# overview
Research is focused on the role of bioactive compounds in dairy products/by-products and botanicals with effects for prevention of chronic/inflammatory diseases using in vitro and in vivo models. Emphasis is on molecular mechanisms modulated by non-digestible bioactive compounds, partially through changes in intestinal bacteria.

Research projects look to integrate microbiome, metabolomics, and proteomics analyses to investigate the biological mechanisms influenced by dietary interventions and their correlations with end point biomarkers of obesity-related diseases including diabetes, cancer, and cardiovascular diseases. Research is funded by the Western Dairy Center, National Raspberry Council, Northwest Cherry Growers/ Washington State Fruit Commission, and Washington State Department of Agriculture.

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Clinical Trials And Supportive Activities

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Atp Binding Cassette Transporter, Subfamily B

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Atp Binding Cassette Transporter, Subfamily B, Member 1

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3 Prevention Of Disease And Conditions, And Promotion Of Well-being

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30 Agricultural, Veterinary And Food Sciences

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5 Development Of Treatments And Therapeutic Interventions

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1.1 Normal Biological Development And Functioning

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5 Development Of Treatments And Therapeutic Interventions

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5 Development Of Treatments And Therapeutic Interventions

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Stem Cell Research - Nonembryonic - Non-human

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5 Development Of Treatments And Therapeutic Interventions

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4.1 Discovery And Preclinical Testing Of Markers And Technologies

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6 Evaluation Of Treatments And Therapeutic Interventions

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Clinical Trials And Supportive Activities

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30 Agricultural, Veterinary And Food Sciences

# educationAndTraining[].organization.label
National Agrarian University - (Lima, Peru)

# educationAndTraining[].organization.label
National Agrarian University - (Lima, Peru)

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Texas A&M University - (College Station, Texas, United States)

# publications[].label
Dietary Supplementation with Raspberry Whole Fruit Modifies the Relative Abundance of Fecal Microbial Communities in Obese Diabetic (db/db) Mice

# publications[].label
Dark Sweet Cherry (Prunus avium) Phenolics Enriched in Anthocyanins Induced Apoptosis in MDA-MB-453 Breast Cancer Cells through MAPK-Dependent Signaling and Reduced Invasion via Akt and PLC-1 Downregulation.

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Jaboticaba (Myrciaria cauliflora) Peel Supplementation Prevents Hepatic Steatosis Through Hypolipidemic Effects and Cholesterol Metabolism Modulation in Diet-Induced Nonalcoholic Fatty Liver Disease Rat Model.

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Influence of whole-wheat consumption on fecal microbial ecology of obese diabetic mice

# publications[].label
Dark Sweet Cherry (DSC) Juice Consumption for Obesity-Related Inflammation and Cognitive Function in Obese Adults: A Human Clinical Pilot Trial

# publications[].label
Technical note: optimization of lactose quantification based on coupled enzymatic reactions.

# publications[].label
Commercial whey products promote intestinal barrier function with glycomacropeptide enhanced activity in downregulating bacterial endotoxin lipopolysaccharides (LPS)-induced inflammation in vitro.

# publications[].label
Antioxidant capacity and secondary metabolites in four species of Andean tuber crops: native potato (Solanum sp.), mashua (Tropaeolum tuberosum Ruiz & Pavon), Oca (Oxalis tuberosa Molina) and ulluco (Ullucus tuberosus Caldas)

# publications[].label
Calotropis Procera Induced Caspase-Dependent Apoptosis and Impaired Akt/mTOR Signaling in 4T1 Breast Cancer Cells.

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Anti-inflammatory activity of polyphenolics from aai (Euterpe oleracea Martius) in intestinal myofibroblasts CCD-18Co cells.

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Effect of genotype, maturity stage and post-harvest storage on phenolic compounds, carotenoid content and antioxidant capacity, of Andean mashua tubers (Tropaeolum tuberosum Ruiz & Pavon)

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Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10.

