{
"id" : "nc4a5cad4",
"class" : "Person",
"name" : "Burgess, Kevin",
"primaryEmail" : "burgess@tamu.edu",
"phone" : "1 979 845 4345",
"preferredTitle" : "Professor",
"positions" : [ {
"id" : "n251f48d5",
"label" : "Professor",
"type" : "FacultyPosition",
"organizations" : [ {
"id" : "nce401957",
"label" : "Chemistry",
"parent" : [ {
"id" : "nfa5c5352",
"label" : "College of Arts and Sciences"
} ]
} ]
} ],
"overview" : "We use novel strategies Exploring Key Orientations (EKO) that feature datamining to compare simulated preferred conformers of chemotypes we design with key features at protein-protein interfaces. Many chemotype candidates can be screened against one PPI, or one chemotype can be screened against all the PPI interfaces in the PDB. Virtual hit chemotypes are prepared in my lab, then tested against protein-protein interactions of biomedicinal interest using an array of biophysical and cellular assays.
We also design small molecules to target cell surface receptors that are selectively overexpressed in cancer cells. Much or our work has been focused on the TrkC receptor that is particularly important to metastatic breast cancer and melanoma. Going forwards we are interested in expanding the targets to include cell surface receptors that are overexpressed when cancer cells undergo aberrant epithelial to mesenchymal transitions (EMT) to produce circulating tumor cells and cancer stem cells. Much of this work involves design and synthesis of the small molecules for this targeting.",
"hrJobTitle" : "Professor",
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Reagents", "Chromatography, High Pressure Liquid", "Sulfonamides", "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization", "Spectrophotometry, Ultraviolet", "Ligands", "Alkynes", "Magnetic Resonance Spectroscopy", "Combinatorial Chemistry Techniques", "Fluorescein", "Luminescent Measurements", "Energy Transfer", "Stereoisomerism", "Fluorescent Dyes", "Molecular Structure", "Sensitivity And Specificity", "Oxazines", "Ethylene Glycol", "Azides", "Alkynes", "Copper", "Cross-Linking Reagents", "Catalysis", "Oxidative Phosphorylation", "Xenograft Model Antitumor Assays", "Female", "Mitochondria", "Antineoplastic Agents", "Animals", "Amines", "Humans", "Molecular Targeted Therapy", "Mice", "Cell Line, Tumor", "Molecular Probes", "Spectrophotometry, Ultraviolet", "Fluorescent Dyes", "Photochemistry", "Fluorescence Resonance Energy Transfer", "Sequence Analysis, DNA", "Biotechnology", "Cyclopropane Amino Acids", "Cyclopropylogs", "2,3-methanologs", "Peptidomimetics", "15 Life On Land", "3404 Medicinal And Biomolecular Chemistry", "3405 Organic Chemistry", "34 Chemical Sciences", "Amino Acid", "Cyclopropane", "Conformationally Constrained", "Cyclic Peptide", "Macromdel Calculations", "Pyrrolidines", "Molecular Dynamics Simulation", "Stereoisomerism", "Peptides, Cyclic", "Carboxylic Acids", "Conformational Studies", "Molecular Conformation", "Quenched Molecular Dynamics", "Peptidomimetics", "Hydrocarbons, Cyclic", "Resins, Plant", "Dimerization", "Molecular Structure", "Polystyrenes", "Indicators And Reagents", "Protein Conformation", "Models, Molecular", "Amino Acid Sequence", "Binding Sites", "Animals", "Ligands", "Humans", "Receptors, Nerve Growth Factor", "Nerve Growth Factors", "Molecular Sequence Data", "3405 Organic Chemistry", "34 