# overview
At the Yan lab, we seek to develop and apply novel mass spectrometric methodologies in disease diagnosis, reaction monitoring, and development of new synthetic methods. In particular, we are motivated by the possibility of enabling new technology for next-generation approaches to precision medicine, and sustainable synthesis.

Our research interests span a range of topics, including i) metabolomics in brain research: we couple dual imaging modality (mass spectrometry imaging and fluorescence imaging) with liquid chromatography mass spectrometry to discover biomarkers and elucidate their biological mechanism in brain aging and brain cancer research. ii) point-of-care diagnostics: we are interested in the development of ambient ionization for fast analysis of enzymatic biomarkers, as well as the design and development of the interface to mini-mass spectrometer (mini-MS) for point-of-care diagnosis. iii) microdroplet reaction: mass spectrometry is universally considered as an analytical tool, however, its new feature was discovered: its use as a unique tool in synthesis. The uniqueness represents in its capabilities of dramatical acceleration of organic reactions and the driving of reactions that cannot occur in bulk. We aim to develop microdroplet reactors for acceleration, explore new reactivity, and study fundamentals of microdroplet acceleration. iv) reaction mechanistic study: reaction mechanisms play an essential role in the study of organic chemistry. We aim to develop new online mass spectrometric reaction monitoring system to explore unknown reaction mechanism, capture short-lived intermediates, study kinetics of fast reactions, and control process of active pharmaceutical ingredient (API) synthesis. The central theme of all the topics above is about droplet chemistry.

This lab is a highly interdisciplinary research group. It provides students the opportunity to obtain hands-on experience in analytical, biological and synthetic chemistry.

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3403 Macromolecular And Materials Chemistry

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3205 Medical Biochemistry And Metabolomics

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Alzheimer's Disease Including Alzheimer's Disease Related Dementias (ad/adrd)

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Ambient Corona Discharge Ionization Mass Spectrometry

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3205 Medical Biochemistry And Metabolomics

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3205 Medical Biochemistry And Metabolomics

# keywords[]
3205 Medical Biochemistry And Metabolomics

# educationAndTraining[].organization.label
Purdue University - (West Lafayette, Indiana, United States)

# educationAndTraining[].organization.label
Purdue University - (West Lafayette, Indiana, United States)

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Faculty Early Career Development (CAREER) Program

# publications[].label
Characterization of glycerophospholipids at multiple isomer levels via Mn(II)-catalyzed epoxidation.

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Chemoselective N-Alkylation of Indoles in Aqueous Microdroplets.

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Voltage-Controlled Divergent Cascade of Electrochemical Reactions for Characterization of Lipids at Multiple Isomer Levels Using Mass Spectrometry.

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Optical imaging of tumors with copper-labeled rhodamine derivatives by targeting mitochondria.

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Efficient and Selective Photogeneration of Stable N-Centered Radicals via Controllable Charge Carrier Imbalance in Cesium Lead Halide Nanocrystals.

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Recent Advances of In-Source Electrochemical Mass Spectrometry.

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Interfacial Electromigration for Analysis of Biofluid Lipids in Small Volumes.

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Mass Spectrometry in Organic Synthesis: Claisen-Schmidt Base-Catalyzed Condensation and Hammett Correlation of Substituent Effects

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OnDemand Electrochemical Epoxidation in NanoElectrospray Ionization Mass Spectrometry to Locate CarbonCarbon Double Bonds

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Emerging microdroplet chemistry for synthesis and analysis

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Lipid Mass Tags via Aziridination for Probing Unsaturated Lipid Isomers and Accurate Relative Quantification**

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Simultaneous Characterization of Lipid sn-Positional and Double-Bond Positional Isomers using On-Demand Electrochemical Mass Spectrometry

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Online Inductive Electrospray Ionization Mass Spectrometry as a Process Analytical Technology Tool To Monitor the Synthetic Route to Anagliptin

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Ambient Ionization Mass Spectrometry Measurement of Aminotransferase Activity.

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Dissecting Hidden Liraglutide Oligomerization Pathways via Direct Mass Technology, Electron-Capture Dissociation, and Molecular Dynamics.

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The Role of the Interface in Thin Film and Droplet Accelerated Reactions Studied by Competitive Substituent Effects

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Unveiling the Hidden: Dissecting Liraglutide Oligomerization Dual Pathways via Direct Mass Technology, Electron-Capture Dissociation, and Molecular Dynamics

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Aziridination-Assisted Mass Spectrometry of Nonpolar Sterol Lipids with Isomeric Resolution.

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Revealing Anisotropic Growth of Liraglutide Oligomers by Native Ion Mobility Mass Spectrometry and Molecular Dynamics Simulation

# publications[].publisher
International Union of Crystallography (IUCr)

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On-line chiral analysis using the kinetic method.

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International Union of Crystallography (IUCr)

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Chemoselective NAlkylation of Indoles in Aqueous Microdroplets

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The Role of the Interface in Thin Film and Droplet Accelerated Reactions Studied by Competitive Substituent Effects.