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Fractions of cottonseed and peanut extracts suppress the proliferation of human LNCaP and DU145 prostate carcinoma cells

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Wheat phenolics can prevent inflammation in human umbilical endothelial cells: effects on biomarkers relevant to development of cardiovascular diseases

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Phenolics from mango (Mangifera indica L.) suppress growth in different cancer cells, targeting pro-apoptotic and cell cycle control proteins

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Prebiotic effects of yacon (Smallanthus sonchifolius Poepp. & Endl), a source of fructooligosaccharides and phenolic compounds with antioxidant activity.

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Sacha inchi (Plukenetia volubillis L.) oil as novel source of dietary fat to prevent inflammation and cardiovascular disease risk

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Dark Sweet Cherry (Prunus avium) Anthocyanins Suppressed ERK1/2-Akt/mTOR Cell Signaling and Oxidative Stress: Implications for TNBC Growth and Invasion.

# publications[].label
Cottonseed and peanut extracts suppress the proliferation of human Caco-2 colon carcinoma cells and human DU145 prostate carcinoma cells

# publications[].label
Effects of Raspberry on Biomarkers of Diabetes, Cardiovascular Disease (CVD) and Oxidative Stress in Obese Diabetic (db/db) Mice

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Dark Sweet Cherry (Prunus avium) Anthocyanins Inhibited the Growth and Biomarkers for Breast Cancer Growth and Invasion in Highly Metastatic 4T1 Tumor Cells

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Standardized Curcuminoids Extract (Curcuma longa L.) Protects against inflammation in Human Umbilical Vein Endothelial Cells (HUVEC)

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Effect of dark sweet cherry powder consumption on the gut microbiota, short-chain fatty acids, and biomarkers of gut health in obese db/db mice.

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Flavonol-rich fractions of yaupon holly leaves (Ilex vomitoria, Aquifoliaceae) induce microRNA-146a and have anti-inflammatory and chemopreventive effects in intestinal myofibroblast CCD-18Co cells.

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Polyphenolic extracts from cowpea (Vigna unguiculata) protect colonic myofibroblasts (CCD18Co cells) from lipopolysaccharide (LPS)-induced inflammation--modulation of microRNA 126.

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Ripening of cheddar cheese with Lactobacillus helveticus as adjunct culture produces peptides that protect human vein endothelial cells against inflammatory markers relevant to cardiovascular disease

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STABILITY OF BETACYANIN PIGMENTS AND ANTIOXIDANTS IN AYRAMPO (OPUNTIA SOEHRENSII BRITTON AND ROSE) SEED EXTRACTS AND AS A YOGURT NATURAL COLORANT

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Effect of barley supplementation on the fecal microbiota, caecal biochemistry, and key biomarkers of obesity and inflammation in obese db/db mice.

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Health Benefits of Phytochemicals for Older Adults

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Ripened Cheddar Cheese Peptides Protect Human Vein Endothelial Cells (HUVEC) Against Expression Of Risk Markers For CVD: Role Of Paroaxonase-2 (PON-2) As Peptide Molecular Target

# publications[].label
Dietary Supplementation with Raspberry Extracts Modifies the Fecal Microbiota in Obese Diabetic db/db Mice.

# publications[].publisher
Korean Society for Microbiology and Biotechnology

# publications[].label
Molecular Mechanisms Involved in the Inhibition of MDA-MB-435 Breast Cancer Cells by Phenolic Acids from the Red Flesh Peach BY00P6653

# publications[].publisher
International Society for Horticultural Science (ISHS)

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Effects of quinoa (Chenopodium quinoa) consumption on fecal microbiome of obese diabetic (db/db) mice

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Turmeric curcuminoids (Curcuma longa L.) interacts with microRNAs in the regulation of inflammation on Human Umbilical Vein Endothelial Cells (HUVEC)

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Whole-Wheat Supplemented Diet Changed Fecal Microbial Ecology of Obese Diabetic Mice

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Polyphenolics from aa ( Euterpe oleracea Mart.) and red muscadine grape (Vitis rotundifolia ) protect human umbilical vascular Endothelial cells (HUVEC) from glucose- and lipopolysaccharide (LPS)-induced inflammation and target microRNA-126.