Chemical Sciences", "Molecular Structure", "Protein Binding", "Humans", "Small Molecule Libraries", "Stereoisomerism", "Drug Design", "Databases, Protein", "Cyclin-dependent Kinase 2", "DNA-Directed RNA Polymerases", "Molecular Dynamics Simulation", "Enzyme Inhibitors", "Cycloparaffins", "Oxazoles", "Hydrogenation", "Stereoisomerism", "Molecular Structure", "Catalysis", "Benzimidazoles", "Homogeneous", "Hydrogenations", "Alkene-acids", "Alkene-esters", "Stereoselective", "3402 Inorganic Chemistry", "34 Chemical Sciences", "Red-shift", "Suzuki-coupling", "Bodipy", "Dyes", "FLUORESCENCE", "Bis(mesityl)niobium", "Catecholborane", "Borane", "Catalysis", "3405 Organic Chemistry", "34 Chemical Sciences", "3405 Organic Chemistry", "34 Chemical Sciences", "3406 Physical Chemistry", "34 Chemical Sciences", "7 Affordable And Clean Energy", "Energy Transfer", "DNA Probes", "Fluorescence Polarization", "Fluorescent Dyes", "Molecular Structure", "Time Factors", "Fluorescence Resonance Energy Transfer", "Animals", "Oligopeptides", "Dose-Response Relationship, Drug", "Rats, Sprague-Dawley", "Rats", "Behavior, Animal", "Injections, Subcutaneous", "Narcotic Antagonists", "Nicotine", "Male", "Molecular Sequence Data", "Amino Acid Sequence", "Neuropeptides", "Nicotinic Agonists", "Substance Withdrawal Syndrome", "Heptamethine", "Cyanine", "Dyes", "Carbocyanines", "Fluorescent Dyes", "FLUORESCENCE", "Isomerism", "Carbene Ligands", "Asymmetric Catalysis", "Hydrogenation", "Density Functional Calculations", "Iridium", "Generic Health Relevance", "Esters", "Hydrogenation", "Alkanes", "Stereoisomerism", "Molecular Structure", "Catalysis", "Coleoptera", "Animals", "Energy Transfer", "Oligodeoxyribonucleotides", "Spectrometry, Fluorescence", "Molecular Structure", "Thymidine", "DNA", "Base Sequence", "3404 Medicinal And Biomolecular Chemistry", "3405 Organic Chemistry", "34 Chemical Sciences", "Proteolysis", "Breast Neoplasms", "Receptor, Trkc", "Chemotherapy", "Trkc Receptors", "Proteasome Endopeptidase Complex", "Active Targeting", "Protein Kinase Inhibitors", "Triple Negative Breast Cancer Cells", "Cell Survival", "Adaptor Proteins, Signal Transducing", "Wound Healing", "Protacs", "Female", "Small Molecule Libraries", "Tumor Cells, Cultured", "Ubiquitin-Protein Ligases", "Dasatinib", "Humans", "Hydrogenation", "Iridium", "Macrolides", "Combinatorial Chemistry Techniques", "Stereoisomerism", "Molecular Structure", "Catalysis", "Methionine", "Molecular Structure", "Neuropeptides", "Morphine Dependence", "Fmrfamide", "Oligopeptides", "Animals", "Male", "Rats", "Endorphins", "Rats, Sprague-Dawley", "Receptors, Neurotransmitter", "Amino Acid Sequence", "Molecular Sequence Data", "In Vitro Techniques", "Cyclobutane", "Amino Acid", "Conformationally Constrained", "0399 Other Chemical Sciences", "Animals", "Nanoparticles", "Silicon Dioxide", "Absorption", "Biological Transport", "Liver", "Rats", "Water", "Organelles", "Energy Transfer", "Capsules", "Molecular Structure", "Ligands", "Taste", "Chemoreceptor Cells", "Biotin", "Spectrometry, Fluorescence", "Fluorescent Dyes", "Humans", "Sweetening Agents", "Drug Design", "Guanidines", "Indicators And Reagents", "Biotinylation", "Cancer", "Drug Design", "Female", "Protein Kinase Inhibitors", "Tumor Targeting", "Theranostic Nanomedicine", "Dasatinib", "Humans", "Mice, Nude", "Indoles", "Animals", "Xenograft