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"name" : "Yan, Xin",
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"overview" : "At the Yan lab, we seek to develop and apply novel mass spectrometric methodologies in disease diagnosis, reaction monitoring, and development of new synthetic methods. In particular, we are motivated by the possibility of enabling new technology for next-generation approaches to precision medicine, and sustainable synthesis.
Our research interests span a range of topics, including i) metabolomics in brain research: we couple dual imaging modality (mass spectrometry imaging and fluorescence imaging) with liquid chromatography mass spectrometry to discover biomarkers and elucidate their biological mechanism in brain aging and brain cancer research. ii) point-of-care diagnostics: we are interested in the development of ambient ionization for fast analysis of enzymatic biomarkers, as well as the design and development of the interface to mini-mass spectrometer (mini-MS) for point-of-care diagnosis. iii) microdroplet reaction: mass spectrometry is universally considered as an analytical tool, however, its new feature was discovered: its use as a unique tool in synthesis. The uniqueness represents in its capabilities of dramatical acceleration of organic reactions and the driving of reactions that cannot occur in bulk. We aim to develop microdroplet reactors for acceleration, explore new reactivity, and study fundamentals of microdroplet acceleration. iv) reaction mechanistic study: reaction mechanisms play an essential role in the study of organic chemistry. We aim to develop new online mass spectrometric reaction monitoring system to explore unknown reaction mechanism, capture short-lived intermediates, study kinetics of fast reactions, and control process of active pharmaceutical ingredient (API) synthesis. The central theme of all the topics above is about droplet chemistry.
This lab is a highly interdisciplinary research group. It provides students the opportunity to obtain hands-on experience in analytical, biological and synthetic chemistry.",
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Structural)", "Carbon−carbon Double-bond Positions", "Ac-esi", "Interfacial Reaction", "Lipidomics", "Free Volume", "Nanoindentation", "Ion Irradiation", "Metallic Glass", "Propargyl Alcohol", "Beta-(7-coumarinthio)ketone", "7-mercapto-4-methylcoumarin", "Rearrangement", "Ion Solvation", "Electrospray Ionization", "Reaction Acceleration", "Interfacial Reactions", "Mass Spectrometry", "Collision Cross Section", "Lipid C=c Bond Isomers", "Cuprous Ion -induced Dissociation", "Ion Mobility", "Mass Spectrometry", "Pyridazine", "Selective Synthesis", "Liquid Microdroplets", "Reaction Acceleration", "Mass Spectrometry", "Bond Activation", "Functionalization", "Organic Synthesis", "Reaction Intermediate", "Ambient Ionization", "Ion Chemistry", "Desorption", "Derivatization", "Electrospray", "Ionization", "3406 Physical Chemistry", "34 Chemical Sciences", "Stevens Oxidation", "Two-phase Reactions", "Phase-transfer Catalysis", "Liquid-liquid Reactions", "Microdroplet Synthesis", "Cell Line, Tumor", "Gemcitabine", "Animals", "Carbocyanines", "Humans", "Deoxycytidine", "Glioblastoma", "Tissue Distribution", "Drug Stability", "Cell Survival", "Antineoplastic Agents", "Female", "Theranostic Nanomedicine", "Transplantation, Heterologous", "Mice", "Mice, Nude", "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization", "Mice", "Neurons", "Spectrometry, Mass, Electrospray Ionization", "Prosencephalon", "Fluorescent Antibody Technique", "Animals", "Astrocytes", "Machine Learning", "Staining And Labeling", "Double Bonds", "Isomers", "Electrochemistry", "Mass Spectrometry", "Lipids", "Lipid Isomer", "Liquid Extraction Surface Analysis", "On-tissue Chemical Derivatization", "Droplet", "Mass Spectrometry", "0306 Physical Chemistry (incl. Structural)", "Cell Line, Tumor", "Molecular Structure", "Rhodamines", "Mice, Nude", "Chromatography, High Pressure Liquid", "Mitochondria", "Female", "Tumor Cells, Cultured", "Mice", "Animals", "Copper Radioisotopes", "Positron-Emission Tomography", "Humans", "Glioma", "Carbonyl Cyanide M-Chlorophenyl Hydrazone", "Reaction Intermediates", "Air-/moisture-sensitive Reactions", "Amination", "Cross-coupling", "Reaction Kinetics", "Palladium", "Mass Spectrometry", "Catalysis", "Glycerides", "Double Bond Positional Isomer", "Lipid Isomer", "Aziridination", "Isobaric Tag", "Lipid Quantification", "Cholesterol Esters", "Isomerism", "Aziridines", "Animals", "Mice", "Biomarkers", "Fatty Acids", "3205 Medical Biochemistry And Metabolomics", "3401 Analytical Chemistry", "34 Chemical Sciences", "32 Biomedical And Clinical Sciences", "3401 Analytical Chemistry", "34 Chemical Sciences", "Ureteral Obstruction", "Spectrometry, Mass, Electrospray Ionization", "Lipid Metabolism", "Lipids", "Biomarkers", "Kidney", "Mice, Inbred C57BL", "Early Diagnosis", "Animals", "Protease Inhibitors", "Viral Nonstructural Proteins", "Antiviral Agents", "Molecular Docking Simulation", "Covid-19", "Sars-cov-2", "Humans", "Spray-based Ionization", "Ambient Ionization", "Microdroplets", "Reaction Kinetics", "Mass Spectrometry", "0305 Organic Chemistry", "3401 Analytical Chemistry", "3406 Physical Chemistry", "34 Chemical Sciences", "0305 Organic Chemistry", "0399 Other Chemical Sciences", "0306 Physical Chemistry (incl. 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