# positions[].organizations[].parent[].label
College of Education and Human Development

# overview
My research focuses on mechanisms associated with protein turnover and glucoregulatory function in muscle and how these mechanisms may be altered by exercise, aging, obesity, diabetes or periods of microgravity.  More currently, we are interested in small molecules arising from contracting skeletal muscle that impact other cells/tissues in the body, including cancer.

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
6 Evaluation Of Treatments And Therapeutic Interventions

# keywords[]
And Proteins Essential To Cholesterol Metabolism

# keywords[]
Sterol Regulatory Element Binding Protein 2

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
6 Evaluation Of Treatments And Therapeutic Interventions

# keywords[]
6 Evaluation Of Treatments And Therapeutic Interventions

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Suppressor Of Cytokine Signaling 3 Protein

# keywords[]
Endosomal Sorting Complexes Required For Transport

# keywords[]
Mechanistic Target Of Rapamycin Complex 1

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Mechanistic Target Of Rapamycin Complex 1

# educationAndTraining[].organization.label
Pennsylvania State University - (State College, Pennsylvania, United States)

# publications[].label
Effects of thyroid hormone on protein synthesis in rat skeletal muscle.

# publications[].label
Exercise Conditioned Perfusate Slows Growth In Cultured Pancreatic Cancer Cells

# publications[].label
Exercise Conditioned Perfusate Slows Growth In Cultured Pancreatic Cancer Cells

# publications[].label
Simulating the Lunar Environment: Partial Weightbearing and High-LET Radiation-Induce Bone Loss and Increase Sclerostin-Positive Osteocytes.

# publications[].label
Estimation of rat muscle blood flow by microdialysis probes perfused with ethanol, [14C]ethanol, and 3H2O.

# publications[].label
Impaired exercise-induced mitochondrial biogenesis in the obese Zucker rat, despite PGC-1 induction, is due to compromised mitochondrial translation elongation.

# publications[].label
Culprits or consequences: Understanding the metabolic dysregulation of muscle in diabetes.

# publications[].label
Low Intake of Choline Is Associated with Diminished Strength and Lean Mass Gains in Older Adults.

# publications[].label
Effects of oral pinitol supplementation on oral and intravenous glucose tolerance in older people

# publications[].label
The capacity of insulin to attenuate rates of protein degradation in rat soleus muscle is maintained after 14 days of hindlimb suspension

# publications[].label
EFFECT OF RESISTANCE EXERCISE TRAINING ON CORTICAL AND CANCELLOUS BONE IN RATS: A HISTOMORPHOMETRIC ANALYSIS: 1241.

# publications[].label
Effects of 28days of beta-alanine and creatine supplementation on muscle carnosine, body composition and exercise performance in recreationally active females.

# publications[].label
The Effects of Dietary Cholesterol and Resistance Training as Countermeasures to Accelerated Muscle Loss

# publications[].label
Hindlimb unloading in adult rats using an alternative tail harness design.

# publications[].label
Skeletal Muscle Anabolic Response Following Incubation with Protein Kinase C Activator OAG

# publications[].label
Increased training loads do not magnify cancellous bone gains with rodent jump resistance exercise.

# publications[].label
The application of 2H2O to measure skeletal muscle protein synthesis.

# publications[].label
The Effect of Caffeine on Protein Synthesis Rates in Rat Gastrocnemius Muscle Tissue

# publications[].label
Inhibition of FoxO Signaling Prevents Mechanical Ventilation-Induced Reduction in Protein Synthesis

# publications[].label
Skeletal muscle PGF(2)(alpha) and PGE(2) in response to eccentric resistance exercise: influence of ibuprofen acetaminophen.

# publications[].label
Amino acids derived from proteolysis are preferred for muscle protein synthesis following hindlimb suspension

# publications[].label
Insulin stimulation of protein synthesis in rat skeletal muscle following resistance exercise is maintained with advancing age

# publications[].label
Responses of skeletal muscle size and anabolism are reproducible with multiple periods of unloading/reloading.