Model Antitumor Assays", "Glioblastoma", "Cyanine", "Imaging Agents", "Fluorescent Dyes", "Cell Line, Tumor", "Antineoplastic Agents", "Src-Family Kinases", "Carbocyanines", "3405 Organic Chemistry", "3402 Inorganic Chemistry", "34 Chemical Sciences", "Hydrogenation", "Alkenes", "Aldehydes", "Stereoisomerism", "Glyceraldehyde", "Lactic Acid", "Molecular Structure", "Catalysis", "Cell Line, Tumor", "Gemcitabine", "Animals", "Carbocyanines", "Humans", "Deoxycytidine", "Glioblastoma", "Tissue Distribution", "Drug Stability", "Cell Survival", "Antineoplastic Agents", "Female", "Theranostic Nanomedicine", "Transplantation, Heterologous", "Mice", "Mice, Nude", "Peptidomimetics", "Quantum Theory", "Protein Structure, Secondary", "Thermodynamics", "Models, Molecular", "Kinetics", "3404 Medicinal And Biomolecular Chemistry", "Hematology", "34 Chemical Sciences", "Enzyme Catalysis", "DNA Sequencing", "Nucleotides", "Molecular Structure", "Organelles", "Fluorescent Dyes", "Animals", "Cells, Cultured", "Solubility", "Tissue Distribution", "Water", "Staining And Labeling", "Quantum Theory", "Oxazines", "Oxidation-Reduction", "Amino Acids", "Biocatalysis", "3402 Inorganic Chemistry", "34 Chemical Sciences", "3405 Organic Chemistry", "34 Chemical Sciences", "Drug Design", "Energy Transfer", "Boron Compounds", "Spectrometry, Fluorescence", "Rats", "Silicates", "Permeability", "Time Factors", "Calcium Phosphates", "Fluorescent Dyes", "Animals", "Molecular Imaging", "Color", "Nanoparticles", "Liver", "Trkc", "Carbonic Anhydrase Ix", "Photoaffinity Labeling", "Click Chemistry", "Targeting", "3402 Inorganic Chemistry", "34 Chemical Sciences", "Sulfur Compounds", "Triazoles", "Esters", "Amides", "Stereoisomerism", "Molecular Structure", "Catalysis", "Peptides", "Circular Dichroism", "Models, Molecular", "Hydrogen Bonding", "Protein Conformation", "Molecular Mimicry", "Methionine", "Oxidation-Reduction", "Indicators And Reagents", "Mass Spectrometry", "Magnetic Resonance Spectroscopy", "Amino Acid", "Cyclopropane", "Conformationally Constrained", "3402 Inorganic Chemistry", "34 Chemical Sciences", "Oxazoles", "Hydrogenation", "Alkenes", "Stereoisomerism", "Substrate Specificity", "Methane", "Catalysis", "0601 Biochemistry And Cell Biology", "Trypsin Inhibitors", "Protein Multimerization", "Animals", "Humans", "Protein Kinase Inhibitors", "Mice", "Protein Binding", "Receptor, TrkA", "Nerve Growth Factor", "Oligopeptides", "NIH 3T3 Cells", "Animals", "Cell Survival", "COS Cells", "Drug Design", "Peptides", "Proteins", "Cattle", "Amino Acid Sequence", "Endocytosis", "Diffusion", "Temperature", "Chlorocebus Aethiops", "Cytosol", "Molecular Sequence Data", "Flow Cytometry", "FLUORESCENCE", "Fmrfamide", "Oligopeptides", "Methionine", "Neuropeptides", "Protein Conformation", "Organelles", "Fluorescent Dyes", "Microscopy, Fluorescence", "3405 Organic Chemistry", "34 Chemical Sciences", "Nucleotides", "Sequence Analysis, DNA", "Breast Cancer", "Cancer", "Peptide", "Peptidomimetics", "Triazoles", "Cancer", "Upar", "Protein Structure, Secondary", "Protein-protein Interactions", "Proteins", "Urokinase-Type Plasminogen Activator", "Biomimetic Materials", "Fluoronitrobenzoic Acid Derivatives", "Beta-turn Peptidomimetics", "Nerve Growth Factor", "Transition Temperature", "Acylation", "Oligonucleotides", "Circular Dichroism", "Organophosphorus