPY fluorescence probes for selective Cu2+detection and their potential in living cell imaging

# publications[].label
Design of novel fluorescence energy transfer cassettes utilizing a nucleobase as part of the donor.

# publications[].label
Targeted Maytansinoid Conjugate Improves Therapeutic Index for Metastatic Breast Cancer Cells.

# publications[].label
Small molecule ligands for active targeting of TrkC-expressing tumor cells

# publications[].label
ADDITION CYCLIZATION CATALYZED BY PALLADIUM(II)

# publications[].label
SUBSTRATE-CONTROLLED DIASTEREOSELECTIVITY IN CATALYZED AND UNCATALYZED HYDROBORATIONS OF ALLYLIC AMINE DERIVATIVES

# publications[].label
Bivalent diketopiperazine-based tropomysin receptor kinase C (TrkC) antagonists.

# publications[].label
STEREOCONTROL IN CATALYZED AND UNCATALYZED HYDROBORATIONS

# publications[].label
Chemiluminescent energy-transfer cassettes based on fluorescein and nile red.

# publications[].label
An iterative route to "decorated" ethylene glycol-based linkers.

# publications[].label
Rosamines targeting the cancer oxidative phosphorylation pathway.

# publications[].label
ASYMMETRIC SYNTHESES OF PROTECTED DERIVATIVES OF CARNOSADINE AND ITS STEREOISOMERS AS CONFORMATIONALLY CONSTRAINED SURROGATES FOR ARGININE

# publications[].label
Conformational preferences of RNase a C-peptide derivatives containing a highly constrained analogue of phenylalanine

# publications[].label
PRACTICAL ASYMMETRIC SYNTHESES OF ALL 4 2,3-METHANOLEUCINE STEREOISOMERS

# publications[].label
Interplay Of Stereochemistry, Conformational Rigidity, And Ease Of Synthesis For 13-Membered Cyclic Peptidomimetics Containing APC Residues.

# publications[].label
Resin effects in solid phase S(n)Ar and S(n)2 macrocyclizations.

# publications[].label
Photochemistry of Os-3(CO)12 with AuPPh3Cl: synthesis and structural characterisation of (mu-AuPPh3)(mu-Cl)Os-3(CO)(10)

# publications[].label
Comparison Of Asymmetric Hydrogenations Of Unsaturated- Carboxylic Acids And -Esters.

# publications[].label
HOMOCHIRAL SULFOXIDES AND THE SPAC REACTION

# publications[].label
An approach to photolabile, fluorescent protecting groups

# publications[].label
High throughput screening of C3 symmetric phosphines for asymmetric catalysis.

# publications[].label
HYDROBORATION REACTIONS MEDIATED BY BIS(MESITYL)NIOBIUM - BEWARE OF THE TROJAN HORSE

# publications[].label
DIASTEREOCONTROL IN RHODIUM-CATALYZED HYDROBORATION OF CHIRAL ACYCLIC ALLYLIC ALCOHOL DERIVATIVES

# publications[].label
Solid phase syntheses of peptidomimetics

# publications[].label
Energy transfer cassettes based on BODIPY (R) dyes

# publications[].label
N-heterocyclic carbene catalysts for hydrogenation of dienes and alkenes.

# publications[].label
Mechanistic insights into iridium-catalyzed asymmetric hydrogenation of dienes.

# publications[].label
Productive Manipulation of Cyanine Dye -Networks.

# publications[].label
beta-Turn peptidomimetics incorporating i+1-i+3 residues: solid phase syntheses and conformational properties

# publications[].label
New, optically active phosphine oxazoline (JM-Phos) ligands: syntheses and applications in allylation reactions.

