# positions[].organizations[].parent[].label
College of Veterinary Medicine and Biomedical Sciences

# overview
My laboratory is interested in the development of vaccines against select agents focusing onBrucellaÂ spp. We incorporate the microencapsulation technology to increase safety and efficacy of vaccines for human and animal use. These studies are principally targeted on the understanding of the response to infection by the host and elucidating the correlates of protective immunity elicited by the encapsulated and non-encapsulated vaccines.

# keywords[]
Platelet Endothelial Cell Adhesion Molecule-1

# keywords[]
Receptors, Tumor Necrosis Factor, Type Ii

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# educationAndTraining[].organization.label
University of La Salle - (Bogotá, Colombia)

# awardsAndHonors[].label
Scialog: Mitigating Zoonotic Threats Fellows

# publications[].label
Human brucellosis: Widespread information deficiency hinders an understanding of global disease frequency.

# publications[].label
Identification of Brucella spp. in feral swine (Sus scrofa) at abattoirs in Texas, USA.

# publications[].label
Characterization of Brucella canis infection in mice.

# publications[].label
Primary and memory immune responses against rough Brucella canis are less robust compared to smooth B. abortus and B. melitensis following intratracheal infection in mice.

# publications[].label
Production of recombinant immunogenic proteins to create multivalent subunit vaccines for zoonotic diseases

# publications[].label
Evaluation of the Efficacy of the Brucella canis RM6/66 Delta vjbR Vaccine Candidate for Protection against B. canis Infection in Mice

# publications[].label
Characterization of epididymal and testicular histologic lesions and use of immunohistochemistry and PCR on formalin-fixed tissues to detect Brucella canis in male dogs.

# publications[].label
A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis.

# publications[].label
Reticulo-ruminal milk accumulation (Ruminal drinking) in five pre-ruminant white-tailed deer (Odocoileus virginianus) in Texas

# publications[].label
Interaction of Brucella abortus with Osteoclasts: a Step toward Understanding Osteoarticular Brucellosis and Vaccine Safety.

# publications[].label
Evaluation of the safety profile of the vaccine candidate Brucella melitensis 16MvjbR strain in goats.

# publications[].label
German shepherd dog with vomiting, retching and tachypnoea

# publications[].label
Porcine Babesiosis Caused by Babesia sp. Suis in a Pot-Bellied Pig in South Africa.

# publications[].label
Enhanced immune response of red deer (Cervus elaphus) to live rb51 vaccine strain using composite microspheres.

# publications[].label
Polymeric particles in vaccine delivery.

# publications[].label
AgSecure Africa ProgrammeTM: ABlended Training Approach for Africa.

# publications[].label
Extended safety and efficacy studies of the attenuated Brucella vaccine candidates 16 M(Delta)vjbR and S19(Delta)vjbR in the immunocompromised IRF-1-/- mouse model.

# publications[].label
The NOD-scid IL2rnull Mouse Model Is Suitable for the Study of Osteoarticular Brucellosis and Vaccine Safety.

# publications[].label
The Brucella abortus S19 DeltavjbR live vaccine candidate is safer than S19 and confers protection against wild-type challenge in BALB/c mice when delivered in a sustained-release vehicle.

# publications[].label
Immersion Foot Syndrome in 6 Equids Exposed to Hurricane Floodwaters.

# publications[].label
Immunization with a single dose of a microencapsulated Brucella melitensis mutant enhances protection against wild-type challenge.

# publications[].label
Intratracheal inoculation results in Brucella-associated reproductive disease in male mouse and guinea pig models of infection.

# publications[].label
Peripheral neuroblastomas in dogs: a case series.

# publications[].label
Oral vaccination with microencapsuled strain 19 vaccine confers enhanced protection against Brucella abortus strain 2308 challenge in red deer (Cervus elaphus elaphus).

# publications[].label
Vaccine Candidate Brucella melitensis 16MvjbR Is Safe in a Pregnant Sheep Model and Confers Protection.

# publications[].label
A fibrous band associated with the non-coronary aortic valve cusp in a dog.

# publications[].label
A Neglected Animal Model for a Neglected Disease: Guinea Pigs and the Search for an Improved Animal Model for Human Brucellosis.

# publications[].label
Seropositivity and risk factors for Brucella in dairy cows in Asella and Bishoftu towns, Oromia Regional State, Ethiopia

# publications[].label
Correction: Characterization of an intratracheal aerosol challenge model of Brucella melitensis in guinea pigs.

# publications[].label
The Case for Live Attenuated Vaccines against the Neglected Zoonotic Diseases Brucellosis and Bovine Tuberculosis.

# publications[].label
Evaluation of the Efficacy of the Brucella canis RM6/66 vjbR Vaccine Candidate for Protection against B. canis Infection in Mice.

# publications[].label
Materials composed of the Drosophila Hox protein Ultrabithorax are biocompatible and non-immunogenic

# publications[].label
Characterization of an intratracheal aerosol challenge model of Brucella melitensis in guinea pigs.