# publications[].label
Changes In PPARd Protein Content Following Acute Aerobic Exercise In Human Vastus Lateralis Muscle.

# publications[].label
Regulation of cellular anabolism by mTOR: or how I learned to stop worrying and love translation.

# publications[].label
Insulin stimulation of muscle protein synthesis in obese Zucker rats is not via a rapamycin-sensitive pathway

# publications[].label
The Effects of Choline Intake and Resistance Exercise Training on Strength Gains in Older Adults

# publications[].label
Effects of short-term ingestion of Russian Tarragon prior to creatine monohydrate supplementation on whole body and muscle creatine retention and anaerobic sprint capacity: a preliminary investigation.

# publications[].label
Blood Lipid is Associated with Skeletal Muscle PPARd Protein Content after a 10-week Resistance Exercise Training

# publications[].label
The effect of simulated 1/6th and 1/3rd gravity on gastrocnemius muscle mass and fractional protein synthesis rates in mice

# publications[].label
Comparison of insulin sensitivity assessment indices with euglycemic-hyperinsulinemic clamp data after a dietary and exercise intervention in older adults.

# publications[].label
Influence of muscle mass and work on post-exercise glucose and insulin responses in young untrained subjects.

# publications[].label
THE EFFECT OF RESISTANCE EXERCISE TRAINING ON CORTICAL AND CANCELLOUS BONE IN MATURE RATS

# publications[].label
127 ARGININE STIMULATED INSULIN SECRETION FROM PANCREATIC ISLETS IS INCREASED FOLLOWING RESISTANCE EXERCISE.

# publications[].label
Hyperglycemia- and hyperinsulinemia-induced insulin resistance causes alterations in cellular bioenergetics and activation of inflammatory signaling in lymphatic muscle.

# publications[].label
Effect of EUK-134 on Insulin Signaling and Morphology Alterations by 7 Days of Hindlimb Unloading in the Rat Soleus

# publications[].label
The insulin-facilitated increase of muscle protein synthesis after resistance exercise involves a MAP-kinase pathway

# publications[].id
 Influence of ibuprofen and acetaminophen

# publications[].label
Skeletal muscle PGF2 and PGE2 in response to eccentric exercise

# publications[].label
Effects of Multiple Bouts of Long-duration Hindlimb Unloading and Recovery on Rat Hindlimb Muscles

# publications[].label
Blockade Of Mtor And Erk1/2 Resulted In Attenuated Protein Synthesis Rates In Differentiated C2c12 Myoblasts.

# publications[].label
The effect of resistance exercise on in vivo-derived tomography measures and mechanical properties of rodent bone: Is more load always better?

# publications[].label
Effects of an ad libitum low-fat, high-carbohydrate diet on body weight, body composition, and fat distribution in older men and women: a randomized controlled trial.

# publications[].label
The Effect of Choline and Resistance Training on Strength and Lean Mass in Older Adults.

# publications[].label
The effects of hindlimb unloading versus dietary cholesterol and resistance training on rat skeletal muscle responses.

# publications[].label
Insulin stimulation of protein synthesis in rat skeletal muscle following resistance exercise is maintained with advancing age.

# publications[].label
Plateau effects of resistance exercise result from overexpression of eIF4EBP1

# publications[].label
Effects of an ad libitum, high carbohydrate diet and aerobic exercise training on insulin action and muscle metabolism in older men and women.

# publications[].label
Regulators of blood lipids and lipoproteins? PPAR and AMPK, induced by exercise, are correlated with lipids and lipoproteins in overweight/obese men and women.

# publications[].label
Regulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation

# publications[].label
mTOR is a Mechanistic Target of Muscle and Cancer Cross-Talk with Exercise

# publications[].label
Acute resistance exercise augments integrative myofibrillar protein synthesis.

# publications[].label
Peroxisome proliferator-activated receptors delta content is increased and associated with altered serum lipid profile with resistance exercise training

# publications[].label
PGC-14 gene expression is suppressed by the IL-6-MEK-ERK 1/2 MAPK signalling axis and altered by resistance exercise, obesity and muscle injury.