Compounds", "Fluorescent Dyes", "Nucleic Acid Denaturation", "Isomerism", "Nucleic Acid Conformation", "Beta-turn", "Solid-phase Synthesis", "Peptidomimetics", "Nucleophilic Aromatic Substitutions", "Macrocyclizations", "Receptors, Urokinase Plasminogen Activator", "Urokinase-Type Plasminogen Activator", "Ligands", "Cardiovascular", "3402 Inorganic Chemistry", "34 Chemical Sciences", "Animals", "Proteins", "CHO Cells", "Polymers", "Guanidine", "Cells, Cultured", "Cell Survival", "Molecular Structure", "Stereoisomerism", "Cations", "Rats", "Amines", "Structure-Activity Relationship", "Cricetinae", "Fluorenes", "Monosaccharides", "Oligonucleotides", "Furans", "Pyrimidines", "Hot Temperature", "Base Sequence", "Molecular Sequence Data", "Biotechnology", "Trkc", "Neurotrophin", "Small Molecule Ligand", "Targeting", "Cancer", "3405 Organic Chemistry", "3402 Inorganic Chemistry", "34 Chemical Sciences", "Cancer Therapy", "Photodynamic Therapy", "Disease Models, Animal", "Nanostructures", "Drug Delivery", "Liposomes", "Photochemotherapy", "Photosensitizing Agents", "Polymers", "Neoplasms", "In Vivo", "Micelles", "Animals", "Polyketides", "Asymmetric Catalysis", "Hydrogenation", "Iridium", "Homogeneous Catalysis", "0306 Physical Chemistry (incl. Structural)", "DNA Replication", "Kinetics", "Boron Compounds", "Base Sequence", "DNA-Directed DNA Polymerase", "Templates, Genetic", "Adenosine Triphosphate", "DNA", "DNA Primers", "Substrate Specificity", "Fluorescent Dyes", "Tetrahedral Zirconia (t-zro2)", "Highly Dispersed", "Nano-sized Zro2 Powders", "Microwave-assisted Hydrothermal Method", "Fluorescent Dyes", "Neoplasms", "Humans", "Naphthols", "Aminophenols", "Hydroxides", "Spectrometry, Fluorescence", "Absorption", "Fluorescent Dyes", "Oxazines", "Water", "Solubility", "Humans", "Cancer", "Phosphorylation", "Peptidomimetics", "ErbB Receptors", "Protein Binding", "Molecular Structure", "Peptides", "Epidermal Growth Factor", "Hydrogen-Ion Concentration", "Protein-protein Interactions", "Solid-phase Synthesis", "Egf", "Taq Polymerase", "RNA-Directed DNA Polymerase", "Sequence Analysis, DNA", "Mass Spectrometry", "Pyrroles", "Deoxyadenine Nucleotides", "Templates, Genetic", "Substrate Specificity", "DNA Polymerase I", "Retroviridae", "DNA-Directed DNA Polymerase", "Nucleotides", "Hiv Protease", "Dimerization", "Small Molecule Libraries", "Fluorescent Dyes", "Algorithms", "Protein Binding", "Models, Molecular", "Structure-Activity Relationship", "Beta-turn", "Conformation Analysis", "Macrocycles", "Peptidomimetics", "Molecular Dynamics", "3402 Inorganic Chemistry", "34 Chemical Sciences", "Glucosidase Inhibitor", "Castanospermine", "1,6,7,8-tetrahydroxyindolizidine", "Magnesium Compounds", "Boron Compounds", "Cyanides", "Molecular Probes", "Fluorides", "Fluorescent Dyes", "Molecular Structure", "Piperidines", "Chlorides", "Hydrocarbons, Halogenated", "Fluoresceins", "Stereoisomerism", "Fluorescent Dyes", "Molecular Structure", "4009 Electronics, Sensors And Digital Hardware", "4018 Nanotechnology", "5102 Atomic, Molecular And Optical Physics", "40 Engineering", "51 Physical Sciences", "Nerve Growth Factor", "Molecular Mimicry", "Oligopeptides", "Receptor, TrkA", "Peptide Library", "Protein Structure, Secondary", "Proteins", "Humans", "Mice, Inbred C57BL", "Cells, Cultured", "Cell Line, Tumor", "Humans", "PC12 