# overview
The overarching theme of my research is to design patient-specific and digital microengineered models of cardiovascular and hematologic diseases (such as, atherosclerosis) for enabling basic scientific discoveries and the advancement of precision and personalized healthcare.

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3201 Cardiovascular Medicine And Haematology

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0914 Resources Engineering And Extractive Metallurgy

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1.1 Normal Biological Development And Functioning

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4606 Distributed Computing And Systems Software

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1.1 Normal Biological Development And Functioning

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5 Development Of Treatments And Therapeutic Interventions

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3201 Cardiovascular Medicine And Haematology

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3201 Cardiovascular Medicine And Haematology

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3201 Cardiovascular Medicine And Haematology

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5 Development Of Treatments And Therapeutic Interventions

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3201 Cardiovascular Medicine And Haematology

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Growth Hormone Secretagogue Receptor (ghsr)

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Boston University - (Boston, Massachusetts, United States)

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Boston University - (Boston, Massachusetts, United States)

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Arizona State University - (Tempe, Arizona, United States)

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Indian Institute of Technology Delhi - (New Delhi, India)

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Rare Blood Cell Separation on a Microfluidic Platform: A Case Study of Circulating Tumor Cells

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Abstract 529: Assessing Hemostasis and Platelet Function Using a Microfluidic Device Lined with Fixed Human Endothelium

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Particle dispersion and separation resolution of pinched flow fractionation.

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LymphangionChip Experimental Platform Supports Coculture and Signaling Between Lymphatic Endothelial and Mural Cells

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Tortuosity-powered microfluidic device for assessment of thrombosis and antithrombotic therapy in whole blood.

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A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling.

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Evaluation of the Morphological and Biological Functions of Vascularized Microphysiological Systems with Supervised Machine Learning.

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Generalizing hydrogel microparticles into a new class of bioinks for extrusion bioprinting.

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American Association for the Advancement of Science (AAAS)

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Multiscale modeling of vascular pathophysiology using 3d bioprinting

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R-PF: Enhancing Service Regularity for Legacy Scheduling Policy

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Institute of Electrical and Electronics Engineers (IEEE)

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A Chemical APC Mimetic Protects Endothelium from Thromboinflammatory Injury

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The prospects of microphysiological systems in modeling platelet pathophysiology in cancer.

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Flow analysis in a model can-type gas turbine combustor

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Evaluation of the morphological and biological functions of vascularized microphysiological systems with supervised machine learning.

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Vascular Transcriptomics: Investigating Endothelial Activation and Vascular Dysfunction Using Blood Outgrowth Endothelial Cells, Organ-Chips, and RNA Sequencing.

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Human tumor microenvironment chip evaluates the consequences of platelet extravasation and combinatorial antitumor-antiplatelet therapy in ovarian cancer.

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American Association for the Advancement of Science (AAAS)

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Thromboresistance of Silicones Modified with PEO-Silane Amphiphiles.

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Engineering Lymphangiogenesis-On-Chip: The Independent and Cooperative Regulation by Biochemical Factors, Gradients, and Interstitial Fluid Flow.

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Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems.

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Tripartite collaboration of blood-derived endothelial cells, next generation RNA sequencing and bioengineered vessel-chip may distinguish vasculopathy and thrombosis among sickle cell disease patients.

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Reevaluating Anti-Inflammatory Therapy: Targeting Senescence to Balance Anti-Cancer Efficacy and Vascular Disease.

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Ovid Technologies (Wolters Kluwer Health)

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In silico analyses of blood flow and oxygen transport in human micro-veins and valves.

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Electrically stimulated gene expression under exogenously applied electric fields.

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Microengineered Human Vein-Chip Recreates Venous Valve Architecture and its Contribution to COVID-19-induced Thrombosis

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A machinelearned microvasculature optimizes physiological insulin secretion in a vascularized pancreaschip

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A microdevice for rapid optical detection of magnetically captured rare blood pathogens.

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Mitigating Vascular Inflammation by Mimicking AIBP Mechanisms: A New Therapeutic End for Atherosclerotic Cardiovascular Disease.

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3D Bioprinted Multicellular Vascular Models.

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AngioMT: A MATLAB based 2D image-to-physics tool to predict oxygen transport in vascularized microphysiological systems.

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Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium.

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2D Nanosilicate for additive manufacturing: Rheological modifier, sacrificial ink and support bath

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Microengineered Human Vein-Chip Recreates Venous Valve Architecture and Its Contribution to Thrombosis.

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Granular Biphasic Colloidal Hydrogels for 3D Bioprinting.

