# overview
Our primary research goals are to develop and apply novel tools for studying DNA damage in the context of chromatin and to explore new avenues for RNA-based therapeutics and diagnostics. By combining expertise in chemical biology, molecular biology, and molecular evolution, our lab addresses challenges associated with studying and targeting noncoding RNAs from a unique perspective. In addition, we utilize modern chemical biology techniques to develop designer chromatin systems for studying DNA damage. We are seeking motivated individuals who wish to gain experience in chemical biology, molecular biology, and in vitro evolution techniques.

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
DNA-(Apurinic Or Apyrimidinic Site) Lyase

# keywords[]
DNA-(Apurinic Or Apyrimidinic Site) Lyase

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1.1 Normal Biological Development And Functioning

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# educationAndTraining[].organization.label
University of Minnesota - (Minneapolis, Minnesota, United States)

# educationAndTraining[].organization.label
Johns Hopkins University - (Baltimore, Maryland, United States)

# publications[].label
Reversible chromatin condensation by the DNA repair and demethylation factor thymine DNA glycosylase.

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Assembly of long L-RNA by native RNA ligation.

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Probing DNA interstrand cross-link formation by an oxidized abasic site using nonnative nucleotides.

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Self-promoted DNA interstrand cross-link formation by an abasic site.

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Synthetic evolving systems that implement a user-specified genetic code of arbitrary design.

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Histone modification via rapid cleavage of C4'-oxidized abasic sites in nucleosome core particles.

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ORGN 114-Interstrand cross-link (ICL) formation by the C4'-oxidized abasic site in DNA

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Targeting a conserved structural element from the SARS-CoV-2 genome using l-DNA aptamers.

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TOXI 85-Scope and mechanism of formation of interstrand crosslinks that give rise to double strand breaks upon nucleotide excision repair

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RNA-Catalyzed Cross-Chiral Polymerization of RNA

# publications[].label
Acetylation of the histone H3 tail domain regulates base excision repair on higher-order chromatin structures.

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Rapid DNA-protein cross-linking and strand scission by an abasic site in a nucleosome core particle.

# publications[].publisher
Proceedings of the National Academy of Sciences

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Polycomb repressive complex 2 binds RNA irrespective of stereochemistry

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Integration of chemically modified nucleotides with DNA strand displacement reactions for applications in living systems.

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Excision of a lyase-resistant oxidized abasic lesion from DNA.

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Nuclease Hydrolysis Does Not Drive the Rapid Signaling Decay of DNA Aptamer-Based Electrochemical Sensors in Biological Fluids.

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Binding of a structured D-RNA molecule by an L-RNA aptamer.

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Double-strand break formation during nucleotide excision repair of a DNA interstrand cross-link.

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Correction: The influence of chirality on the behavior of oligonucleotides inside cells: revealing the potent cytotoxicity of G-rich l-RNA.

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Thymine DNA glycosylase is an RNA-binding protein with high selectivity for G-rich sequences.

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Cover Feature: An lRNA Aptamer with Expanded Chemical Functionality that Inhibits MicroRNA Biogenesis (ChemBioChem 18/2017)

# publications[].label
Os(II/III) complex supports pH-insensitive electrochemical DNA-based sensing with superior operational stability than the benchmark methylene blue reporter.

# publications[].label
Plug-and-Play Approach for Preparing Chromatin Containing Site-Specific DNA Modifications: The Influence of Chromatin Structure on Base Excision Repair.

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Inverse In Vitro Selection Enables Comprehensive Analysis of Cross-Chiral L-Aptamer Interactions.

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Human Cyclophilin B Nuclease Activity Revealed via Nucleic Acid-Based Electrochemical Sensors.

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Chromatin Structure and the Pioneering Transcription Factor FOXA1 Regulate TDG-Mediated Removal of 5‑Formylcytosine from DNA

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Kinetics of heterochiral strand displacement from PNA-DNA heteroduplexes.

# publications[].label
Nucleosome core particle-catalyzed strand scission at abasic sites.

# publications[].label
Scope and mechanism of interstrand cross-link formation by the C4'-oxidized abasic site.

# publications[].label
Synthesis and evolution of genetically encoded cross-replicating ribozymes

# publications[].label
Specific Inhibition of MicroRNA Processing Using L-RNA Aptamers.

# publications[].label
In vitro selection of l-DNA aptamers that bind a structured d-RNA molecule

# publications[].label
Thymine DNA glycosylase mediates chromatin phase separation in a DNA methylationdependent manner

# publications[].label
Chimeric d/l-DNA Probes of Base Excision Repair Enable Real-Time Monitoring of Thymine DNA Glycosylase Activity in Live Cells.

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Direct Comparison of d‑DNA and l‑DNA Strand-Displacement Reactions in Living Mammalian Cells

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Photochemical generation and reactivity of the 5,6-dihydrouridin-6-yl radical.

# publications[].label
Mechanistic studies on histone catalyzed cleavage of apyrimidinic/apurinic sites in nucleosome core particles.

# publications[].label
Rapid DNA strand scission at a basic sites in nucleosome core particles

# publications[].label
The influence of chirality on the behavior of oligonucleotides inside cells: revealing the potent cytotoxicity of G-rich l-RNA.

# publications[].label
Scope and Mechanism of Formation of Interstrand Cross-Links That Give Rise to Double Strand Breaks upon Nucleotide Excision Repair

# publications[].label
A Mirror Image Fluorogenic Aptamer Sensor for Live-Cell Imaging of MicroRNAs

# publications[].label
Correction to "Nuclease Hydrolysis Does Not Drive the Rapid Signaling Decay of DNA Aptamer-Based Electrochemical Sensors in Biological Fluids".

# publications[].label
l-DNA-Based Catalytic Hairpin Assembly Circuit.

# publications[].label
An l‐RNA Aptamer with Expanded Chemical Functionality that Inhibits MicroRNA Biogenesis

# researcherOn[].label
Mirror image DNA circuitry for complex microRNA analysis in live cells

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of BioMedical Imaging and BioEngineering

# researcherOn[].label
Mirror Image Aptamers: Next Generation RNA-Binding Reagents for Basic Research and Therapeutic Applications

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of General Medical Science

# researcherOn[].label
CLAP-seq: An Aptamer-Based Platform for Transcriptome-Wide Mapping of RNA Modifications

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-Eunice Kennedy Shriver National Institute of Child Health & Human Development

# streetAddress
Texas A&M University; Chemistry; 3255 TAMU