# publications[].label
Changes in Body Composition with Six Weeks of Resistance Training

# publications[].label
Regulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation.

# publications[].label
Autophagy Is Required For Mtor Mediated Anabolism In Skeletal Muscle

# publications[].label
Distinct regulation of bone and muscle maintenance during hindlimb suspension by a concentric resistance exercise regimen

# publications[].label
Insulin action on rates of muscle protein synthesis following eccentric, muscle-damaging exercise

# publications[].label
Canonical Mitochondrial Biogenesis And Mitochondrial Translation Following Multiple Bouts Of Disuse

# publications[].label
Acute insulin is not necessary for post exercise elevations of muscle protein synthesis after 5 weeks of resistance exercise training

# publications[].label
Insulin resistance syndrome blunts the mitochondrial anabolic response following resistance exercise.

# publications[].label
Single muscle fibre contractile properties in young and old men and women.

# publications[].label
Effect of Electrical Pulse Stimulation on Anabolic Signaling in L6 Myotubes

# publications[].label
Increased resistance during jump exercise does not enhance cortical bone formation.

# publications[].label
Insulin facilitation of muscle protein synthesis following resistance exercise in hindlimb-suspended rats is independent of a rapamycin-sensitive pathway.

# publications[].label
The effect of vivo-Morpholinos on Dopamine Receptor 1 (Drd1) and physical activity in mice

# publications[].label
Insulin stimulation of muscle protein synthesis in obese Zucker rats is not via a rapamycin-sensitive pathway.

# publications[].label
Effects of age on insulin-stimulated rates of protein synthesis after resistance exercise in rats.

# publications[].label
Impact of chronic voluntary resistance training during recovery following hindlimb unloading on rat hindlimb muscles

# publications[].label
Anabolic Characterization Of Immortalized Murine L6, And Canine Myok9 Skeletal Myotubes

# publications[].label
The assessment of in vivo protein synthesis following chronic resistance exercise using 2H2O

# publications[].label
Cumulative responses of muscle protein synthesis are augmented with chronic resistance exercise training.

# publications[].label
Skeletal Muscle PGF2and PGE2 in Response to Eccentric Resistance Exercise: Influence of Ibuprofen and Acetaminophen

# publications[].label
Acute and chronic safety and efficacy of dose dependent creatine nitrate supplementation and exercise performance.

# publications[].label
Effect of exercise training on in vivo insulin-stimulated glucose uptake in intra-abdominal adipose tissue in rats.

# publications[].label
Anabolic responses to acute and chronic resistance exercise are enhanced when combined with aquatic treadmill exercise.

# publications[].label
Augmented insulin action on rates of protein synthesis after resistance exercise in rats.

# publications[].label
Use of deuterium oxide (2H2O) to assess muscle protein synthesis in juvenile red drum (Sciaenops ocellatus) fed complete, and valine-deficient diets.

# publications[].label
Lower Choline Intake is Associated with Diminished Strength and Lean Mass Gains in Older Adults

# publications[].label
The Insulin-Facilitated Increase of Muscle Protein Synthesis after Resistance Exercise Involves a MAP-Kinase Pathway

# publications[].label
Resistance training using eccentric overload induces early adaptations in skeletal muscle size.

# publications[].label
Myokines derived from contracting skeletal muscle suppress anabolism in MCF7 breast cancer cells by inhibiting mTOR.

# publications[].label
Effects of resistance exercise on glucose tolerance in normal and glucose-intolerant subjects.

# publications[].label
Active involvement of PKC for insulin-mediated rates of muscle protein synthesis in Zucker rats.

# publications[].label
Effect of combined fish oil & Curcumin on murine skeletal muscle morphology and stress response proteins during mechanical unloading.

# publications[].label
Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner.

# publications[].label
The Effects of Choline Intake and Resistance Exercise Training on Strength Gains in Older Adults

# publications[].label
Insulin stimulation of muscle protein synthesis in obese Zucker rats is not via a rapamycin-sensitive pathway

# publications[].label
Interorgan Metabolism of Amino Acids in Human Health and Disease.

# publications[].label
Effect of exercise training on in vivo lipolysis in intra-abdominal adipose tissue in rats

# publications[].label
Insulin stimulation of muscle protein synthesis in obese Zucker rats is not via a rapamycin-sensitive pathway.