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Intracellular calcium dynamics of lymphatic endothelial and muscle cells co-cultured in a Lymphangion-Chip under pulsatile flow.

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Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics.

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Mechanotransduction-on-chip: vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response.

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Engineered models of the lymphatic vascular system: Past, present, and future.

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Vascular architecture-on-chip: engineering complex blood vessels for reproducing physiological and heterogeneous hemodynamics and endothelial function.

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Lymphangion-chip: a microphysiological system which supports co-culture and bidirectional signaling of lymphatic endothelial and muscle cells.

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Self-Oscillating 3D Printed Hydrogel Shapes

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Chapter 9 Organ-on-a-chip and 3D printing as preclinical models for medical research and practice

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Abstract 11425: Vascular Organ-Chips Made from Blood

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Hemorheology and pathophysiology of COVID-19 induced thrombosis predicted by Vein- Chip

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Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models.

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American Association for the Advancement of Science (AAAS)

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Abstract 111: Vein-Chip Is A New Experimental Model To Predict Pathophysiology Of SARS-CoV-2 Induced Thrombosis

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Biomimetic postcapillary expansions for enhancing rare blood cell separation on a microfluidic chip.

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A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function.

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Machine learning chained neural network analysis of oxygen transport amplifies the physiological relevance of vascularized microphysiological systems.

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Engineering "Endothelialized" Microfluidics for Investigating Vascular and Hematologic Processes Using Non-Traditional Fabrication Techniques.

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Transforming Growth Factors in Venous Thrombus Formation and Resolution.

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Ovid Technologies (Wolters Kluwer Health)

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An Innate YAP/TAZ Mechanosensing Deficit in Hutchinson-Gilford Progeria Syndrome

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Abstract 342: Analysis of Mechanism of a Novel Drug Candidate using an Organ-level Functional Microdevice that Reconstitutes Human Pulmonary Thrombosis

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OvCa-Chip microsystem recreates vascular endothelium-mediated platelet extravasation in ovarian cancer.

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Determinants of Leukocyte Margination in Rectangular Microchannels

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Emerging trends in multiscale modeling of vascular pathophysiology: Organ-on-a-chip and 3D printing.

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Next generation personalized blood vesselonchip: Mimicking patientspecific pathophysiology in sickle cell disease through bloodderived endothelial progenitors

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Thromboresistance of Polyurethanes Modified with PEO-Silane Amphiphiles.

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Determinants of leukocyte margination in rectangular microchannels.

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Impulsive stimulated Brillouin spectroscopy for non-invasive microfluidic-based viscoelastic measurements in vitro

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SPIE, the international society for optics and photonics

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Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips.

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Engineering and Evaluating Vascularized Organotypic Spheroids On-Chip.

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PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury.

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Proceedings of the National Academy of Sciences

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Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for Endotheliopathy.

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Houston Methodist DeBakey Heart & Vascular Center

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GHSR Deletion in -Cells of Male Mice: Ineffective in Obesity, but Effective in Protecting against Streptozotocin-Induced -Cell Injury in Aging.

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AngioMT: An in silico platform for digital sensing of oxygen transport through heterogenous microvascular networks.

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Thrombosis-on-a-chip: Prospective impact of microphysiological models of vascular thrombosis.

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Comparative Analysis of Blood-Derived Endothelial Cells for Designing Next-Generation Personalized Organ-on-Chips.

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CAREER: Modeling human veins and venous pathology with organ-on-chip engineering for basic, translational and educational research

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Directorate for Engineering - (Arlington, Virginia, United States)

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An artery-on-a-chip containing blood outgrowth endothelium as a model of vaso-occlusion and drug testing in sickle cell disease

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National Institutes of Health - (Bethesda, Maryland, United States)

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DHHS-NIH-National Institute of BioMedical Imaging and BioEngineering

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Determinants of COVID19-induced venous thrombosis and targeted therapy assessed with bioengineered vein-chip

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National Heart Lung and Blood Institute - (Bethesda, Maryland, United States)

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Texas A&M University; Biomedical Engineering; 3120 TAMU

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Doctoral Student Finds Alternative Cell Option For Organs-On-Chips

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Researchers Find New Way To Detect Blood Clots

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Texas A&M Researchers Explore Connections Between Ovarian Cancer And Blood Cells

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Biomedical Engineering Assistant Professor Recognized With NSF CAREER Award

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Researchers Go To The Source To Find New Tools To Treat Vascular Diseases

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A&M researchers developing new tools to fight ovarian cancer