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The antiinflammatory effects of manniflavanone extracted from Garcinia buchananii bark in obesityinduced mice model (259.3)

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Red raspberry decreases heart biomarkers of cardiac remodeling associated with oxidative and inflammatory stress in obese diabetic db/db mice.

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Consumption of polyphenol-rich peach and plum juice prevents risk factors for obesity-related metabolic disorders and cardiovascular disease in Zucker rats.

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Potential of tara (Caesalpinia spinosa) gallotannins and hydrolysates as natural antibacterial compounds.

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Influence of whole-wheat consumption on fecal microbial community structure of obese diabetic mice.

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Identifying peach and plum polyphenols with chemopreventive potential against estrogen-independent breast cancer cells.

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Reduced expression of pro-invasive genes in xenographs of MDA-MB-231 breast cancer cells by Betulinic Acid is mediated by down-regulation of microRNA27a

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The Impact of Mushroom Polysaccharides on Gut Microbiota and Its Beneficial Effects to Host: A Review.

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Anticarcinogenic effects of polyphenolics from mango (Mangifera indica) varieties.

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Pro-apoptotic activities of polyphenolics from aai (Euterpe oleracea Martius) in human SW-480 colon cancer cells.

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Whole Wheat-supplemented Diet Prevents Risk Biomarkers of Cardiovascular Diseases in Obese Diabetic Mice

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Lepidium meyenii (maca) consumption prevent benign prostatic hyperplasia

# publications[].label
Assessing non-digestible compounds in apple cultivars and their potential as modulators of obese faecal microbiota in vitro.

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Dark Sweet Cherry (DSC) Juice Consumption for Obesity-Related Inflammation and Cognitive Function in Obese Adults: A Human Clinical Pilot Trial

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Health Benefits of Peach, Nectarine and Plums

# publications[].publisher
International Society for Horticultural Science (ISHS)

# publications[].label
Dark Sweet Cherry (Prunus Avium L.) Phenolics Induce Apoptosis and Inhibit Invasion on Breast Cancer MDA-MB-453 Through MAPK-dependent and Independent Pathways (P05-007-19)

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Andean yacon root (Smallanthus sonchifolius Poepp. Endl) fructooligosaccharides as a potential novel source of prebiotics.

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Effects of Polyphenolics from Grape (Vitis rotundifolia) and acai (Euterpe oleracea Mart.) on the expresion of microRNAs relevant to inflammation in vascular diseases

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Quinoa intake reduces plasma and liver cholesterol, lessens obesity-associated inflammation, and helps to prevent hepatic steatosis in obese db/db mouse.

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Antitumor potential of dark sweet cherry sweet (Prunus avium) phenolics in suppressing xenograft tumor growth of MDA-MB-453 breast cancer cells.

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Dark Sweet Cherry phenolics as Dietary Chemopreventive/therapeutic Compounds for Aggressive Breast Cancer Cell Growth with No Toxicity to Normal Breast Cells (FS13-03-19)

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Anthocyanins Enriched Dark Sweet Cherry (Prunus Avium) Juice Extract Suppressed 4T1 Tumor Cell Growth and Invasive Potential

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Human gene expression as a tool to determine horticultural maturity in a bioactive plant (Echinacea purpurea L. Moench).

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Non-anthocyanin phenolics in cherry (Prunus avium L.) modulate IL-6, liver lipids and expression of PPAR and LXRs in obese diabetic (db/db) mice.