# publications[].label
STEREOCHEMICALLY MATCHED (AND MISMATCHED) BISPHOSPHINE LIGANDS - DIOP-DIPAMP HYBRIDS

# publications[].label
CONJUGATE NUCLEOPHILIC RING-OPENING OF ACTIVATED VINYLCYCLOPROPANES FACILITATED BY HOMOGENOUS PALLADIUM CATALYSIS

# publications[].label
Aldol-type chirons from asymmetric hydrogenations of trisubstituted alkenes.

# publications[].label
PYRIDINIUMS AS POTENTIAL SYNTHETIC SUBSTITUTES FOR NITROGEN MUSTARDS

# publications[].label
Small Molecule Probes That Perturb A Protein-protein Interface In Antithrombin.

# publications[].label
ORGN 222-Design and syntheses of some new beta-turn peptidomimetics of neurotrophins

# publications[].label
Intracellular imaging of organelles with new water-soluble benzophenoxazine dyes.

# publications[].label
Asymmetric syntheses of -methyl -amino acid derivatives.

# publications[].label
New optically active N-heterocyclic carbene complexes for hydrogenation: A tale with an atropisomeric twist

# publications[].label
Deprotection of BOC group on Rink amide resin with tmsotf and lutidine.

# publications[].label
Encapsulated energy-transfer cassettes with extremely well resolved fluorescent outputs.

# publications[].label
A chemoselective route to -enamino esters and thioesters.

# publications[].label
Synthesis and spectroscopic properties of a new 4-bora-3a,4a-diaza-s-indacene (BODIPY (R)) dye

# publications[].label
Asymmetric hydrogenation approaches to valuable, acyclic 1,3-hydroxymethyl chirons.

# publications[].label
Small molecule peptidomimetic trypsin inhibitors: validation of an EKO binding mode, but with a twist.

# publications[].label
Comparisons of the conformational biases imposed by trans-2,3-methanomethionine and alpha-methylmethionine.

# publications[].label
Organelle-selective energy transfer: a fluorescent indicator of intracellular environment.

# publications[].label
STEREOCONTROL IN CATALYZED AND UNCATALYZED HYDROBORATIONS

# publications[].label
A zwitterionic near-infrared dye linked TrkC targeting agent for imaging metastatic breast cancer.

# publications[].label
Oligonucleotides with strongly fluorescent groups pi-conjugated to a nucleobase: syntheses, melting temperatures, and conformation.

# publications[].label
Fluorinated and iodinated templates for syntheses of beta-turn peptidomimetics

# publications[].label
Small Molecule Inhibitors of the PCSK9LDLR Interaction.

# publications[].label
Cationic polyfluorenes for intracellular delivery of proteins.

# publications[].label
Water-soluble Nile Blue derivatives: syntheses and photophysical properties.

# publications[].label
Cheap, catalytic, scalable, and environmentally benign method for alkene epoxidation.

# publications[].label
Exploring key orientations at protein-protein interfaces with small molecule probes.

# publications[].label
THE SYNTHESIS AND CHARACTERIZATION OF NEW TRIOSMIUM AND TRIRUTHENIUM MAIN-GROUP METAL-CLUSTERS M3(H)(CO)11(M'R3) AND OS3(H)(CO)10(CH3CN)(M'R3) (M = OS, RU - M' = GE, SN - R= ARYL, ALKYL)

# publications[].label
Solid-phase syntheses of beta-turn analogues to mimic or disrupt protein-protein interactions.

# publications[].label
FURTHER EVIDENCE FOR THE ROLE OF D-PI-P-PI-BONDING IN DIASTEREOSELECTIVE RHODIUM-MEDIATED HYDROBORATIONS

# publications[].label
Metal-catalyzed epoxidations of alkenes with hydrogen peroxide.

# publications[].label
Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors.

# publications[].label
CD investigations of rnase a C-peptide analogs-2,3 methanoamino acids as stabilizers of secondary structural elements.

# publications[].label
SYNTHESIS AND REACTIVITY OF TRIOSMIUM CLUSTERS CONTAINING A 2-SUBSTITUTED PYRIDINE MOIETY

# publications[].label
New cytotoxic rosamine derivatives selectively accumulate in the mitochondria of cancer cells.

# publications[].label
ASYMMETRIC SYNTHESES OF 2,3-METHANOAMINO ACIDS

# publications[].label
SOLID-PHASE SYNTHESES OF UNNATURAL BIOPOLYMERS CONTAINING REPEATING UREA UNITS

# publications[].label
A NEW APPROACH TO SWAINSONINE AND CASTANOSPERMINE ANALOGS

# publications[].label
Evaluating minimalist mimics by exploring key orientations on secondary structures (EKOS).

# publications[].label
Correlations between secondary structure- and protein-protein interface-mimicry: the interface mimicry hypothesis.