Cells", "Peptidomimetics", "Animals", "Combinatorial Chemistry Techniques", "Blotting, Western", "NIH 3T3 Cells", "Receptor, Trkc", "Brain-derived Neurotrophic Factor", "Small Molecule Libraries", "Molecular Structure", "Receptor, TrkA", "Neurotrophin 3", "Cell Survival", "Rats", "Nerve Growth Factor", "Models, Chemical", "Mice", "3402 Inorganic Chemistry", "34 Chemical Sciences", "Structure-Activity Relationship", "Molecular Structure", "Antineoplastic Agents", "Xanthenes", "Cell Proliferation", "Apoptosis", "Cell Cycle", "Inhibitory Concentration 50", "Mitochondria", "Cell Line, Tumor", "Membrane Potential, Mitochondrial", "Cell Culture Techniques", "Humans", "Cyclopropylog", "Methanolog", "Cyclopropane", "Constraints", "Solid-phase Syntheses", "Urea", "Benzothiazoles", "Carbocyanines", "Fluorescent Dyes", "Neoplasms", "Positron-Emission Tomography", "Humans", "Fmrfa", "2,3-methanoleucine", "Anti-opiate", "Molecular Mimicry", "Protein Structure, Secondary", "Molecular Mimicry", "Protein Structure, Secondary", "Models, Chemical", "Proteins", "Protein Binding", "Models, Molecular", "Photosensitizing Agents", "Humans", "Boron Compounds", "Intracellular Space", "Porphobilinogen", "Cell Cycle", "Structure-Activity Relationship", "Apoptosis", "Chorioallantoic Membrane", "Chickens", "Cell Line, Tumor", "Animals", "Singlet Oxygen", "Boron", "Photochemotherapy", "Blood Vessels", "Biological Transport", "Atropisomerism", "Vancomycin", "Nucleophilic Aromatic Substitutions", "Total Synthesis", "Antibiotics", "3404 Medicinal And Biomolecular Chemistry", "3405 Organic Chemistry", "34 Chemical Sciences", "0305 Organic Chemistry", "Pyrrole", "Bodipy (r)", "Labelling", "Dye", "FLUORESCENCE", "Solid-phase Syntheses", "Palladium Catalysis", "Peptidomimetics", "Beta-turns", "Protein Structure, Secondary", "Transfection", "Combinatorial Chemistry Techniques", "Receptors, Nerve Growth Factor", "Neurotrophin 3", "Kinetics", "Molecular Mimicry", "Ligands", "Humans", "Dimerization", "Peptides", "Receptor, Trkc", "Cell Line", "Structure-Activity Relationship", "Asymmetric Synthesis", "Polyketides", "Hydrogenation", "Iridium", "Catalysis", "Receptor, Trkc", "NIH 3T3 Cells", "Molecular Structure", "Cell Survival", "Signal Transduction", "Mice", "Receptor, TrkA", "Neurotrophin 3", "Molecular Mimicry", "Receptor, IGF Type 1", "Peptides", "Animals", "Diazepam Binding Inhibitor", "Animals", "Mice", "Recombinant Proteins", "Phosphatidylcholines", "Fluorescent Dyes", "Thermodynamics", "Proteins", "Lipid Bilayers", "Diffusion", "Models, Chemical", "Chemistry", "Computer Simulation", "Statistics As Topic", "Structure-Activity Relationship", "Candida-cylindracea Lipase", "Kinetic Amplification Of Diastereomeric Excess", "Acylation", "Catalysis", "Asymmetric Hydrogenations", "Metathesis", "Combinatorial", "Alkaloids", "Catalysis", "Boron Compounds", "Pyrroles", "Spectrophotometry, Ultraviolet", "Spectrometry, Fluorescence", "Coloring Agents", "Electrochemistry", "Molecular Conformation", "15 Life On Land", "Chemical Phenomena", "Spectroscopy, Fourier Transform Infrared", "Stereoisomerism", "Circular Dichroism", "Models, Molecular", "Molecular Structure", "Protein Conformation", "Oligopeptides", "Cyclopropanes", "Magnetic Resonance Spectroscopy", "Methionine", "Chemistry, Physical", "Protein