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Apple Consumption Protects Sprague Dawley Rats Against High Fat Diet-induced Metabolic Disorders Associated With Obesity

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Calotropis procera Selectively Impaired the 4T1 Breast Cancer Cells Growth by Preferentially Blocking Akt/mTOR Signaling

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Gallotannin derivatives from mango (Mangifera indica L.) suppress adipogenesis and increase thermogenesis in 3T3-L1 adipocytes in part through the AMPK pathway

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Chemopreventive Potential of DSC Anthocyanins and Total Phenolics Extracted from Dark Sweet Cherry (DSC) Through Modulation of MDA-MB-453 Breast Tumor Proteomic Profile

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The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis.

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Tropaeolum tuberosum (mashua) extracts suppress tumor cell proliferation

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Chemopreventive Potential of DSC Anthocyanins and Total Phenolics Extracted from Dark Sweet Cherry (DSC) Through Modulation of MDA-MB-453 Breast Tumor Proteomic Profile

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Potential of glycated proteins produced during aging of cheddar cheese to modulate fecal bacteria from obese mice ex vivo and protect against colon inflammation

# publications[].label
Dark Sweet Cherry (Prunus avium) Supplementation Reduced Blood Pressure and Pro-Inflammatory Interferon Gamma (IFN) in Obese Adults without Affecting Lipid Profile, Glucose Levels and Liver Enzymes.

# publications[].label
Dark Sweet Cherry (DSC) Intake and Cognitive Function in Obese Adults: A Human Clinical Pilot Trial

# publications[].label
Dark Sweet Cherry (Prunus avium) Anthocyanins Inhibited the Growth and Biomarkers for Breast Cancer Growth and Invasion in Highly Metastatic 4T1 Tumor Cells

# publications[].label
Different analysis strategies of 16S rRNA gene data from rodent studies generate contrasting views of gut bacterial communities associated with diet, health and obesity.

# publications[].label
Influence of whole-wheat consumption on fecal microbial ecology of obese diabetic mice

# publications[].label
Red Sweet Cherry Ameliorates Inflammation in Obese Diabetic (db/db) Mice

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Red wine polyphenolics reduce the expression of inflammation markers in human colon-derived CCD-18Co myofibroblast cells: potential role of microRNA-126.

# publications[].label
Assessing Cheese Whey Components for Their Potential to Improve Intestinal Health (P06-097-19)

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Carbohydrate-Free Peach (Prunus persica) and Plum (Prunus domestica) Juice Affects Fecal Microbial Ecology in an Obese Animal Model (vol 9, e101723, 2014)

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Assessment of Whey Functional Ingredients in the Modulation of Fecal Bacteria from Donors with Chronic Gastrointestinal Disease In Vitro

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Assessing Cheese Whey Components for Their Potential to Improve Intestinal Health (P06-097-19)

# publications[].label
Caffeine free polyphenolic extracts from Yaupon holly (Ilex vomitoria) have chemopreventive potential and reduce the expression of inflammatory genes in non-cancer human myofibroblast (CCD-18) cells

# publications[].label
Phenolics in Peaches and Plums Preferentially Suppress the Growth of Estrogen-Independent MDA-MB-435 Breast Cancer Cells

# publications[].publisher
International Society for Horticultural Science (ISHS)

# publications[].label
Protective effects of standardized pomegranate (Punica granatum L.) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts.

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Resveratrol and quercetin target microRNA 27a in their anticancer effects in colon cancer cells

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Anti-lipidaemic and anti-inflammatory effect of acai (Euterpe oleracea Martius) polyphenols on 3T3-L1 adipocytes

# publications[].label
Quinoa (Chenopodium Quinoa) Peptides Protect Human Umbilical Vein Endothelial Cells (HUVEC) Against Risk Markers For Cardiovascular Disease (CVD)

# publications[].label
Micropropagation effect on the anti-carcinogenic activitiy of polyphenolics from Mexican oregano (Poliomintha glabrescens Gray) in human colon cancer cells HT-29.