# publications[].label
In vitro and in vivo photocytotoxicity of boron dipyrromethene derivatives for photodynamic therapy.

# publications[].label
METALATION OF 2-ETHENYLPYRIDINE AT TRIOSMIUM CLUSTERS - X-RAY CRYSTAL-STRUCTURES OF THE OPEN TRINUCLEAR CLUSTERS [OS3H(CO)9CO(NC5H4CH=CH)], [OS3H(CO)9PME2PH(NC5H4CH=CH)]

# publications[].label
Acyclic nucleoside triphosphate analogs as terminators in biocatalytic DNA replication

# publications[].label
BODIPY dyes and their derivatives: syntheses and spectroscopic properties.

# publications[].label
A new solid-phase linker for Suzuki coupling with concomitant macrocyclization: synthesis of beta-turn mimics

# publications[].label
Highly Stereoselective Syntheses of All 1,2,3-Me,OH,Me Triads via Asymmetric Hydrogenation Reactions

# publications[].label
Chiral imidazolylidine ligands for asymmetric catalysis.

# publications[].label
Conformations of cis- and trans-2,3-methanomethionine stereoisomers in the tripeptide mimic system Ac[cyclo-M]NHiPr.

# publications[].label
Large scale syntheses of N-protected 2,3-methanomethionine stereoisomers

# publications[].label
REACTIONS OF CATECHOLBORANE WITH WILKINSON CATALYST - IMPLICATIONS FOR TRANSITION METAL-CATALYZED HYDROBORATIONS OF ALKENES

# publications[].label
Small molecules inhibitors of PCSK9-LDLR protein-protein interaction

# publications[].label
SYNTHESES OF 2,3-METHANOAMINO ACIDS AS SURROGATES FOR PROTEIN AMINO-ACIDS

# publications[].label
Photolytic mass laddering for fast characterization of oligomers on single resin beads

# publications[].label
JM-PHOS ligands: Second-generation phosphine oxazolines for asymmetric catalysis

# publications[].label
Cyclopropane amino acids that mimic two chi(1)-conformations of phenylalanine

# publications[].label
Cytotoxicities of Tumor-Seeking Dyes: Impact on Future Clinical Trials.

# publications[].label
Novel Small Molecule Probes for Metastatic Melanoma.

# publications[].label
QuatCy: A Heptamethine Cyanine Modification With Improved Characteristics.

# publications[].label
Fluorescent, through-bond energy transfer cassettes for labeling multiple biological molecules in one experiment.

# publications[].label
Role of Albumin in Accumulation and Persistence of Tumor-Seeking Cyanine Dyes.

# publications[].label
Chiral N-heterocyclic carbene-transition metal complexes in asymmetric catalysis

# publications[].label
Expanding the scope of oligo-pyrrolinone-pyrrolidines as protein-protein interface mimics.

# publications[].label
Chiral imidazolylidine ligands for asymmetric hydrogenation of aryl alkenes.

# publications[].label
Fluorescent proton sensors based on energy transfer.

# publications[].label
SYNTHESES AND BIOACTIVITIES OF PEPTIDOMIMETICS FROM CYCLOPROPYL ANALOGS OF METHIONINE

# publications[].label
PROTACs suppression of CDK4/6, crucial kinases for cell cycle regulation in cancer.

# publications[].label
Enantioselective hydrogenations of arylalkenes mediated by [Ir(cod) (JM-Phos) ]+ complexes.

# publications[].label
Aza-BODIPY dyes with enhanced hydrophilicity.

# publications[].label
BIOCATALYTIC RESOLUTIONS OF SULFINYLALKANOATES - A FACILE ROUTE TO OPTICALLY-ACTIVE SULFOXIDES

# publications[].label
Rapid and efficient solid phase syntheses of cyclic peptides with endocyclic biaryl ether bonds

# publications[].label
Iridium-catalyzed asymmetric hydrogenation routes to g-amino acids derivatives

# publications[].label
Electronic effects steer the mechanism of asymmetric hydrogenations of unfunctionalized aryl-substituted alkenes.