Structure, Secondary", "Ligands", "Transfection", "Mice", "Animals", "Receptor, Trkc", "Neurotrophin 3", "Small Molecule Libraries", "Biomimetics", "Neurogenesis", "Cell Survival", "NIH 3T3 Cells", "Protein Binding", "Signal Transduction", "Pyrrolidines", "Peptidomimetics", "Pyrroles", "Protein Structure, Secondary", "Models, Molecular", "3404 Medicinal And Biomolecular Chemistry", "3405 Organic Chemistry", "Generic Health Relevance", "34 Chemical Sciences", "1.1 Normal Biological Development And Functioning", "1 Underpinning Research", "3404 Medicinal And Biomolecular Chemistry", "34 Chemical Sciences", "Photosensitizing Agents", "Boron Compounds", "Photochemotherapy", "Fluorescent Dyes", "Energy Transfer", "Molecular Structure", "Proteins", "Water", "3405 Organic Chemistry", "3402 Inorganic Chemistry", "34 Chemical Sciences", "C-n Couplings", "Squaraines", "Energy-transfer", "FLUORESCENCE", "3402 Inorganic Chemistry", "34 Chemical Sciences", "Opioid Peptides", "Morphine Dependence", "Receptors, Neuropeptide", "Molecular Sequence Data", "Stereoisomerism", "Oligopeptides", "Neuropeptides", "Phenylalanine", "Invertebrate Hormones", "Fmrfamide", "Rats", "Male", "Leucyl Aminopeptidase", "Amino Acid Sequence", "Methionine", "Animals", "Rats, Sprague-Dawley", "FLUORESCENCE", "Oxazines", "Water", "Solubility", "Peptidomimetics", "Cyclopropane", "Molecular Dynamics", "Amino Acids", "Microwave Acceleration Of Reactions", "Fluorescent Labels", "Suzuki Coupling", "Sonogashira Coupling", "Borylation", "N-Heterocyclic Carbenes", "Asymmetric Catalysis", "Enol Ethers", "Hydrogenation", "Alkenes", "Iridium", "Fluorescent Dyes", "Carbocyanines", "Humans", "Serum Albumin, Human", "Animals", "Albumin Adducts", "Neoplasms", "Cyanine", "Cytotoxicity", "Antineoplastic Agents", "Mice", "Small Molecule Ligand", "Melanoma", "Targeting", "Cancer", "Neurodegeneration", "Neuroectoderm", "Stroke", "Alzheimer's Disease", "Pain", "Peptidomimetics", "Receptor", "Therapy", "Tumour", "Nerve Growth Factor", "Immunophilins", "Drugs", "Neurotrophin", "Parkinson's Disease", "Ligand", "Solubility", "Molecular Structure", "Mice", "Culture Media", "Heptamethine Cyanine", "Fluorescent Dyes", "Tumor Seeking", "Near-infrared", "Fluorescence Imaging", "Neoplasms", "Carbocyanines", "Optical Imaging", "Animals", "Cell Survival", "Cell Line, Tumor", "Fluoresceins", "Rhodamines", "Fluorescent Dyes", "Fluorescence Resonance Energy Transfer", "DNA", "Humans", "Indoles", "Albumins", "Mice, Inbred C57BL", "Hep G2 Cells", "Cell Line, Tumor", "Organic Anion Transporters", "Optical Imaging", "Animals", "Neoplasms", "Carbocyanines", "Fluorescent Dyes", "Pyrrolidines", "Caco-2 Cells", "Molecular Structure", "Proteins", "Protein Binding", "Models, Molecular", "Crystallography, X-Ray", "Humans", "3405 Organic Chemistry", "3402 Inorganic Chemistry", "34 Chemical Sciences", "Molecular Conformation", "Metals", "Boron", "Spectrometry, Fluorescence", "Humans", "Aza Compounds", "Hep G2 Cells", "Water", "Microscopy, Fluorescence", "Boron Compounds", "Copper", "Fluorometry", "Limit Of Detection", "Fluorescent Dyes", "Boron Compounds", "Crystallography, X-Ray", "Hydrogen-Ion Concentration", "FLUORESCENCE", "Quantum Theory", "Energy Transfer", "Molecular Structure", "Models, Molecular", "Electrochemistry", "Stereoisomerism", "Cyclin-dependent Kinase 6", "Purines", "Piperazines", "Protein Kinase Inhibitors", "Cyclin-dependent