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Mass Spectrometry for Synthesis and Analysis.

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Bifunctional Tagging through N-Doped Ozonide for Charge Switching and Isomeric Characterization of Glycerophospholipids Using Tandem Mass Spectrometry.

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Chemical Reactivity Assessment Using Reactive Paper Spray Ionization Mass Spectrometry: The Katritzky Reaction.

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Functionalization of saturated hydrocarbons using nitrogen ion insertion reactions in mass spectrometry

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Mass spectrometry distinguishing C=C location and cis/trans isomers: A strategy initiated by water radical cations.

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Scanning Electrochemical Cell Microscopy for Sub-Micrometer Mass Spectrometric Studies of Electrochemical Reactions

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Two New Devices for Identifying Electrochemical Reaction Intermediates with Desorption Electrospray Ionization Mass Spectrometry.

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Incorporating Electro-Epoxidation into Electrospray Ionization Mass Spectrometry for Simultaneous Analysis of Negatively and Positively Charged Unsaturated Glycerophospholipids.

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Interfacial Electromigration for Accelerated Reactions and Small-Volume Analysis

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Mechanisms for the free volume tuning the mechanical properties of metallic glass through ion irradiation

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Interfacial Electro-Epoxidation in Electrospray Ionization Mass Spectrometry for Simultaneous Analysis of Negatively and Positively Charged Unsaturated Glycerophospholipids

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Accelerated Reaction Kinetics in Microdroplets: Overview and Recent Developments.

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Unexpected rearrangement in the reaction of 7-mercapto-4-methylcoumarin with 1-mono- and 1,1-dimethyl propargyl alcohols

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Inhibition of Subunit Exchange and N-Finger Rearrangement in SARS-CoV-2 Main Protease by Peptidomimetic Inhibitors

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Characterization of lipid carbon-carbon double-bond isomerism via ion mobility-mass spectrometry (IMS-MS) combined with cuprous ion-induced fragmentation.

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Magnifying Minds: Exploring the Concepts of Size and Scale with a Public Mural and Integrated Activities

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Selective Synthesis in Microdroplets of 2-Phenyl-2,3-dihydrophthalazine-1,4-dione from Phenyl Hydrazine with Phthalic Anhydride or Phthalic Acid.

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Beyond the flask: Reactions on the fly in ambient mass spectrometry

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Two-Phase Reactions in Microdroplets without the Use of Phase-Transfer Catalysts.

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Bifunctional Tagging Through N-doped Ozonide for Charge Switch-ing and Isomeric Characterization of Glycerophospholipids Using Tandem Mass Spectrometry

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Cell-Type-Specific Metabolic Profiling Achieved by Combining Desorption Electrospray Ionization Mass Spectrometry Imaging and Immunofluorescence Staining.

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Cyanine-Gemcitabine Conjugates as Targeted Theranostic Agents for Glioblastoma Tumor Cells.

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BRD4354 Is a Potent Covalent Inhibitor against the SARS-CoV-2 Main Protease.

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In situ droplet-based on-tissue chemical derivatization for lipid isomer characterization using LESA.

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On-Demand Electrochemical Epoxidation in Nano-Electrospray Ionization Mass Spectrometry to Locate Carbon-Carbon Double Bonds.

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64Cu-labeled lissamine rhodamine B: a promising PET radiotracer targeting tumor mitochondria.

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Colonic Dysregulation of Major Metabolic Pathways in Experimental Ulcerative Colitis.

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Interfacing High-Throughput Electrosynthesis and Mass Spectrometric Analysis of Azines.

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Lipid Isobaric Mass Tagging for Enhanced Relative Quantification of Unsaturated sn-Positional Isomers.

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Picomole-Scale Transition Metal Electrocatalysis Screening Platform for Discovery of Mild C-C Coupling and C-H Arylation through in Situ Anodically Generated Cationic Pd.

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On-line reaction monitoring and mechanistic studies by mass spectrometry: Negishi cross-coupling, hydrogenolysis, and reductive amination.

# publications[].label
Lipid Mass Tags via Aziridination for Probing Unsaturated Lipid Isomers and Accurate Relative Quantification.

# publications[].label
Lipid Isobaric Mass Tags via Aziridination for Probing Isomeric Structures and Accurate Quantification

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Dual Metal Electrolysis in Theta Capillary for Lipid Analysis.

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Early detection of unilateral ureteral obstruction by desorption electrospray ionization mass spectrometry.

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Organic Reactions in Microdroplets: Reaction Acceleration Revealed by Mass Spectrometry.

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A Novel Y-Shaped, S-O-N-O-S-Bridged Cross-Link between Three Residues C22, C44, and K61 Is Frequently Observed in the SARS-CoV-2 Main Protease.

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Can all bulk-phase reactions be accelerated in microdroplets?

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Preparative microdroplet synthesis of carboxylic acids from aerobic oxidation of aldehydes.

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Aziridination-assisted mass spectrometry of nonpolar lipids with isomeric resolution

# streetAddress
Texas A&M University; Chemistry; 3255 TAMU