# overview
Our research interest is biomolecular engineering for applications in health, agriculture, and energy. The research themes include discovery of biological molecules involved in microbe- and host-microbe interactions, elucidating the biosynthesis of bioactive molecules, and harnessing the knowledge to design bio-based systems for diagnostics and treatment. To advance our research, we use principles in microbiology, molecular biology, biochemistry, analytical chemistry, protein engineering, metabolic engineering, as well as emerging tools in chemical biology and synthetic biology.

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4007 Control Engineering, Mechatronics And Robotics

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University of California, Berkeley - (Berkeley, California, United States)

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Tools for investigation of the RNA endonuclease activity of mammalian Argonaute2 protein.

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Conjugative type IV secretion systems enable bacterial antagonism that operates independently of plasmid transfer.

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Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning.

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A fluorogenic screening platform enables directed evolution of an alkyne biosynthetic tool.

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Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning

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An electrochemical biosensor for clenbuterol detection and pharmacokinetics investigation.

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Characterization of AntB, a promiscuous acyltransferase involved in antimycin biosynthesis.

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Identification of Gut Bacterial Enzymes for Keto-Reductive Metabolism of Xenobiotics.

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Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidase.

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Proceedings of the National Academy of Sciences

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Specific residues and conformational plasticity define the substrate specificity of short-chain dehydrogenases/reductases.

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Research on Autonomous Navigation of Two Wheel-leg Robot in Indoor Dynamic Environment

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Association for Computing Machinery (ACM)

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Biosynthesis of antimycins with a reconstituted 3-formamidosalicylate pharmacophore in Escherichia coli.

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Identifying the Minimal Enzymes Required for Biosynthesis of Epoxyketone Proteasome Inhibitors.

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Biosynthesis of isonitrile lipopeptides by conserved nonribosomal peptide synthetase gene clusters in Actinobacteria.

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Proceedings of the National Academy of Sciences

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Terminal Alkyne Biosynthesis in Marine Microbes.

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Probing the Acyl Carrier Protein-Enzyme Interactions within Terminal Alkyne Biosynthetic Machinery.

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De novo biosynthesis of terminal alkyne-labeled natural products.

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Substrate-Triggered Formation of a Peroxo-Fe2(III/III) Intermediate during Fatty Acid Decarboxylation by UndA.

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Polyethylene Degradation by a Rhodococcous Strain Isolated from Naturally Weathered Plastic Waste Enrichment.

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Investigation of secondary metabolism in the industrial butanol hyper-producer Clostridium saccharoperbutylacetonicum N1-4.

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An E. coli-Based Biosynthetic Platform Expands the Structural Diversity of Natural Benzoxazoles.

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Bacterial Genome Mining of Enzymatic Tools for Alkyne Biosynthesis.

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Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications.

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Interaction between curcumin and mimetic biomembrane.