# publications[].label
Dark sweet cherry (Prunus avium) phenolics enriched in anthocyanins exhibit enhanced activity against the most aggressive breast cancer subtypes without toxicity to normal breast cells

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Anti-obesity and Anti-inflammatory Effect of Acai Polyphenols in 3T3-L1 Adipocytes

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Calotropis procera Selectively Impaired the 4T1 Breast Cancer Cells Growth by Preferentially Blocking Akt/mTOR Signaling

# publications[].label
Apple consumption is associated with a distinctive microbiota, proteomics and metabolomics profile in the gut of Dawley Sprague rats fed a high-fat diet.

# publications[].label
Dark Sweet Cherry phenolics as Dietary Chemopreventive/therapeutic Compounds for Aggressive Breast Cancer Cell Growth with No Toxicity to Normal Breast Cells (FS13-03-19)

# publications[].label
Polyphenolics from peach (Prunus persica var. Rich Lady) inhibit tumor growth and metastasis of MDA-MB-435 breast cancer cells in vivo.

# publications[].label
Carbohydrate-Free Peach (Prunus persica) and Plum (Prunus salicina) [corrected] Juice Affects Fecal Microbial Ecology in an Obese Animal Model.

# publications[].label
Assessment of Whey Functional Ingredients in the Modulation of Fecal Bacteria from Donors with Chronic Gastrointestinal Disease In Vitro

# publications[].label
Plum polyphenolics decrease oxidative stress and inflammation in vascular endothelial cells

# publications[].label
The Effect of Gluten-Free Diet on Health and the Gut Microbiota Cannot Be Extrapolated from One Population to Others.

# publications[].label
The role of dietary polyphenols in osteosarcoma: A possible clue about the molecular mechanisms involved in a process that is just in its infancy.

# publications[].label
Dark Sweet Cherry (Prunus Avium L.) Phenolics Induce Apoptosis and Inhibit Invasion on Breast Cancer MDA-MB-453 Through MAPK-dependent and Independent Pathways (P05-007-19)

# publications[].label
Plum polyphenolics prevent adipogenesis, inflammation and obesity-induced metabolic disorders in obese Zucker rats

# publications[].label
Curcuminoids from tumeric (Curcuma longa) target microRNA148 and microRNA146 in their anti-inflammatory effects in non-cancer colon cells

# publications[].label
Molecular exploration of fecal microbiome in quinoa-supplemented obese mice.

# publications[].label
Aged American Cheddar Cheese as Source of Protein Derived Compounds that Modulate Obese Mice Fecal Bacteria and Colon Inflammation In Vitro

# publications[].label
Influence of Daily Dark Sweet Cherry (DSC) Juice Consumption for 4 Weeks in Obesity-Associated Inflammation and Cognitive Decline: A Randomized Controlled Trial

# publications[].label
Red raspberry (Rubus idaeus L.) intake decreases oxidative stress in obese diabetic (db/db) mice.

# publications[].label
Standardized curcuminoid extract (Curcuma longa l.) decreases gene expression related to inflammation and interacts with associated microRNAs in human umbilical vein endothelial cells (HUVEC).

# publications[].label
Anthocyanins Reduce Cell Invasion and Migration through Akt/mTOR Downregulation and Apoptosis Activation in Triple-Negative Breast Cancer Cells: A Systematic Review and Meta-Analysis.

# publications[].label
Effects of Raspberry Dietary Supplementation on Risk Biomarkers of Diabetes Related Complications and Heart Disease in Diabetic Mice

# publications[].label
Effect of different fractions of chia (Salvia hispanica L.) on glucose metabolism, in vivo and in vitro

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Quinoa as source of bioactive compounds with potential for intestinal health (647.18)

# publications[].label
Optimized methodology for the simultaneous extraction of glucosinolates, phenolic compounds and antioxidant capacity from maca (Lepidium meyenii)

# streetAddress
Texas A&M Agrilife Research; Food Science and Technology; 2253 TAMUS