# publications[].label
Carbene-metal hydrides can be much less acidic than phosphine-metal hydrides: significance in hydrogenations.

# publications[].label
Syntheses of second generation, 14-membered ring beta-turn mimics.

# publications[].label
Targeted theranostics featuring near infra-red dyes

# publications[].label
Nucleophilic aromatic substitution - A possible key step in total syntheses of vancomycin

# publications[].label
Incorporation of unnatural nucleotides by DNA polymerases.

# publications[].label
Syntheses of highly fluorescent GFP-chromophore analogues.

# publications[].label
Selective small molecule peptidomimetic ligands of TrkC and TrkA receptors afford discrete or complete neurotrophic activities.

# publications[].label
TRANSITION-METAL MEDIATED ADDITIONS OF CATECHOLBORNAE TO ALKENES USING CATALYSTS OTHER THAN RHODIUM(+1) COMPLEXES

# publications[].label
Filling gaps in asymmetric hydrogenation methods for acyclic stereocontrol: application to chirons for polyketide-derived natural products.

# publications[].label
Enhanced antiopiate activity and enzyme resistance in peptidomimetics of FMRFamide containing (E)-2,3-methanomethionine.

# publications[].label
REACTIONS OF [OS3(MU-H)2(CO)10] WITH ORGANIC AZIDES - STRUCTURAL CHARACTERIZATION OF [OS3(MU-H)(CO)10(MU-HN3PH)] AND [OS3(MU-H)2(CO)9(MU3-NPH)]

# publications[].label
Chiral triaryl monophosphines for asymmetric catalysis.

# publications[].label
Selective formation of homo- and heterobivalent peptidomimetics.

# publications[].label
REACTIONS OF TRIOSMIUM CLUSTERS WITH ORGANIC AZIDES - X-RAY CRYSTAL-STRUCTURES OF [OS3(CO)10(NCME)(N3COPH)], [OS3(MU-H)(CO)10(HN3PH)], AND [OS3(MU-H)2(CO)9(MU-3-NPH)]

# publications[].label
SYNTHESIS OF A VALUABLE CYCLOPROPYL CHIRON FOR PREPARATIONS OF 2,3-METHANOAMINO ACIDS

# publications[].label
Synthesis of fluorescent through-bond energy transfer cassettes.

# publications[].label
SOME EFFECTS OF 2,3-METHANOAMINO ACIDS ON THE SOLUTION STRUCTURE AND BIOACTIVITY OF SMALL PEPTIDES

# publications[].label
Fluorescent amino- and thiopyronin dyes.

# publications[].label
Novel linker for solid-phase synthesis of dimeric compounds.

# publications[].label
Energy transfer dyads based on Nile Red.

# publications[].label
A ROUTE TO SEVERAL STEREOISOMERS OF CASTANOSPERMINE

# publications[].label
ORGN 467-Ring closure to beta-turn mimics via copper-catalyzed azide/alkyne cycloadditions

# publications[].label
A new photolabile protecting group for nucleotides

# publications[].label
THE IMPORTANCE OF PHOSPHINE-TO-RHODIUM RATIOS IN ENANTIOSELECTIVE HYDROBORATIONS

# publications[].label
Synthesis and solution conformation of cyclo[RGDRGD]: a cyclic peptide with selectivity for the alpha V beta 3 receptor.