Kinase 4", "Humans", "Cell Line, Tumor", "Phosphorylation", "Retinoblastoma Protein", "Aminopyridines", "Kinetics", "Cell Cycle Checkpoints", "Pyridines", "Neoplasms", "N Ligands", "P Ligands", "Asymmetric Catalysis", "Hydrogenation", "Alkenes", "Homogeneous Catalysis", "Aza Compounds", "Boron Compounds", "Fluorescent Dyes", "Hydrophobic And Hydrophilic Interactions", "Mice", "Sulfonic Acids", "Cell Line, Tumor", "Cysteic Acid", "Microscopy, Fluorescence", "Animals", "Water", "Spectrophotometry, Ultraviolet", "Spectrometry, Fluorescence", "Coloring Agents", "Amines", "Solvents", "Protein Binding", "Water", "Solubility", "Cyanine", "Photocytotoxicity", "Photodynamic Therapy", "Near-infrared", "Singlet Oxygen", "Cancer", "3405 Organic Chemistry", "34 Chemical Sciences", "0601 Biochemistry And Cell Biology", "0302 Inorganic Chemistry", "Peptides, Cyclic", "Biomimetics", "Molecular Structure", "3404 Medicinal And Biomolecular Chemistry", "3101 Biochemistry And Cell Biology", "3405 Organic Chemistry", "34 Chemical Sciences", "31 Biological Sciences", "Chemistry", "Protein Conformation", "Antibodies, Monoclonal", "Epitope Mapping", "Mutation", "Ligands", "Transcription Factors", "Protein Binding", "Amino Acid Sequence", "Mutagenesis, Site-Directed", "Plasmids", "Amino Acids", "Molecular Sequence Data", "Peptide Library", "Binding, Competitive", "Peptides", "Total Syntheses", "Biaryl Ethers", "Vancomycin", "Synthetic Methods", "Peptides", "Peptoids", "Peptides, Cyclic", "Molecular Mimicry", "Molecular Structure", "Amino Acids", "Protein Conformation", "Models, Molecular", "3402 Inorganic Chemistry", "34 Chemical Sciences", "Loop Mimicry", "Virtual Screening", "Macrocycles", "Protein-protein Interactions", "Hippurates", "Aldehydes", "Stereoisomerism", "Fluorescent Dyes", "FLUORESCENCE", "Glycine", "Molecular Structure", "Green Fluorescent Proteins", "Models, Molecular", "Ligands", "Signal Transduction", "Rats", "NIH 3T3 Cells", "Molecular Mimicry", "Kinetics", "PC12 Cells", "Receptor, TrkA", "Protein Binding", "Receptor, Trkc", "Cell Differentiation", "Peptides", "Animals", "Mice", "0305 Organic Chemistry", "0399 Other Chemical Sciences", "0302 Inorganic Chemistry", "Borohydride", "Borane", "Bis(cyclopentadienyl)titanium Dichloride", "Catalysis", "0306 Physical Chemistry (incl. Structural)", "Nitriles", "Boranes", "2,2'-Dipyridyl", "Coloring Agents", "Solvents", "Photochemistry", "Molecular Structure", "Spectrum Analysis", "Rats", "Hydrolysis", "Leucyl Aminopeptidase", "Stereoisomerism", "Protein Binding", "Substance Withdrawal Syndrome", "Rats, Sprague-Dawley", "Neuropeptides", "Narcotic Antagonists", "Amino Acid Sequence", "Male", "Animals", "Methionine", "Fmrfamide", "Oligopeptides", "Molecular Sequence Data", "Receptors, Neuropeptide", "Receptors, Opioid", "Flavylium", "Polymethine Dye", "Excitation Multiplexing", "Dyes And Pigments", "Imaging", "Boron Compounds", "Aldehydes", "Spectrophotometry, Ultraviolet", "Spectrometry, Fluorescence", "Coloring Agents", "Absorption", "Lytacs", "Mab Conjugate", "Native Mass Spectrometry", "Protacs", "Data Mining", "Ubiquitin-Protein Ligases", "Ubiquitination", "Receptors, Cell Surface", "Humans", "Molecular Mimicry", "Fluorescent Dyes", "Nerve Growth Factors", "Receptor, TrkA", "Heterocyclic Compounds, 2-ring", 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