# publications[].label
Protective efficacy and safety of Brucella melitensis 16MmucR against intraperitoneal and aerosol challenge in BALB/c mice.

# publications[].label
Immunomodulation of Theiler's virus-induced demyelination [TVID] using encapsulated ovine interferon-tau [IFNT]: The novel administration of a novel type IIFN in an animal model of multiple sclerosis [MS]

# publications[].label
Caprine brucellosis: A historically neglected disease with significant impact on public health.

# publications[].label
Epithelioid haemangiosarcoma in the ocular tissue of horses.

# publications[].label
Protective Efficacy and Safety of Brucella melitensis 16MmucR against Intraperitoneal and Aerosol Challenge in BALB/c Mice (vol 79, pg 3653, 2011)

# publications[].label
Bench to Shop: An Interdisciplinary Training Program for Transitioning of Transboundary Animal Disease Research to Commercialization.

# publications[].label
Brucellosis in the Middle East: Current situation and a pathway forward.

# publications[].label
Vaccine safety studies of Brucella abortus S19 and S19vjbR in pregnant swine.

# publications[].label
Scoping review of brucellosis in Cameroon: Where do we stand, and where are we going?

# publications[].label
Brucella abortus and Pregnancy in Mice: Impact of Chronic Infection on Fertility and the Role of Regulatory T Cells in Tissue Colonization.

# publications[].label
Materials composed of the Drosophila Hox protein Ultrabithorax are biocompatible and nonimmunogenic.

# publications[].label
Brucellosis remains a neglected disease in the developing world: a call for interdisciplinary action.

# publications[].label
Building the Evidence Base for the Prevention of Raw Milk-Acquired Brucellosis: A Systematic Review.

# publications[].label
Sclerosing cholangitis in baboons (Papio spp) resembling primary sclerosing cholangitis of humans.

# publications[].label
Aerosol infection of BALB/c mice with Brucella melitensis and Brucella abortus and protective efficacy against aerosol challenge.

# publications[].label
Intratracheal Inoculation with Brucella melitensis in the Pregnant Guinea Pig Is an Improved Model for Reproductive Pathogenesis and Vaccine Studies.

# publications[].label
MELANOMA IN GOLDEN AND KING WILDEBEESTS ( CONNOCHAETES TAURINUS).

# publications[].publisher
American Association of Zoo Veterinarians

# publications[].label
Aerosol-induced brucellosis increases TLR-2 expression and increased complexity in the microanatomy of astroglia in rhesus macaques.

# publications[].label
Human Brucellosis and Adverse Pregnancy Outcomes.

# publications[].label
Brucellosis in Colombia: Current Status and Challenges in the Control of an Endemic Disease.

# publications[].label
Brucellosis: the case for live, attenuated vaccines.

# publications[].label
Isolation and Identification of Brucella Species from Dairy Cattle by Biochemical Tests: The First Report from Ethiopia

# publications[].label
Brucellosis in Dogs and Public Health Risk.

# publications[].publisher
Centers for Disease Control and Prevention (CDC)

# researcherOn[].label
A Collaborative Interdisciplinary Approach to an Endemic Zoonotic Disease in Cameroon: Enhancing Capabilities to Prevent, Detect, and Respond to Brucellosis

# researcherOn[].awardedBy.label
United States Department of Defense - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.label
United States Department of Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
The use of the pregnant sheep model in vaccine safety studies against brucellosis

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.label
United States Department of Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
The Use of Goat Model to Test Human Brucella Vaccines in Argentina

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Use of the goat model to test human Brucella vaccines in Argentina

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.label
United States Department of Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
From the Bench to the Shop: Creation and Implementation of a Scientific Business Development Management Program to Transition High Consequence Livestock Disease Research and Development Technology for Commercialization

# researcherOn[].awardedBy.label
United States Department of Homeland Security - (New York, New York, United States)

# streetAddress
Texas A&M University; Vet Med Pathobiology; 4467 TAMU

# organizations[]
College of Veterinary Medicine and Biomedical Sciences

# organizations[]
"College of Veterinary Medicine and Biomedical Sciences"@en-US

# schools[]
College of Veterinary Medicine and Biomedical Sciences

# schools[]
"College of Veterinary Medicine and Biomedical Sciences"@en-US

# etdChairOf[].label
Hensel, Martha (2020-08). INTRATRACHEAL INOCULATION OF THE GUINEA PIG IS AN IMPROVED MODEL FOR BRUCELLOSIS. Doctoral Dissertation.

# etdChairOf[].label
Adetunji, Shakirat Adeola (2020-05). THE ROLE OF REGULATORY T CELLS IN THE PATHOGENESIS AND PERSISTENCE OF BRUCELLA ABORTUS IN THE REPRODUCTIVE SYSTEM OF FEMALE MICE. Doctoral Dissertation.

# etdChairOf[].label
Zriba, Slim (2017-05). Towards the Development of an Improved Vaccine for Swine Against Brucellosis. Master's Thesis.

# etdChairOf[].label
Khalaf, Omar (2019-12). Towards the Understanding of Brucella-Induced  Arthritis for Vaccine Development. Doctoral Dissertation.