# publications[].label
ASYMMETRIC SYNTHESES OF ALL 4 STEREOISOMERS OF 2,3-METHANOMETHIONINE

# publications[].label
Synthetic helical peptide capping strategies.

# publications[].label
A method for removal of N-BOC protecting groups from substrates on TFA-sensitive resins

# publications[].label
Subcutaneous injection of an analog of neuropeptide FF precipitates morphine abstinence syndrome.

# publications[].label
34 well plate screening of a cyclopropanation reaction.

# publications[].label
ENANTIOSELECTIVE HYDROBORATION MEDIATED BY HOMOCHIRAL RHODIUM CATALYSTS

# publications[].label
Blocking Coronavirus 19 Infection via the SARS-CoV-2 Spike Protein: Initial Steps.

# publications[].label
A Near-IR Fluorescent Dasatinib Derivative That Localizes in Cancer Cells.

# publications[].label
Solid-phase SN2 macrocyclization reactions to form beta-turn mimics.

# publications[].label
SYNTHESIS AND REACTIVITY OF ISOCYANATOGOLDTRIOSMIUM CLUSTERS

# publications[].label
On the efficacy of propeller-shaped, C-3-symmetric triarylphosphines in asymmetric catalysis

# publications[].label
REACTIONS OF TRIOSMIUM CLUSTERS WITH ORGANIC-COMPOUNDS

# publications[].label
TOWARDS THE DEVELOPMENT OF A CONCEPTUALLY NEW APPROACH TO DNA-SEQUENCING WITHOUT GEL-ELECTROPHORESIS

# publications[].label
On formation of thiohydantoins from amino acids under acylation conditions.

# publications[].label
Solution- and solid-phase syntheses of substituted guanidinocarboxylic acids.

# publications[].label
Comparison of 2,3-methanoamino acids and alpha-methylamino acids in peptidomimetics

# publications[].label
Brilliant BODIPY-fluorene Copolymers With Dispersed Absorption and Emission Maxima.

# publications[].label
A ratiometric pH reporter for imaging protein-dye conjugates in living cells.

# publications[].label
SYNTHESIS OF TRIOSMIUM CLUSTERS CONTAINING AMIDINE LIGANDS - X-RAY STRUCTURAL CHARACTERIZATION OF [OS3(MU-H)(CO)9(NPHC(PH)NH)]

# publications[].label
An agent for optical imaging of TrkC-expressing, breast cancer.

# publications[].label
On the Mechanisms of Uptake of Tumor-Seeking Cyanine Dyes.

# publications[].label
Synthesis of a new water-soluble rhodamine derivative and application to protein labeling and intracellular imaging.

# publications[].label
New chemistry of BODIPY dyes, and BODIPY dye cassettes featuring through-bond energy transfer

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Conformational analyses of FMRF peptidomimetics containing 2,3-methanoamino acids

# publications[].label
Fluorescent indicators for intracellular pH.

# publications[].label
Subcutaneous injection of an analog of neuropeptide FF prevents naloxone-precipitated morphine abstinence syndrome.

# publications[].label
Targeting TrkC expressing tumors in vitro and in vivo using a TrkC ligand conjugated to a BODIPY-based photodynamic therapy (PDT) agent

# publications[].label
OPTICALLY-ACTIVE BUILDING-BLOCKS FROM THE SPAC REACTION - A COMPLETELY ASYMMETRIC-SYNTHESIS OF (4S-CIS)-5-(CYCLOHEXYLMETHYL)-4-HYDROXY-2-PYRROLIDINONE, A STATINE ANALOG

# publications[].label
Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA.

# publications[].label
Continuous flow biocatalytic resolutions of methyl sulfinylacetates

# publications[].label
3- and 5-Functionalized BODIPYs via the Liebeskind-Srogl reaction.

# publications[].label
An asymmetric hydrogenation route to (-)-spongidepsin.

# publications[].label
Divergent syntheses of ligands for high throughput screening of catalyst libraries

# publications[].label
CD5 ACTS AS A TYROSINE KINASE SUBSTRATE WITHIN A RECEPTOR COMPLEX COMPRISING TCR-ZETA/CD3 P56ICK AND P59FYN

# publications[].label
A multifaceted secondary structure mimic based on piperidine-piperidinones.

# publications[].label
Oligoethylene glycol-substituted aza-BODIPY dyes as red emitting ER-probes.

# publications[].label
New templates for syntheses of ring-fused, C(10) beta-turn peptidomimetics leading to the first reported small-molecule mimic of neurotrophin-3.

# publications[].label
Application of novel phosphine oxazoline ligands in asymmetric allylations of 4-acyloxy-2-pentene derivatives

# publications[].label
Preferred secondary structures as a possible driving force for macrocyclization

# publications[].label
An approach to 2,3-methanoamino acids with extended side chains: Syntheses of trans-BOC-cyclo-Lys(CBZ)-OH, trans-BOC-cyclo-Glu-OEt, and trans-BOC-cyclo-Arg(CBZ)-OH

# publications[].label
Fluorescent PARP Inhibitors Applied To Intracranial Glioblastoma: Accumulation and Persistence In Vivo.