# publications[].label
Pinitol supplementation does not affect insulin-mediated glucose metabolism and muscle insulin receptor content and phosphorylation in older humans.

# publications[].label
Fiber Type-Dependent Suppression of Myocellular Anabolic Response in the Obese Zucker Rat

# publications[].label
Effect of resistance exercise training on cortical and cancellous bone in mature male rats.

# publications[].label
Cumulative Muscle Protein Synthesis and Protein Intake Requirements.

# publications[].label
The influence of chronic IL-6 exposure, in vivo, on rat Achilles tendon extracellular matrix.

# publications[].label
Mitochondrial Translation Elongation Limits Mitochondrial Biogenesis In The Obese Response To Resistance Exercise

# publications[].label
Comparisons of vegetarian and beef-containing diets on hematological indexes and iron stores during a period of resistive training in older men.

# publications[].label
Elevations in Myofibrillar Protein Fractional Synthesis Rates Following 5-Weeks of Dynamic Resistance Exercise

# publications[].label
Influence of sibutramine on energy expenditure in African-Americans

# publications[].label
REDUCED SKELETAL MUSCLE MASS IN MODERATELY DIABETIC RATS IS PARTIALLY RESTORED BY RESISTANCE EXERCISE

# publications[].label
Combined effects of heavy ion exposure and simulated Lunar gravity on skeletal muscle.

# publications[].label
A rat resistance exercise regimen attenuates losses of musculoskeletal mass during hindlimb suspension.

# publications[].label
Effect of flywheel-based resistance exercise on processes contributing to muscle atrophy during unloading in adult rats.

# publications[].label
Insulin signaling in sedentary human skeletal muscle via PI3K is necessary for protein synthesis

# publications[].label
A comparison of 2H2O and phenylalanine flooding dose to investigate muscle protein synthesis with acute exercise in rats.

# publications[].label
Mechanisms associated with hypoxia- and contraction-mediated glucose transport in muscle are fibre-dependent.

# publications[].label
Distinct regulation of bone and muscle maintenance during hindlimb suspension by concentric and eccentric exercise.

# publications[].label
microRNA-16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion.

# publications[].label
Aquatic treadmill training reduces blood pressure reactivity to physical stress.

# publications[].label
The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle.

# publications[].label
Regulation of mitochondrial quality following repeated bouts of hindlimb unloading.

# publications[].label
Elucidating the Role of DEPTOR in Cultured Glioblastoma Multiforme Cancer Cells

# publications[].label
A novel approach for assessing protein synthesis in channel catfish, Ictalurus punctatus.

# publications[].label
Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity.

# publications[].label
Anabolic Characterization Of Immortalized Murine L6, And Canine Myok9 Skeletal Myotubes

# publications[].label
Impact of prolonged mechanical ventilation on diaphragmatic protein synthesis

# publications[].label
Augmented insulin action on rates of protein synthesis after resistance exercise in rats

# publications[].label
Effect of exercise training on in vivo lipolysis in intra-abdominal adipose tissue in rats.

# publications[].label
Gene Expression Of Novel Regulators Of Skeletal Muscle Hypertrophy In Obesity: PGC-14 And Deptor

# publications[].label
Greater gains in strength and power with intraset rest intervals in hypertrophic training.

# publications[].label
Active involvement of PKC for insulin-mediated rates of rat muscle protein synthesis

# publications[].label
Regulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation

# publications[].label
Attenuated insulin action on glucose uptake and transport in muscle following resistance exercise in rats.

# publications[].label
Short Term High Intensity Resistance Exercise-induced Muscle Soreness Is Attenuated with Dietary Cholesterol

# publications[].label
Influence of Mechanistic Target of Rapamycin (mTOR)-Regulated Anabolic Pathways on Equine Skeletal Muscle Health.

# publications[].label
Insulin-facilitated increase of muscle protein synthesis after resistance exercise involves a MAP kinase pathway.

# publications[].label
Low dose X-ray but not silicon radiation exposure can exacerbate cancellous bone loss during partial weightbearing

# publications[].label
Reply to letter to the editor: to D2O or not to D2O? What are the reasons we D2O it at all?

# publications[].label
Partial or Complete Unloading of Skeletal Muscle Leads to Specific Alterations of Anabolic Signal Transduction

# publications[].label
Pancreatic islet insulin secretion is increased after resistance exercise in rats.

# publications[].label
Blood Lipid is Associated with Skeletal Muscle PPAR Protein Content after a 10-week Resistance Exercise Training

# publications[].label
Insulin action on rates of muscle protein synthesis following eccentric, muscle-damaging contractions.

# publications[].label
Nuclear translocation of EndoG at the initiation of disuse muscle atrophy and apoptosis is specific to myonuclei.

# publications[].label
Characterization of Protein Metabolism in Undifferentiated and Differentiated Murine Muscle Tissue

# publications[].label
Effect of exercise training on in vivo insulin-stimulated glucose uptake in intra-abdominal adipose tissue in rats

# publications[].label
A novel approach to hind limb suspension in mature rats

# publications[].label
Augmented insulin action on rates of protein synthesis after resistance exercise in rats

# publications[].label
Fluid snacks to help persons with type 1 diabetes avoid late onset postexercise hypoglycemia.

# publications[].label
Hypertrophy of skeletal muscle in diabetic rats in response to chronic resistance exercise.

# publications[].label
Human soleus and vastus lateralis muscle protein metabolism with an amino acid infusion

# publications[].label
microRNAs In Skeletal Muscle and Their Response to Resistance Exercise in Insulin Resistant Diabetes

# publications[].label
Cover Image, Volume 117, Number 8, August 2016.

# publications[].label
Skeletal muscle myosin and actin content with aging

# publications[].label
Partial Support Ventilation and Mitochondrial-Targeted Antioxidants Protect against Ventilator-Induced Decreases in Diaphragm Muscle Protein Synthesis.

# publications[].label
Human soleus and vastus lateralis muscle protein metabolism with an amino acid infusion.

# publications[].label
Obese Zucker rats exhibit insulin sensitivity with respect to rates of protein synthesis.

# publications[].label
Effect of Eukarion-134 on Akt-mTOR signalling in the rat soleus during 7days of mechanical unloading.

# publications[].label
A buffered form of creatine does not promote greater changes in muscle creatine content, body composition, or training adaptations than creatine monohydrate.

# publications[].label
MCF7 Human Breast Cancer Cells Engineered to Stably Overexpress DEPTOR via CRISPR/Cas9 to Reduce Anabolic Capacity

# publications[].label
Effect of various levels of dietary starch on glycogen replenishment in the light working horse

# publications[].publisher
American Registry of Professional Animal Scientists

# publications[].label
Acute Resistance Exercise Augments Cumulative Myofibrillar, But Not Mixed Muscle Protein Synthesis

# publications[].label
Estimation of rat muscle blood flow by microdialysis probes perfused with ethanol, [14C]ethanol and 3H2O.

# researcherOn[].label
Upstream Regulation of Nox2 and Skeletal Muscle Atrophy During Microgravity and Countermeasure Development

# researcherOn[].awardedBy.label
Ames Research Center - (Mountain View, California, United States)

# researcherOn[].label
Redox Regulation of Nnos Translocation and Muscle Atrophy During Mechanical Unloading

# researcherOn[].awardedBy.label
Ames Research Center - (Mountain View, California, United States)

# researcherOn[].label
Pre-Treatment Approaches for Improving the Response of Bone to Disuse and Recovery -

# researcherOn[].awardedBy.label
National Aeronautics and Space Administration - (Washington D.C., District of Columbia, United States)

# streetAddress
Texas A&M University; Health And Kinesiology; 4243 TAMU

# organizations[]
College of Education and Human Development

# schools[]
College of Education and Human Development