# publications[].label
Targeted PDT agent eradicates TrkC expressing tumors via photodynamic therapy (PDT).

# publications[].label
STEREOCHEMICALLY MATCHED SULFINYLACETATES FOR DOUBLE DIASTEREOSELECTION IN THE SPAC REACTION

# publications[].label
SNAr cyclizations to form cyclic peptidomimetics of beta-turns

# publications[].label
Elimination of residual natural nucleotides from 3'-O-modified-dNTP syntheses by enzymatic mop-up.

# publications[].label
Practical epoxidation method utilizing manganese and hydrogen peroxide.

# publications[].label
New templates for solid-phase synthesis of cyclic peptidomimetics.

# publications[].label
Naturally Assembled Excimers in Xanthenes as Singular and Highly Efficient Laser Dyes in Liquid and Solid Media

# publications[].label
Syntheses and spectral properties of functionalized, water-soluble BODIPY derivatives.

# publications[].label
THE INFRARED VIBRATIONAL ASSIGNMENT FOR THE MU-2-BRIDGING METHYLENE LIGAND IN METAL CLUSTER COMPLEXES AND ITS COMPARISON WITH FREQUENCIES ASSIGNED TO CH2 SPECIES CHEMISORBED ON METAL-SURFACES

# researcherOn[].label
Small Molecules to Perturb A Novel PPI Target For Chemotherapy

# researcherOn[].awardedBy.label
Cancer Prevention and Research Institute of Texas - (Austin, Texas, United States)

# researcherOn[].label
Theranostics Targeting Metastatic Breast Cancer

# researcherOn[].awardedBy.label
United States Army - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
DOD-Army-Medical Research and Materiel Command

# researcherOn[].label
Evaluation of Trk Probes in Models for Dry Eye Disease

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Development of An Potimized System for Non-Covalent Delivery of Proteins Into Cells

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
CDS&E: Cyclic Tetrapeptide Probes for Protein Binding

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# streetAddress
Texas A&M University; Chemistry Department; 3255 TAMU

# inTheNews[].label
Texas A&M Chemist David Powers Earns Sloan Research Fellowship

# etdChairOf[].label
Zhou, Hua (2014-12). Synthesis and Application of Useful Organic Building Blocks and Cyclic Tetrapeptide. Master's Thesis.

# etdChairOf[].label
Liu, Jing (2009-05). Heterocyclic small molecule peptidomimetics. Doctoral Dissertation.

# etdChairOf[].label
Castro, Juan C. (2009-12). Fluorescein and Rosamine Derivatives as Donors/Acceptors for "Through-bond" Energy Transfer Cassettes. Master's Thesis.

# etdChairOf[].label
Ogle, James William (2009-05). N-heterocyclic carbene catalysis: expansion of. Doctoral Dissertation.

# etdChairOf[].label
Li, Lingling (2009-05). Water-soluble bodipys: syntheses, derivatization and photophysical studies. Master's Thesis.

# etdChairOf[].label
Xia, Zebin (2005-08). Peptidomimetics to mimic protein-protein interactions. Doctoral Dissertation.

# etdChairOf[].label
Reyes, Samuel Onofre J. (2009-06). Expanding beta-turn analogs for mimicking protein-protein hot spots. Doctoral Dissertation.

# etdChairOf[].label
Lam, Sang Q. (2007-04). Contributions to peptidomimetic design: predictive computational studies and syntheses of linker molecules. Master's Thesis.

# etdChairOf[].label
Wu, Liangxing (2009-08). Design, Syntheses and Applications of Fluorescent Dyes. Doctoral Dissertation.

# etdChairOf[].label
Ueno, Yuichiro (2010-07). THROUGH-BOND ENERGY TRANSFER CASSETTES FOR MULTIPLEXING & DEVELOPMENT OF METHODS FOR PROTEIN MONO-LABELING. Doctoral Dissertation.